RU2008127844A - Способы идентификации и таргетинга раковых стволовых клеток на основе морфологии ядра - Google Patents
Способы идентификации и таргетинга раковых стволовых клеток на основе морфологии ядра Download PDFInfo
- Publication number
- RU2008127844A RU2008127844A RU2008127844/13A RU2008127844A RU2008127844A RU 2008127844 A RU2008127844 A RU 2008127844A RU 2008127844/13 A RU2008127844/13 A RU 2008127844/13A RU 2008127844 A RU2008127844 A RU 2008127844A RU 2008127844 A RU2008127844 A RU 2008127844A
- Authority
- RU
- Russia
- Prior art keywords
- cancer stem
- stem cells
- agent
- molecule
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 25
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 23
- 201000011510 cancer Diseases 0.000 title claims abstract 23
- 210000000130 stem cell Anatomy 0.000 title claims abstract 23
- 230000008685 targeting Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 claims abstract 12
- 108020004414 DNA Proteins 0.000 claims abstract 6
- 102000053602 DNA Human genes 0.000 claims abstract 6
- 108020004682 Single-Stranded DNA Proteins 0.000 claims abstract 6
- 102000004190 Enzymes Human genes 0.000 claims abstract 4
- 108090000790 Enzymes Proteins 0.000 claims abstract 4
- 239000013043 chemical agent Substances 0.000 claims abstract 4
- 230000002401 inhibitory effect Effects 0.000 claims abstract 4
- 230000035755 proliferation Effects 0.000 claims abstract 4
- 238000005204 segregation Methods 0.000 claims abstract 4
- 230000004614 tumor growth Effects 0.000 claims abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74895105P | 2005-12-09 | 2005-12-09 | |
| US60/748,951 | 2005-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008127844A true RU2008127844A (ru) | 2010-02-10 |
Family
ID=38099345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008127844/13A RU2008127844A (ru) | 2005-12-09 | 2006-12-08 | Способы идентификации и таргетинга раковых стволовых клеток на основе морфологии ядра |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090304662A1 (enExample) |
| EP (1) | EP1963490A2 (enExample) |
| JP (1) | JP2009518438A (enExample) |
| KR (1) | KR20080079302A (enExample) |
| CN (1) | CN101426903A (enExample) |
| AU (1) | AU2006321710A1 (enExample) |
| BR (1) | BRPI0619599A2 (enExample) |
| CA (1) | CA2632754A1 (enExample) |
| IL (1) | IL191746A0 (enExample) |
| RU (1) | RU2008127844A (enExample) |
| WO (1) | WO2007067795A2 (enExample) |
| ZA (1) | ZA200804973B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005265122A1 (en) * | 2004-06-17 | 2006-01-26 | Massachusetts Institute Of Technology | Methods for identifying stem cells based on nuclear morphotypes |
| US20100284905A1 (en) * | 2007-06-13 | 2010-11-11 | Massachusetts Institute of Tehnology | Methods and Agents for Inhibiting Tumor Growth by Targeting the SSDNA Replication Intermediate of Tumor Stem Cells |
| IT1392908B1 (it) | 2008-09-29 | 2012-04-02 | Italfarmaco Spa | Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative |
| US8217079B2 (en) | 2010-03-26 | 2012-07-10 | Italfarmaco Spa | Method for treating Philadelphia-negative myeloproliferative syndromes |
| US9499851B2 (en) | 2010-10-25 | 2016-11-22 | Massachusetts Institute Of Technology | Wound healing metakaryotic stem cells and methods of use thereof |
| JP2014516551A (ja) * | 2011-06-02 | 2014-07-17 | マサチューセッツ インスティテュート オブ テクノロジー | メタカリオート（ｍｅｔａｋａｒｙｏｔｉｃ）幹細胞のｄｓＲＮＡ／ＤＮＡハイブリッドゲノム複製中間体 |
| CN110118875B (zh) * | 2019-05-09 | 2020-08-28 | 量准(武汉)生命科技有限公司 | 一种人类唾液中c型反应性蛋白彩色成像的方法及装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7361336B1 (en) * | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| AU2005265122A1 (en) * | 2004-06-17 | 2006-01-26 | Massachusetts Institute Of Technology | Methods for identifying stem cells based on nuclear morphotypes |
-
2006
- 2006-12-08 WO PCT/US2006/047136 patent/WO2007067795A2/en not_active Ceased
- 2006-12-08 EP EP06847546A patent/EP1963490A2/en not_active Withdrawn
- 2006-12-08 BR BRPI0619599-7A patent/BRPI0619599A2/pt not_active Application Discontinuation
- 2006-12-08 KR KR1020087016673A patent/KR20080079302A/ko not_active Withdrawn
- 2006-12-08 AU AU2006321710A patent/AU2006321710A1/en not_active Abandoned
- 2006-12-08 US US12/085,533 patent/US20090304662A1/en not_active Abandoned
- 2006-12-08 JP JP2008544572A patent/JP2009518438A/ja not_active Withdrawn
- 2006-12-08 RU RU2008127844/13A patent/RU2008127844A/ru not_active Application Discontinuation
- 2006-12-08 CN CNA2006800525889A patent/CN101426903A/zh active Pending
- 2006-12-08 CA CA002632754A patent/CA2632754A1/en not_active Abandoned
-
2008
- 2008-05-27 IL IL191746A patent/IL191746A0/en unknown
- 2008-06-06 ZA ZA200804973A patent/ZA200804973B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2632754A1 (en) | 2007-06-14 |
| CN101426903A (zh) | 2009-05-06 |
| IL191746A0 (en) | 2008-12-29 |
| BRPI0619599A2 (pt) | 2011-10-11 |
| EP1963490A2 (en) | 2008-09-03 |
| AU2006321710A1 (en) | 2007-06-14 |
| ZA200804973B (en) | 2009-11-25 |
| KR20080079302A (ko) | 2008-08-29 |
| JP2009518438A (ja) | 2009-05-07 |
| US20090304662A1 (en) | 2009-12-10 |
| WO2007067795A3 (en) | 2007-08-23 |
| WO2007067795A2 (en) | 2007-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20100315 |