JP2009518438A - 核形態に基づく腫瘍幹細胞の同定および標的のための方法 - Google Patents

核形態に基づく腫瘍幹細胞の同定および標的のための方法 Download PDF

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JP2009518438A
JP2009518438A JP2008544572A JP2008544572A JP2009518438A JP 2009518438 A JP2009518438 A JP 2009518438A JP 2008544572 A JP2008544572 A JP 2008544572A JP 2008544572 A JP2008544572 A JP 2008544572A JP 2009518438 A JP2009518438 A JP 2009518438A
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bell
nuclei
shaped
cells
tumor
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Japanese (ja)
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JP2009518438A5 (enExample
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ティリー，ウィリアム，ジー．
ゴストジェバ，エレナ，ブイ．
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Massachusetts Institute of Technology
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0695—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008544572A 2005-12-09 2006-12-08 核形態に基づく腫瘍幹細胞の同定および標的のための方法 Withdrawn JP2009518438A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74895105P 2005-12-09 2005-12-09
PCT/US2006/047136 WO2007067795A2 (en) 2005-12-09 2006-12-08 Methods for identifying and targeting tumor stem cells based on nuclear morphology

Publications (2)

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JP2009518438A true JP2009518438A (ja) 2009-05-07
JP2009518438A5 JP2009518438A5 (enExample) 2009-11-19

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JP2008544572A Withdrawn JP2009518438A (ja) 2005-12-09 2006-12-08 核形態に基づく腫瘍幹細胞の同定および標的のための方法

Country Status (12)

Country Link
US (1) US20090304662A1 (enExample)
EP (1) EP1963490A2 (enExample)
JP (1) JP2009518438A (enExample)
KR (1) KR20080079302A (enExample)
CN (1) CN101426903A (enExample)
AU (1) AU2006321710A1 (enExample)
BR (1) BRPI0619599A2 (enExample)
CA (1) CA2632754A1 (enExample)
IL (1) IL191746A0 (enExample)
RU (1) RU2008127844A (enExample)
WO (1) WO2007067795A2 (enExample)
ZA (1) ZA200804973B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014516551A (ja) * 2011-06-02 2014-07-17 マサチューセッツ インスティテュート オブ テクノロジー メタカリオート（ｍｅｔａｋａｒｙｏｔｉｃ）幹細胞のｄｓＲＮＡ／ＤＮＡハイブリッドゲノム複製中間体

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007101496A (ru) 2004-06-17 2008-07-27 Массачусетс Инститьют Оф Текнолоджи (Us) Способы идентификации стволовых клеток, основанные на ядерных морфотипах
CA2692072A1 (en) * 2007-06-13 2008-12-24 Massachusetts Institute Of Technology Methods and agents for inhibiting tumor growth
IT1392908B1 (it) 2008-09-29 2012-04-02 Italfarmaco Spa Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative
US8217079B2 (en) 2010-03-26 2012-07-10 Italfarmaco Spa Method for treating Philadelphia-negative myeloproliferative syndromes
CA2815787A1 (en) 2010-10-25 2012-05-10 Massachusetts Institute Of Technology Wound healing metakaryotic stem cells and methods of use thereof
CN110118875B (zh) * 2019-05-09 2020-08-28 量准(武汉)生命科技有限公司 一种人类唾液中c型反应性蛋白彩色成像的方法及装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7361336B1 (en) * 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
RU2007101496A (ru) * 2004-06-17 2008-07-27 Массачусетс Инститьют Оф Текнолоджи (Us) Способы идентификации стволовых клеток, основанные на ядерных морфотипах

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014516551A (ja) * 2011-06-02 2014-07-17 マサチューセッツ インスティテュート オブ テクノロジー メタカリオート（ｍｅｔａｋａｒｙｏｔｉｃ）幹細胞のｄｓＲＮＡ／ＤＮＡハイブリッドゲノム複製中間体

Also Published As

Publication number Publication date
WO2007067795A3 (en) 2007-08-23
AU2006321710A1 (en) 2007-06-14
WO2007067795A2 (en) 2007-06-14
RU2008127844A (ru) 2010-02-10
IL191746A0 (en) 2008-12-29
KR20080079302A (ko) 2008-08-29
ZA200804973B (en) 2009-11-25
CA2632754A1 (en) 2007-06-14
CN101426903A (zh) 2009-05-06
EP1963490A2 (en) 2008-09-03
US20090304662A1 (en) 2009-12-10
BRPI0619599A2 (pt) 2011-10-11

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