RU2014108478A - Клеточная композиция, фармацевтическая композиция, набор и способ лечения дегенеративного заболевания сетчатки глаза (варианты) - Google Patents
Клеточная композиция, фармацевтическая композиция, набор и способ лечения дегенеративного заболевания сетчатки глаза (варианты) Download PDFInfo
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- RU2014108478A RU2014108478A RU2014108478/10A RU2014108478A RU2014108478A RU 2014108478 A RU2014108478 A RU 2014108478A RU 2014108478/10 A RU2014108478/10 A RU 2014108478/10A RU 2014108478 A RU2014108478 A RU 2014108478A RU 2014108478 A RU2014108478 A RU 2014108478A
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- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims abstract 6
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- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims abstract 6
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- MDWJZBVEVLTXDE-UHFFFAOYSA-N 2-methyl-1h-indol-5-ol Chemical compound OC1=CC=C2NC(C)=CC2=C1 MDWJZBVEVLTXDE-UHFFFAOYSA-N 0.000 claims abstract 3
- GOVXKUCVZUROAN-UHFFFAOYSA-N 3-ethyl-1h-indole Chemical compound C1=CC=C2C(CC)=CNC2=C1 GOVXKUCVZUROAN-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims abstract 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims abstract 3
- FABQUVYDAXWUQP-UHFFFAOYSA-N N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine Chemical compound COC1=CC=CC(C=2N=C(N)N=C(NCC=3C=C4OCOC4=CC=3)C=2)=C1 FABQUVYDAXWUQP-UHFFFAOYSA-N 0.000 claims abstract 3
- 102000001708 Protein Isoforms Human genes 0.000 claims abstract 3
- 108010029485 Protein Isoforms Proteins 0.000 claims abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 3
- 230000007850 degeneration Effects 0.000 claims 9
- 208000002780 macular degeneration Diseases 0.000 claims 9
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- 239000002243 precursor Substances 0.000 claims 4
- 208000002177 Cataract Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 3
- 208000001140 Night Blindness Diseases 0.000 claims 3
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 3
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- 208000027073 Stargardt disease Diseases 0.000 claims 3
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 230000007170 pathology Effects 0.000 claims 3
- 125000006288 3,5-difluorobenzyl group Chemical group [H]C1=C(F)C([H])=C(C([H])=C1F)C([H])([H])* 0.000 claims 2
- BHFFSIFXFHJJNJ-UHFFFAOYSA-N 5-(benzenesulfonyl)-n-[3-(dimethylamino)propyl]-2-ethylbenzenesulfonamide Chemical compound C1=C(S(=O)(=O)NCCCN(C)C)C(CC)=CC=C1S(=O)(=O)C1=CC=CC=C1 BHFFSIFXFHJJNJ-UHFFFAOYSA-N 0.000 claims 2
- 241000508725 Elymus repens Species 0.000 claims 2
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims 2
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
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- 239000003937 drug carrier Substances 0.000 claims 2
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- 201000003533 Leber congenital amaurosis Diseases 0.000 claims 1
- 208000014769 Usher Syndromes Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
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- 239000000790 retinal pigment Substances 0.000 claims 1
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- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- XTVTWYSUSYRBQW-RGURZIINSA-N OC[C@H](Cc1c[nH]cn1)NC1N=CC=CN1 Chemical compound OC[C@H](Cc1c[nH]cn1)NC1N=CC=CN1 XTVTWYSUSYRBQW-RGURZIINSA-N 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P27/06—Antiglaucoma agents or miotics
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11176713A EP2554662A1 (en) | 2011-08-05 | 2011-08-05 | Methods of treatment of retinal degeneration diseases |
| EP11176713.3 | 2011-08-05 | ||
| PCT/EP2012/065327 WO2013020945A1 (en) | 2011-08-05 | 2012-08-06 | Methods of treatment of retinal degeneration diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014108478A true RU2014108478A (ru) | 2015-09-10 |
Family
ID=46826437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014108478/10A RU2014108478A (ru) | 2011-08-05 | 2012-08-06 | Клеточная композиция, фармацевтическая композиция, набор и способ лечения дегенеративного заболевания сетчатки глаза (варианты) |
Country Status (15)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140071455A (ko) * | 2011-09-29 | 2014-06-11 | 더 프로보스트, 펠로우스, 파운데이션 스콜라스, 앤드 디 아더 멤버스 오브 보오드 오브 더 칼리지 오브 더 홀리 앤드 언디바이디드 트리니티 오브 퀸 엘리자베스 니어 더블린 | 망막 변성 병태의 치료를 위한 조성물 및 방법 |
| WO2015107738A1 (ja) | 2014-01-17 | 2015-07-23 | 住友化学株式会社 | 毛様体周縁部幹細胞の製造方法 |
| SG10201913430VA (en) * | 2014-09-16 | 2020-03-30 | Genzyme Corp | Adeno-associated viral vectors for treating myocilin (myoc) glaucoma |
| RU2578526C1 (ru) * | 2014-12-25 | 2016-03-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ получения органной культуры хороидально-пигментного комплекса из глаза взрослого донора-трупа |
| RU2569481C1 (ru) * | 2014-12-25 | 2015-11-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ получения культуры клеток ретинального пигментного эпителия из глаза взрослого донора-трупа |
| KR101779932B1 (ko) * | 2015-09-15 | 2017-09-21 | 주식회사 스템랩 | 나노그(Nanog)를 도입한 양수 내 태아 유래 중간엽 줄기세포를 이용한 육모 촉진용 조성물의 제조방법 |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| KR101674622B1 (ko) * | 2016-07-07 | 2016-11-09 | 국민대학교산학협력단 | 세스퀴테르펜 유도체의 신규한 용도 |
| AU2017312499B2 (en) * | 2016-08-19 | 2023-02-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selective estrogen-receptor modulators (SERMs) confer protection against photoreceptor degeneration |
| US11180537B2 (en) * | 2016-11-06 | 2021-11-23 | Nancoscope Technologies LLC | Optogenetic modulation by Multi-Characteristic Opsins for vision restoration and other applications |
| EP3616120B1 (en) | 2017-04-27 | 2024-09-04 | Retinascan Limited | System and method for automated funduscopic image analysis |
| TWI768043B (zh) | 2017-05-18 | 2022-06-21 | 瑞士商愛杜西亞製藥有限公司 | N-取代吲哚衍生物 |
| EP3625227B1 (en) | 2017-05-18 | 2022-09-14 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as pge2 receptor modulators |
| SI3625222T1 (sl) | 2017-05-18 | 2021-11-30 | Idorsia Pharmaceuticals Ltd | Derivati fenila kot modulatorji receptorja pge2 |
| WO2018210992A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
| AR111808A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| US20210139844A1 (en) * | 2017-06-15 | 2021-05-13 | University Of North Texas Health Science Center | Reprogramming fibroblasts to retinal cells |
| JP7299889B2 (ja) * | 2017-08-20 | 2023-06-28 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア | 緑内障を治療するためのＷｎｔ５ａの調節 |
| EP3773638A4 (en) * | 2018-04-06 | 2022-04-06 | Icahn School of Medicine at Mount Sinai | COMPOSITIONS AND METHODS FOR TREATING LOSS OF VISION BY GENERATION OF ROD PHOTORECEPTORS FROM MÜLLER GLIAL CELLS |
| US20230090462A1 (en) * | 2019-03-15 | 2023-03-23 | The Schepens Eye Research Institute, Inc. | Isolation, enrichment and expansion of cone progenitor cells and uses thereof |
| CN110706164A (zh) * | 2019-09-03 | 2020-01-17 | 北京爱博同心医学科技有限公司 | 基于增强现实的管状视野图像变形显示方法及眼镜 |
| US20230034053A1 (en) * | 2019-09-25 | 2023-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Metabolic rescue of retinal degeneration |
| KR20210119766A (ko) * | 2020-03-25 | 2021-10-06 | 서울대학교병원 | 인간 배아줄기세포 유래 중간엽 줄기세포를 포함하는 망막색소변성의 예방 또는 치료용 약학적 조성물 |
| KR102655748B1 (ko) * | 2023-06-08 | 2024-04-05 | 충북대학교 산학협력단 | 고포도당 조건에서의 중간엽 줄기세포의 생존율을 증가시키는 방법 |
| KR102655735B1 (ko) * | 2023-06-09 | 2024-04-05 | 충북대학교 산학협력단 | 당뇨성 망막병증의 예방 및 치료를 위한 타크로리무스 전처리 줄기세포 |
| WO2025229177A1 (en) | 2024-05-02 | 2025-11-06 | Idorsia Pharmaceuticals Ltd | Crystalline forms of an n-substituted indole derivative |
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| US6128654A (en) | 1997-02-14 | 2000-10-03 | Advanced Micro Devices, Inc. | Method and apparatus for transmitting multiple copies by replicating data identifiers |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
| KR100711817B1 (ko) | 1999-12-17 | 2007-05-02 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 글리코겐 신타아제 키나제 3의 2고리 저해제 |
| ATE384704T1 (de) | 1999-12-17 | 2008-02-15 | Novartis Vaccines & Diagnostic | Pyrazin-basierte hemmer der glycogen-synthase- kinase 3 |
| AU2001295026B2 (en) | 2000-09-06 | 2008-04-03 | Novartis Vaccines And Diagnostics, Inc. | Inhibitors of glycogen synthase kinase 3 |
| DE60132937T2 (de) | 2000-09-11 | 2009-02-12 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zur Herstellung von Benzimidazol-2-yl -Chinolinonderivaten |
| DE60214703T2 (de) | 2001-06-01 | 2007-09-13 | Vertex Pharmaceuticals Inc., Cambridge | Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen |
| MXPA04007697A (es) | 2002-02-06 | 2004-11-10 | Vertex Pharma | Compuestos de heteroarilo utiles como inhibidores de gsk-3. |
| JP2005525362A (ja) | 2002-03-01 | 2005-08-25 | カイロン コーポレイション | 虚血の処置のための方法および組成物 |
| US20050129665A1 (en) * | 2002-07-25 | 2005-06-16 | Martin Friedlander | Isolated lineage negative hematopoietic stem cells and methods of treatment therewith |
| US7838290B2 (en) * | 2002-07-25 | 2010-11-23 | The Scripps Research Institute | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| JP2006501243A (ja) | 2002-08-23 | 2006-01-12 | カイロン コーポレイション | グリコーゲンシンターゼキナーゼ３のピロールベースのインヒビター |
| AU2003282976A1 (en) | 2002-10-21 | 2004-05-13 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| CA2524063C (en) * | 2003-05-02 | 2015-02-17 | The Scripps Research Institute | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| WO2005039485A2 (en) | 2003-08-13 | 2005-05-06 | Chiron Corporation | Gsk-3 inhibitors and uses thereof |
| EP1802199A4 (en) * | 2004-09-03 | 2008-08-27 | Scripps Research Inst | HEMATOPOIETIC STEM CELLS OF ISOLATED NEGATIVE LINES AND METHODS OF TREATMENT THEREOF |
| US7850960B2 (en) * | 2004-12-30 | 2010-12-14 | University Of Washington | Methods for regulation of stem cells |
| PL1935976T3 (pl) | 2005-02-24 | 2012-07-31 | Scripps Research Inst | Transfekowane komórki mieloidopodobne do leczenia retinopatii wcześniaków i pokrewnych chorób |
| US20070231306A1 (en) * | 2005-02-24 | 2007-10-04 | The Scripps Research Institute | Isolated myeloid-like cell populations and methods of treatment therewith |
| CN101484575B (zh) * | 2005-06-08 | 2013-10-02 | 森托科尔公司 | 用于眼变性的细胞疗法 |
| KR20100035648A (ko) * | 2007-06-15 | 2010-04-05 | 가넷 바이오쎄라퓨틱스 인크. | 체외 배양 및 증식 자기재생성 집락 형성 세포를 이용한 질환 및 장애 치료방법 |
| EP2090649A1 (en) * | 2008-02-13 | 2009-08-19 | Fondazione Telethon | Method for reprogramming differentiated cells |
| GB0816577D0 (en) * | 2008-09-11 | 2008-10-15 | Axordia Ltd | Growth factor |
| EP2486126B1 (en) * | 2009-10-06 | 2017-12-06 | SNU R & DB Foundation | Method for differentiation into retinal cells from stem cells |
-
2011
- 2011-08-05 EP EP11176713A patent/EP2554662A1/en not_active Withdrawn
-
2012
- 2012-08-06 US US14/237,297 patent/US20140199277A1/en not_active Abandoned
- 2012-08-06 SG SG2014008080A patent/SG2014008080A/en unknown
- 2012-08-06 JP JP2014523346A patent/JP2014527407A/ja active Pending
- 2012-08-06 CA CA2844106A patent/CA2844106A1/en not_active Abandoned
- 2012-08-06 KR KR1020147006060A patent/KR20140068936A/ko not_active Withdrawn
- 2012-08-06 RU RU2014108478/10A patent/RU2014108478A/ru not_active Application Discontinuation
- 2012-08-06 AR ARP120102872A patent/AR087471A1/es unknown
- 2012-08-06 WO PCT/EP2012/065327 patent/WO2013020945A1/en not_active Ceased
- 2012-08-06 AU AU2012293681A patent/AU2012293681A1/en not_active Abandoned
- 2012-08-06 CN CN201280049453.2A patent/CN104011203A/zh active Pending
- 2012-08-06 BR BR112014002718A patent/BR112014002718A8/pt not_active IP Right Cessation
- 2012-08-06 MX MX2014001475A patent/MX2014001475A/es not_active Application Discontinuation
- 2012-08-06 EP EP12756386.4A patent/EP2739723A1/en not_active Withdrawn
-
2014
- 2014-02-05 IL IL230830A patent/IL230830A0/en unknown
- 2014-03-05 CO CO14047158A patent/CO7081142A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014001475A (es) | 2014-07-22 |
| US20140199277A1 (en) | 2014-07-17 |
| EP2554662A1 (en) | 2013-02-06 |
| KR20140068936A (ko) | 2014-06-09 |
| NZ621345A (en) | 2015-09-25 |
| AU2012293681A1 (en) | 2014-03-06 |
| WO2013020945A1 (en) | 2013-02-14 |
| CN104011203A (zh) | 2014-08-27 |
| IL230830A0 (en) | 2014-03-31 |
| JP2014527407A (ja) | 2014-10-16 |
| CA2844106A1 (en) | 2013-02-14 |
| AR087471A1 (es) | 2014-03-26 |
| WO2013020945A9 (en) | 2013-04-04 |
| BR112014002718A2 (pt) | 2017-06-13 |
| BR112014002718A8 (pt) | 2017-06-20 |
| CO7081142A2 (es) | 2014-10-10 |
| SG2014008080A (en) | 2014-03-28 |
| EP2739723A1 (en) | 2014-06-11 |
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| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
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