RU2013152013A - Офтальмологическая композиция с системой увеличения вязкости, имеющей два различных увеличивающих вязкость агента - Google Patents
Офтальмологическая композиция с системой увеличения вязкости, имеющей два различных увеличивающих вязкость агента Download PDFInfo
- Publication number
- RU2013152013A RU2013152013A RU2013152013/15A RU2013152013A RU2013152013A RU 2013152013 A RU2013152013 A RU 2013152013A RU 2013152013/15 A RU2013152013/15 A RU 2013152013/15A RU 2013152013 A RU2013152013 A RU 2013152013A RU 2013152013 A RU2013152013 A RU 2013152013A
- Authority
- RU
- Russia
- Prior art keywords
- viscosity
- composition according
- ophthalmic composition
- agent
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 42
- 230000001965 increasing effect Effects 0.000 title claims abstract 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract 22
- 150000002500 ions Chemical class 0.000 claims abstract 8
- 229920002125 Sokalan® Polymers 0.000 claims abstract 5
- 229920000642 polymer Polymers 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 4
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract 3
- 235000010418 carrageenan Nutrition 0.000 claims abstract 3
- 239000000679 carrageenan Substances 0.000 claims abstract 3
- 229920001525 carrageenan Polymers 0.000 claims abstract 3
- 229940113118 carrageenan Drugs 0.000 claims abstract 3
- 229920006184 cellulose methylcellulose Polymers 0.000 claims abstract 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract 3
- 230000000699 topical effect Effects 0.000 claims abstract 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract 3
- 229920002148 Gellan gum Polymers 0.000 claims abstract 2
- 235000010443 alginic acid Nutrition 0.000 claims abstract 2
- 239000000783 alginic acid Substances 0.000 claims abstract 2
- 229920000615 alginic acid Polymers 0.000 claims abstract 2
- 229960001126 alginic acid Drugs 0.000 claims abstract 2
- 150000004781 alginic acids Chemical class 0.000 claims abstract 2
- 235000010492 gellan gum Nutrition 0.000 claims abstract 2
- 239000000216 gellan gum Substances 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000002924 anti-infective effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 239000000030 antiglaucoma agent Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478081P | 2011-04-22 | 2011-04-22 | |
| US61/478,081 | 2011-04-22 | ||
| PCT/US2012/034171 WO2012145460A2 (en) | 2011-04-22 | 2012-04-19 | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013152013A true RU2013152013A (ru) | 2015-05-27 |
Family
ID=46025951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013152013/15A RU2013152013A (ru) | 2011-04-22 | 2012-04-19 | Офтальмологическая композиция с системой увеличения вязкости, имеющей два различных увеличивающих вязкость агента |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120269862A1 (https=) |
| EP (1) | EP2699228A2 (https=) |
| JP (2) | JP2014525891A (https=) |
| KR (1) | KR20140022900A (https=) |
| CN (1) | CN104039307A (https=) |
| AU (1) | AU2012245538B2 (https=) |
| CA (1) | CA2833591A1 (https=) |
| MX (1) | MX2013012307A (https=) |
| RU (1) | RU2013152013A (https=) |
| WO (1) | WO2012145460A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10174006B2 (en) * | 2013-06-06 | 2019-01-08 | Novartis Ag | Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease |
| RU2595837C2 (ru) * | 2014-09-29 | 2016-08-27 | Открытое Акционерное Общество "Татхимфармпрепараты" | Состав и способ получения глазных капель |
| JP7492967B2 (ja) | 2019-01-30 | 2024-05-30 | ボシュ・アンド・ロム・インコーポレイテッド | 架橋ポリマーネットワークおよびその使用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5037647A (en) | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| DK0999825T3 (da) | 1997-07-29 | 2004-02-09 | Alcon Lab Inc | Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater |
| US6174524B1 (en) * | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| ES2396598T3 (es) * | 2000-08-25 | 2013-02-22 | Senju Pharmaceutical Co., Ltd. | Preparaciones en forma de suspensiones acuosas |
| PE20020578A1 (es) * | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
| AU2004249137B2 (en) * | 2003-06-13 | 2010-03-11 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| JP4850513B2 (ja) * | 2003-07-03 | 2012-01-11 | 株式会社メニコン | 点眼用組成物 |
| JP4963359B2 (ja) * | 2005-01-12 | 2012-06-27 | ロート製薬株式会社 | 眼局所適用製剤 |
| CN101057966B (zh) * | 2007-05-16 | 2011-04-13 | 中国科学院上海药物研究所 | 一种表皮生长因子眼用脂质纳米载体原位凝胶制剂 |
| CN101073556A (zh) * | 2007-06-25 | 2007-11-21 | 苏州瑞桥医药科技有限公司 | 一种散瞳眼用制剂及其制备方法 |
| ES2638771T3 (es) | 2008-03-17 | 2017-10-24 | Novartis Ag | Composiciones farmacéuticas acuosas que contienen complejos de borato-poliol |
| CN101564374A (zh) * | 2008-04-25 | 2009-10-28 | 北京和润创新医药科技发展有限公司 | 一种药物眼用即型凝胶 |
| BRPI0920326A2 (pt) * | 2008-10-09 | 2016-02-23 | Ramscor Inc | composição e método para tratamento da síndrome do olho ressecado |
| US8501800B2 (en) * | 2009-03-05 | 2013-08-06 | Insite Vision Incorporated | Controlled-release ophthalmic vehicles |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
-
2012
- 2012-04-19 US US13/450,613 patent/US20120269862A1/en not_active Abandoned
- 2012-04-19 CA CA2833591A patent/CA2833591A1/en not_active Abandoned
- 2012-04-19 RU RU2013152013/15A patent/RU2013152013A/ru not_active Application Discontinuation
- 2012-04-19 MX MX2013012307A patent/MX2013012307A/es unknown
- 2012-04-19 KR KR1020137030487A patent/KR20140022900A/ko not_active Ceased
- 2012-04-19 AU AU2012245538A patent/AU2012245538B2/en not_active Expired - Fee Related
- 2012-04-19 EP EP12718521.3A patent/EP2699228A2/en not_active Withdrawn
- 2012-04-19 JP JP2014506532A patent/JP2014525891A/ja not_active Withdrawn
- 2012-04-19 CN CN201280019447.2A patent/CN104039307A/zh active Pending
- 2012-04-19 WO PCT/US2012/034171 patent/WO2012145460A2/en not_active Ceased
-
2017
- 2017-02-27 JP JP2017034992A patent/JP2017088629A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012245538A1 (en) | 2013-10-17 |
| CA2833591A1 (en) | 2012-10-26 |
| CN104039307A (zh) | 2014-09-10 |
| AU2012245538B2 (en) | 2017-06-15 |
| WO2012145460A2 (en) | 2012-10-26 |
| JP2014525891A (ja) | 2014-10-02 |
| KR20140022900A (ko) | 2014-02-25 |
| WO2012145460A3 (en) | 2014-07-24 |
| US20120269862A1 (en) | 2012-10-25 |
| JP2017088629A (ja) | 2017-05-25 |
| MX2013012307A (es) | 2014-01-31 |
| EP2699228A2 (en) | 2014-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102164592B (zh) | 可与核黄素一起使用的增强剂制备用于在圆锥角膜的治疗中进行角膜交联的眼用组合物的用途以及相应眼用组合物 | |
| US8299079B2 (en) | Preparations and methods for ameliorating or reducing presbyopia | |
| JP2013526572A5 (https=) | ||
| US20230285443A1 (en) | Ophthalmic compositions with improved dessication protection and retention | |
| AR089962A1 (es) | Composiciones farmaceuticas oftalmicas y metodos para su elaboracion y uso | |
| EP2439579B1 (en) | Wettable hydrogel contact lens and method for producing same | |
| WO2010135731A1 (en) | Preparations and methods for ameliorating or reducing presbyopia | |
| JP7614069B2 (ja) | ジクアホソルまたはその塩、およびポリビニルピロリドンを含有する水性眼科用組成物 | |
| RU2017146716A (ru) | Способ образования наночастиц циклоспорина а/ циклодекстрина | |
| JP2004262777A (ja) | アセチル化ヒアルロン酸含有眼用医薬組成物 | |
| RU2014140885A (ru) | Фармацевтическая композиция ибупрофена и трамадола для офтальмологического применения | |
| RU2013152013A (ru) | Офтальмологическая композиция с системой увеличения вязкости, имеющей два различных увеличивающих вязкость агента | |
| RU2011100108A (ru) | Гелеобразующие in situ системы для пролонгированной доставки на переднюю часть глаза | |
| JP2016506966A5 (https=) | ||
| RU2013141546A (ru) | Применение вязкоэластичной жидкости для получения медицинского продукта для хирургического лечения глаз | |
| US10849978B2 (en) | Pharmaceutical composition for administration to nasal mucosa | |
| EP3295932A3 (en) | Stable odf composition containing hardly soluble therapeutic agent | |
| JP2014210807A5 (https=) | ||
| JP2014525891A5 (https=) | ||
| CN103919717A (zh) | 一种酒石酸溴莫尼定眼用凝胶制剂及其制备方法和用途 | |
| WO2015041193A1 (ja) | 両性イオン性ソフトコンタクトレンズ用眼科用組成物 | |
| US9913840B2 (en) | Formulations for aripiprazole delivery transdermally | |
| JP2010106015A (ja) | 点眼剤 | |
| JP2006143590A (ja) | 粘膜適用組成物 | |
| WO2022113970A1 (ja) | 涙液層破壊時間短縮型ドライアイ治療剤および該治療剤を含む点眼剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170912 |