RU2015118886A - A method of producing nanocapsules of rosuvastatin in konjac gum - Google Patents

A method of producing nanocapsules of rosuvastatin in konjac gum Download PDF

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Publication number
RU2015118886A
RU2015118886A RU2015118886A RU2015118886A RU2015118886A RU 2015118886 A RU2015118886 A RU 2015118886A RU 2015118886 A RU2015118886 A RU 2015118886A RU 2015118886 A RU2015118886 A RU 2015118886A RU 2015118886 A RU2015118886 A RU 2015118886A
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RU
Russia
Prior art keywords
rosuvastatin
konjac gum
nanocapsules
producing
producing nanocapsules
Prior art date
Application number
RU2015118886A
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Russian (ru)
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RU2605847C2 (en
Inventor
Татьяна Алексеевна Денисюк
Александр Александрович Кролевец
Карен Ванушович Сароян
Михаил Владимирович Ситник
Полина Игоревна Лосенок
Михаил Владимирович Покровский
Илья Александрович Богачев
Валентина Валерьевна Автина
Александр Петрович Григорьенко
Original Assignee
Татьяна Алексеевна Денисюк
Александр Александрович Кролевец
Карен Ванушович Сароян
Михаил Владимирович Ситник
Полина Игоревна Лосенок
Михаил Владимирович Покровский
Илья Александрович Богачев
Валентина Валерьевна Автина
Александр Петрович Григорьенко
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Татьяна Алексеевна Денисюк, Александр Александрович Кролевец, Карен Ванушович Сароян, Михаил Владимирович Ситник, Полина Игоревна Лосенок, Михаил Владимирович Покровский, Илья Александрович Богачев, Валентина Валерьевна Автина, Александр Петрович Григорьенко filed Critical Татьяна Алексеевна Денисюк
Priority to RU2015118886/15A priority Critical patent/RU2605847C2/en
Publication of RU2015118886A publication Critical patent/RU2015118886A/en
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Publication of RU2605847C2 publication Critical patent/RU2605847C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Способ получения нанокапсул розувастатина, характеризующийся тем, что розувастатин медленно добавляют в суспензию конжаковой камеди в гексане, в присутствии 0,005 г препарата Е472с при перемешивании 1000 об/мин, при массовом соотношении оболочка:ядро 3:1 или 1:5, затем приливают бензол, полученную суспензию отфильтровывают и сушат при комнатной температуре.A method of producing rosuvastatin nanocapsules, characterized in that rosuvastatin is slowly added to a suspension of konjac gum in hexane, in the presence of 0.005 g of the preparation E472c with stirring 1000 rpm, with a shell: core mass ratio of 3: 1 or 1: 5, then benzene is added, the resulting suspension is filtered and dried at room temperature.

Claims (1)

Способ получения нанокапсул розувастатина, характеризующийся тем, что розувастатин медленно добавляют в суспензию конжаковой камеди в гексане, в присутствии 0,005 г препарата Е472с при перемешивании 1000 об/мин, при массовом соотношении оболочка:ядро 3:1 или 1:5, затем приливают бензол, полученную суспензию отфильтровывают и сушат при комнатной температуре. A method of producing rosuvastatin nanocapsules, characterized in that rosuvastatin is slowly added to a suspension of konjac gum in hexane, in the presence of 0.005 g of the preparation E472c with stirring 1000 rpm, with a shell: core mass ratio of 3: 1 or 1: 5, then benzene is added, the resulting suspension is filtered and dried at room temperature.
RU2015118886/15A 2015-05-19 2015-05-19 Method of producing nanocapsules of rosuvastatin in konjac gum RU2605847C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2015118886/15A RU2605847C2 (en) 2015-05-19 2015-05-19 Method of producing nanocapsules of rosuvastatin in konjac gum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2015118886/15A RU2605847C2 (en) 2015-05-19 2015-05-19 Method of producing nanocapsules of rosuvastatin in konjac gum

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RU2015118886A true RU2015118886A (en) 2016-12-10
RU2605847C2 RU2605847C2 (en) 2016-12-27

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RU2015118886/15A RU2605847C2 (en) 2015-05-19 2015-05-19 Method of producing nanocapsules of rosuvastatin in konjac gum

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2678973C1 (en) * 2018-04-04 2019-02-05 Александр Александрович Кролевец Method for producing nanocapsules of dry extract of nettle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2134967C1 (en) * 1997-05-30 1999-08-27 Шестаков Константин Алексеевич Method of preparing microcapsulated preparations containing pyrethroid insecticides

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20170520