JP2014525891A5 - - Google Patents
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- Publication number
- JP2014525891A5 JP2014525891A5 JP2014506532A JP2014506532A JP2014525891A5 JP 2014525891 A5 JP2014525891 A5 JP 2014525891A5 JP 2014506532 A JP2014506532 A JP 2014506532A JP 2014506532 A JP2014506532 A JP 2014506532A JP 2014525891 A5 JP2014525891 A5 JP 2014525891A5
- Authority
- JP
- Japan
- Prior art keywords
- viscosity
- composition
- ophthalmic
- enhancer
- dissipative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims description 75
- 239000003623 enhancer Substances 0.000 claims description 37
- 150000002500 ions Chemical class 0.000 claims description 20
- 230000002708 enhancing effect Effects 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000000699 topical effect Effects 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 229940124597 therapeutic agent Drugs 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 229920002148 Gellan gum Polymers 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- 235000010418 carrageenan Nutrition 0.000 claims description 4
- 239000000679 carrageenan Substances 0.000 claims description 4
- 229920001525 carrageenan Polymers 0.000 claims description 4
- 229940113118 carrageenan Drugs 0.000 claims description 4
- 229920006184 cellulose methylcellulose Polymers 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 239000000783 alginic acid Substances 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 150000004781 alginic acids Chemical class 0.000 claims description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000000043 antiallergic agent Substances 0.000 claims description 2
- 239000000030 antiglaucoma agent Substances 0.000 claims description 2
- 229960005475 antiinfective agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 235000010492 gellan gum Nutrition 0.000 claims description 2
- 239000000216 gellan gum Substances 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000003018 immunosuppressive agent Substances 0.000 claims description 2
- 229940023490 ophthalmic product Drugs 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003889 eye drop Substances 0.000 description 2
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478081P | 2011-04-22 | 2011-04-22 | |
| US61/478,081 | 2011-04-22 | ||
| PCT/US2012/034171 WO2012145460A2 (en) | 2011-04-22 | 2012-04-19 | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017034992A Division JP2017088629A (ja) | 2011-04-22 | 2017-02-27 | 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014525891A JP2014525891A (ja) | 2014-10-02 |
| JP2014525891A5 true JP2014525891A5 (https=) | 2015-05-28 |
Family
ID=46025951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506532A Withdrawn JP2014525891A (ja) | 2011-04-22 | 2012-04-19 | 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物 |
| JP2017034992A Pending JP2017088629A (ja) | 2011-04-22 | 2017-02-27 | 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017034992A Pending JP2017088629A (ja) | 2011-04-22 | 2017-02-27 | 二つの異なる粘性増強剤を有する粘性増強システムを備えた眼科用組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120269862A1 (https=) |
| EP (1) | EP2699228A2 (https=) |
| JP (2) | JP2014525891A (https=) |
| KR (1) | KR20140022900A (https=) |
| CN (1) | CN104039307A (https=) |
| AU (1) | AU2012245538B2 (https=) |
| CA (1) | CA2833591A1 (https=) |
| MX (1) | MX2013012307A (https=) |
| RU (1) | RU2013152013A (https=) |
| WO (1) | WO2012145460A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10174006B2 (en) * | 2013-06-06 | 2019-01-08 | Novartis Ag | Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease |
| RU2595837C2 (ru) * | 2014-09-29 | 2016-08-27 | Открытое Акционерное Общество "Татхимфармпрепараты" | Состав и способ получения глазных капель |
| JP7492967B2 (ja) | 2019-01-30 | 2024-05-30 | ボシュ・アンド・ロム・インコーポレイテッド | 架橋ポリマーネットワークおよびその使用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5037647A (en) | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| DK0999825T3 (da) | 1997-07-29 | 2004-02-09 | Alcon Lab Inc | Oftalmiske sammensætninger indeholdende galactomannanpolymerer og borater |
| US6174524B1 (en) * | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| ES2396598T3 (es) * | 2000-08-25 | 2013-02-22 | Senju Pharmaceutical Co., Ltd. | Preparaciones en forma de suspensiones acuosas |
| PE20020578A1 (es) * | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
| AU2004249137B2 (en) * | 2003-06-13 | 2010-03-11 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of two polymers |
| JP4850513B2 (ja) * | 2003-07-03 | 2012-01-11 | 株式会社メニコン | 点眼用組成物 |
| JP4963359B2 (ja) * | 2005-01-12 | 2012-06-27 | ロート製薬株式会社 | 眼局所適用製剤 |
| CN101057966B (zh) * | 2007-05-16 | 2011-04-13 | 中国科学院上海药物研究所 | 一种表皮生长因子眼用脂质纳米载体原位凝胶制剂 |
| CN101073556A (zh) * | 2007-06-25 | 2007-11-21 | 苏州瑞桥医药科技有限公司 | 一种散瞳眼用制剂及其制备方法 |
| ES2638771T3 (es) | 2008-03-17 | 2017-10-24 | Novartis Ag | Composiciones farmacéuticas acuosas que contienen complejos de borato-poliol |
| CN101564374A (zh) * | 2008-04-25 | 2009-10-28 | 北京和润创新医药科技发展有限公司 | 一种药物眼用即型凝胶 |
| BRPI0920326A2 (pt) * | 2008-10-09 | 2016-02-23 | Ramscor Inc | composição e método para tratamento da síndrome do olho ressecado |
| US8501800B2 (en) * | 2009-03-05 | 2013-08-06 | Insite Vision Incorporated | Controlled-release ophthalmic vehicles |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
-
2012
- 2012-04-19 US US13/450,613 patent/US20120269862A1/en not_active Abandoned
- 2012-04-19 CA CA2833591A patent/CA2833591A1/en not_active Abandoned
- 2012-04-19 RU RU2013152013/15A patent/RU2013152013A/ru not_active Application Discontinuation
- 2012-04-19 MX MX2013012307A patent/MX2013012307A/es unknown
- 2012-04-19 KR KR1020137030487A patent/KR20140022900A/ko not_active Ceased
- 2012-04-19 AU AU2012245538A patent/AU2012245538B2/en not_active Expired - Fee Related
- 2012-04-19 EP EP12718521.3A patent/EP2699228A2/en not_active Withdrawn
- 2012-04-19 JP JP2014506532A patent/JP2014525891A/ja not_active Withdrawn
- 2012-04-19 CN CN201280019447.2A patent/CN104039307A/zh active Pending
- 2012-04-19 WO PCT/US2012/034171 patent/WO2012145460A2/en not_active Ceased
-
2017
- 2017-02-27 JP JP2017034992A patent/JP2017088629A/ja active Pending
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