RU2007111864A - Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы - Google Patents

Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы Download PDF

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Publication number
RU2007111864A
RU2007111864A RU2007111864/04A RU2007111864A RU2007111864A RU 2007111864 A RU2007111864 A RU 2007111864A RU 2007111864/04 A RU2007111864/04 A RU 2007111864/04A RU 2007111864 A RU2007111864 A RU 2007111864A RU 2007111864 A RU2007111864 A RU 2007111864A
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RU
Russia
Prior art keywords
cys
modulation
cell proliferation
carcinoma cell
trp
Prior art date
Application number
RU2007111864/04A
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English (en)
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RU2352578C2 (ru
Inventor
УБЕРТИ Этторе Чиро ДЕЛЬИ (IT)
УБЕРТИ Этторе Чиро ДЕЛЬИ
Мари Кь ра ДЗАТЕЛЛИ (IT)
Мария Кьяра ДЗАТЕЛЛИ
Майкл ДеВитт КАЛЛЕР (US)
Майкл Девитт КАЛЛЕР
Original Assignee
Иль Консорцио Феррара Ричерке (It)
Иль Консорцио Феррара Ричерке
Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С. (Fr)
Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Иль Консорцио Феррара Ричерке (It), Иль Консорцио Феррара Ричерке, Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С. (Fr), Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик С.А.С. filed Critical Иль Консорцио Феррара Ричерке (It)
Publication of RU2007111864A publication Critical patent/RU2007111864A/ru
Application granted granted Critical
Publication of RU2352578C2 publication Critical patent/RU2352578C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (4)

1. Соединение формулы Сра-с(D-Cys-4-Pal-D-Trp-Lys-Thr-Cys)-NaI-NH2.
2. Соединение по п.1, где соединение обладает антагонистической активностью в отношении SSTR2.
3. Применение соединения по п.1 для ингибирования выхода внутриклеточного кальция, стимулированного SS2.
4. Способ ингибирования выхода внутриклеточного кальция, стимулированного SS2, где способ предусматривает контактирование клеток с соединением по п.1.
RU2007111864/04A 2001-03-06 2002-03-06 Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы RU2352578C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27369901P 2001-03-06 2001-03-06
US60/273,699 2001-03-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2005132456/14A Division RU2317824C2 (ru) 2001-03-06 2005-10-20 Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы

Publications (2)

Publication Number Publication Date
RU2007111864A true RU2007111864A (ru) 2008-10-10
RU2352578C2 RU2352578C2 (ru) 2009-04-20

Family

ID=23045039

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2007111864/04A RU2352578C2 (ru) 2001-03-06 2002-03-06 Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы
RU2003129515/14A RU2275934C2 (ru) 2001-03-06 2002-03-06 Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы
RU2005132456/14A RU2317824C2 (ru) 2001-03-06 2005-10-20 Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы

Family Applications After (2)

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RU2003129515/14A RU2275934C2 (ru) 2001-03-06 2002-03-06 Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы
RU2005132456/14A RU2317824C2 (ru) 2001-03-06 2005-10-20 Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы

Country Status (10)

Country Link
US (3) US20050124549A1 (ru)
EP (3) EP1390406B1 (ru)
JP (2) JP4294959B2 (ru)
AT (3) ATE430162T1 (ru)
CA (2) CA2743731C (ru)
DE (3) DE60236225D1 (ru)
ES (3) ES2345280T3 (ru)
NO (1) NO20033881L (ru)
RU (3) RU2352578C2 (ru)
WO (1) WO2002070555A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262229B1 (en) * 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
CA2743731C (en) * 2001-03-06 2014-05-06 The Administrators Of The Tulane Educational Fund Method of modulating the proliferation of medullary thyroid carcinoma cells
EP1372688B1 (en) * 2001-03-08 2008-05-07 The Administrators of The Tulane Educational Fund Somatostatin antagonists
EP1522311A1 (fr) * 2003-10-10 2005-04-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée
GB0602639D0 (en) 2006-02-09 2006-03-22 Novartis Ag Organic compounds
EP2003967B1 (en) 2006-03-23 2011-09-07 Ipsen Pharma Use of somatostatin agonists to treat medullary thyroid carcinoma
EP2835136A1 (en) 2013-08-07 2015-02-11 PregLem S.A. Somatostatin Receptor Modulator for the treatment of infertility

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661472A (en) * 1985-05-09 1987-04-28 The Salk Institute For Biological Studies GnRH antagonists IX
PT1288223E (pt) 1993-08-09 2005-03-31 Sod Conseils Rech Applic Derivados de peptidos terapeuticos
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
DE69812084T2 (de) 1997-05-01 2003-12-24 Cedars Sinai Medical Center Verfahren zur behandlung von hyperprolaktinämia und prolaktinomen
US5972893A (en) * 1997-05-06 1999-10-26 Cedars-Sinai Medical Center Method of treating hyperprolactinemia and prolactinomas
US6180082B1 (en) * 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
CN1250361A (zh) 1997-11-24 2000-04-12 路易斯安那州州立大学及农业机械学院管理委员会 提高放射性标记化合物的组织积累的方法
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
PL346361A1 (en) 1998-07-30 2002-02-11 Sod Conseils Rech Applic Methods of using a somatostatin analogue
HUP0201696A3 (en) * 1999-06-25 2002-10-28 Sod Conseils Rech Applic Cyclic peptides, pharmaceutical compositions comprising thereof and their use
CA2743731C (en) * 2001-03-06 2014-05-06 The Administrators Of The Tulane Educational Fund Method of modulating the proliferation of medullary thyroid carcinoma cells

Also Published As

Publication number Publication date
US20110183416A1 (en) 2011-07-28
RU2317824C2 (ru) 2008-02-27
US20050124549A1 (en) 2005-06-09
JP2007145854A (ja) 2007-06-14
JP4294959B2 (ja) 2009-07-15
EP1897889A2 (en) 2008-03-12
NO20033881L (no) 2003-10-10
US9220760B2 (en) 2015-12-29
WO2002070555A3 (en) 2003-12-04
ATE466029T1 (de) 2010-05-15
EP1390406A2 (en) 2004-02-25
US20070259811A1 (en) 2007-11-08
ES2328077T3 (es) 2009-11-06
DE60236225D1 (de) 2010-06-10
DE60220157T2 (de) 2008-01-17
ES2345280T3 (es) 2010-09-20
ES2284859T3 (es) 2007-11-16
EP1897889B1 (en) 2010-04-28
EP1897889A3 (en) 2008-03-26
CA2743731C (en) 2014-05-06
EP1813625A1 (en) 2007-08-01
JP2005506289A (ja) 2005-03-03
CA2440214C (en) 2012-05-22
JP4828438B2 (ja) 2011-11-30
EP1390406B1 (en) 2007-05-16
ATE362489T1 (de) 2007-06-15
CA2743731A1 (en) 2002-09-12
EP1813625B1 (en) 2009-04-29
RU2275934C2 (ru) 2006-05-10
RU2003129515A (ru) 2005-03-27
ATE430162T1 (de) 2009-05-15
RU2005132456A (ru) 2007-04-27
DE60232203D1 (de) 2009-06-10
CA2440214A1 (en) 2002-09-12
WO2002070555A2 (en) 2002-09-12
NO20033881D0 (no) 2003-09-02
DE60220157D1 (de) 2007-06-28
RU2352578C2 (ru) 2009-04-20

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