RU2010130155A - Покрытие для медицинского устройства, содержащее антитромбоцитарный коньюгат - Google Patents
Покрытие для медицинского устройства, содержащее антитромбоцитарный коньюгат Download PDFInfo
- Publication number
- RU2010130155A RU2010130155A RU2010130155/15A RU2010130155A RU2010130155A RU 2010130155 A RU2010130155 A RU 2010130155A RU 2010130155/15 A RU2010130155/15 A RU 2010130155/15A RU 2010130155 A RU2010130155 A RU 2010130155A RU 2010130155 A RU2010130155 A RU 2010130155A
- Authority
- RU
- Russia
- Prior art keywords
- heparin
- coating according
- group
- coating
- conjugate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Покрытие, содержащее конъюгат гепарина и биоабсорбируемого полимера, который не имеет дополнительных фармацевтически или биологически активных функциональных групп, где биоабсорбируемый полимер образован по меньшей мере из одного циклического лактона путем полимеризации с раскрытием кольца. ! 2. Покрытие по п.1, где гепарин выбран из группы, состоящей из немодифицированного гепарина, частично разложенного гепарина, низкомолекулярного гепарина (LMWH) и десульфированного гепарина. !3. Покрытие по п.1, где циклический лактон выбран из группы, состоящей из L,L-лактидов, D,L-лактида, гликолидов, капралактона, триметиленхлорида (TMC), диоксанона и их лактонов. ! 4. Покрытие по п.1, имеющее следующую структуру ! ! где n и m независимо друг от друга представляют собой целое число от 1 до 1000. ! 5. Покрытие по п.1, наносимое на поверхность медицинского устройства способом напыления, погружения или струйного впрыска. ! 6. Покрытие по п.1, дополнительно включающее фармацевтически или биологически активное соединение, выбранное из группы, состоящей из антирестенозных, противовоспалительных, антитромбоцитарных и антипролиферативных соединений.
Claims (6)
1. Покрытие, содержащее конъюгат гепарина и биоабсорбируемого полимера, который не имеет дополнительных фармацевтически или биологически активных функциональных групп, где биоабсорбируемый полимер образован по меньшей мере из одного циклического лактона путем полимеризации с раскрытием кольца.
2. Покрытие по п.1, где гепарин выбран из группы, состоящей из немодифицированного гепарина, частично разложенного гепарина, низкомолекулярного гепарина (LMWH) и десульфированного гепарина.
3. Покрытие по п.1, где циклический лактон выбран из группы, состоящей из L,L-лактидов, D,L-лактида, гликолидов, капралактона, триметиленхлорида (TMC), диоксанона и их лактонов.
4. Покрытие по п.1, имеющее следующую структуру
где n и m независимо друг от друга представляют собой целое число от 1 до 1000.
5. Покрытие по п.1, наносимое на поверхность медицинского устройства способом напыления, погружения или струйного впрыска.
6. Покрытие по п.1, дополнительно включающее фармацевтически или биологически активное соединение, выбранное из группы, состоящей из антирестенозных, противовоспалительных, антитромбоцитарных и антипролиферативных соединений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/505,869 US20090281059A1 (en) | 2007-02-21 | 2009-07-20 | Coating for a medical device having an anti-thrombotic conjugate |
| US12/505,869 | 2009-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010130155A true RU2010130155A (ru) | 2012-01-27 |
Family
ID=43126919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010130155/15A RU2010130155A (ru) | 2009-07-20 | 2010-07-19 | Покрытие для медицинского устройства, содержащее антитромбоцитарный коньюгат |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090281059A1 (ru) |
| EP (1) | EP2277564A3 (ru) |
| JP (1) | JP2011019918A (ru) |
| KR (1) | KR20110009055A (ru) |
| CN (1) | CN101954125A (ru) |
| BR (1) | BRPI1015518A2 (ru) |
| IL (1) | IL206882A (ru) |
| MX (1) | MX2010007897A (ru) |
| RU (1) | RU2010130155A (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10426943B2 (en) | 2011-08-11 | 2019-10-01 | Attwill Medical Solutions Sterilflow L.P. | Insert for luer connection |
| KR101278204B1 (ko) * | 2011-12-22 | 2013-06-27 | 경북대학교 산학협력단 | 다중 약물전달계를 갖는 생체의료용 금속합금 재료의 제조방법 |
| AU2013245011B2 (en) | 2012-04-04 | 2017-11-23 | Intervet International B.V. | Solid oral pharmaceutical compositions for isoxazoline compounds |
| WO2015179548A2 (en) | 2014-05-21 | 2015-11-26 | Attwill Medical Solutions Steriflow L.P. | Insert for catheter system |
| ES2671844B1 (es) * | 2015-06-11 | 2019-03-22 | Attwill Medical Solutions Inc | Dispositivos médicos, sistemas y métodos que utilizan composiciones de anti-trombina heparina. |
| WO2020190214A1 (en) * | 2019-03-19 | 2020-09-24 | Jmedtech Coating Technologies Pte Ltd | Medical device comprising covalently bonded heparin coating |
| CN113476669A (zh) * | 2021-06-17 | 2021-10-08 | 北京永益润成科技有限公司 | 一种药物涂层组合物及其涂覆工艺 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US5525348A (en) * | 1989-11-02 | 1996-06-11 | Sts Biopolymers, Inc. | Coating compositions comprising pharmaceutical agents |
| US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| KR100314496B1 (ko) * | 1998-05-28 | 2001-11-22 | 윤동진 | 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도 |
| US6153252A (en) * | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
| NO984144L (no) * | 1998-09-09 | 2000-03-10 | Carmeda Ab | Sammensetning som omfatter heparin som et ikke-trombogent overflatebelegg |
| NO984143L (no) * | 1998-09-09 | 2000-03-10 | Norsk Hydro As | Ny prosess for å fremstille overflatemodifiserende stoffer |
| US6093792A (en) * | 1998-09-16 | 2000-07-25 | University Of Massachusetts | Bioresorbable copolymers |
| US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
| KR100378109B1 (ko) * | 2000-10-24 | 2003-03-29 | 주식회사 메디프렉스 | 소수성 다중복합 헤파린 결합체, 그의 제조방법 및 용도 |
| US6767405B2 (en) * | 2002-07-10 | 2004-07-27 | Carmeda Ab | Apparatus and process for coating articles |
| US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
| US6702850B1 (en) * | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
| US7318944B2 (en) * | 2003-08-07 | 2008-01-15 | Medtronic Vascular, Inc. | Extrusion process for coating stents |
| US20050112170A1 (en) * | 2003-11-20 | 2005-05-26 | Hossainy Syed F. | Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same |
| EP2329852A1 (en) | 2004-03-26 | 2011-06-08 | SurModics, Inc. | Composition and method for preparing biocompatible surfaces |
| US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
| EP1879552B1 (en) | 2005-03-14 | 2016-02-17 | Biotegra, Inc. | Drug delivery compositions comprising a polyelectrolyte complex within a polymeric matrix |
| US20070212387A1 (en) * | 2006-03-08 | 2007-09-13 | Sahajanand Medical Technologies Pvt. Ltd. | Coatings for implantable medical devices |
| US20080200421A1 (en) * | 2007-02-21 | 2008-08-21 | Zhao Jonathon Z | Coating for a medical device having an anti-thrombotic conjugate |
| US8383156B2 (en) * | 2007-04-30 | 2013-02-26 | Cordis Corporation | Coating for a medical device having an anti-thrombotic conjugate |
| US20090018646A1 (en) * | 2007-07-10 | 2009-01-15 | Zhao Jonathon Z | Coating Employing an Anti-Thrombotic Conjugate |
-
2009
- 2009-07-20 US US12/505,869 patent/US20090281059A1/en not_active Abandoned
-
2010
- 2010-07-05 EP EP10168486A patent/EP2277564A3/en not_active Withdrawn
- 2010-07-08 IL IL206882A patent/IL206882A/en not_active IP Right Cessation
- 2010-07-16 JP JP2010161311A patent/JP2011019918A/ja active Pending
- 2010-07-19 BR BRPI1015518-0A patent/BRPI1015518A2/pt not_active Application Discontinuation
- 2010-07-19 RU RU2010130155/15A patent/RU2010130155A/ru unknown
- 2010-07-19 MX MX2010007897A patent/MX2010007897A/es active IP Right Grant
- 2010-07-20 CN CN201010233938XA patent/CN101954125A/zh active Pending
- 2010-07-20 KR KR1020100070145A patent/KR20110009055A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011019918A (ja) | 2011-02-03 |
| IL206882A0 (en) | 2010-12-30 |
| EP2277564A2 (en) | 2011-01-26 |
| IL206882A (en) | 2016-02-29 |
| US20090281059A1 (en) | 2009-11-12 |
| EP2277564A3 (en) | 2011-11-16 |
| KR20110009055A (ko) | 2011-01-27 |
| BRPI1015518A2 (pt) | 2014-03-18 |
| CN101954125A (zh) | 2011-01-26 |
| MX2010007897A (es) | 2011-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2010130155A (ru) | Покрытие для медицинского устройства, содержащее антитромбоцитарный коньюгат | |
| MX351986B (es) | Composiciones polimericas bioabsorbibles, metodos de procesamiento y dispositivos medicos de estas. | |
| AU2014355413B2 (en) | Anti-thrombotic material | |
| MX2009008064A (es) | Soporte vascular biodegradable. | |
| CY1114575T1 (el) | Διαλυμα ακετονης διμεθοξυ δοσεταξελης και η διαδικασια παρασκευης του | |
| Davachi et al. | Investigating thermal degradation, crystallization and surface behavior of l-lactide, glycolide and trimethylene carbonate terpolymers used for medical applications | |
| WO2007133782A1 (en) | Antimicrobial coatings | |
| JP2005517062A5 (ru) | ||
| AR058529A1 (es) | Copolimeros producidos reaccionando un glicidil ester y/o eter con un poliol y uso de los copolimerpos en composiciones de recubrimiento | |
| WO2008127889A3 (en) | Degradable polymers incorporating gamma- butyrolactone | |
| EA200700435A1 (ru) | Рентгеноконтрастные полимерные стенты | |
| MX2016006913A (es) | Composiciones de mezclas polimericas absorbibles con velocidades de absorcion controlables de manera precisa, metodos de procesamiento y dispositivos medicos dimensionalmente estables elaborados a partir de estas. | |
| DK1606339T3 (da) | Polymer film eller belægning omfattende hemicellulose | |
| BR9910605A (pt) | Catalizadores de cianeto de duplo metal contendo agentes complexantes bidentados cìclicos | |
| US10213530B2 (en) | Polymer film and antiadhesive material using the same | |
| Kiriratnikom et al. | Stereoselective ring-opening (co) polymerization of β-butyrolactone and ε-decalactone using an yttrium bis (phenolate) catalytic system | |
| WO2011070282A3 (fr) | Procède de préparation d'un polymère d'au moins un monomère cyclique | |
| RU2017111079A (ru) | Фармацевтическая композиция с улучшенной стабильностью | |
| CN103055354A (zh) | 一种生物可降解的医用手术防粘连膜及其制备方法 | |
| RU2015111533A (ru) | Материалы, генерирующие реакционноспособные окислительные частицы, а также способы их применения | |
| RU2019110782A (ru) | Сополимер и медицинский материал, содержащий его | |
| RU2010141752A (ru) | Полимерсодержащая композиция, ее получение и применение | |
| RU2014104678A (ru) | Имплантируемый стент | |
| JP2016524011A5 (ru) | ||
| RU2015144169A (ru) | Полилактоновые полимеры, получаемые с помощью моноольных и диольных инициаторов полимеризации, содержащих две или более карбоксильные группы |