RU2012144612A - Способ и композиции для интраназальной доставки - Google Patents
Способ и композиции для интраназальной доставки Download PDFInfo
- Publication number
- RU2012144612A RU2012144612A RU2012144612/15A RU2012144612A RU2012144612A RU 2012144612 A RU2012144612 A RU 2012144612A RU 2012144612/15 A RU2012144612/15 A RU 2012144612/15A RU 2012144612 A RU2012144612 A RU 2012144612A RU 2012144612 A RU2012144612 A RU 2012144612A
- Authority
- RU
- Russia
- Prior art keywords
- antigens
- dry powder
- vaccine
- specified
- paragraph
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 54
- 238000000034 method Methods 0.000 title claims 66
- 239000000427 antigen Substances 0.000 claims abstract 69
- 102000036639 antigens Human genes 0.000 claims abstract 69
- 108091007433 antigens Proteins 0.000 claims abstract 69
- 239000000843 powder Substances 0.000 claims abstract 50
- 229960005486 vaccine Drugs 0.000 claims abstract 45
- 241000712461 unidentified influenza virus Species 0.000 claims abstract 24
- 241000700605 Viruses Species 0.000 claims abstract 16
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 12
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract 7
- 230000002238 attenuated effect Effects 0.000 claims abstract 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract 7
- 206010069767 H1N1 influenza Diseases 0.000 claims abstract 6
- 201000010740 swine influenza Diseases 0.000 claims abstract 6
- 230000001580 bacterial effect Effects 0.000 claims abstract 4
- 230000003612 virological effect Effects 0.000 claims abstract 4
- 239000000277 virosome Substances 0.000 claims abstract 4
- 241001500350 Influenzavirus B Species 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims 9
- 230000008014 freezing Effects 0.000 claims 8
- 238000007710 freezing Methods 0.000 claims 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims 8
- 241000894006 Bacteria Species 0.000 claims 6
- 102000018697 Membrane Proteins Human genes 0.000 claims 6
- 108010052285 Membrane Proteins Proteins 0.000 claims 6
- 239000000872 buffer Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 4
- 239000000969 carrier Substances 0.000 claims 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 4
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- 206010064097 avian influenza Diseases 0.000 claims 3
- 229960003983 diphtheria toxoid Drugs 0.000 claims 3
- 239000008101 lactose Substances 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000008363 phosphate buffer Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 229960000814 tetanus toxoid Drugs 0.000 claims 3
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241001591005 Siga Species 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04M—TELEPHONIC COMMUNICATION
- H04M3/00—Automatic or semi-automatic exchanges
- H04M3/42—Systems providing special services or facilities to subscribers
- H04M3/50—Centralised arrangements for answering calls; Centralised arrangements for recording messages for absent or busy subscribers ; Centralised arrangements for recording messages
- H04M3/51—Centralised call answering arrangements requiring operator intervention, e.g. call or contact centers for telemarketing
- H04M3/5116—Centralised call answering arrangements requiring operator intervention, e.g. call or contact centers for telemarketing for emergency applications
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
- H04W4/90—Services for handling of emergency or hazardous situations, e.g. earthquake and tsunami warning systems [ETWS]
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W76/00—Connection management
- H04W76/50—Connection management for emergency connections
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W76/00—Connection management
- H04W76/10—Connection setup
- H04W76/15—Setup of multiple wireless link connections
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04W—WIRELESS COMMUNICATION NETWORKS
- H04W8/00—Network data management
- H04W8/18—Processing of user or subscriber data, e.g. subscribed services, user preferences or user profiles; Transfer of user or subscriber data
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Signal Processing (AREA)
- Business, Economics & Management (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Computer Networks & Wireless Communication (AREA)
- Emergency Management (AREA)
- Environmental & Geological Engineering (AREA)
- Tropical Medicine & Parasitology (AREA)
- Marketing (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32454210P | 2010-04-15 | 2010-04-15 | |
| US61/324,542 | 2010-04-15 | ||
| PCT/JP2011/002225 WO2011129120A1 (en) | 2010-04-15 | 2011-04-15 | Methods and compositions for intranasal delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012144612A true RU2012144612A (ru) | 2014-05-20 |
Family
ID=44798502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012144612/15A RU2012144612A (ru) | 2010-04-15 | 2011-04-15 | Способ и композиции для интраназальной доставки |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9687536B2 (https=) |
| EP (2) | EP2689785B1 (https=) |
| JP (5) | JP5771626B2 (https=) |
| KR (3) | KR20130083376A (https=) |
| CN (3) | CN103126996A (https=) |
| BR (1) | BR112012026116A2 (https=) |
| CA (2) | CA2796593C (https=) |
| CU (1) | CU20120148A7 (https=) |
| ES (1) | ES2874817T3 (https=) |
| RU (1) | RU2012144612A (https=) |
| SG (1) | SG184304A1 (https=) |
| WO (1) | WO2011129120A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126996A (zh) | 2010-04-15 | 2013-06-05 | 株式会社新日本科学 | 用于鼻内递送的方法和组合物 |
| BR112014014594B1 (pt) | 2011-12-16 | 2021-02-17 | Indosys Limited | dispositivo de liberação de medicamento seco em pó |
| TWI690322B (zh) * | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| WO2014186754A2 (en) | 2013-05-16 | 2014-11-20 | Board Of Regents The University Of Texas System | Dry solid aluminum adjuvant-containing vaccines and related methods thereof |
| CN104208029B (zh) * | 2013-05-30 | 2017-06-06 | 上海医药工业研究院 | 一种鼻用疫苗组合物粉体制剂及其制备方法 |
| EP3041504B1 (en) | 2013-09-03 | 2021-08-25 | Georgia Tech Research Corporation | Thermally stable vaccine formulations and microneedles |
| DK3049059T3 (da) | 2013-09-24 | 2022-01-31 | Satsuma Pharmaceuticals Inc | Intranasal dhe formulering til behandlingen af hovedpine |
| IL310015B2 (en) * | 2013-12-31 | 2026-02-01 | Access To Advanced Health Inst | Single vial formulation |
| EP3127550A1 (en) * | 2015-08-07 | 2017-02-08 | HSC Development GmbH | Stabilizing composition for dry formulation of virus |
| WO2017047089A1 (en) * | 2015-09-16 | 2017-03-23 | Shin Nippon Biomedical Laboratories, Ltd. | Vaccine compositions |
| GB201610628D0 (en) * | 2016-06-17 | 2016-08-03 | Mihranyan Albert | New compositions |
| US20190275136A1 (en) * | 2016-09-19 | 2019-09-12 | Vaxess Technologies, Inc. | Vaccine formulations with increased stability |
| US11022115B2 (en) | 2017-06-02 | 2021-06-01 | Purdue Research Foundation | Controlled variable delivery external gear machine |
| JPWO2019021957A1 (ja) * | 2017-07-25 | 2020-07-09 | 第一三共株式会社 | 点鼻用乾燥粉末医薬組成物 |
| GB201713899D0 (en) | 2017-08-30 | 2017-10-11 | Indosys Ltd | Multi-dose medicament delivery device |
| WO2019118393A1 (en) | 2017-12-11 | 2019-06-20 | Board Of Regents, The University Of Texas System | Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration |
| AU2019336940B2 (en) * | 2018-09-06 | 2025-09-11 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| CN120284965A (zh) | 2018-12-11 | 2025-07-11 | 小蜜橘制药公司 | 用于治疗或预防头痛的组合物、装置和方法 |
| BR112021016059A2 (pt) * | 2019-02-15 | 2021-10-13 | Serum Institute Of India Pvt Ltd. | Composição de vacina de vírus de influenza atenuada viva e processo para a preparação da mesma |
| EP3698773A1 (en) | 2019-02-21 | 2020-08-26 | Università degli Studi di Parma | Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination |
| US11621604B2 (en) | 2020-02-16 | 2023-04-04 | Purdue Research Foundation | Integrated electro-hydraulic machine |
| WO2021194038A1 (ko) * | 2020-03-24 | 2021-09-30 | 안병철 | 어린 포유동물의 점막관련 전염성 질병을 예방 또는 치료하기 위한 혈청 조성물의 제조방법, 상기 방법에 의해 제조된 혈청 조성물 및 이의 용도 |
| CN113583970B (zh) * | 2021-07-29 | 2023-05-12 | 吉林大学 | 一种用于预防或抗冠状病毒传播、致病的药物及其制备方法 |
| CN119866231A (zh) | 2022-09-01 | 2025-04-22 | 锡拉坎岛有限公司 | 干粉药物递送装置 |
| JP2025540325A (ja) * | 2022-12-07 | 2025-12-11 | ズー，ダオチョン | 融合タンパク質の製剤および使用 |
| WO2024228212A1 (en) * | 2023-05-01 | 2024-11-07 | Biovet Private Limited | Bio-lumpivaxin formulations and method of preparation thereof |
| AU2024282997A1 (en) * | 2023-05-31 | 2026-01-22 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions for enhanced mucosal penetration |
| GB202403611D0 (en) | 2024-03-13 | 2024-04-24 | Therakind Ltd | Improved multi-dose medicament delivery device |
| CN118924744A (zh) * | 2024-07-29 | 2024-11-12 | 复旦大学 | 小分子抑制剂ha15在抗乙型肝炎病毒中的应用 |
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|---|---|---|---|---|
| WO1994009819A1 (en) * | 1992-11-03 | 1994-05-11 | Secretech, Inc. | Microcrystalline cellulose as an immune adjuvant |
| US20030092145A1 (en) | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| CN1193745C (zh) * | 2001-02-27 | 2005-03-23 | 国家医药管理局上海医药工业研究院 | 一种鼻用鲑降钙素粉末吸入剂及制备方法 |
| AU2002346424A1 (en) | 2001-11-19 | 2003-06-10 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| US20040042972A1 (en) | 2002-04-11 | 2004-03-04 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| EP1701738B1 (en) * | 2003-12-17 | 2015-03-11 | Wyeth LLC | Method for producing storage stable RSV compositions |
| US20060292173A1 (en) * | 2004-12-13 | 2006-12-28 | Macadam Donald H | Multibacterial vaccines and uses thereof |
| EP1954308B1 (en) | 2005-09-16 | 2011-09-07 | Merial Ltd. | Stabilizers for freeze-dried vaccines |
| AU2006299310A1 (en) | 2005-10-04 | 2007-04-12 | Alk-Abello A/S | Solid vaccine formulation |
| BRPI0616879A2 (pt) * | 2005-10-04 | 2011-07-05 | Alk Abello As | formulação de vacina sólida |
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