RU2012127383A - Композиции и способы для увеличения времени полужизни fc-слитых белков в сыворотке - Google Patents
Композиции и способы для увеличения времени полужизни fc-слитых белков в сыворотке Download PDFInfo
- Publication number
- RU2012127383A RU2012127383A RU2012127383/10A RU2012127383A RU2012127383A RU 2012127383 A RU2012127383 A RU 2012127383A RU 2012127383/10 A RU2012127383/10 A RU 2012127383/10A RU 2012127383 A RU2012127383 A RU 2012127383A RU 2012127383 A RU2012127383 A RU 2012127383A
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- Prior art keywords
- fusion protein
- modified
- amino acid
- heterologous
- linked glycosylation
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 40
- 210000002966 serum Anatomy 0.000 title claims abstract 12
- 102000004169 proteins and genes Human genes 0.000 title claims 4
- 108090000623 proteins and genes Proteins 0.000 title claims 4
- 239000000203 mixture Substances 0.000 title claims 2
- 108091006020 Fc-tagged proteins Proteins 0.000 claims abstract 37
- 230000004988 N-glycosylation Effects 0.000 claims abstract 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 17
- 102000039446 nucleic acids Human genes 0.000 claims abstract 9
- 108020004707 nucleic acids Proteins 0.000 claims abstract 9
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 9
- 108020001756 ligand binding domains Proteins 0.000 claims abstract 7
- 239000003446 ligand Substances 0.000 claims abstract 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract 4
- 230000027455 binding Effects 0.000 claims abstract 4
- 238000004113 cell culture Methods 0.000 claims abstract 4
- 241000282693 Cercopithecidae Species 0.000 claims abstract 3
- 238000004458 analytical method Methods 0.000 claims abstract 3
- 230000004071 biological effect Effects 0.000 claims abstract 2
- 238000001727 in vivo Methods 0.000 claims abstract 2
- 108020001507 fusion proteins Proteins 0.000 claims 33
- 102000037865 fusion proteins Human genes 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 150000001413 amino acids Chemical class 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 230000013595 glycosylation Effects 0.000 claims 15
- 238000006206 glycosylation reaction Methods 0.000 claims 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 10
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 1
- 108010032605 Nerve Growth Factor Receptors Proteins 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 239000004161 brilliant blue FCF Substances 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000001279 glycosylating effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 229940053128 nerve growth factor Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000001698 pyrogenic effect Effects 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 102000027257 transmembrane receptors Human genes 0.000 claims 1
- 108091008578 transmembrane receptors Proteins 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Psychology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26609509P | 2009-12-02 | 2009-12-02 | |
| US61/266,095 | 2009-12-02 | ||
| US32758210P | 2010-04-23 | 2010-04-23 | |
| US61/327,582 | 2010-04-23 | ||
| PCT/US2010/058765 WO2011068993A1 (en) | 2009-12-02 | 2010-12-02 | Compositions and methods for increasing serum half-life of fc fusion proteins. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012127383A true RU2012127383A (ru) | 2014-01-10 |
Family
ID=44115295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012127383/10A RU2012127383A (ru) | 2009-12-02 | 2010-12-02 | Композиции и способы для увеличения времени полужизни fc-слитых белков в сыворотке |
Country Status (11)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8889621B2 (en) | 2009-10-30 | 2014-11-18 | New York University | Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia |
| JP2013512674A (ja) | 2009-12-02 | 2013-04-18 | アクセルロン ファーマ， インコーポレイテッド | Ｆｃ融合タンパク質の血清半減期を増加させるための組成物および方法 |
| EP2718328A4 (en) * | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF SERUM |
| US9657075B2 (en) | 2012-06-07 | 2017-05-23 | New York University | Chimeric fibroblast growth factor 23 proteins and methods of use |
| DK2875045T3 (en) * | 2012-07-18 | 2018-07-02 | Apogenix Ag | COMPOSITION comprising a mixture of CD95-FC ISOFORMs |
| US9550820B2 (en) | 2013-02-22 | 2017-01-24 | New York University | Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
| EP2969009B1 (en) * | 2013-03-15 | 2018-11-28 | Pyranose Biotherapeutics, Inc. | Modified fc fusion proteins |
| GB201316592D0 (en) * | 2013-09-18 | 2013-10-30 | Levicept Ltd | Fusion protein |
| PL3063275T3 (pl) | 2013-10-31 | 2020-03-31 | Resolve Therapeutics, Llc | Terapeutyczne fuzje nukleaza-albumina i sposoby |
| DK3099713T3 (da) | 2014-02-02 | 2020-04-14 | Medimmune Ltd | Kimært protein bestående af et ngf-antagonistdomæne og et tnfa-antagonistdomæne |
| JP2017517272A (ja) * | 2014-03-28 | 2017-06-29 | ニューヨーク・ユニバーシティ | Ｆｇｆ２３融合タンパク質 |
| CN105273087A (zh) * | 2014-07-14 | 2016-01-27 | 复旦大学 | NGF-Fc融合蛋白及其制备方法 |
| WO2016069889A1 (en) | 2014-10-31 | 2016-05-06 | Resolve Therapeutics, Llc | Therapeutic nuclease-transferrin fusions and methods |
| JP2018510637A (ja) * | 2015-03-26 | 2018-04-19 | アクセルロン ファーマ， インコーポレイテッド | フォリスタチン関連融合タンパク質およびその使用 |
| US10781246B2 (en) | 2015-06-05 | 2020-09-22 | New York University | Compositions and methods for anti-staphylococcal biologic agents |
| US11866736B2 (en) | 2015-07-31 | 2024-01-09 | The General Hospital Corporation | Protein prostheses for mitochondrial diseases or conditions |
| CA3004830A1 (en) * | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| CN119120423A (zh) | 2016-07-01 | 2024-12-13 | 分解治疗有限责任公司 | 优化的二核酸酶融合体和方法 |
| KR102777015B1 (ko) | 2017-08-22 | 2025-03-10 | 사나바이오, 엘엘씨 | 가용성 인터페론 수용체 및 그의 용도 |
| KR102263105B1 (ko) * | 2018-09-05 | 2021-06-09 | 주식회사 엘지화학 | O-글리코실화 가능한 폴리펩타이드 영역을 포함하는 융합 폴리펩타이드 |
| CN113597319A (zh) | 2019-01-04 | 2021-11-02 | 分解治疗有限责任公司 | 用核酸酶融合蛋白治疗干燥症 |
| EP4171614A1 (en) | 2020-06-29 | 2023-05-03 | Resolve Therapeutics, LLC | Treatment of sjogren's syndrome with nuclease fusion proteins |
| WO2025147696A1 (en) | 2024-01-05 | 2025-07-10 | Resolve Therapeutics, Llc | Treatment of symptoms associated with sars-cov viral infection or a prior sars-cov viral infection with nuclease agents |
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-
2010
- 2010-12-02 JP JP2012542194A patent/JP2013512674A/ja not_active Withdrawn
- 2010-12-02 US US12/959,220 patent/US8722615B2/en active Active
- 2010-12-02 KR KR1020127017129A patent/KR20140015152A/ko not_active Withdrawn
- 2010-12-02 EP EP10835138.8A patent/EP2507267B1/en active Active
- 2010-12-02 WO PCT/US2010/058765 patent/WO2011068993A1/en active Application Filing
- 2010-12-02 AU AU2010325943A patent/AU2010325943A1/en not_active Abandoned
- 2010-12-02 BR BR112012013330A patent/BR112012013330A2/pt not_active IP Right Cessation
- 2010-12-02 IN IN5169DEN2012 patent/IN2012DN05169A/en unknown
- 2010-12-02 RU RU2012127383/10A patent/RU2012127383A/ru not_active Application Discontinuation
- 2010-12-02 CN CN2010800629282A patent/CN102770458A/zh active Pending
- 2010-12-02 CA CA2782320A patent/CA2782320A1/en not_active Abandoned
-
2014
- 2014-04-24 US US14/261,212 patent/US20150010555A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2507267A4 (en) | 2013-05-29 |
| EP2507267B1 (en) | 2016-09-14 |
| JP2013512674A (ja) | 2013-04-18 |
| IN2012DN05169A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-10-23 |
| BR112012013330A2 (pt) | 2017-03-28 |
| US8722615B2 (en) | 2014-05-13 |
| US20110171218A1 (en) | 2011-07-14 |
| CN102770458A (zh) | 2012-11-07 |
| WO2011068993A1 (en) | 2011-06-09 |
| CA2782320A1 (en) | 2011-06-09 |
| US20150010555A1 (en) | 2015-01-08 |
| EP2507267A1 (en) | 2012-10-10 |
| AU2010325943A1 (en) | 2012-06-21 |
| KR20140015152A (ko) | 2014-02-06 |
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