AU2006321710A1 - Methods for identifying and targeting tumor stem cells based on nuclear morphology - Google Patents

Methods for identifying and targeting tumor stem cells based on nuclear morphology Download PDF

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Publication number
AU2006321710A1
AU2006321710A1 AU2006321710A AU2006321710A AU2006321710A1 AU 2006321710 A1 AU2006321710 A1 AU 2006321710A1 AU 2006321710 A AU2006321710 A AU 2006321710A AU 2006321710 A AU2006321710 A AU 2006321710A AU 2006321710 A1 AU2006321710 A1 AU 2006321710A1
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Australia
Prior art keywords
bell
nuclei
cells
nuclear
shaped
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2006321710A
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English (en)
Inventor
Elena V. Gostjeva
William G. Thilly
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of AU2006321710A1 publication Critical patent/AU2006321710A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells
    • C12N5/0695Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2006321710A 2005-12-09 2006-12-08 Methods for identifying and targeting tumor stem cells based on nuclear morphology Abandoned AU2006321710A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74895105P 2005-12-09 2005-12-09
US60/748,951 2005-12-09
PCT/US2006/047136 WO2007067795A2 (en) 2005-12-09 2006-12-08 Methods for identifying and targeting tumor stem cells based on nuclear morphology

Publications (1)

Publication Number Publication Date
AU2006321710A1 true AU2006321710A1 (en) 2007-06-14

Family

ID=38099345

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006321710A Abandoned AU2006321710A1 (en) 2005-12-09 2006-12-08 Methods for identifying and targeting tumor stem cells based on nuclear morphology

Country Status (12)

Country Link
US (1) US20090304662A1 (enExample)
EP (1) EP1963490A2 (enExample)
JP (1) JP2009518438A (enExample)
KR (1) KR20080079302A (enExample)
CN (1) CN101426903A (enExample)
AU (1) AU2006321710A1 (enExample)
BR (1) BRPI0619599A2 (enExample)
CA (1) CA2632754A1 (enExample)
IL (1) IL191746A0 (enExample)
RU (1) RU2008127844A (enExample)
WO (1) WO2007067795A2 (enExample)
ZA (1) ZA200804973B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101209833B1 (ko) * 2004-06-17 2012-12-07 메사추세츠 인스티튜트 오브 테크놀로지 핵 형태에 기초하여 줄기 세포를 동정하는 방법
CN101720436A (zh) * 2007-06-13 2010-06-02 麻省理工学院 用于通过靶向肿瘤干细胞的ssDNA复制中间物而抑制肿瘤生长的方法和药剂
IT1392908B1 (it) 2008-09-29 2012-04-02 Italfarmaco Spa Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative
US8217079B2 (en) 2010-03-26 2012-07-10 Italfarmaco Spa Method for treating Philadelphia-negative myeloproliferative syndromes
KR20140016241A (ko) 2010-10-25 2014-02-07 메사추세츠 인스티튜트 오브 테크놀로지 상처 치유 메타카리오틱 줄기 세포 및 그 사용방법
US20140369934A1 (en) * 2011-06-02 2014-12-18 Massachusetts Institute Of Technology dsRNA/DNA Hybrid Genome Replication Intermediate Of Metakaryotic Stem Cells
CN110118875B (zh) * 2019-05-09 2020-08-28 量准(武汉)生命科技有限公司 一种人类唾液中c型反应性蛋白彩色成像的方法及装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7361336B1 (en) * 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
KR101209833B1 (ko) * 2004-06-17 2012-12-07 메사추세츠 인스티튜트 오브 테크놀로지 핵 형태에 기초하여 줄기 세포를 동정하는 방법

Also Published As

Publication number Publication date
CA2632754A1 (en) 2007-06-14
EP1963490A2 (en) 2008-09-03
JP2009518438A (ja) 2009-05-07
WO2007067795A2 (en) 2007-06-14
ZA200804973B (en) 2009-11-25
KR20080079302A (ko) 2008-08-29
BRPI0619599A2 (pt) 2011-10-11
IL191746A0 (en) 2008-12-29
US20090304662A1 (en) 2009-12-10
CN101426903A (zh) 2009-05-06
RU2008127844A (ru) 2010-02-10
WO2007067795A3 (en) 2007-08-23

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application