RU2012129900A - Регуляция микро-рнк при ишемии и ишемически-реперфузионном повреждении - Google Patents
Регуляция микро-рнк при ишемии и ишемически-реперфузионном повреждении Download PDFInfo
- Publication number
- RU2012129900A RU2012129900A RU2012129900/15A RU2012129900A RU2012129900A RU 2012129900 A RU2012129900 A RU 2012129900A RU 2012129900/15 A RU2012129900/15 A RU 2012129900/15A RU 2012129900 A RU2012129900 A RU 2012129900A RU 2012129900 A RU2012129900 A RU 2012129900A
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- Russia
- Prior art keywords
- mir
- subject
- micro
- agonist
- rnas
- Prior art date
Links
- 108091070501 miRNA Proteins 0.000 title claims abstract 18
- 206010063837 Reperfusion injury Diseases 0.000 title 1
- 208000028867 ischemia Diseases 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 33
- 239000000556 agonist Substances 0.000 claims abstract 12
- 108091034117 Oligonucleotide Proteins 0.000 claims abstract 9
- 239000000074 antisense oligonucleotide Substances 0.000 claims abstract 9
- 238000012230 antisense oligonucleotides Methods 0.000 claims abstract 9
- 239000003112 inhibitor Substances 0.000 claims abstract 8
- 108091048308 miR-210 stem-loop Proteins 0.000 claims abstract 7
- 108091060302 Mir-320 Proteins 0.000 claims abstract 6
- 108091025686 miR-199a stem-loop Proteins 0.000 claims abstract 6
- 108091028066 Mir-126 Proteins 0.000 claims abstract 4
- 108091027766 Mir-143 Proteins 0.000 claims abstract 4
- 108091057645 miR-15 stem-loop Proteins 0.000 claims abstract 4
- 108091062762 miR-21 stem-loop Proteins 0.000 claims abstract 4
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims abstract 4
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims abstract 4
- 108091056170 miR-499 stem-loop Proteins 0.000 claims abstract 4
- 108091050885 miR-499-1 stem-loop Proteins 0.000 claims abstract 4
- 108091038523 miR-499-2 stem-loop Proteins 0.000 claims abstract 4
- 108091034121 miR-92a stem-loop Proteins 0.000 claims abstract 4
- 108091041519 miR-92a-3 stem-loop Proteins 0.000 claims abstract 4
- 230000000694 effects Effects 0.000 claims abstract 3
- 108091033319 polynucleotide Proteins 0.000 claims abstract 3
- 102000040430 polynucleotide Human genes 0.000 claims abstract 3
- 239000002157 polynucleotide Substances 0.000 claims abstract 3
- 108091026807 MiR-214 Proteins 0.000 claims abstract 2
- 108091060568 Mir-133 microRNA precursor family Proteins 0.000 claims abstract 2
- 108091028684 Mir-145 Proteins 0.000 claims abstract 2
- 230000000295 complement effect Effects 0.000 claims abstract 2
- 210000002064 heart cell Anatomy 0.000 claims abstract 2
- 108091007423 let-7b Proteins 0.000 claims abstract 2
- 108091028606 miR-1 stem-loop Proteins 0.000 claims abstract 2
- 108091027857 miR-101a stem-loop Proteins 0.000 claims abstract 2
- 108091031328 miR-101a-1 stem-loop Proteins 0.000 claims abstract 2
- 108091085105 miR-101a-2 stem-loop Proteins 0.000 claims abstract 2
- 108091087432 miR-101b stem-loop Proteins 0.000 claims abstract 2
- 108091035155 miR-10a stem-loop Proteins 0.000 claims abstract 2
- 108091064399 miR-10b stem-loop Proteins 0.000 claims abstract 2
- 108091091360 miR-125b stem-loop Proteins 0.000 claims abstract 2
- 108091023685 miR-133 stem-loop Proteins 0.000 claims abstract 2
- 108091047758 miR-185 stem-loop Proteins 0.000 claims abstract 2
- 108091061970 miR-26a stem-loop Proteins 0.000 claims abstract 2
- 108091029119 miR-34a stem-loop Proteins 0.000 claims abstract 2
- 108091055140 miR-574 stem-loop Proteins 0.000 claims abstract 2
- 108091058485 miR-574-1 stem-loop Proteins 0.000 claims abstract 2
- 108091055064 miR-574-2 stem-loop Proteins 0.000 claims abstract 2
- 230000004048 modification Effects 0.000 claims abstract 2
- 238000012986 modification Methods 0.000 claims abstract 2
- 208000031225 myocardial ischemia Diseases 0.000 claims abstract 2
- 239000002773 nucleotide Substances 0.000 claims abstract 2
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 210000004413 cardiac myocyte Anatomy 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 102000015427 Angiotensins Human genes 0.000 claims 1
- 108010064733 Angiotensins Proteins 0.000 claims 1
- 108090000312 Calcium Channels Proteins 0.000 claims 1
- 102000003922 Calcium Channels Human genes 0.000 claims 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 239000002308 endothelin receptor antagonist Substances 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- -1 ionotropic Substances 0.000 claims 1
- 230000001057 ionotropic effect Effects 0.000 claims 1
- 230000020874 response to hypoxia Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28662209P | 2009-12-15 | 2009-12-15 | |
| US61/286,622 | 2009-12-15 | ||
| PCT/US2010/060460 WO2011084460A1 (en) | 2009-12-15 | 2010-12-15 | Micro-rna regulation in ischemia and ischemia-reperfusion injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012129900A true RU2012129900A (ru) | 2014-01-27 |
Family
ID=44305697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012129900/15A RU2012129900A (ru) | 2009-12-15 | 2010-12-15 | Регуляция микро-рнк при ишемии и ишемически-реперфузионном повреждении |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20130005658A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2513307A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2013514372A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102791859A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010340062A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2784118A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2012129900A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011084460A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| EP2683411B1 (en) * | 2011-03-09 | 2016-01-13 | The Brigham and Women's Hospital, Inc. | Methods of using microrna-26a to promote angiogenesis |
| US8871731B2 (en) | 2011-03-16 | 2014-10-28 | Migagen Therapeutics, Inc. | Micro-RNA for the regulation of cardiac apoptosis and contractile function |
| SG194901A1 (en) * | 2011-05-09 | 2013-12-30 | Univ Glasgow | Methods of modulating micrornas in the treatment of pulmonary arterial hypertension |
| EP2584040A1 (en) | 2011-10-17 | 2013-04-24 | Pharmahungary 2000 Kft. | Compounds for treatment of ischemic injury |
| WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| CN102965429B (zh) * | 2012-03-15 | 2015-03-04 | 汪道文 | microRNA-320(miR-320a)及其反义核苷酸在诊断、防治心血管疾病中的用途 |
| WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| US9828603B2 (en) | 2012-08-13 | 2017-11-28 | Cedars Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| US9845465B2 (en) | 2012-08-15 | 2017-12-19 | University Of Virginia Patent Foundation | Compositions and methods for treating peripheral arterial disease |
| US20160076026A1 (en) * | 2013-03-15 | 2016-03-17 | The Hospital For Sick Children | Diagnostic and therapeutic methods relating to microrna-144 |
| KR101668518B1 (ko) * | 2014-05-23 | 2016-10-24 | 강원대학교산학협력단 | 혈관신생을 촉진하는 마이크로rna-101 |
| EP3200808B1 (en) | 2014-10-03 | 2024-07-31 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2016113702A1 (en) * | 2015-01-16 | 2016-07-21 | Bioup Sagl | Isolated genetically modified cell population |
| CN105251014B (zh) * | 2015-08-17 | 2018-10-19 | 南昌大学 | Nonratt021972小干扰rna在制备心肌缺血损伤、交感神经疾病药物中的应用 |
| US10119139B2 (en) | 2015-09-14 | 2018-11-06 | Vanderbilt University | Treatment for conditions associated with fibrosis and collagen deposition |
| US11253551B2 (en) | 2016-01-11 | 2022-02-22 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| CN105695612A (zh) * | 2016-04-19 | 2016-06-22 | 中南大学 | microRNA-126-5p在心肌损伤中的表达检测方法 |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| CN106692175A (zh) * | 2016-12-26 | 2017-05-24 | 大连医科大学附属第二医院 | miR‑665‑3p抑制物在制备防治缺血再灌注损伤药物中的应用 |
| CN108245687A (zh) * | 2016-12-29 | 2018-07-06 | 贾中芝 | 一种IpostC在抗肠再灌注损伤中所起作用的实验方法 |
| WO2018183594A1 (en) * | 2017-03-29 | 2018-10-04 | Children's Hospital Medical Center | Nucleic acid molecules and their methods of use |
| CA3059910A1 (en) | 2017-04-19 | 2018-10-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| EP3727351A4 (en) | 2017-12-20 | 2021-10-06 | Cedars-Sinai Medical Center | MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE |
| US12146137B2 (en) | 2018-02-05 | 2024-11-19 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and Y-RNAS |
| US11591597B2 (en) * | 2018-04-20 | 2023-02-28 | Texas Tech University System | MicroRNAs as therapeutic targets for ischemic stroke |
| CN110205374A (zh) * | 2019-06-17 | 2019-09-06 | 昆山德诺瑞尔生物科技有限公司 | 检测血小板中miR-34a基因表达量的引物、试剂盒、检测方法及其应用 |
| CN110257508A (zh) * | 2019-07-12 | 2019-09-20 | 宁夏医科大学 | 一种在衰老心肌缺血后处理缺血再灌注损伤治疗用miRNA标志物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008275877B2 (en) * | 2007-07-18 | 2015-01-22 | The Regents Of The University Of Colorado, A Body Corporate | Differential expression of microRNAs in nonfailing versus failing human hearts |
| EP2182969B1 (en) * | 2007-07-31 | 2016-11-16 | The Board of Regents of The University of Texas System | A micro-rna family that modulates fibrosis and uses thereof |
| WO2009114681A2 (en) * | 2008-03-13 | 2009-09-17 | Dharmacon, Inc. | Identification of mirna profiles that are diagnostic of hypertrophic cardiomyopathy |
-
2010
- 2010-12-15 EP EP10842523.2A patent/EP2513307A4/en not_active Withdrawn
- 2010-12-15 RU RU2012129900/15A patent/RU2012129900A/ru not_active Application Discontinuation
- 2010-12-15 CA CA2784118A patent/CA2784118A1/en not_active Abandoned
- 2010-12-15 AU AU2010340062A patent/AU2010340062A1/en not_active Abandoned
- 2010-12-15 US US13/516,189 patent/US20130005658A1/en not_active Abandoned
- 2010-12-15 WO PCT/US2010/060460 patent/WO2011084460A1/en not_active Ceased
- 2010-12-15 CN CN2010800639335A patent/CN102791859A/zh active Pending
- 2010-12-15 JP JP2012544748A patent/JP2013514372A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011084460A1 (en) | 2011-07-14 |
| US20130005658A1 (en) | 2013-01-03 |
| EP2513307A1 (en) | 2012-10-24 |
| CN102791859A (zh) | 2012-11-21 |
| EP2513307A4 (en) | 2014-02-26 |
| CA2784118A1 (en) | 2011-07-14 |
| JP2013514372A (ja) | 2013-04-25 |
| AU2010340062A1 (en) | 2012-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20151007 |