RU2015114320A - Пептидные антагонисты рецептора 2 вазопрессина - Google Patents
Пептидные антагонисты рецептора 2 вазопрессина Download PDFInfo
- Publication number
- RU2015114320A RU2015114320A RU2015114320A RU2015114320A RU2015114320A RU 2015114320 A RU2015114320 A RU 2015114320A RU 2015114320 A RU2015114320 A RU 2015114320A RU 2015114320 A RU2015114320 A RU 2015114320A RU 2015114320 A RU2015114320 A RU 2015114320A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- amino acid
- protein
- terminal deletion
- acid residues
- Prior art date
Links
- 102000004136 Vasopressin Receptors Human genes 0.000 title claims abstract 3
- 108090000643 Vasopressin Receptors Proteins 0.000 title claims abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 235000018102 proteins Nutrition 0.000 claims abstract 26
- 102000004169 proteins and genes Human genes 0.000 claims abstract 26
- 108090000623 proteins and genes Proteins 0.000 claims abstract 26
- 125000000539 amino acid group Chemical group 0.000 claims abstract 10
- 238000012217 deletion Methods 0.000 claims abstract 10
- 230000037430 deletion Effects 0.000 claims abstract 10
- 150000001413 amino acids Chemical group 0.000 claims abstract 8
- 201000010099 disease Diseases 0.000 claims abstract 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract 5
- 210000004899 c-terminal region Anatomy 0.000 claims abstract 5
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims abstract 4
- 238000003745 diagnosis Methods 0.000 claims abstract 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000004471 Glycine Substances 0.000 claims abstract 3
- 235000001014 amino acid Nutrition 0.000 claims abstract 3
- 229940024606 amino acid Drugs 0.000 claims abstract 3
- 230000003042 antagnostic effect Effects 0.000 claims abstract 3
- 229960001230 asparagine Drugs 0.000 claims abstract 3
- 235000009582 asparagine Nutrition 0.000 claims abstract 3
- 230000002209 hydrophobic effect Effects 0.000 claims abstract 3
- 210000003734 kidney Anatomy 0.000 claims abstract 3
- 230000007170 pathology Effects 0.000 claims abstract 3
- 230000037361 pathway Effects 0.000 claims abstract 3
- 206010021036 Hyponatraemia Diseases 0.000 claims abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims abstract 2
- 208000007536 Thrombosis Diseases 0.000 claims abstract 2
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims abstract 2
- 201000011510 cancer Diseases 0.000 claims abstract 2
- 208000003611 congenital autoimmune diabetes mellitus Diseases 0.000 claims abstract 2
- 230000003247 decreasing effect Effects 0.000 claims abstract 2
- 238000001727 in vivo Methods 0.000 claims abstract 2
- 230000005764 inhibitory process Effects 0.000 claims abstract 2
- 229960000310 isoleucine Drugs 0.000 claims abstract 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract 2
- 229930182817 methionine Natural products 0.000 claims abstract 2
- 230000002988 nephrogenic effect Effects 0.000 claims abstract 2
- 230000001575 pathological effect Effects 0.000 claims abstract 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims abstract 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims abstract 2
- 208000011580 syndromic disease Diseases 0.000 claims abstract 2
- 210000002700 urine Anatomy 0.000 claims abstract 2
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306120.2A EP2708235A1 (en) | 2012-09-17 | 2012-09-17 | Peptide antagonists of the vasopressin-2 receptor |
| EP12306120.2 | 2012-09-17 | ||
| PCT/IB2013/058615 WO2014041526A1 (en) | 2012-09-17 | 2013-09-17 | Peptide antagonists of the vasopressin-2 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015114320A true RU2015114320A (ru) | 2016-11-10 |
Family
ID=46963639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015114320A RU2015114320A (ru) | 2012-09-17 | 2013-09-17 | Пептидные антагонисты рецептора 2 вазопрессина |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9631001B2 (enExample) |
| EP (2) | EP2708235A1 (enExample) |
| JP (1) | JP6392758B2 (enExample) |
| KR (1) | KR102135954B1 (enExample) |
| CN (1) | CN104684574B (enExample) |
| AU (1) | AU2013316700B2 (enExample) |
| BR (1) | BR112015005750B1 (enExample) |
| CA (1) | CA2884361C (enExample) |
| DK (1) | DK2895189T3 (enExample) |
| ES (1) | ES2664747T3 (enExample) |
| MX (1) | MX362664B (enExample) |
| NZ (1) | NZ706202A (enExample) |
| RU (1) | RU2015114320A (enExample) |
| WO (1) | WO2014041526A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021528476A (ja) * | 2018-06-28 | 2021-10-21 | サルアクア ダイアグノスティックス， インコーポレイテッド | ハプトグロビン関連タンパク質と関係する組成物および方法 |
| EP3929209A1 (en) * | 2020-06-24 | 2021-12-29 | Commissariat à l'Energie Atomique et aux Energies Alternatives | Vasopressin-2 receptor antagonist peptides and uses thereof |
| CN115820734B (zh) * | 2022-11-11 | 2024-12-13 | 北京希诺谷生物科技有限公司 | 中枢性尿崩症疾病模型犬的建立方法 |
| CN116425888B (zh) * | 2023-04-24 | 2024-11-05 | 徐州医科大学 | 一种多肽tat-v2r1c及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| WO2007019267A1 (en) | 2005-08-03 | 2007-02-15 | Mineuet Therapeutics Ltd. | MODULATING THE KV1.1 VOLTAGE-GATED POTASSIUM CHANNEL IN T-CELLS FOR REGULATING THE SYNTHESIS AND SECRETION OF TUMOR NECROSIS FACTOR α (TNF-α) AND TREATING HUMAN DISEASES OR INJURIES MEDIATED BY DETRIMENTALLY HIGH OR LOW LEVELS OF TNF-α |
| US8343760B2 (en) * | 2008-06-05 | 2013-01-01 | University Of Maryland, Baltimore | p53 activator peptides |
-
2012
- 2012-09-17 EP EP12306120.2A patent/EP2708235A1/en not_active Withdrawn
-
2013
- 2013-09-17 CA CA2884361A patent/CA2884361C/en active Active
- 2013-09-17 NZ NZ706202A patent/NZ706202A/en unknown
- 2013-09-17 EP EP13801742.1A patent/EP2895189B1/en active Active
- 2013-09-17 ES ES13801742.1T patent/ES2664747T3/es active Active
- 2013-09-17 JP JP2015531678A patent/JP6392758B2/ja active Active
- 2013-09-17 KR KR1020157009903A patent/KR102135954B1/ko active Active
- 2013-09-17 US US14/427,733 patent/US9631001B2/en active Active
- 2013-09-17 RU RU2015114320A patent/RU2015114320A/ru not_active Application Discontinuation
- 2013-09-17 WO PCT/IB2013/058615 patent/WO2014041526A1/en not_active Ceased
- 2013-09-17 BR BR112015005750-0A patent/BR112015005750B1/pt active IP Right Grant
- 2013-09-17 DK DK13801742.1T patent/DK2895189T3/en active
- 2013-09-17 AU AU2013316700A patent/AU2013316700B2/en active Active
- 2013-09-17 CN CN201380048382.9A patent/CN104684574B/zh active Active
- 2013-09-17 MX MX2015003225A patent/MX362664B/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| NZ706202A (en) | 2018-06-29 |
| CN104684574B (zh) | 2018-08-31 |
| MX362664B (es) | 2019-01-31 |
| AU2013316700A1 (en) | 2015-04-09 |
| ES2664747T3 (es) | 2018-04-23 |
| WO2014041526A1 (en) | 2014-03-20 |
| AU2013316700B2 (en) | 2017-10-12 |
| EP2708235A1 (en) | 2014-03-19 |
| EP2895189B1 (en) | 2018-01-10 |
| CA2884361C (en) | 2022-03-22 |
| BR112015005750A8 (pt) | 2018-04-17 |
| KR102135954B1 (ko) | 2020-07-21 |
| JP6392758B2 (ja) | 2018-09-19 |
| EP2895189A1 (en) | 2015-07-22 |
| KR20150070172A (ko) | 2015-06-24 |
| BR112015005750B1 (pt) | 2022-08-16 |
| MX2015003225A (es) | 2015-11-16 |
| BR112015005750A2 (pt) | 2017-12-12 |
| CA2884361A1 (en) | 2014-03-20 |
| CN104684574A (zh) | 2015-06-03 |
| DK2895189T3 (en) | 2018-04-16 |
| JP2016500001A (ja) | 2016-01-07 |
| US9631001B2 (en) | 2017-04-25 |
| US20150252086A1 (en) | 2015-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20160919 |