RU2009113585A - Производные дибензофурана в качестве ингибиторов pde-4 и pde-10 - Google Patents
Производные дибензофурана в качестве ингибиторов pde-4 и pde-10 Download PDFInfo
- Publication number
- RU2009113585A RU2009113585A RU2009113585/04A RU2009113585A RU2009113585A RU 2009113585 A RU2009113585 A RU 2009113585A RU 2009113585/04 A RU2009113585/04 A RU 2009113585/04A RU 2009113585 A RU2009113585 A RU 2009113585A RU 2009113585 A RU2009113585 A RU 2009113585A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- furan
- methoxydibenzo
- compound
- cyano
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims 2
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 53
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 18
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 16
- 239000001257 hydrogen Substances 0.000 claims abstract 16
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract 11
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 11
- -1 cyano, carboxy Chemical group 0.000 claims abstract 10
- 125000005842 heteroatom Chemical group 0.000 claims abstract 10
- 125000004122 cyclic group Chemical group 0.000 claims abstract 9
- 125000003118 aryl group Chemical group 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 7
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 6
- 125000002723 alicyclic group Chemical group 0.000 claims abstract 5
- 229910052736 halogen Inorganic materials 0.000 claims abstract 5
- 150000002367 halogens Chemical class 0.000 claims abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 239000012453 solvate Substances 0.000 claims abstract 4
- 150000001204 N-oxides Chemical class 0.000 claims abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000003368 amide group Chemical group 0.000 claims abstract 2
- 150000004677 hydrates Chemical class 0.000 claims abstract 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 11
- 230000004968 inflammatory condition Effects 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 210000003169 central nervous system Anatomy 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 208000006673 asthma Diseases 0.000 claims 5
- 208000010668 atopic eczema Diseases 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 206010039085 Rhinitis allergic Diseases 0.000 claims 4
- 201000010105 allergic rhinitis Diseases 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 201000008383 nephritis Diseases 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 3
- 206010006458 Bronchitis chronic Diseases 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 3
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 206010012434 Dermatitis allergic Diseases 0.000 claims 3
- 206010069698 Langerhans' cell histiocytosis Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 3
- 206010040070 Septic Shock Diseases 0.000 claims 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 3
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 206010006451 bronchitis Diseases 0.000 claims 3
- 208000007451 chronic bronchitis Diseases 0.000 claims 3
- 208000037976 chronic inflammation Diseases 0.000 claims 3
- 230000006020 chronic inflammation Effects 0.000 claims 3
- 208000003401 eosinophilic granuloma Diseases 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 201000008482 osteoarthritis Diseases 0.000 claims 3
- 230000036303 septic shock Effects 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 claims 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 239000006072 paste Substances 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- ZFVYYLHRPOSPAG-FYWRMAATSA-N (3e)-3-(dimethylaminomethylidene)-1-(4-methoxydibenzofuran-1-yl)-4-oxocyclohexane-1-carbonitrile Chemical compound C1=2C3=CC=CC=C3OC=2C(OC)=CC=C1C1(C#N)CCC(=O)\C(=C\N(C)C)C1 ZFVYYLHRPOSPAG-FYWRMAATSA-N 0.000 claims 1
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- LVFLQDXYFYWNSJ-UHFFFAOYSA-N 1-(4-methoxydibenzofuran-1-yl)-4-methoxyiminocyclohexane-1-carbonitrile Chemical compound C1CC(=NOC)CCC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 LVFLQDXYFYWNSJ-UHFFFAOYSA-N 0.000 claims 1
- DEOOIBVIBRHOOO-UHFFFAOYSA-N 1-(4-methoxydibenzofuran-1-yl)-4-oxocyclohexane-1-carbonitrile Chemical compound O1C2=CC=CC=C2C2=C1C(OC)=CC=C2C1(C#N)CCC(=O)CC1 DEOOIBVIBRHOOO-UHFFFAOYSA-N 0.000 claims 1
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical group CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 claims 1
- KEOIXQQDQABMPL-UHFFFAOYSA-N 2-[6-cyano-6-(4-methoxydibenzofuran-1-yl)-4-oxo-7,8-dihydro-5h-quinazolin-3-yl]acetic acid Chemical compound N1=CN(CC(O)=O)C(=O)C(C2)=C1CCC2(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 KEOIXQQDQABMPL-UHFFFAOYSA-N 0.000 claims 1
- FDJDWXHNIUYDQQ-UHFFFAOYSA-N 2-[[6-cyano-6-(4-methoxydibenzofuran-1-yl)-7,8-dihydro-5h-quinazolin-2-yl]amino]acetic acid Chemical compound C1CC2=NC(NCC(O)=O)=NC=C2CC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 FDJDWXHNIUYDQQ-UHFFFAOYSA-N 0.000 claims 1
- NMBMYZIIGIVTTK-UHFFFAOYSA-N 2-amino-6-(4-methoxydibenzofuran-1-yl)-4-oxo-1,5,7,8-tetrahydroquinazoline-6-carbonitrile Chemical compound N1=C(N)NC(=O)C(C2)=C1CCC2(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 NMBMYZIIGIVTTK-UHFFFAOYSA-N 0.000 claims 1
- VXLSJDHGLZNWCZ-UHFFFAOYSA-N 2-amino-6-(4-methoxydibenzofuran-1-yl)-7,8-dihydro-5h-quinazoline-6-carbonitrile Chemical compound C1CC2=NC(N)=NC=C2CC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 VXLSJDHGLZNWCZ-UHFFFAOYSA-N 0.000 claims 1
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 claims 1
- SZBXZDLWKDKXRL-UHFFFAOYSA-N 4-cyano-4-(4-methoxydibenzofuran-1-yl)cyclohexane-1-carboxylic acid Chemical compound C1=2C3=CC=CC=C3OC=2C(OC)=CC=C1C1(C#N)CCC(C(O)=O)CC1 SZBXZDLWKDKXRL-UHFFFAOYSA-N 0.000 claims 1
- QIZKODSPPKGICU-UHFFFAOYSA-N 5-(4-ethoxydibenzofuran-1-yl)-6,7-dihydro-4h-2,1-benzoxazole-5-carbonitrile Chemical compound C1CC2=NOC=C2CC1(C#N)C1=CC=C(OCC)C2=C1C1=CC=CC=C1O2 QIZKODSPPKGICU-UHFFFAOYSA-N 0.000 claims 1
- JAARYBGJMQKFRG-UHFFFAOYSA-N 5-(4-methoxydibenzofuran-1-yl)-1,4,6,7-tetrahydroindazole-5-carbonitrile Chemical compound C1CC2=NNC=C2CC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 JAARYBGJMQKFRG-UHFFFAOYSA-N 0.000 claims 1
- LWSHOUNKKLOUGA-UHFFFAOYSA-N 5-(4-methoxydibenzofuran-1-yl)-1-phenyl-6,7-dihydro-4h-indazole-5-carbonitrile Chemical compound C1=2C3=CC=CC=C3OC=2C(OC)=CC=C1C(C1)(C#N)CCC2=C1C=NN2C1=CC=CC=C1 LWSHOUNKKLOUGA-UHFFFAOYSA-N 0.000 claims 1
- YOIULBPZMKZVOO-UHFFFAOYSA-N 5-(4-methoxydibenzofuran-1-yl)-2-phenyl-6,7-dihydro-4h-indazole-5-carbonitrile Chemical compound C1=2C3=CC=CC=C3OC=2C(OC)=CC=C1C(CC1=C2)(C#N)CCC1=NN2C1=CC=CC=C1 YOIULBPZMKZVOO-UHFFFAOYSA-N 0.000 claims 1
- MIWJDIQCBMZBPS-UHFFFAOYSA-N 5-(4-methoxydibenzofuran-1-yl)-3-oxo-3a,4,6,7-tetrahydro-2h-indazole-5-carbonitrile Chemical compound C1CC2=NNC(=O)C2CC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 MIWJDIQCBMZBPS-UHFFFAOYSA-N 0.000 claims 1
- WNPVRTAIVIPCLC-UHFFFAOYSA-N 6-(4-methoxydibenzofuran-1-yl)-2-methyl-4-oxo-1,5,7,8-tetrahydroquinazoline-6-carbonitrile Chemical compound N1=C(C)NC(=O)C(C2)=C1CCC2(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 WNPVRTAIVIPCLC-UHFFFAOYSA-N 0.000 claims 1
- KYAZWEZZTAVVAH-UHFFFAOYSA-N 6-(4-methoxydibenzofuran-1-yl)-3-methyl-4-oxo-7,8-dihydro-5h-quinazoline-6-carbonitrile Chemical compound N1=CN(C)C(=O)C(C2)=C1CCC2(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 KYAZWEZZTAVVAH-UHFFFAOYSA-N 0.000 claims 1
- LTLBUSHXQYASQU-UHFFFAOYSA-N 6-(4-methoxydibenzofuran-1-yl)-4-oxo-1,5,7,8-tetrahydroquinazoline-6-carbonitrile Chemical compound N1=CNC(=O)C(C2)=C1CCC2(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 LTLBUSHXQYASQU-UHFFFAOYSA-N 0.000 claims 1
- VSFHCICWCLDERG-UHFFFAOYSA-N 6-(4-methoxydibenzofuran-1-yl)-7,8-dihydro-5h-quinazoline-6-carbonitrile Chemical compound C1CC2=NC=NC=C2CC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 VSFHCICWCLDERG-UHFFFAOYSA-N 0.000 claims 1
- KACYDLOZYXBEMS-UHFFFAOYSA-N 6-cyano-6-(4-methoxydibenzofuran-1-yl)-2-methyl-7,8-dihydro-5h-quinoline-3-carboxylic acid Chemical compound C1CC2=NC(C)=C(C(O)=O)C=C2CC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 KACYDLOZYXBEMS-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000031091 Amnestic disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 claims 1
- 239000002841 Lewis acid Substances 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 claims 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims 1
- 230000006986 amnesia Effects 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000007257 deesterification reaction Methods 0.000 claims 1
- GRTGGSXWHGKRSB-UHFFFAOYSA-N dichloromethyl methyl ether Chemical compound COC(Cl)Cl GRTGGSXWHGKRSB-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- COVGASLWHQOIGR-UHFFFAOYSA-N ethyl 2-[6-cyano-6-(4-methoxydibenzofuran-1-yl)-4-oxo-7,8-dihydro-5h-quinazolin-3-yl]acetate Chemical compound O1C2=CC=CC=C2C2=C1C(OC)=CC=C2C1(C#N)CCC(N=CN(C2=O)CC(=O)OCC)=C2C1 COVGASLWHQOIGR-UHFFFAOYSA-N 0.000 claims 1
- YNSHWPAODITADD-UHFFFAOYSA-N ethyl 2-[[6-cyano-6-(4-methoxydibenzofuran-1-yl)-2-methyl-7,8-dihydro-5h-quinazolin-4-yl]oxy]acetate Chemical compound O1C2=CC=CC=C2C2=C1C(OC)=CC=C2C1(C#N)CCC(N=C(C)N=C2OCC(=O)OCC)=C2C1 YNSHWPAODITADD-UHFFFAOYSA-N 0.000 claims 1
- JKGAGDVQMVAZPO-UHFFFAOYSA-N ethyl 6-cyano-6-(4-methoxydibenzofuran-1-yl)-2-methyl-7,8-dihydro-5h-quinoline-3-carboxylate Chemical compound O1C2=CC=CC=C2C2=C1C(OC)=CC=C2C1(C#N)CC(C=C(C(=N2)C)C(=O)OCC)=C2CC1 JKGAGDVQMVAZPO-UHFFFAOYSA-N 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 230000022244 formylation Effects 0.000 claims 1
- 238000006170 formylation reaction Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 150000007517 lewis acids Chemical class 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- HIGCNPFUSCKGDA-UHFFFAOYSA-N methyl 5-cyano-5-(4-methoxydibenzofuran-1-yl)-2-oxocyclohexane-1-carboxylate Chemical compound C1CC(=O)C(C(=O)OC)CC1(C#N)C1=CC=C(OC)C2=C1C1=CC=CC=C1O2 HIGCNPFUSCKGDA-UHFFFAOYSA-N 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- WZUXAFMNSHCLIL-UHFFFAOYSA-N n-[4-cyano-4-(4-methoxydibenzofuran-1-yl)cyclohexyl]methanesulfonamide Chemical compound C1=2C3=CC=CC=C3OC=2C(OC)=CC=C1C1(C#N)CCC(NS(C)(=O)=O)CC1 WZUXAFMNSHCLIL-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 238000007363 ring formation reaction Methods 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1647/CHE/2006 | 2006-09-11 | ||
| IN1647CH2006 | 2006-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009113585A true RU2009113585A (ru) | 2010-10-20 |
Family
ID=38969801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009113585/04A RU2009113585A (ru) | 2006-09-11 | 2007-09-10 | Производные дибензофурана в качестве ингибиторов pde-4 и pde-10 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8263648B2 (https=) |
| EP (1) | EP2074106B1 (https=) |
| JP (1) | JP2010502689A (https=) |
| CN (1) | CN101573348A (https=) |
| AU (1) | AU2007297221B2 (https=) |
| BR (1) | BRPI0716804A2 (https=) |
| CA (1) | CA2663178C (https=) |
| IL (1) | IL197507A (https=) |
| MX (1) | MX2009002657A (https=) |
| NZ (1) | NZ575389A (https=) |
| RU (1) | RU2009113585A (https=) |
| SG (1) | SG174810A1 (https=) |
| WO (1) | WO2008032171A1 (https=) |
| ZA (1) | ZA200901714B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2759626C1 (ru) * | 2018-04-26 | 2021-11-16 | И-Нишиэйт Биофармасьютикалс (Ханчжоу) Ко., Лтд | Противовоспалительное соединение, его получение и применение |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009115874A2 (en) * | 2008-03-17 | 2009-09-24 | Matrix Laboratories Ltd. | Novel heterocyclic compounds, pharmaceutical compositions containing them and processes for their preparation |
| JP5487214B2 (ja) | 2008-12-19 | 2014-05-07 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物 |
| WO2010084402A2 (en) * | 2009-01-22 | 2010-07-29 | Orchid Research Laboratories Ltd. | Heterocyclic compounds as phosphodiesterase inhibitors |
| WO2011132051A2 (en) * | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceuticals S.A. | Tricycle compounds as phosphodiesterase-10 inhibitors |
| CN103476757A (zh) | 2011-02-18 | 2013-12-25 | 阿勒根公司 | 作为磷酸二酯酶10(pde10a)的抑制剂的取代的6,7-二烷氧基-3-异喹啉醇衍生物 |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| WO2014210087A1 (en) | 2013-06-25 | 2014-12-31 | Bristol-Myers Squibb Company | Carbazole carboxamide compounds useful as kinase inhibitors |
| TWI648272B (zh) | 2013-06-25 | 2019-01-21 | 美商必治妥美雅史谷比公司 | 經取代之四氫咔唑及咔唑甲醯胺化合物 |
| WO2015006689A1 (en) | 2013-07-12 | 2015-01-15 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| KR102280686B1 (ko) | 2014-02-11 | 2021-07-22 | 삼성전자주식회사 | 카바졸계 화합물 및 이를 포함한 유기 발광 소자 |
| KR102433463B1 (ko) | 2014-08-13 | 2022-08-18 | 메르크 파텐트 게엠베하 | 유기 전계발광 소자용 재료 |
| EA034931B1 (ru) | 2014-10-24 | 2020-04-08 | Бристол-Майерс Сквибб Компани | Индолкарбоксамидные соединения |
| SI3209651T1 (sl) | 2014-10-24 | 2019-12-31 | Bristol-Myers Squibb Company | Derivati karbazola |
| JP6592512B2 (ja) | 2014-10-24 | 2019-10-16 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 三環式アトロプ異性体の化合物 |
| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20170145025A1 (en) | 2015-11-19 | 2017-05-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2916874T3 (es) | 2015-12-17 | 2022-07-06 | Incyte Corp | Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1 |
| AU2016379372A1 (en) | 2015-12-22 | 2018-08-02 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| BR112018076534A2 (pt) | 2016-06-20 | 2019-04-02 | Incyte Corporation | compostos heterocíclicos como imunomoduladores |
| MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2874756T3 (es) | 2016-12-22 | 2021-11-05 | Incyte Corp | Derivados de triazolo[1,5-A]piridina como inmunomoduladores |
| AU2017382870B2 (en) | 2016-12-22 | 2022-03-24 | Incyte Corporation | Benzooxazole derivatives as immunomodulators |
| WO2018119286A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| ES2899402T3 (es) | 2016-12-22 | 2022-03-11 | Incyte Corp | Derivados de piridina como inmunomoduladores |
| CN108084128B (zh) * | 2017-12-28 | 2020-01-03 | 福建中医药大学 | 一种二苯并呋喃衍生物及其制备方法和用途 |
| CR20200520A (es) | 2018-03-30 | 2021-03-09 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| WO2019217821A1 (en) | 2018-05-11 | 2019-11-14 | Incyte Corporation | Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators |
| EP4010342A1 (en) | 2019-08-09 | 2022-06-15 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| WO2021067217A1 (en) | 2019-09-30 | 2021-04-08 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| BR112022009031A2 (pt) | 2019-11-11 | 2022-10-11 | Incyte Corp | Sais e formas cristalinas de um inibidor de pd-1/pd-l1 |
| GB202002926D0 (en) * | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
| WO2022099075A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Crystalline form of a pd-1/pd-l1 inhibitor |
| US11866434B2 (en) | 2020-11-06 | 2024-01-09 | Incyte Corporation | Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA010408B1 (ru) * | 2002-10-23 | 2008-08-29 | Гленмарк Фармасьютикалс Лтд. | Трициклические соединения для лечения воспалительных и аллергических нарушений, способы их приготовления и содержащие их фармацевтические составы |
| OA13154A (en) * | 2003-04-11 | 2006-12-13 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them. |
| WO2004111044A1 (en) * | 2003-06-17 | 2004-12-23 | Glenmark Pharmaceuticals Ltd. | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders:process for their preparation |
| WO2006011024A2 (en) * | 2004-07-19 | 2006-02-02 | Glenmark Pharmaceuticals Ltd. | New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
| WO2006051390A1 (en) * | 2004-11-10 | 2006-05-18 | Glenmark Pharmaceuticals S.A. | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders, pharmaceutical compositions containing them, and methods of preparing them |
| AP2334A (en) * | 2004-12-17 | 2011-12-06 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflamatory and allergic disorders. |
-
2007
- 2007-09-10 AU AU2007297221A patent/AU2007297221B2/en not_active Ceased
- 2007-09-10 RU RU2009113585/04A patent/RU2009113585A/ru not_active Application Discontinuation
- 2007-09-10 CN CNA2007800399908A patent/CN101573348A/zh active Pending
- 2007-09-10 WO PCT/IB2007/002596 patent/WO2008032171A1/en not_active Ceased
- 2007-09-10 JP JP2009527220A patent/JP2010502689A/ja active Pending
- 2007-09-10 BR BRPI0716804-7A2A patent/BRPI0716804A2/pt not_active IP Right Cessation
- 2007-09-10 SG SG2011065927A patent/SG174810A1/en unknown
- 2007-09-10 EP EP07825083.4A patent/EP2074106B1/en not_active Not-in-force
- 2007-09-10 US US12/440,810 patent/US8263648B2/en not_active Expired - Fee Related
- 2007-09-10 NZ NZ575389A patent/NZ575389A/en not_active IP Right Cessation
- 2007-09-10 CA CA2663178A patent/CA2663178C/en not_active Expired - Fee Related
- 2007-09-10 MX MX2009002657A patent/MX2009002657A/es active IP Right Grant
-
2009
- 2009-03-10 ZA ZA2009/01714A patent/ZA200901714B/en unknown
- 2009-03-10 IL IL197507A patent/IL197507A/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2759626C1 (ru) * | 2018-04-26 | 2021-11-16 | И-Нишиэйт Биофармасьютикалс (Ханчжоу) Ко., Лтд | Противовоспалительное соединение, его получение и применение |
| US11440886B2 (en) | 2018-04-26 | 2022-09-13 | E-nitiate Biopharmaceuticals (Hangzhou) Co., Ltd. | Anti-inflammatory compound, and preparation and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| IL197507A (en) | 2014-05-28 |
| CN101573348A (zh) | 2009-11-04 |
| NZ575389A (en) | 2012-03-30 |
| CA2663178C (en) | 2016-01-12 |
| BRPI0716804A2 (pt) | 2013-11-05 |
| JP2010502689A (ja) | 2010-01-28 |
| SG174810A1 (en) | 2011-10-28 |
| ZA200901714B (en) | 2010-02-24 |
| EP2074106B1 (en) | 2013-04-17 |
| CA2663178A1 (en) | 2008-03-20 |
| AU2007297221B2 (en) | 2012-11-08 |
| AU2007297221A1 (en) | 2008-03-20 |
| MX2009002657A (es) | 2009-08-18 |
| US20090281131A1 (en) | 2009-11-12 |
| EP2074106A1 (en) | 2009-07-01 |
| US8263648B2 (en) | 2012-09-11 |
| WO2008032171A1 (en) | 2008-03-20 |
| IL197507A0 (en) | 2009-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2009113585A (ru) | Производные дибензофурана в качестве ингибиторов pde-4 и pde-10 | |
| JP2010502689A5 (https=) | ||
| CN112601750B (zh) | Ptpn11（shp2）抑制剂 | |
| AU2016203192B2 (en) | Bicyclo[3.2.1]octyl amide derivatives and uses of same | |
| US8829190B2 (en) | Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases | |
| US6734203B2 (en) | Fused imidazolium derivatives | |
| ZA200603474B (en) | Alkoxy substituted imidazoquinolines | |
| CA3118904A1 (en) | Pyridazinone compounds and uses thereof | |
| JP2017522339A (ja) | ２−アミノ−ベンゾイミダゾール誘導体ならびにこれらの５−リポキシゲナーゼおよび／またはプロスタグランジンｅシンターゼ阻害剤としての使用 | |
| CA2612176C (en) | Dihydrothieno[2,3-d]pyramidine-6-carboxylic acid derivatives as pde9 inhibitors | |
| CA3178372A1 (en) | Enpp1 modulators and uses thereof | |
| TW202033529A (zh) | 作為magl抑制劑之雜環螺環化合物 | |
| CA2879816C (en) | Methanethione compounds having antiviral activity | |
| AU2020211253B2 (en) | A fused ring heteroaryl compound as an ALK4/5 inhibitor | |
| AU2021266141A1 (en) | New imidazolone derivatives as inhibitors of protein kinases in particular DYRK1A, CLK1 and/or CLK4 | |
| CN107286110A (zh) | 四唑类化合物在抗癫痫药中的应用 | |
| WO2021039961A1 (ja) | 縮環ピラゾール誘導体 | |
| JP6031719B2 (ja) | アルファ２アドレナリン作動性受容体のモジュレーターとしてのｎ−（イミダゾリジン−２−イリデン）キノリン誘導体 | |
| JP2002308774A (ja) | Ｉｖ型ホスホジエステラーゼ選択的阻害剤 | |
| KR20230056618A (ko) | Stat3 저해제로서 벤조싸이오펜-1,1-다이옥사이드 유도체 화합물 및 이의 용도 | |
| WO2023072966A1 (en) | Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 | |
| WO2010066253A1 (en) | Selective inhibitors of excitatory amino acid transporter subtype 1 (eaat1 /glast) | |
| US20160280669A1 (en) | Compounds and methods | |
| TW200530191A (en) | Imidazoline derivatives having CB1-antagonistic activity | |
| WO2013128927A1 (ja) | 新規アンドロゲン受容体アンタゴニスト |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20130129 |