RU2010129685A - Предупреждение оппортунистических инфекций у индивидуумов с нарушенным иммунитетом - Google Patents

Предупреждение оппортунистических инфекций у индивидуумов с нарушенным иммунитетом Download PDF

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RU2010129685A
RU2010129685A RU2010129685/15A RU2010129685A RU2010129685A RU 2010129685 A RU2010129685 A RU 2010129685A RU 2010129685/15 A RU2010129685/15 A RU 2010129685/15A RU 2010129685 A RU2010129685 A RU 2010129685A RU 2010129685 A RU2010129685 A RU 2010129685A
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composition according
probiotic
composition
bifidobacterium
opportunistic infections
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Норберт ШПРЕНГЕР (CH)
Норберт ШПРЕНГЕР
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Нестек С.А. (Ch)
Нестек С.А.
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745Bifidobacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

1. Композиция, подходящая для применения в предупреждении оппортунистических инфекций у индивидуумов с нарушенным иммунитетом, содержащая пробиотик Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium breve или Bifidobacterium longum и фукозилированный олигосахарид, выбираемый из группы, состоящей из 2'-фукозиллактозы, 3'-фукозиллактозы, дифукозиллактозы, лакто-N-фукопентаозы, лакто-N-фукогексаозы, фукозиллакто-N-гексаозы и фукозиллакто-N-неогексаозы. ! 2. Композиция по п.1, в которой фукозилированным олигосахаридом является 2'-фукозиллактоза. ! 3. Композиция по п.1 или 2, в которой пробиотиком является Bifidobacterium lactis CNCM 1-3446 или Bifidobacterium longum АТСС BAA-999. ! 4. Композиция по п.1, которая является детской смесью. ! 5. Композиция по п.4, которая содержит от 0,1 до 3 г фукозилированного олигосахарида на 100 г композиции. ! 6. Композиция по п.4 или 5, которая содержит от 103 до 1012 КОЕ пробиотика на 1 г детской смеси. ! 7. Композиция по п.5, которая содержит от 106 до 109 КОЕ пробиотика на 1 г детской смеси. ! 8. Композиция по п.5, которая дополнительно содержит по меньшей мере один пребиотик в количестве от 0,3 до 19 мас.% от композиции. ! 9. Композиция по п.1, которая является биологически активной добавкой и которая содержит в разовой дозе от 0,1 до 3 г фукозилированного олигосахарида и от 105 до 1012 КОЕ пробиотика. ! 10. Применение композиции по любому из пп.1-9 в производстве лекарственных средств или терапевтической питательной композиции для предупреждения оппортунистических инфекций у индивидуумов с нарушенным иммунитетом. ! 11. Применение по п.10, в котором возбудителем оппортунистической инфекции является Pseudomonas aeroginosa. ! 12. Применение по п.10, в котором инфекция, возбуждаемая Pseudomonas aeroginosa, явл�

Claims (12)

1. Композиция, подходящая для применения в предупреждении оппортунистических инфекций у индивидуумов с нарушенным иммунитетом, содержащая пробиотик Bifidobacterium lactis, Bifidobacterium infantis, Bifidobacterium breve или Bifidobacterium longum и фукозилированный олигосахарид, выбираемый из группы, состоящей из 2'-фукозиллактозы, 3'-фукозиллактозы, дифукозиллактозы, лакто-N-фукопентаозы, лакто-N-фукогексаозы, фукозиллакто-N-гексаозы и фукозиллакто-N-неогексаозы.
2. Композиция по п.1, в которой фукозилированным олигосахаридом является 2'-фукозиллактоза.
3. Композиция по п.1 или 2, в которой пробиотиком является Bifidobacterium lactis CNCM 1-3446 или Bifidobacterium longum АТСС BAA-999.
4. Композиция по п.1, которая является детской смесью.
5. Композиция по п.4, которая содержит от 0,1 до 3 г фукозилированного олигосахарида на 100 г композиции.
6. Композиция по п.4 или 5, которая содержит от 103 до 1012 КОЕ пробиотика на 1 г детской смеси.
7. Композиция по п.5, которая содержит от 106 до 109 КОЕ пробиотика на 1 г детской смеси.
8. Композиция по п.5, которая дополнительно содержит по меньшей мере один пребиотик в количестве от 0,3 до 19 мас.% от композиции.
9. Композиция по п.1, которая является биологически активной добавкой и которая содержит в разовой дозе от 0,1 до 3 г фукозилированного олигосахарида и от 105 до 1012 КОЕ пробиотика.
10. Применение композиции по любому из пп.1-9 в производстве лекарственных средств или терапевтической питательной композиции для предупреждения оппортунистических инфекций у индивидуумов с нарушенным иммунитетом.
11. Применение по п.10, в котором возбудителем оппортунистической инфекции является Pseudomonas aeroginosa.
12. Применение по п.10, в котором инфекция, возбуждаемая Pseudomonas aeroginosa, является инфекцией дыхательных, мочевых или желудочно-кишечного путей.
RU2010129685/15A 2007-12-17 2008-12-05 Предупреждение оппортунистических инфекций у индивидуумов с нарушенным иммунитетом RU2486910C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07123390A EP2072052A1 (en) 2007-12-17 2007-12-17 Prevention of opportunistic infections in immune-compromised subjects
EP07123390.2 2007-12-17
PCT/EP2008/066850 WO2009077352A1 (en) 2007-12-17 2008-12-05 Prevention of opportunistic infections in immune-compromised subjects

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RU2010129685A true RU2010129685A (ru) 2012-01-27
RU2486910C2 RU2486910C2 (ru) 2013-07-10

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US (2) US9217133B2 (ru)
EP (2) EP2072052A1 (ru)
CN (1) CN101909644A (ru)
AU (1) AU2008337646B2 (ru)
BR (1) BRPI0820837A2 (ru)
CA (1) CA2709396A1 (ru)
ES (1) ES2576642T3 (ru)
IN (1) IN2010DE04311A (ru)
MX (1) MX2010006690A (ru)
MY (1) MY185938A (ru)
PH (1) PH12010501367B1 (ru)
PL (1) PL2234627T3 (ru)
PT (1) PT2234627T (ru)
RU (1) RU2486910C2 (ru)
SG (1) SG186657A1 (ru)
UA (1) UA102830C2 (ru)
WO (1) WO2009077352A1 (ru)
ZA (1) ZA201005088B (ru)

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