CA2771672A1 - Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis - Google Patents

Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis Download PDF

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Publication number
CA2771672A1
CA2771672A1 CA2771672A CA2771672A CA2771672A1 CA 2771672 A1 CA2771672 A1 CA 2771672A1 CA 2771672 A CA2771672 A CA 2771672A CA 2771672 A CA2771672 A CA 2771672A CA 2771672 A1 CA2771672 A1 CA 2771672A1
Authority
CA
Canada
Prior art keywords
cps
nucleic acid
udp
carbohydrate
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2771672A
Other languages
English (en)
French (fr)
Inventor
Rita Gerardyschahn
Martina Muehlenhoff
Andrea Bethe
Katharina Stummeyer
Friedrich Freiberger
Sebastian Damerow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medizinische Hochschule Hannover
Original Assignee
Medizinische Hochschule Hannover
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medizinische Hochschule Hannover filed Critical Medizinische Hochschule Hannover
Publication of CA2771672A1 publication Critical patent/CA2771672A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2771672A 2009-08-26 2010-08-26 Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis Abandoned CA2771672A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09168765 2009-08-26
EP09168765.7 2009-08-26
PCT/EP2010/062481 WO2011023764A1 (en) 2009-08-26 2010-08-26 Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis

Publications (1)

Publication Number Publication Date
CA2771672A1 true CA2771672A1 (en) 2011-03-03

Family

ID=43086450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2771672A Abandoned CA2771672A1 (en) 2009-08-26 2010-08-26 Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis

Country Status (8)

Country Link
US (1) US20130012471A1 (OSRAM)
EP (1) EP2470203A1 (OSRAM)
CN (1) CN102596241A (OSRAM)
BR (1) BR112012007877A2 (OSRAM)
CA (1) CA2771672A1 (OSRAM)
IN (1) IN2012DN01695A (OSRAM)
RU (1) RU2012111424A (OSRAM)
WO (1) WO2011023764A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013265336A1 (en) * 2012-05-22 2014-12-04 Novartis Ag Meningococcus serogroup X conjugate
US10407703B2 (en) * 2014-04-17 2019-09-10 Medizinische Hochschule Hannover Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity
SG11201700325SA (en) * 2014-08-08 2017-02-27 Glycovaxyn Ag Modified host cells and hybrid oligosaccharides for use in bioconjugate production
CN107001450A (zh) * 2014-11-18 2017-08-01 巴斯德研究所 特异于脑膜炎奈瑟球菌的血清群x的多克隆抗体及其在诊断中的用途
BE1024282B1 (fr) * 2015-07-01 2018-01-15 Glaxosmithkline Biologicals Sa Compositions immunogènes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
CN1401774A (zh) * 2002-07-19 2003-03-12 大连理工大学 一种尿苷二磷酸葡萄糖焦磷酸化酶基因及其克隆

Also Published As

Publication number Publication date
RU2012111424A (ru) 2013-10-10
IN2012DN01695A (OSRAM) 2015-06-05
CN102596241A (zh) 2012-07-18
US20130012471A1 (en) 2013-01-10
EP2470203A1 (en) 2012-07-04
WO2011023764A1 (en) 2011-03-03
BR112012007877A2 (pt) 2019-09-24

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FZDE Dead

Effective date: 20150826