RU2012114832A - Питательные композиции для модулирования воспаления, содержащие экзогенный витамин к2 - Google Patents
Питательные композиции для модулирования воспаления, содержащие экзогенный витамин к2 Download PDFInfo
- Publication number
- RU2012114832A RU2012114832A RU2012114832/13A RU2012114832A RU2012114832A RU 2012114832 A RU2012114832 A RU 2012114832A RU 2012114832/13 A RU2012114832/13 A RU 2012114832/13A RU 2012114832 A RU2012114832 A RU 2012114832A RU 2012114832 A RU2012114832 A RU 2012114832A
- Authority
- RU
- Russia
- Prior art keywords
- inflammation
- effects
- exogenous vitamin
- modulation
- effective amount
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title claims abstract 19
- 230000004054 inflammatory process Effects 0.000 title claims abstract 19
- 239000000203 mixture Substances 0.000 title claims abstract 12
- 235000016709 nutrition Nutrition 0.000 title claims abstract 12
- 239000011782 vitamin Substances 0.000 title abstract 2
- 235000013343 vitamin Nutrition 0.000 title abstract 2
- 229940088594 vitamin Drugs 0.000 title abstract 2
- 229930003231 vitamin Natural products 0.000 title abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract 31
- PFRQBZFETXBLTP-UHFFFAOYSA-N Vitamin K2 Natural products C1=CC=C2C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-UHFFFAOYSA-N 0.000 claims abstract 17
- DKHGMERMDICWDU-GHDNBGIDSA-N menaquinone-4 Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 DKHGMERMDICWDU-GHDNBGIDSA-N 0.000 claims abstract 16
- 235000019143 vitamin K2 Nutrition 0.000 claims abstract 14
- 239000011728 vitamin K2 Substances 0.000 claims abstract 14
- 230000000694 effects Effects 0.000 claims abstract 13
- 150000001413 amino acids Chemical class 0.000 claims abstract 4
- 238000009472 formulation Methods 0.000 claims abstract 4
- 239000011700 menaquinone-7 Substances 0.000 claims abstract 3
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 claims abstract 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims abstract 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract 2
- CNIUEVQJABPUIJ-QMMMGPOBSA-N N-hydroxytyrosine Chemical compound ON[C@H](C(O)=O)CC1=CC=C(O)C=C1 CNIUEVQJABPUIJ-QMMMGPOBSA-N 0.000 claims abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000003963 antioxidant agent Substances 0.000 claims abstract 2
- 230000003078 antioxidant effect Effects 0.000 claims abstract 2
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000005911 diet Nutrition 0.000 claims abstract 2
- 230000000378 dietary effect Effects 0.000 claims abstract 2
- 235000015872 dietary supplement Nutrition 0.000 claims abstract 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims abstract 2
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 claims abstract 2
- 235000019197 fats Nutrition 0.000 claims abstract 2
- 235000021323 fish oil Nutrition 0.000 claims abstract 2
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 claims abstract 2
- 229960002591 hydroxyproline Drugs 0.000 claims abstract 2
- 239000011676 menaquinone-4 Substances 0.000 claims abstract 2
- 239000002773 nucleotide Substances 0.000 claims abstract 2
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims abstract 2
- 229940012843 omega-3 fatty acid Drugs 0.000 claims abstract 2
- 239000006014 omega-3 oil Substances 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 235000013406 prebiotics Nutrition 0.000 claims abstract 2
- 239000006041 probiotic Substances 0.000 claims abstract 2
- 235000018291 probiotics Nutrition 0.000 claims abstract 2
- 239000000047 product Substances 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims abstract 2
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 claims 3
- 208000015943 Coeliac disease Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 206010002261 Androgen deficiency Diseases 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010012559 Developmental delay Diseases 0.000 claims 1
- 102100022466 Eukaryotic translation initiation factor 4E-binding protein 1 Human genes 0.000 claims 1
- 108050000946 Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 102000008934 Muscle Proteins Human genes 0.000 claims 1
- 108010074084 Muscle Proteins Proteins 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 102000004264 Osteopontin Human genes 0.000 claims 1
- 108010081689 Osteopontin Proteins 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 102000003861 Ribosomal protein S6 Human genes 0.000 claims 1
- 108090000221 Ribosomal protein S6 Proteins 0.000 claims 1
- 206010049416 Short-bowel syndrome Diseases 0.000 claims 1
- 102000005747 Transcription Factor RelA Human genes 0.000 claims 1
- 108010031154 Transcription Factor RelA Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 229930003316 Vitamin D Natural products 0.000 claims 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 1
- 230000002232 neuromuscular Effects 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 235000019166 vitamin D Nutrition 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
- 229940046008 vitamin d Drugs 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Pediatric Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24208709P | 2009-09-14 | 2009-09-14 | |
| US61/242,087 | 2009-09-14 | ||
| US25084709P | 2009-10-12 | 2009-10-12 | |
| US61/250,847 | 2009-10-12 | ||
| US34794510P | 2010-05-25 | 2010-05-25 | |
| US61/347,945 | 2010-05-25 | ||
| US37184610P | 2010-08-09 | 2010-08-09 | |
| US61/371,846 | 2010-08-09 | ||
| PCT/US2010/047468 WO2011031602A1 (en) | 2009-09-14 | 2010-09-01 | Nutritional compositions for modulating inflammation including exogenous vitamin k2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012114832A true RU2012114832A (ru) | 2013-10-27 |
Family
ID=43098924
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012114832/13A RU2012114832A (ru) | 2009-09-14 | 2010-09-01 | Питательные композиции для модулирования воспаления, содержащие экзогенный витамин к2 |
| RU2012114786/15A RU2012114786A (ru) | 2009-09-14 | 2010-09-01 | Питательные композиции, содержащие экзогенный витамин к2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012114786/15A RU2012114786A (ru) | 2009-09-14 | 2010-09-01 | Питательные композиции, содержащие экзогенный витамин к2 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20130052274A1 (enExample) |
| EP (2) | EP2477618A2 (enExample) |
| JP (3) | JP2013504572A (enExample) |
| CN (2) | CN102596190A (enExample) |
| AU (2) | AU2010292439A1 (enExample) |
| BR (1) | BR112012005783A2 (enExample) |
| CA (2) | CA2773957C (enExample) |
| DK (1) | DK2477510T3 (enExample) |
| ES (1) | ES2669004T3 (enExample) |
| IN (2) | IN2012DN02245A (enExample) |
| MX (2) | MX2012003081A (enExample) |
| PH (2) | PH12012500489A1 (enExample) |
| RU (2) | RU2012114832A (enExample) |
| SG (2) | SG179064A1 (enExample) |
| TR (1) | TR201808128T4 (enExample) |
| WO (2) | WO2011031601A2 (enExample) |
| ZA (2) | ZA201202711B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130028864A1 (en) * | 1998-04-08 | 2013-01-31 | Theta Biomedical Consulting & Development Co., Inc. | Anti-inflammatory compositions for treating brain inflammation |
| JP2013504572A (ja) * | 2009-09-14 | 2013-02-07 | ネステク ソシエテ アノニム | 外因性ビタミンｋ２を含む炎症調節用栄養組成物 |
| BR112013026706A2 (pt) * | 2011-04-18 | 2016-12-27 | Nestec Sa | composições nutricionais compreendendo ácido alfa-hidroxi-isocaproico |
| US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| CN102772401A (zh) * | 2011-10-02 | 2012-11-14 | 南京大学 | 鼠尾草酚的抗骨质疏松新用途 |
| WO2013144268A1 (en) * | 2012-03-29 | 2013-10-03 | Nestec S.A. | Nutrition and exercise against drug-associated malnutrition in children |
| WO2013144267A2 (en) * | 2012-03-29 | 2013-10-03 | Nestec S.A. | Improvement of musculoskeletal health by nutrition and exercise |
| BR112015001884B1 (pt) | 2012-07-31 | 2020-12-01 | Société des Produits Nestlé S.A. | composição nutricional para promover a saúde musculoesquelética em pacientes com doença inflamatória intestinal (ibd), seu uso, e formulação farmacêutica, formulação nutricional, formulação de alimentação por tubo, suplemento alimentar, alimento funcional ou produto de bebida |
| US20150250839A1 (en) * | 2012-09-11 | 2015-09-10 | Dakota Star Capital Llc | Nutritional supplement containing iron |
| CN103142640A (zh) * | 2013-04-01 | 2013-06-12 | 李拖平 | 含有维生素k2的具有预防与治疗骨质疏松症的保健品 |
| EP3397960B1 (en) * | 2015-12-30 | 2020-01-29 | Société des Produits Nestlé S.A. | Method for determining fat free body mass |
| CN105815791B (zh) * | 2016-03-24 | 2018-12-18 | 刘超 | 一种具有增肌功能并消除不良反应的组合物 |
| AU2017274438A1 (en) * | 2016-06-02 | 2018-12-13 | Ana Pharmaceuticals, Inc. | Methods and compositions for treatment of hypercalciuria and nephrolithiasis |
| US20220175851A1 (en) * | 2019-03-13 | 2022-06-09 | The Regents Of The University California | Compositions, methods for regulating uterine, placental growth |
| CN110122866A (zh) * | 2019-05-31 | 2019-08-16 | 广东双骏生物科技有限公司 | 一种慢性肾脏病血管钙化的特殊医学用途食品及制备方法 |
| TR202002698A2 (tr) * | 2020-02-21 | 2021-09-21 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Kemoterapi̇ ve/veya radyoterapi̇ alan ve/veya cerrahi̇ öncesi̇ ve |
| WO2023275183A1 (en) | 2021-06-29 | 2023-01-05 | Kappa Bioscience As | Composition comprising vitamin k, vitamin d, xanthophyll and epa and/or dha |
| CN115989871A (zh) * | 2021-10-20 | 2023-04-21 | 安琪纽特股份有限公司 | 一种促进生长发育的组合物及其制备方法和应用 |
| CN115590198B (zh) * | 2022-09-26 | 2024-06-18 | 黑龙江飞鹤乳业有限公司 | 核苷酸的用途、营养组合物、食品及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US347945A (en) | 1886-08-24 | vavtu | ||
| US242087A (en) | 1881-05-24 | Machine for making laps on belting | ||
| US371846A (en) | 1887-10-18 | Tennis-racket | ||
| US250847A (en) | 1881-12-13 | Vehicle-top | ||
| JPH07119191B2 (ja) * | 1990-08-16 | 1995-12-20 | 株式会社日本触媒 | メナジオン亜硫酸水素塩の安定化方法及びメナジオン亜硫酸水素塩組成物 |
| US5132113A (en) * | 1990-10-26 | 1992-07-21 | Maurizio Luca | Nutritional composition containing essential amino acids |
| EP0689835A3 (en) * | 1994-06-30 | 1996-04-17 | Ajinomoto Kk | Composition containing an amino acid mixture and at least one N-3 fatty acid |
| WO1997039746A1 (en) * | 1996-04-22 | 1997-10-30 | Advanced Polymer Systems, Inc. | Method of and composition for treating disorders of the skin using vitamin k |
| JP3459932B2 (ja) * | 1996-07-23 | 2003-10-27 | 株式会社ホーネンコーポレーション | 抗骨粗鬆症組成物 |
| US6566064B1 (en) * | 1999-05-18 | 2003-05-20 | Nipro Corporation | Method for anticipating sensitivity to medicine for osteoporosis |
| PT1153548E (pt) * | 2000-05-12 | 2007-08-08 | Nattopharma Asa | Produto alimentar contendo vitamina k |
| NZ507335A (en) * | 2000-10-05 | 2004-10-29 | New Zealand Dairy Board | Bone health compositions derived from milk comprising an acidic protein fraction but that does not contain CGMP |
| GB2370503A (en) * | 2000-12-27 | 2002-07-03 | Novartis Nutrition Ag | Compositions comprising vitamin K |
| JP4131443B2 (ja) * | 2001-08-27 | 2008-08-13 | 株式会社Ｊ−オイルミルズ | 抗骨粗鬆症組成物 |
| JP2004155658A (ja) * | 2002-11-01 | 2004-06-03 | Kyowa Hakko Kogyo Co Ltd | ＴＮＦ−α産生抑制剤 |
| WO2005030190A1 (en) * | 2003-09-26 | 2005-04-07 | Natural Asa | Natural menaquinone 7 compositions |
| WO2005107731A1 (ja) * | 2004-05-12 | 2005-11-17 | Eisai R & D Management Co., Ltd. | ビタミンk2を有効成分として含む治療剤 |
| CN102696941A (zh) * | 2004-06-04 | 2012-10-03 | 视界科技有限公司 | 天然甜味剂 |
| US20060223730A1 (en) * | 2005-04-04 | 2006-10-05 | Hl Distribution Company | Calcium supplements |
| JP2006325487A (ja) * | 2005-05-26 | 2006-12-07 | Pola Chem Ind Inc | 栄養補給用固形食品 |
| US20090137614A1 (en) | 2005-05-27 | 2009-05-28 | Shionogi & Co., Ltd. | Pharmaceutical combination comprising vitamin k |
| BE1016895A6 (fr) * | 2005-12-16 | 2007-09-04 | Psaltopoulos Emmanuel | MOLECULE INCORPORANT LE CALCIUM (CA), LA VITAMINE "D" ET LA VITAMINE "K" POUR LA PREVENTION ET LE TRAITEMENT DE l'OSTEOPOROSE AINSI QUE POUR LA PREVENTION DE LA CALCIFICATION VASCULAIRE ET POUR LA PREVENTION DE LA CALCIFICATION DU CARTILAGE DES ARTICULATIONS. |
| CA2641315A1 (en) * | 2006-02-06 | 2007-08-16 | Tethys Bioscience, Inc. | Osteoporosis associated markers and methods of use thereof |
| US9011930B2 (en) * | 2006-05-01 | 2015-04-21 | Zycal Bioceuticals Healthcare Company, Inc. | Nutritional supplement and use thereof |
| WO2008006607A2 (en) * | 2006-07-14 | 2008-01-17 | Nattopharma Asa | Pharmaceutical and nutraceutical products comprising vitamin k2 |
| FR2906816B1 (fr) * | 2006-10-04 | 2012-04-06 | Gervais Danone Sa | Variants de bacteries lactiques utiles pour produire la vitamine k2 et leurs applications a la preparation de produits alimentaires |
| US20080220094A1 (en) * | 2006-11-01 | 2008-09-11 | Wyeth | Compositions and methods for the treatment and/or prevention of osteoporosis |
| BRPI0812686A2 (pt) * | 2007-07-24 | 2011-10-18 | Viridis Biopharma Pvt Ltd | meios de aplicação de análogos da vitamina k e derivados para o tratamento de condições de doença humana e distúrbios |
| NL1034964C2 (nl) * | 2008-01-28 | 2009-07-30 | Friesland Brands Bv | Werkwijze en composities voor de behandeling van botaandoeningen. |
| WO2009105234A2 (en) * | 2008-02-19 | 2009-08-27 | Combinatorx, Incorporated | Methods and compositions for the treatment of disorders associated with defects of the cystic fibrosis transmembrane conductance regulator gene or protein |
| US8815953B2 (en) * | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
| JP2013504572A (ja) * | 2009-09-14 | 2013-02-07 | ネステク ソシエテ アノニム | 外因性ビタミンｋ２を含む炎症調節用栄養組成物 |
-
2010
- 2010-09-01 JP JP2012528831A patent/JP2013504572A/ja active Pending
- 2010-09-01 IN IN2245DEN2012 patent/IN2012DN02245A/en unknown
- 2010-09-01 PH PH1/2012/500489A patent/PH12012500489A1/en unknown
- 2010-09-01 BR BR112012005783A patent/BR112012005783A2/pt not_active IP Right Cessation
- 2010-09-01 SG SG2012016614A patent/SG179064A1/en unknown
- 2010-09-01 US US13/395,054 patent/US20130052274A1/en not_active Abandoned
- 2010-09-01 RU RU2012114832/13A patent/RU2012114832A/ru not_active Application Discontinuation
- 2010-09-01 MX MX2012003081A patent/MX2012003081A/es not_active Application Discontinuation
- 2010-09-01 AU AU2010292439A patent/AU2010292439A1/en not_active Abandoned
- 2010-09-01 MX MX2012003080A patent/MX2012003080A/es unknown
- 2010-09-01 WO PCT/US2010/047465 patent/WO2011031601A2/en not_active Ceased
- 2010-09-01 US US13/395,060 patent/US20120208893A1/en not_active Abandoned
- 2010-09-01 DK DK10752497.7T patent/DK2477510T3/en active
- 2010-09-01 TR TR2018/08128T patent/TR201808128T4/tr unknown
- 2010-09-01 CA CA2773957A patent/CA2773957C/en active Active
- 2010-09-01 SG SG2012016622A patent/SG179065A1/en unknown
- 2010-09-01 ES ES10752497.7T patent/ES2669004T3/es active Active
- 2010-09-01 PH PH1/2012/500488A patent/PH12012500488A1/en unknown
- 2010-09-01 EP EP10752687A patent/EP2477618A2/en not_active Withdrawn
- 2010-09-01 CA CA2773940A patent/CA2773940A1/en not_active Abandoned
- 2010-09-01 AU AU2010292440A patent/AU2010292440B2/en active Active
- 2010-09-01 RU RU2012114786/15A patent/RU2012114786A/ru not_active Application Discontinuation
- 2010-09-01 JP JP2012528830A patent/JP2013504571A/ja active Pending
- 2010-09-01 EP EP10752497.7A patent/EP2477510B1/en active Active
- 2010-09-01 WO PCT/US2010/047468 patent/WO2011031602A1/en not_active Ceased
- 2010-09-01 IN IN2184DEN2012 patent/IN2012DN02184A/en unknown
- 2010-09-01 CN CN2010800508998A patent/CN102596190A/zh active Pending
- 2010-09-01 CN CN2010800504018A patent/CN102781258A/zh active Pending
-
2012
- 2012-04-13 ZA ZA2012/02711A patent/ZA201202711B/en unknown
- 2012-04-13 ZA ZA2012/02712A patent/ZA201202712B/en unknown
-
2013
- 2013-08-09 US US13/963,244 patent/US20130323361A1/en not_active Abandoned
-
2015
- 2015-10-02 JP JP2015196933A patent/JP2016041705A/ja active Pending
-
2016
- 2016-04-14 US US15/099,257 patent/US9687456B2/en active Active
- 2016-12-23 US US15/389,945 patent/US20170105948A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2012114832A (ru) | Питательные композиции для модулирования воспаления, содержащие экзогенный витамин к2 | |
| JP2016041705A5 (enExample) | ||
| Susanto et al. | Senyawa fungsional dari ikan: aplikasinya dalam pangan | |
| Puangkaew et al. | Nonspecific immune response of rainbow trout (Oncorhynchus mykiss Walbaum) in relation to different status of vitamin E and highly unsaturated fatty acids | |
| JP6495245B2 (ja) | がんの治療及び／又は後治療のための魚油及びジュースを含む組成物の使用 | |
| KR20140135695A (ko) | 유리 산 형태의 오메가-3 다중불포화 지방산의 ｄｐａ-농축 조성물 | |
| NZ734905A (en) | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same | |
| WO2013153071A3 (en) | A nutritional composition | |
| CA2660291A1 (en) | Methods of improving bone health and muscle health | |
| AU2018302797B2 (en) | Compositions comprising thymoquinone and omega-3 fatty acids | |
| KR102373207B1 (ko) | 스테아리돈산 및 올리브 오일을 포함하는 식용 지질 조성물 | |
| Radcliffe et al. | Serum and liver lipids in rats fed diets containing corn oil, cottonseed oil, or a mixture of corn and cottonseed oils | |
| US7579374B2 (en) | Agent for improving bone metabolism | |
| WO2010032964A2 (ko) | 에나활성미네랄 a 활성수를 유효성분으로 함유하는 간손상 방지 또는 간기능 개선용 약학조성물 | |
| BE1021010B1 (nl) | Kit met meerdere voedingssupplementen en werkwijze voor het samenstellen ervan. | |
| JP7023732B2 (ja) | 炎症を伴う肝疾患の治療または予防剤 | |
| JP6067558B2 (ja) | 恐怖記憶の軽減方法 | |
| ES2413497A1 (es) | Composición con alto contenido en Omega 3, Omega 6 y Omega 9 | |
| HASBAL-CELIKOK | NUTRITIONAL SUPPLEMENTS FOR BRAIN HEALTH | |
| Lee et al. | A comprehensive review of dietary supplements mission-specific health and performance enhancement in military soldiers | |
| US20120135104A1 (en) | Enhanced Absorption of Omega Fatty Acid Oils | |
| JP2021052708A (ja) | アンジオテンシン変換酵素阻害剤 | |
| Abbott et al. | Enhanced nutrient content of Grass Fed Beef: Justification for Health Benefit Label Claim | |
| MX2022001238A (es) | Composicion lipidica que comprende antioxidantes y polifenoles naturales como alternativa no farmacologica para el tratamiento y la prevencion de nafld. | |
| EA025844B1 (ru) | Средство для коррекции гиперхолестеринемии |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140905 |