RU2013152013A - Офтальмологическая композиция с системой увеличения вязкости, имеющей два различных увеличивающих вязкость агента - Google Patents
Офтальмологическая композиция с системой увеличения вязкости, имеющей два различных увеличивающих вязкость агента Download PDFInfo
- Publication number
- RU2013152013A RU2013152013A RU2013152013/15A RU2013152013A RU2013152013A RU 2013152013 A RU2013152013 A RU 2013152013A RU 2013152013/15 A RU2013152013/15 A RU 2013152013/15A RU 2013152013 A RU2013152013 A RU 2013152013A RU 2013152013 A RU2013152013 A RU 2013152013A
- Authority
- RU
- Russia
- Prior art keywords
- viscosity
- composition according
- ophthalmic composition
- agent
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 42
- 230000001965 increasing effect Effects 0.000 title claims abstract 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract 22
- 150000002500 ions Chemical class 0.000 claims abstract 8
- 229920002125 Sokalan® Polymers 0.000 claims abstract 5
- 229920000642 polymer Polymers 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 4
- 229940124597 therapeutic agent Drugs 0.000 claims abstract 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract 3
- 235000010418 carrageenan Nutrition 0.000 claims abstract 3
- 239000000679 carrageenan Substances 0.000 claims abstract 3
- 229920001525 carrageenan Polymers 0.000 claims abstract 3
- 229940113118 carrageenan Drugs 0.000 claims abstract 3
- 229920006184 cellulose methylcellulose Polymers 0.000 claims abstract 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract 3
- 230000000699 topical effect Effects 0.000 claims abstract 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract 3
- 229920002148 Gellan gum Polymers 0.000 claims abstract 2
- 235000010443 alginic acid Nutrition 0.000 claims abstract 2
- 239000000783 alginic acid Substances 0.000 claims abstract 2
- 229920000615 alginic acid Polymers 0.000 claims abstract 2
- 229960001126 alginic acid Drugs 0.000 claims abstract 2
- 150000004781 alginic acids Chemical class 0.000 claims abstract 2
- 235000010492 gellan gum Nutrition 0.000 claims abstract 2
- 239000000216 gellan gum Substances 0.000 claims abstract 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 230000002924 anti-infective effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 239000000030 antiglaucoma agent Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478081P | 2011-04-22 | 2011-04-22 | |
| US61/478,081 | 2011-04-22 | ||
| PCT/US2012/034171 WO2012145460A2 (en) | 2011-04-22 | 2012-04-19 | Ophthalmic composition with a viscosity enhancement system having two different viscosity enhancing agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013152013A true RU2013152013A (ru) | 2015-05-27 |
Family
ID=46025951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013152013/15A RU2013152013A (ru) | 2011-04-22 | 2012-04-19 | Офтальмологическая композиция с системой увеличения вязкости, имеющей два различных увеличивающих вязкость агента |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120269862A1 (enExample) |
| EP (1) | EP2699228A2 (enExample) |
| JP (2) | JP2014525891A (enExample) |
| KR (1) | KR20140022900A (enExample) |
| CN (1) | CN104039307A (enExample) |
| AU (1) | AU2012245538B2 (enExample) |
| CA (1) | CA2833591A1 (enExample) |
| MX (1) | MX2013012307A (enExample) |
| RU (1) | RU2013152013A (enExample) |
| WO (1) | WO2012145460A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10174006B2 (en) * | 2013-06-06 | 2019-01-08 | Novartis Ag | Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease |
| RU2595837C2 (ru) * | 2014-09-29 | 2016-08-27 | Открытое Акционерное Общество "Татхимфармпрепараты" | Состав и способ получения глазных капель |
| CN113366025A (zh) | 2019-01-30 | 2021-09-07 | 鲍希与洛姆伯股份有限公司 | 交联的聚合物网络及其用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5037647A (en) | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| CN100408100C (zh) | 1997-07-29 | 2008-08-06 | 阿尔康实验室公司 | 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物 |
| US6174524B1 (en) * | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
| JP5000835B2 (ja) * | 2000-08-25 | 2012-08-15 | 千寿製薬株式会社 | 水性懸濁液剤 |
| AR031135A1 (es) * | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
| KR20110134525A (ko) * | 2003-06-13 | 2011-12-14 | 알콘, 인코퍼레이티드 | 시너지성의 2개의 폴리머 배합물을 포함하는 안과용 조성물 |
| JP4850513B2 (ja) * | 2003-07-03 | 2012-01-11 | 株式会社メニコン | 点眼用組成物 |
| JP4963359B2 (ja) * | 2005-01-12 | 2012-06-27 | ロート製薬株式会社 | 眼局所適用製剤 |
| CN101057966B (zh) * | 2007-05-16 | 2011-04-13 | 中国科学院上海药物研究所 | 一种表皮生长因子眼用脂质纳米载体原位凝胶制剂 |
| CN101073556A (zh) * | 2007-06-25 | 2007-11-21 | 苏州瑞桥医药科技有限公司 | 一种散瞳眼用制剂及其制备方法 |
| PL2254549T5 (pl) | 2008-03-17 | 2019-12-31 | Alcon Research, Ltd. | Wodne kompozycje farmaceutyczne zawierające kompleksy boran-poliole |
| CN101564374A (zh) * | 2008-04-25 | 2009-10-28 | 北京和润创新医药科技发展有限公司 | 一种药物眼用即型凝胶 |
| CN102238949A (zh) * | 2008-10-09 | 2011-11-09 | 拉姆斯科股份有限公司 | 治疗干眼综合征的组合物和方法 |
| US8501800B2 (en) * | 2009-03-05 | 2013-08-06 | Insite Vision Incorporated | Controlled-release ophthalmic vehicles |
| TWI489997B (zh) | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
-
2012
- 2012-04-19 RU RU2013152013/15A patent/RU2013152013A/ru not_active Application Discontinuation
- 2012-04-19 US US13/450,613 patent/US20120269862A1/en not_active Abandoned
- 2012-04-19 JP JP2014506532A patent/JP2014525891A/ja not_active Withdrawn
- 2012-04-19 EP EP12718521.3A patent/EP2699228A2/en not_active Withdrawn
- 2012-04-19 AU AU2012245538A patent/AU2012245538B2/en not_active Expired - Fee Related
- 2012-04-19 CA CA2833591A patent/CA2833591A1/en not_active Abandoned
- 2012-04-19 WO PCT/US2012/034171 patent/WO2012145460A2/en not_active Ceased
- 2012-04-19 MX MX2013012307A patent/MX2013012307A/es unknown
- 2012-04-19 KR KR1020137030487A patent/KR20140022900A/ko not_active Ceased
- 2012-04-19 CN CN201280019447.2A patent/CN104039307A/zh active Pending
-
2017
- 2017-02-27 JP JP2017034992A patent/JP2017088629A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN104039307A (zh) | 2014-09-10 |
| EP2699228A2 (en) | 2014-02-26 |
| WO2012145460A2 (en) | 2012-10-26 |
| US20120269862A1 (en) | 2012-10-25 |
| AU2012245538B2 (en) | 2017-06-15 |
| AU2012245538A1 (en) | 2013-10-17 |
| JP2014525891A (ja) | 2014-10-02 |
| JP2017088629A (ja) | 2017-05-25 |
| KR20140022900A (ko) | 2014-02-25 |
| CA2833591A1 (en) | 2012-10-26 |
| WO2012145460A3 (en) | 2014-07-24 |
| MX2013012307A (es) | 2014-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20170912 |