RU2012111424A - Средства и способы производства искусственных капсульных полисахаридов neisseria meningitidis - Google Patents
Средства и способы производства искусственных капсульных полисахаридов neisseria meningitidis Download PDFInfo
- Publication number
- RU2012111424A RU2012111424A RU2012111424/10A RU2012111424A RU2012111424A RU 2012111424 A RU2012111424 A RU 2012111424A RU 2012111424/10 A RU2012111424/10 A RU 2012111424/10A RU 2012111424 A RU2012111424 A RU 2012111424A RU 2012111424 A RU2012111424 A RU 2012111424A
- Authority
- RU
- Russia
- Prior art keywords
- nucleic acid
- acid molecule
- capsular
- carbohydrate
- seq
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title claims abstract 32
- 229920001282 polysaccharide Polymers 0.000 title claims abstract 32
- 239000005017 polysaccharide Substances 0.000 title claims abstract 32
- 238000000034 method Methods 0.000 title claims abstract 29
- 241000588650 Neisseria meningitidis Species 0.000 title claims abstract 9
- 239000002775 capsule Substances 0.000 title claims abstract 4
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 21
- 239000002773 nucleotide Substances 0.000 claims abstract 15
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 15
- 230000000405 serological effect Effects 0.000 claims abstract 6
- 230000003213 activating effect Effects 0.000 claims abstract 5
- 238000000338 in vitro Methods 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 102000039446 nucleic acids Human genes 0.000 claims 33
- 108020004707 nucleic acids Proteins 0.000 claims 33
- 150000007523 nucleic acids Chemical class 0.000 claims 33
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 4
- XCCTYIAWTASOJW-UHFFFAOYSA-N UDP-Glc Natural products OC1C(O)C(COP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 XCCTYIAWTASOJW-UHFFFAOYSA-N 0.000 claims 3
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical group CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 claims 2
- 241000588653 Neisseria Species 0.000 claims 2
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- TXCIAUNLDRJGJZ-UHFFFAOYSA-N CMP-N-acetyl neuraminic acid Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-UHFFFAOYSA-N 0.000 claims 1
- TXCIAUNLDRJGJZ-BILDWYJOSA-N CMP-N-acetyl-beta-neuraminic acid Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@]1(C(O)=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-BILDWYJOSA-N 0.000 claims 1
- HXXFSFRBOHSIMQ-GASJEMHNSA-N D-glucopyranose 1-phosphate Chemical compound OC[C@H]1OC(OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O HXXFSFRBOHSIMQ-GASJEMHNSA-N 0.000 claims 1
- HXXFSFRBOHSIMQ-UHFFFAOYSA-N Di-K salt-alpha-D-Pyranose-Galactose 1-dihydrogen phosphate Natural products OCC1OC(OP(O)(O)=O)C(O)C(O)C1O HXXFSFRBOHSIMQ-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 102000003960 Ligases Human genes 0.000 claims 1
- 108090000364 Ligases Proteins 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- SQVRNKJHWKZAKO-LUWBGTNYSA-N N-acetylneuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-LUWBGTNYSA-N 0.000 claims 1
- HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical group O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 claims 1
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09168765 | 2009-08-26 | ||
| EP09168765.7 | 2009-08-26 | ||
| PCT/EP2010/062481 WO2011023764A1 (en) | 2009-08-26 | 2010-08-26 | Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012111424A true RU2012111424A (ru) | 2013-10-10 |
Family
ID=43086450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012111424/10A RU2012111424A (ru) | 2009-08-26 | 2010-08-26 | Средства и способы производства искусственных капсульных полисахаридов neisseria meningitidis |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20130012471A1 (OSRAM) |
| EP (1) | EP2470203A1 (OSRAM) |
| CN (1) | CN102596241A (OSRAM) |
| BR (1) | BR112012007877A2 (OSRAM) |
| CA (1) | CA2771672A1 (OSRAM) |
| IN (1) | IN2012DN01695A (OSRAM) |
| RU (1) | RU2012111424A (OSRAM) |
| WO (1) | WO2011023764A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013265336A1 (en) * | 2012-05-22 | 2014-12-04 | Novartis Ag | Meningococcus serogroup X conjugate |
| US10407703B2 (en) * | 2014-04-17 | 2019-09-10 | Medizinische Hochschule Hannover | Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity |
| SG11201700325SA (en) * | 2014-08-08 | 2017-02-27 | Glycovaxyn Ag | Modified host cells and hybrid oligosaccharides for use in bioconjugate production |
| CN107001450A (zh) * | 2014-11-18 | 2017-08-01 | 巴斯德研究所 | 特异于脑膜炎奈瑟球菌的血清群x的多克隆抗体及其在诊断中的用途 |
| BE1024282B1 (fr) * | 2015-07-01 | 2018-01-15 | Glaxosmithkline Biologicals Sa | Compositions immunogènes |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| CA1223831A (en) | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5792608A (en) | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5525711A (en) | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| CN1401774A (zh) * | 2002-07-19 | 2003-03-12 | 大连理工大学 | 一种尿苷二磷酸葡萄糖焦磷酸化酶基因及其克隆 |
-
2010
- 2010-08-26 EP EP10757740A patent/EP2470203A1/en not_active Withdrawn
- 2010-08-26 US US13/390,424 patent/US20130012471A1/en not_active Abandoned
- 2010-08-26 CN CN2010800483045A patent/CN102596241A/zh active Pending
- 2010-08-26 IN IN1695DEN2012 patent/IN2012DN01695A/en unknown
- 2010-08-26 BR BR112012007877A patent/BR112012007877A2/pt not_active IP Right Cessation
- 2010-08-26 WO PCT/EP2010/062481 patent/WO2011023764A1/en not_active Ceased
- 2010-08-26 CA CA2771672A patent/CA2771672A1/en not_active Abandoned
- 2010-08-26 RU RU2012111424/10A patent/RU2012111424A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IN2012DN01695A (OSRAM) | 2015-06-05 |
| CN102596241A (zh) | 2012-07-18 |
| US20130012471A1 (en) | 2013-01-10 |
| EP2470203A1 (en) | 2012-07-04 |
| CA2771672A1 (en) | 2011-03-03 |
| WO2011023764A1 (en) | 2011-03-03 |
| BR112012007877A2 (pt) | 2019-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Saxena et al. | Multidomain architecture of beta-glycosyl transferases: implications for mechanism of action | |
| DeAngelis | Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses | |
| DeAngelis et al. | Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F | |
| Mühlenhoff et al. | Polysialic acid: three-dimensional structure, biosynthesis and function | |
| US9938549B2 (en) | Process for producing monosaccharides | |
| Hay et al. | Bacterial biosynthesis of alginates | |
| JP4731013B2 (ja) | ヒアルロナンシンターゼ遺伝子およびその使用 | |
| Wang et al. | The O-antigen gene cluster of Escherichia coli O55: H7 and identification of a new UDP-GlcNAc C4 epimerase gene | |
| Coste et al. | Production of sulfated oligosaccharides from the seaweed Ulva sp. using a new ulvan-degrading enzymatic bacterial crude extract | |
| CN105452479B (zh) | 可逆肝素分子 | |
| RU2012111424A (ru) | Средства и способы производства искусственных капсульных полисахаридов neisseria meningitidis | |
| JP2002530087A (ja) | オリゴ糖の安価な産生 | |
| Chavaroche et al. | Production methods for heparosan, a precursor of heparin and heparan sulfate | |
| CN103228781B (zh) | 软骨素的生物技术制备 | |
| CZ20003576A3 (cs) | Nukleová kyselina kódující pro hyaluronan syntázu a způsoby jejího použití | |
| Itano et al. | Hyaluronan Synthase New Directions for Hyaluronan Research | |
| Mathews | Polyanionic proteoglycans | |
| US10273517B2 (en) | Methods of producing testosteronan polymers using testosteronan synthase | |
| WO2015158898A2 (en) | Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity | |
| CN113528482B (zh) | 高活性肝素骨架合酶PmHS2突变体及其应用 | |
| CN110643586B (zh) | 一种肝素骨架合酶及其编码基因与应用 | |
| Arioli et al. | Plant Cell Biology Group Research School of Biological Sciences Australian National University | |
| Class et al. | Patent application title: Production of Defined Monodisperse Heparosan Polymers and Unnatural Polymers with Polysaccharide Synthases Inventors: Paul L. Deangelis (Edmond, OK, US) Paul L. Deangelis (Edmond, OK, US) Alison Sismey-Ragatz (Cassville, WI, US) | |
| ITMI20101300A1 (it) | Produzione biotecnologica di condroitina | |
| ITMI20101264A1 (it) | Produzione biotecnologica di condroitina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150320 |