RU2012127364A - Химеры фибронектин: фактор роста - Google Patents
Химеры фибронектин: фактор роста Download PDFInfo
- Publication number
- RU2012127364A RU2012127364A RU2012127364/10A RU2012127364A RU2012127364A RU 2012127364 A RU2012127364 A RU 2012127364A RU 2012127364/10 A RU2012127364/10 A RU 2012127364/10A RU 2012127364 A RU2012127364 A RU 2012127364A RU 2012127364 A RU2012127364 A RU 2012127364A
- Authority
- RU
- Russia
- Prior art keywords
- protein complex
- isolated protein
- growth factor
- complex according
- seq
- Prior art date
Links
- 108010067306 Fibronectins Proteins 0.000 title claims abstract 28
- 239000003102 growth factor Substances 0.000 title claims abstract 8
- 102000016359 Fibronectins Human genes 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 claims abstract 30
- 108090000623 proteins and genes Proteins 0.000 claims abstract 30
- 102100037362 Fibronectin Human genes 0.000 claims abstract 27
- 150000001413 amino acids Chemical group 0.000 claims abstract 14
- 102000006495 integrins Human genes 0.000 claims abstract 7
- 108010044426 integrins Proteins 0.000 claims abstract 7
- 239000012634 fragment Substances 0.000 claims abstract 6
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 claims abstract 4
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 claims abstract 4
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims abstract 4
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims abstract 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims abstract 3
- 102000009465 Growth Factor Receptors Human genes 0.000 claims abstract 3
- 108010009202 Growth Factor Receptors Proteins 0.000 claims abstract 3
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims abstract 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims abstract 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims abstract 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims abstract 2
- 102000037865 fusion proteins Human genes 0.000 claims abstract 2
- 108020001507 fusion proteins Proteins 0.000 claims abstract 2
- 102000028416 insulin-like growth factor binding Human genes 0.000 claims abstract 2
- 108091022911 insulin-like growth factor binding Proteins 0.000 claims abstract 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 230000002068 genetic effect Effects 0.000 claims 3
- 230000005012 migration Effects 0.000 claims 3
- 238000013508 migration Methods 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 2
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- PBYFVIQRFLNQCO-GUBZILKMSA-N Gln-Pro-Gln Chemical compound [H]N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O PBYFVIQRFLNQCO-GUBZILKMSA-N 0.000 claims 1
- PAWIVEIWWYGBAM-YUMQZZPRSA-N Gly-Leu-Ala Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O PAWIVEIWWYGBAM-YUMQZZPRSA-N 0.000 claims 1
- HNDWYLYAYNBWMP-AJNGGQMLSA-N Leu-Ile-Lys Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(C)C)N HNDWYLYAYNBWMP-AJNGGQMLSA-N 0.000 claims 1
- IRVONVRHHJXWTK-RWMBFGLXSA-N Met-Lys-Pro Chemical compound CSCC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)O)N IRVONVRHHJXWTK-RWMBFGLXSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 108010078144 glutaminyl-glycine Proteins 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 108010022588 methionyl-lysyl-proline Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/627,647 US20100143442A1 (en) | 2003-02-05 | 2009-11-30 | Growth factor complexes and modulation of cell migration and growth |
| US12/627,647 | 2009-11-30 | ||
| US12/793,386 US8871709B2 (en) | 2003-02-05 | 2010-06-03 | Synthetic chimeric proteins comprising epidermal growth factor and vitronectin |
| US12/793,386 | 2010-06-03 | ||
| PCT/AU2010/001613 WO2011063477A1 (en) | 2009-11-30 | 2010-11-30 | Fibronectin: growth factor chimeras |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012127364A true RU2012127364A (ru) | 2014-01-10 |
Family
ID=44065756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012127364/10A RU2012127364A (ru) | 2009-11-30 | 2010-11-30 | Химеры фибронектин: фактор роста |
Country Status (12)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8871709B2 (en) | 2003-02-05 | 2014-10-28 | Queensland University of Technolgy | Synthetic chimeric proteins comprising epidermal growth factor and vitronectin |
| CN103834664B (zh) * | 2014-03-27 | 2016-05-04 | 吉林大学 | 重组表皮生长因子egf及其制备方法 |
| CN110023325B (zh) * | 2016-10-14 | 2023-07-04 | 尼优美特里克斯医疗有限公司 | 具有提高的生物活性和降低的对嗜中性粒细胞弹性蛋白酶降解易感性的来源于纤连蛋白的肽 |
| WO2019010533A1 (en) * | 2017-07-12 | 2019-01-17 | Factor Therapeutics Limited | TREATMENT OF OCULAR DISORDERS |
| CN110123732A (zh) * | 2019-04-03 | 2019-08-16 | 广州市拉凯尔干细胞研究所 | 一种含有纤连蛋白化妆品原料制备方法 |
| CN114040923B (zh) * | 2019-04-05 | 2024-11-26 | 韩国窑业技术院 | 利用肌集钙蛋白标签的蛋白质的表达及纯化方法 |
| KR102440312B1 (ko) * | 2020-08-28 | 2022-09-05 | 한국해양과학기술원 | 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도 |
| CN119264240B (zh) * | 2024-09-10 | 2025-03-25 | 浙江诸暨聚源生物技术有限公司 | 功能增强的重组纤连蛋白及其制备方法和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4843000A (en) | 1979-12-26 | 1989-06-27 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4849338A (en) | 1982-07-16 | 1989-07-18 | Syntex (U.S.A.) Inc. | Simultaneous calibration heterogeneous immunoassay |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JP3178714B2 (ja) | 1988-07-15 | 2001-06-25 | セントラル・シドニー・エリア・ヘルス・サービス | インスリン様成長因子（ｉｇｆ）結合蛋白複合体の酸不安定サブユニット（ａｌｓ） |
| US6090790A (en) | 1989-12-14 | 2000-07-18 | Eriksson; Elof | Gene delivery by microneedle injection |
| JP2866134B2 (ja) * | 1990-02-05 | 1999-03-08 | 寳酒造株式会社 | 機能性ポリペプチド |
| AU649066B2 (en) | 1990-07-25 | 1994-05-12 | Syngene, Inc. | Circular extension for generating multiple nucleic acid complements |
| US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| JP2829405B2 (ja) * | 1991-10-14 | 1998-11-25 | 寳酒造株式会社 | 機能性ポリペプチド |
| US5958764A (en) | 1992-04-30 | 1999-09-28 | Baylor College Of Medicine | Specific expression vectors and methods of use |
| WO1994018232A1 (en) | 1993-02-12 | 1994-08-18 | Repligen Corporation | Methods for generating broadly neutralizing anti-hiv antibodies and antigens capable of eliciting same |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5962427A (en) | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
| AUPM672594A0 (en) | 1994-07-08 | 1994-08-04 | Royal Children's Hospital Research Foundation | A method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders |
| ATE195555T1 (de) * | 1994-11-29 | 2000-09-15 | Takara Shuzo Co | Verfahren zur herstellung transformierter zellen |
| AU709831B2 (en) * | 1995-11-13 | 1999-09-09 | Takara Bio Inc. | Method for gene transfer into target cells with retrovirus |
| DK0862656T3 (da) | 1995-11-21 | 2001-04-09 | Univ Yale | Unimolekylær segmentamplifikation og -detektering |
| US5752019A (en) | 1995-12-22 | 1998-05-12 | International Business Machines Corporation | System and method for confirmationally-flexible molecular identification |
| US5835382A (en) | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
| US6077987A (en) | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
| WO1999047070A1 (en) | 1998-03-18 | 1999-09-23 | Wake Forest University | Improved implantable biomaterials, compositions and methods for their preparation and uses thereof |
| AUPP298498A0 (en) | 1998-04-17 | 1998-05-07 | Gropep Pty Ltd | Matrix binding factor |
| US6436897B2 (en) | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
| AU3897200A (en) | 1999-03-18 | 2000-10-04 | Hope Heart Institute, The | Endothelial cell stimulation by a complex of fibronectin and vascular endothelial growth factor |
| AU2003900481A0 (en) * | 2003-02-05 | 2003-02-20 | Queensland University Of Technology | Synthetic modulators of cell migration and growth |
| JP2008125460A (ja) * | 2006-11-22 | 2008-06-05 | Institute Of Physical & Chemical Research | フィブリン結合性成長因子 |
| CA2690734A1 (en) * | 2007-06-14 | 2008-12-24 | Richard A. Clark | Polypeptides and methods of use |
-
2010
- 2010-11-30 AU AU2010324554A patent/AU2010324554B2/en not_active Ceased
- 2010-11-30 ES ES10832439.3T patent/ES2619938T3/es active Active
- 2010-11-30 CN CN201080062313XA patent/CN102725308A/zh active Pending
- 2010-11-30 RU RU2012127364/10A patent/RU2012127364A/ru not_active Application Discontinuation
- 2010-11-30 EP EP10832439.3A patent/EP2507261B1/en not_active Not-in-force
- 2010-11-30 JP JP2012540231A patent/JP2013511960A/ja active Pending
- 2010-11-30 CA CA2781474A patent/CA2781474C/en not_active Expired - Fee Related
- 2010-11-30 BR BR112012013035A patent/BR112012013035A8/pt not_active Application Discontinuation
- 2010-11-30 NZ NZ600454A patent/NZ600454A/en not_active IP Right Cessation
- 2010-11-30 KR KR1020127016766A patent/KR101930916B1/ko not_active Expired - Fee Related
- 2010-11-30 WO PCT/AU2010/001613 patent/WO2011063477A1/en not_active Ceased
-
2012
- 2012-05-29 ZA ZA2012/03915A patent/ZA201203915B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ600454A (en) | 2014-10-31 |
| AU2010324554A1 (en) | 2012-06-21 |
| EP2507261B1 (en) | 2016-12-21 |
| EP2507261A1 (en) | 2012-10-10 |
| CA2781474C (en) | 2019-06-18 |
| ES2619938T3 (es) | 2017-06-27 |
| JP2013511960A (ja) | 2013-04-11 |
| KR101930916B1 (ko) | 2018-12-19 |
| EP2507261A4 (en) | 2013-04-10 |
| CA2781474A1 (en) | 2011-06-03 |
| KR20120114277A (ko) | 2012-10-16 |
| BR112012013035A8 (pt) | 2018-04-03 |
| WO2011063477A1 (en) | 2011-06-03 |
| BR112012013035A2 (pt) | 2017-05-16 |
| AU2010324554B2 (en) | 2014-07-31 |
| ZA201203915B (en) | 2018-11-28 |
| CN102725308A (zh) | 2012-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HZ9A | Changing address for correspondence with an applicant | ||
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160905 |