MX2012007671A - Agente terapeutico (y-39983) para la disfuncion endotelial de la cornea. - Google Patents

Agente terapeutico (y-39983) para la disfuncion endotelial de la cornea.

Info

Publication number
MX2012007671A
MX2012007671A MX2012007671A MX2012007671A MX2012007671A MX 2012007671 A MX2012007671 A MX 2012007671A MX 2012007671 A MX2012007671 A MX 2012007671A MX 2012007671 A MX2012007671 A MX 2012007671A MX 2012007671 A MX2012007671 A MX 2012007671A
Authority
MX
Mexico
Prior art keywords
corneal endothelial
endothelial cells
compound
therapeutic agent
agent
Prior art date
Application number
MX2012007671A
Other languages
English (en)
Inventor
Yuji Sakamoto
Tetsuo Kida
Hiroaki Takahashi
Takeshi Tarui
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of MX2012007671A publication Critical patent/MX2012007671A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La invención presente se propone proporcionar medios para tratar conveniente y efectivamente enfermedades en donde las células endoteliales de la córnea deficientes en capacidad proliferativa in vivo están dañadas; la invención presente proporciona un agente terapéutico para la disfunción endotelial de la córnea que contiene (R)-(+)-N-(1H-pirrolo[2,3- b]piridin-4-iI)-4-(1-aminoetil )benzamida <Y-39983> o una sal farmacológicamente aceptable del mismo (compuesto (la)) como ingrediente activo, un agente para promover la adhesión de células endoteliales de la córnea, que contiene el compuesto (la), un medio de cultivo para células endoteliales de la córnea, que contiene al agente para promover la adhesión, un implante para la queratoplastía endotelial de la córnea, que contiene células endoteliales de la córnea, un andamio y el compuesto (la), y un método de producción de una preparación endotelial de la córnea, incluyendo un paso de cultivar células endoteliales de la córnea utilizando el medio de cultivo.
MX2012007671A 2009-12-29 2010-12-28 Agente terapeutico (y-39983) para la disfuncion endotelial de la cornea. MX2012007671A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009299180 2009-12-29
PCT/JP2010/071424 WO2011080984A1 (en) 2009-12-29 2010-11-24 Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction
PCT/JP2010/073904 WO2011081221A1 (en) 2009-12-29 2010-12-28 Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction

Publications (1)

Publication Number Publication Date
MX2012007671A true MX2012007671A (es) 2012-08-23

Family

ID=43598277

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007671A MX2012007671A (es) 2009-12-29 2010-12-28 Agente terapeutico (y-39983) para la disfuncion endotelial de la cornea.

Country Status (10)

Country Link
US (1) US20120288482A1 (es)
EP (1) EP2519237A1 (es)
JP (2) JP5750444B2 (es)
KR (1) KR20120099147A (es)
CN (1) CN102770136A (es)
BR (1) BR112012016128A8 (es)
CA (1) CA2785851A1 (es)
MX (1) MX2012007671A (es)
RU (1) RU2563141C2 (es)
WO (2) WO2011080984A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9752118B2 (en) * 2011-12-06 2017-09-05 Astellas Institute For Regenerative Medicine Method of directed differentiation producing corneal endothelial cells from neural crest stem cells by PDGFB and DKK2, compositions thereof, and uses thereof
JP6470286B2 (ja) 2013-11-27 2019-02-13 京都府公立大学法人 ラミニンの角膜内皮細胞培養への応用
WO2015097920A1 (ja) * 2013-12-27 2015-07-02 京都府公立大学法人 角膜内皮細胞の細胞治療併用剤
KR102432692B1 (ko) 2014-09-24 2022-08-12 교와 가부시키가이샤 각막 두께 조절제
RU2718062C2 (ru) * 2014-10-31 2020-03-30 Сэндзю Фармасьютикал Ко., Лтд. Новое лечение роговицы с применением ламинина
WO2016067629A1 (ja) 2014-10-31 2016-05-06 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
JP7008337B2 (ja) * 2016-02-15 2022-02-10 京都府公立大学法人 ヒト機能性角膜内皮細胞およびその応用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1195372A1 (en) 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
KR100883077B1 (ko) 2001-04-11 2009-02-10 센주 세이야꾸 가부시키가이샤 시각 기능 장애 개선제
JP2004024852A (ja) 2002-04-30 2004-01-29 Amniotec:Kk 角膜内皮様シート、及びその作製方法
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
JP4932480B2 (ja) * 2004-06-03 2012-05-16 千寿製薬株式会社 アミド化合物を含有する角膜知覚回復剤
JPWO2006057270A1 (ja) * 2004-11-26 2008-06-05 旭化成ファーマ株式会社 含窒素３環化合物
JP4766653B2 (ja) * 2005-01-28 2011-09-07 株式会社林原生物化学研究所 眼科用医薬組成物
US20090062295A1 (en) * 2005-03-10 2009-03-05 Mitsubishi Pharma Corporation Pharmaceutical Products
EP1980274B1 (en) * 2006-01-19 2016-03-23 Senju Pharmaceutical Co., Ltd. Corneal endothelial preparation which enables cells to grow in vivo
MX2009001037A (es) * 2006-07-31 2009-05-15 Senju Pharma Co Preparacion liquida acuosa que contiene compuesto de amida.
CN103931608B (zh) 2007-08-29 2016-02-03 千寿制药株式会社 促进角膜内皮细胞粘附的药剂
JP5251632B2 (ja) 2008-05-13 2013-07-31 新日鐵住金株式会社 耐遅れ破壊特性に優れた高強度鋼材、高強度ボルト及びその製造方法
JP2010071424A (ja) 2008-09-19 2010-04-02 Toyota Motor Corp 変速機の制御装置

Also Published As

Publication number Publication date
BR112012016128A2 (pt) 2016-05-31
US20120288482A1 (en) 2012-11-15
RU2012132443A (ru) 2014-02-10
EP2519237A1 (en) 2012-11-07
WO2011081221A1 (en) 2011-07-07
CN102770136A (zh) 2012-11-07
WO2011080984A1 (en) 2011-07-07
BR112012016128A8 (pt) 2017-12-05
JP2015155460A (ja) 2015-08-27
KR20120099147A (ko) 2012-09-06
JP2013515676A (ja) 2013-05-09
JP5750444B2 (ja) 2015-07-22
CA2785851A1 (en) 2011-07-07
RU2563141C2 (ru) 2015-09-20

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