RU2008153006A - METHOD FOR PRODUCING N, N-DIMETHYL-N- (4-CHINOLINYLMETHYL) AMINE - Google Patents

METHOD FOR PRODUCING N, N-DIMETHYL-N- (4-CHINOLINYLMETHYL) AMINE Download PDF

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RU2008153006A
RU2008153006A RU2008153006/04A RU2008153006A RU2008153006A RU 2008153006 A RU2008153006 A RU 2008153006A RU 2008153006/04 A RU2008153006/04 A RU 2008153006/04A RU 2008153006 A RU2008153006 A RU 2008153006A RU 2008153006 A RU2008153006 A RU 2008153006A
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dimethyl
amine
iodaniline
butyn
licl
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RU2008153006/04A
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Russian (ru)
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RU2404165C2 (en
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Усеин Меметович Джемилев (RU)
Усеин Меметович Джемилев
Мария Геннадьевна Шайбакова (RU)
Мария Геннадьевна Шайбакова
Гилемдар Адыхамович Махмудияров (RU)
Гилемдар Адыхамович Махмудияров
Асхат Габдрахманович Ибрагимов (RU)
Асхат Габдрахманович Ибрагимов
Леонард Мухибович Халилов (RU)
Леонард Мухибович Халилов
Евгений Александрович Парамонов (RU)
Евгений Александрович Парамонов
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Учреждение Российской академии наук ИНСТИТУТ НЕФТЕХИМИИ И КАТАЛИЗА РАН (RU)
Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Способ получения N,N-диметил-N-(4-хинолинилметил)амина формулы (1): ! ! характеризующийся тем, что о-иоданилин подвергают взаимодействию с N1,N1,N4,N4-тетраметил-2-бутин-1,4-диамином в присутствии солей хлорида лития (LiCl), карбоната калия (К2СО3), палладиевого катализатора Pd(OAc)2, при мольном соотношении о-иоданилин: N1,N1,N4,N4-тетраметил-2-бутин-1,4-диамин:LiCl:К2СO3:Pd(OAc)2=10:(10-14):10:50:(0,3-0,7), при температуре 100°С и атмосферном давлении в течение 18-22 ч в ДМФА в качестве растворителя. The method of obtaining N, N-dimethyl-N- (4-quinolinylmethyl) amine of the formula (1):! ! characterized in that o-iodaniline is reacted with N1, N1, N4, N4-tetramethyl-2-butyn-1,4-diamine in the presence of salts of lithium chloride (LiCl), potassium carbonate (K2CO3), palladium catalyst Pd (OAc) 2, with a molar ratio of o-iodaniline: N1, N1, N4, N4-tetramethyl-2-butyn-1,4-diamine: LiCl: K2CO3: Pd (OAc) 2 = 10: (10-14): 10: 50 : (0.3-0.7), at a temperature of 100 ° C and atmospheric pressure for 18-22 hours in DMF as a solvent.

Claims (1)

Способ получения N,N-диметил-N-(4-хинолинилметил)амина формулы (1):The method of obtaining N, N-dimethyl-N- (4-quinolinylmethyl) amine of the formula (1):
Figure 00000001
Figure 00000001
 характеризующийся тем, что о-иоданилин подвергают взаимодействию с N1,N1,N4,N4-тетраметил-2-бутин-1,4-диамином в присутствии солей хлорида лития (LiCl), карбоната калия (К2СО3), палладиевого катализатора Pd(OAc)2, при мольном соотношении о-иоданилин: N1,N1,N4,N4-тетраметил-2-бутин-1,4-диамин:LiCl:К2СO3:Pd(OAc)2=10:(10-14):10:50:(0,3-0,7), при температуре 100°С и атмосферном давлении в течение 18-22 ч в ДМФА в качестве растворителя. characterized in that o-iodaniline is reacted with N 1 , N 1 , N 4 , N 4 -tetramethyl-2-butyn-1,4-diamine in the presence of salts of lithium chloride (LiCl), potassium carbonate (K 2 CO 3 ) palladium catalyst Pd (OAc) 2 , with a molar ratio of o-iodaniline: N 1 , N 1 , N 4 , N 4 -tetramethyl-2-butyn-1,4-diamine: LiCl: K 2 CO 3 : Pd (OAc ) 2 = 10: (10-14): 10: 50: (0.3-0.7), at a temperature of 100 ° C and atmospheric pressure for 18-22 hours in DMF as a solvent.
RU2008153006/04A 2008-12-31 2008-12-31 N,n-dimethyl-n-(4-quinolinenylmethyl)amine synthesis method RU2404165C2 (en)

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