IN2012DN01695A - - Google Patents

Download PDF

Info

Publication number
IN2012DN01695A
IN2012DN01695A IN1695DEN2012A IN2012DN01695A IN 2012DN01695 A IN2012DN01695 A IN 2012DN01695A IN 1695DEN2012 A IN1695DEN2012 A IN 1695DEN2012A IN 2012DN01695 A IN2012DN01695 A IN 2012DN01695A
Authority
IN
India
Prior art keywords
capsular polysaccharides
provides
neisseria meningitidis
capsular
polysaccharides
Prior art date
Application number
Inventor
Rita Gerardy-Schahn
Martina Muhlenhoff
Andrea Bethe
Katharina Stummeyer
Friedrich Freiberger
Sebastian Damerow
Original Assignee
Hannover Med Hochschule
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hannover Med Hochschule filed Critical Hannover Med Hochschule
Publication of IN2012DN01695A publication Critical patent/IN2012DN01695A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention provides for an in vitro method for producing capsular polysaccharides of Neisseria meningitidis. The invention also provides capsular polysaccharides obtainable by the methods described herein. The capsular polysaccharides comprise capsular polysaccharide specific for Neisseria meningitidis serogroups W-135, Y, X and A. Also encompassed are chimeric capsular polysaccharides comprising or composed of CPS of Neisseria meningitidis serogroups Y/W-135, W-135/Y, B/Y, C/Y, B/W-135, C/W-135, B/Y/W-135, C/Y/W-135, B/M-135/Y, C/W-135/Y. X/A or A/X. The invention also provides for the use of these capsular polysaccharides for as pharmaceuticals, particularly as vaccines and/or diagnostics.
IN1695DEN2012 2009-08-26 2010-08-26 IN2012DN01695A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09168765 2009-08-26
PCT/EP2010/062481 WO2011023764A1 (en) 2009-08-26 2010-08-26 Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis

Publications (1)

Publication Number Publication Date
IN2012DN01695A true IN2012DN01695A (en) 2015-06-05

Family

ID=43086450

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1695DEN2012 IN2012DN01695A (en) 2009-08-26 2010-08-26

Country Status (8)

Country Link
US (1) US20130012471A1 (en)
EP (1) EP2470203A1 (en)
CN (1) CN102596241A (en)
BR (1) BR112012007877A2 (en)
CA (1) CA2771672A1 (en)
IN (1) IN2012DN01695A (en)
RU (1) RU2012111424A (en)
WO (1) WO2011023764A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201407440WA (en) * 2012-05-22 2014-12-30 Novartis Ag Meningococcus serogroup x conjugate
WO2015158898A2 (en) 2014-04-17 2015-10-22 Medizinische Hochschule Hannover Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity
US10307474B2 (en) 2014-08-08 2019-06-04 Glaxosmithkline Biologicals S.A. Modified host cells and hybrid oligosaccharides for use in bioconjugate production
MA40974B1 (en) * 2014-11-18 2021-02-26 Pasteur Institut Polyclonal antibodies specific for serogroup x of n. Meningitidis and their uses in diagnosis
WO2017001586A1 (en) * 2015-07-01 2017-01-05 Glaxosmithkline Biologicals S.A. Immunogenic compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
CN1401774A (en) * 2002-07-19 2003-03-12 大连理工大学 Uridine diphosphate glucose pyrophosphorylase gene and clone thereof

Also Published As

Publication number Publication date
RU2012111424A (en) 2013-10-10
WO2011023764A1 (en) 2011-03-03
EP2470203A1 (en) 2012-07-04
CN102596241A (en) 2012-07-18
CA2771672A1 (en) 2011-03-03
US20130012471A1 (en) 2013-01-10
BR112012007877A2 (en) 2019-09-24

Similar Documents

Publication Publication Date Title
BR112012007876A2 (en) "ion exchange membranes"
IN2014DN09791A (en)
AU2016204319A1 (en) Methods and compositions for producing squalene using yeast
MX364229B (en) COMPOSITIONS and METHODS FOR TREATING CARDIOVASCULAR DISEASES.
IN2012DN01695A (en)
BRPI0607374A2 (en) gna1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
GB0900127D0 (en) Method of producing miningococcal meningitis vaccine for neisseria menningitis serotyes A, C, Y and W-135
MX2009008928A (en) Compositions comprising polysaccharide conjugates and their use as vaccines.
MY168661A (en) Methods for modulating cell-mediated immunity using human milk oligosaccharides
GB0503936D0 (en) Method
WO2010000127A9 (en) Method to induce and expand therapeutic alloantigen- specific human regulatory t cells in large-scale
MY198870A (en) Producing edible residues from ethanol production
MY163889A (en) Wellbore servicing compositions and methods of making and using same
PH12015500497A1 (en) Production method for capsular polysaccharide having pneumococcal serotype
MX2014014576A (en) Vaccines for serogroup x meningococcus.
MX2018010920A (en) Novel polysaccharide-protein conjugates and process to obtain thereof.
WO2015066668A8 (en) Methods of removing alpha-galactose
WO2018042017A3 (en) Vaccines for neisseria gonorrhoeae
BRPI0918226A2 (en) immunogenic composition, method for producing an immunogenic composition, method for eliciting an immune response against neisseria, use of the immunogenic composition, and vaccine
MX2011006721A (en) Pharmaceutical formulation of nanonised fenofibrate.
MX367780B (en) Immunogenic complex for vaccination and method for the production thereof.
EP2155244A4 (en) Antigenic polysaccharides and process for their preparation
WO2010129457A3 (en) Vaccines against tularemia
WO2012166554A3 (en) Extracellular matrix material conduits and methods of making and using same
WO2015158898A3 (en) Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity