JP2014527407A5 - - Google Patents
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- Publication number
- JP2014527407A5 JP2014527407A5 JP2014523346A JP2014523346A JP2014527407A5 JP 2014527407 A5 JP2014527407 A5 JP 2014527407A5 JP 2014523346 A JP2014523346 A JP 2014523346A JP 2014523346 A JP2014523346 A JP 2014523346A JP 2014527407 A5 JP2014527407 A5 JP 2014527407A5
- Authority
- JP
- Japan
- Prior art keywords
- wnt
- pharmaceutical composition
- cells
- retinal
- catenin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000013814 Wnt Human genes 0.000 claims 20
- 102000015735 Beta-catenin Human genes 0.000 claims 18
- 108060000903 Beta-catenin Proteins 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 14
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 14
- 230000002207 retinal effect Effects 0.000 claims 14
- 208000002780 macular degeneration Diseases 0.000 claims 12
- 230000019491 signal transduction Effects 0.000 claims 11
- 208000015122 neurodegenerative disease Diseases 0.000 claims 9
- 239000003112 inhibitor Substances 0.000 claims 8
- 239000012190 activator Substances 0.000 claims 7
- 230000037361 pathway Effects 0.000 claims 7
- 208000035719 Maculopathy Diseases 0.000 claims 6
- 206010064930 age-related macular degeneration Diseases 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 210000000130 stem cell Anatomy 0.000 claims 6
- 208000002177 Cataract Diseases 0.000 claims 4
- 206010010356 Congenital anomaly Diseases 0.000 claims 4
- 208000036443 AIPL1-related retinopathy Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 3
- 208000032578 Inherited retinal disease Diseases 0.000 claims 3
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims 3
- 208000001140 Night Blindness Diseases 0.000 claims 3
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims 3
- 201000007737 Retinal degeneration Diseases 0.000 claims 3
- 208000032430 Retinal dystrophy Diseases 0.000 claims 3
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 3
- 208000027073 Stargardt disease Diseases 0.000 claims 3
- 208000014769 Usher Syndromes Diseases 0.000 claims 3
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims 3
- 201000006754 cone-rod dystrophy Diseases 0.000 claims 3
- 230000003412 degenerative effect Effects 0.000 claims 3
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 3
- 229960003964 deoxycholic acid Drugs 0.000 claims 3
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 201000006321 fundus dystrophy Diseases 0.000 claims 3
- -1 indan-5-yloxy Chemical group 0.000 claims 3
- 208000017532 inherited retinal dystrophy Diseases 0.000 claims 3
- 230000007170 pathology Effects 0.000 claims 3
- 230000004258 retinal degeneration Effects 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- BHFFSIFXFHJJNJ-UHFFFAOYSA-N 5-(benzenesulfonyl)-n-[3-(dimethylamino)propyl]-2-ethylbenzenesulfonamide Chemical compound C1=C(S(=O)(=O)NCCCN(C)C)C(CC)=CC=C1S(=O)(=O)C1=CC=CC=C1 BHFFSIFXFHJJNJ-UHFFFAOYSA-N 0.000 claims 2
- 206010007747 Cataract congenital Diseases 0.000 claims 2
- 208000033810 Choroidal dystrophy Diseases 0.000 claims 2
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims 2
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 230000005540 biological transmission Effects 0.000 claims 2
- 208000003571 choroideremia Diseases 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000008672 reprogramming Effects 0.000 claims 2
- WKBXGYLBOOBRIK-UHFFFAOYSA-N 2-(3-methoxyphenyl)pyrimidine Chemical compound COC1=CC=CC(C=2N=CC=CN=2)=C1 WKBXGYLBOOBRIK-UHFFFAOYSA-N 0.000 claims 1
- ALJIEVIJBAJISI-UHFFFAOYSA-N 2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide Chemical compound C1=CC(C(=O)C)=CC=C1NN=C(C(N)=O)C1=NC(C)(C)CC2=CC=CC=C12 ALJIEVIJBAJISI-UHFFFAOYSA-N 0.000 claims 1
- OXPDQFOKSZYEMJ-UHFFFAOYSA-N 2-phenylpyrimidine Chemical compound C1=CC=CC=C1C1=NC=CC=N1 OXPDQFOKSZYEMJ-UHFFFAOYSA-N 0.000 claims 1
- 241000206607 Porphyra umbilicalis Species 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11176713A EP2554662A1 (en) | 2011-08-05 | 2011-08-05 | Methods of treatment of retinal degeneration diseases |
| EP11176713.3 | 2011-08-05 | ||
| PCT/EP2012/065327 WO2013020945A1 (en) | 2011-08-05 | 2012-08-06 | Methods of treatment of retinal degeneration diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014527407A JP2014527407A (ja) | 2014-10-16 |
| JP2014527407A5 true JP2014527407A5 (cg-RX-API-DMAC7.html) | 2016-01-21 |
Family
ID=46826437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014523346A Pending JP2014527407A (ja) | 2011-08-05 | 2012-08-06 | 網膜変性疾患の処置方法 |
Country Status (15)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103889441A (zh) * | 2011-09-29 | 2014-06-25 | 伊丽莎白女王在都柏林附近神圣不可分割的三一学院教务长、研究员、学者及董事会其他成员 | 用于治疗退行性视网膜病况的组合物和方法 |
| MY193954A (en) | 2014-01-17 | 2022-11-02 | Sumitomo Chemical Co | Method for manufacturing ciliary margin stem cells |
| US10821193B2 (en) * | 2014-09-16 | 2020-11-03 | Genzyme Corporation | Adeno-associated viral vectors for treating myocilin (MYOC) glaucoma |
| RU2569481C1 (ru) * | 2014-12-25 | 2015-11-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ получения культуры клеток ретинального пигментного эпителия из глаза взрослого донора-трупа |
| RU2578526C1 (ru) * | 2014-12-25 | 2016-03-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ получения органной культуры хороидально-пигментного комплекса из глаза взрослого донора-трупа |
| KR101779932B1 (ko) * | 2015-09-15 | 2017-09-21 | 주식회사 스템랩 | 나노그(Nanog)를 도입한 양수 내 태아 유래 중간엽 줄기세포를 이용한 육모 촉진용 조성물의 제조방법 |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| KR101674622B1 (ko) * | 2016-07-07 | 2016-11-09 | 국민대학교산학협력단 | 세스퀴테르펜 유도체의 신규한 용도 |
| WO2018034945A1 (en) * | 2016-08-19 | 2018-02-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selective estrogen-receptor modulators (serms) confer protection against photoreceptor degeneration |
| AU2017372351B2 (en) * | 2016-11-06 | 2019-12-12 | Nanoscope Technologies Llc | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
| BR112019022447A2 (pt) | 2017-04-27 | 2020-06-09 | Retinopathy Answer Limited | sistema e método para análise de imagem funduscópica automatizada |
| ES2896476T3 (es) | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina |
| PE20191787A1 (es) | 2017-05-18 | 2019-12-24 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituidos |
| KR102626982B1 (ko) | 2017-05-18 | 2024-01-18 | 이도르시아 파마슈티컬스 리미티드 | Pge2 수용체 조절제로서의 피리미딘 유도체 |
| WO2018210994A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as pge2 receptor modulators |
| CA3063632A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as pge2 receptor modulators |
| WO2018232258A1 (en) * | 2017-06-15 | 2018-12-20 | University Of North Texas Health Science Center | Reprogramming fibroblasts to retinal cells |
| CN117159463A (zh) * | 2017-08-20 | 2023-12-05 | 加州大学董事会 | 治疗青光眼的Wnt5a的调节 |
| US20220040236A1 (en) * | 2018-04-06 | 2022-02-10 | Icahn School Of Medicine At Mount Sinai | Compositions and methods of treatment of vision loss through generation of rod photoreceptors from müller glial cells |
| WO2020190848A1 (en) * | 2019-03-15 | 2020-09-24 | The Schepens Eye Research Institute, Inc. | Isolation, enrichment and expansion of cone progenitor cells and uses thereof |
| CN110706164A (zh) * | 2019-09-03 | 2020-01-17 | 北京爱博同心医学科技有限公司 | 基于增强现实的管状视野图像变形显示方法及眼镜 |
| WO2021062022A1 (en) * | 2019-09-25 | 2021-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Metabolic rescue of retinal degeneration |
| KR20210119766A (ko) * | 2020-03-25 | 2021-10-06 | 서울대학교병원 | 인간 배아줄기세포 유래 중간엽 줄기세포를 포함하는 망막색소변성의 예방 또는 치료용 약학적 조성물 |
| KR102655748B1 (ko) * | 2023-06-08 | 2024-04-05 | 충북대학교 산학협력단 | 고포도당 조건에서의 중간엽 줄기세포의 생존율을 증가시키는 방법 |
| KR102655735B1 (ko) * | 2023-06-09 | 2024-04-05 | 충북대학교 산학협력단 | 당뇨성 망막병증의 예방 및 치료를 위한 타크로리무스 전처리 줄기세포 |
| WO2025229177A1 (en) | 2024-05-02 | 2025-11-06 | Idorsia Pharmaceuticals Ltd | Crystalline forms of an n-substituted indole derivative |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6128654A (en) | 1997-02-14 | 2000-10-03 | Advanced Micro Devices, Inc. | Method and apparatus for transmitting multiple copies by replicating data identifiers |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
| AU782858B2 (en) | 1999-12-17 | 2005-09-01 | Novartis Vaccines And Diagnostics, Inc. | Pyrazine based inhibitors of glycogen synthase kinase 3 |
| DE60022388T2 (de) | 1999-12-17 | 2006-06-14 | Chiron Corp | Bizyklische inhibitoren von glycogensynthasekinase 3 |
| WO2002020495A2 (en) | 2000-09-06 | 2002-03-14 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| DE60132937T2 (de) | 2000-09-11 | 2009-02-12 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Verfahren zur Herstellung von Benzimidazol-2-yl -Chinolinonderivaten |
| CA2446756C (en) | 2001-06-01 | 2011-03-08 | Vertex Pharmaceuticals Incorporated | Thiazole compounds useful as inhibitors of protein kinase |
| MXPA04007697A (es) | 2002-02-06 | 2004-11-10 | Vertex Pharma | Compuestos de heteroarilo utiles como inhibidores de gsk-3. |
| WO2003074072A1 (en) | 2002-03-01 | 2003-09-12 | Chiron Corporation | Methods and compositions for the treatment of ischemia |
| US20050129665A1 (en) * | 2002-07-25 | 2005-06-16 | Martin Friedlander | Isolated lineage negative hematopoietic stem cells and methods of treatment therewith |
| US7838290B2 (en) * | 2002-07-25 | 2010-11-23 | The Scripps Research Institute | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| KR20050038631A (ko) | 2002-08-23 | 2005-04-27 | 카이론 코포레이션 | 글리코겐 신타제 키나제 3의 피롤 기제 억제제 |
| CA2502819A1 (en) | 2002-10-21 | 2004-05-06 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| MXPA05011750A (es) * | 2003-05-02 | 2006-06-06 | Scripps Research Inst | Celulas madre hematopoyeticas y metodos de tratamiento de enfermedades oculares neovasculares con las mismas. |
| EP1653970A4 (en) | 2003-08-13 | 2008-10-15 | Novartis Vaccines & Diagnostic | GSK-3 HEMMER AND ITS USES |
| MX2007002639A (es) * | 2004-09-03 | 2007-08-06 | Scripps Research Inst | Celulas madre hematopoyeticas de linaje negativo aisladas y metodos de tratamiento con las mismas. |
| US7850960B2 (en) * | 2004-12-30 | 2010-12-14 | University Of Washington | Methods for regulation of stem cells |
| CN101356268A (zh) | 2005-02-24 | 2009-01-28 | 斯克里普斯研究学院 | 未熟儿视网膜病和相关视网膜疾病的治疗方法 |
| US20070231306A1 (en) * | 2005-02-24 | 2007-10-04 | The Scripps Research Institute | Isolated myeloid-like cell populations and methods of treatment therewith |
| PL1888123T3 (pl) * | 2005-06-08 | 2013-06-28 | Janssen Biotech Inc | Terapia komórkowa chorób degeneracyjnych oka |
| NZ582616A (en) * | 2007-06-15 | 2012-07-27 | Garnet Biotherapeutics Inc | Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro |
| EP2090649A1 (en) | 2008-02-13 | 2009-08-19 | Fondazione Telethon | Method for reprogramming differentiated cells |
| GB0816577D0 (en) * | 2008-09-11 | 2008-10-15 | Axordia Ltd | Growth factor |
| EP2486126B1 (en) * | 2009-10-06 | 2017-12-06 | SNU R & DB Foundation | Method for differentiation into retinal cells from stem cells |
-
2011
- 2011-08-05 EP EP11176713A patent/EP2554662A1/en not_active Withdrawn
-
2012
- 2012-08-06 BR BR112014002718A patent/BR112014002718A8/pt not_active IP Right Cessation
- 2012-08-06 AU AU2012293681A patent/AU2012293681A1/en not_active Abandoned
- 2012-08-06 AR ARP120102872A patent/AR087471A1/es unknown
- 2012-08-06 US US14/237,297 patent/US20140199277A1/en not_active Abandoned
- 2012-08-06 KR KR1020147006060A patent/KR20140068936A/ko not_active Withdrawn
- 2012-08-06 CN CN201280049453.2A patent/CN104011203A/zh active Pending
- 2012-08-06 CA CA2844106A patent/CA2844106A1/en not_active Abandoned
- 2012-08-06 MX MX2014001475A patent/MX2014001475A/es not_active Application Discontinuation
- 2012-08-06 JP JP2014523346A patent/JP2014527407A/ja active Pending
- 2012-08-06 SG SG2014008080A patent/SG2014008080A/en unknown
- 2012-08-06 WO PCT/EP2012/065327 patent/WO2013020945A1/en not_active Ceased
- 2012-08-06 RU RU2014108478/10A patent/RU2014108478A/ru not_active Application Discontinuation
- 2012-08-06 EP EP12756386.4A patent/EP2739723A1/en not_active Withdrawn
-
2014
- 2014-02-05 IL IL230830A patent/IL230830A0/en unknown
- 2014-03-05 CO CO14047158A patent/CO7081142A2/es unknown
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