RU2006132389A - Ингибитор гиперплазии интимы сосудов - Google Patents
Ингибитор гиперплазии интимы сосудов Download PDFInfo
- Publication number
- RU2006132389A RU2006132389A RU2006132389/15A RU2006132389A RU2006132389A RU 2006132389 A RU2006132389 A RU 2006132389A RU 2006132389/15 A RU2006132389/15 A RU 2006132389/15A RU 2006132389 A RU2006132389 A RU 2006132389A RU 2006132389 A RU2006132389 A RU 2006132389A
- Authority
- RU
- Russia
- Prior art keywords
- inhibitor
- intimal hyperplasia
- hydrogen atom
- vascular intimal
- halogen atom
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
1. Ингибитор гиперплазии интимы сосудов, содержащий соединение 3(2H)-пиридазинона, представленное формулой (I), или его фармакологически приемлемую соль:
где каждый из R1, R2 и R3 независимо представляет собой атом водорода или С1-6 алкильную группу, X представляет собой атом галогена, циано или атом водорода, Y представляет собой атом галогена, трифторметил или атом водорода, и A представляет собой С1-8 алкилен, который может быть замещен гидроксильной группой.
2. Ингибитор гиперплазии интимы сосудов по п. 1, где соединение представлено формулой (I), в которой R1 и R2 представляют собой атомы водорода, R3 представляет собой атом водорода или С1-4 алкильную группу, X представляет собой атом галогена, Y представляет собой атом галогена или атом водорода, A представляет собой C1-5 алкилен, который может быть замещен гидроксильной группой.
3. Ингибитор гиперплазии интимы сосудов по п.1, где соединение, представленное формулой (I), представляет собой 4-бром-6-[3-(4-хлорфенил)пропокси]-5-(3-пиридилметиламино)-3(2Н)-пиридазинон или 4-бром-6-[3-(4-хлорфенил)-3-гидроксипропокси]-5-(3-пиридилметиламино)-3(2H)-пиридазинон.
4. Ингибитор гиперплазии интимы сосудов по пп.1, 2 или 3, где фармакологически приемлемая соль представляет собой соль неорганической или неорганической кислоты.
5. Ингибитор гиперплазии интимы сосудов по пп.1, 2 или 3, где фармакологически приемлемая соль представляет собой гидрохлорид.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004-032551 | 2004-02-09 | ||
| JP2004032551 | 2004-02-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006132389A true RU2006132389A (ru) | 2008-03-20 |
| RU2339381C2 RU2339381C2 (ru) | 2008-11-27 |
Family
ID=34836093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006132389/15A RU2339381C2 (ru) | 2004-02-09 | 2005-02-02 | Ингибитор гиперплазии интимы сосудов |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070161642A1 (ru) |
| EP (1) | EP1714654A4 (ru) |
| JP (1) | JP4783152B2 (ru) |
| KR (1) | KR20070029133A (ru) |
| CN (1) | CN100506230C (ru) |
| AU (1) | AU2005210326B2 (ru) |
| BR (1) | BRPI0507518A8 (ru) |
| CA (1) | CA2553915C (ru) |
| HK (1) | HK1098377A1 (ru) |
| IL (1) | IL176795A (ru) |
| RU (1) | RU2339381C2 (ru) |
| TW (1) | TWI357409B (ru) |
| WO (1) | WO2005074938A1 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005068445A2 (en) * | 2004-01-08 | 2005-07-28 | Syngenta Participations Ag | Pesticidal heterocyclic dihaloallyl compounds |
| EP1604988A1 (en) * | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
| MX2009008531A (es) * | 2007-02-16 | 2009-08-26 | Amgen Inc | Cetonas de heterociclilo que contienen nitrogeno y su uso como inhibidores de c-met. |
| FR2948939B1 (fr) * | 2009-08-05 | 2013-03-22 | Pf Medicament | Derives de 2h pyridazin-3-ones, leur preparation et leur application en therapeutique humaine |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU208124B (en) * | 1990-04-25 | 1993-08-30 | Nissan Chemical Ind Ltd | Process for producing pyridazinone derivatives and pharmaceutical compositions comprising such derivatives as active ingredient |
| JP3666042B2 (ja) * | 1994-01-25 | 2005-06-29 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| CA2181901C (en) * | 1994-01-25 | 2005-09-13 | Keizo Tanikawa | Pyridazinone derivatives |
| JP2964029B2 (ja) * | 1995-10-05 | 1999-10-18 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| TW338037B (en) * | 1995-10-05 | 1998-08-11 | Otsuka Pharma Co Ltd | Carbostyril derivatives possessing platelet aggregation inhibitory activity, antithrombotic activity, intima thinkening, inhibitory activity and phosphoriesterase inhibitory activity, their preparation and pharmaceutical composition |
| WO1999011268A1 (fr) * | 1997-08-28 | 1999-03-11 | Yoshitomi Pharmaceutical Industries, Ltd. | Agents promoteurs et agents potentialisateurs de la neovascularisation |
| KR100573376B1 (ko) * | 1998-09-01 | 2006-04-25 | 닛산 가가쿠 고교 가부시키 가이샤 | 척추관 협착증 치료제 |
| RU2229885C2 (ru) * | 1998-12-07 | 2004-06-10 | Ниссан Кемикал Индастриз, Лтд. | Средство для лечения нарушения функции эрекции |
| JP2001131088A (ja) * | 1999-11-02 | 2001-05-15 | Kyurin:Kk | シンドロームｘ症候群治療剤 |
| CA2304906A1 (en) * | 2000-04-07 | 2001-10-07 | 1411198 Ontario Limited | 13-hode, a regulator of vascular biocompatibility and an inhibitor of cell hyperplasia |
-
2005
- 2005-02-02 KR KR1020067014583A patent/KR20070029133A/ko not_active Application Discontinuation
- 2005-02-02 WO PCT/JP2005/001518 patent/WO2005074938A1/ja active Application Filing
- 2005-02-02 JP JP2005517709A patent/JP4783152B2/ja not_active Expired - Fee Related
- 2005-02-02 CN CNB2005800017340A patent/CN100506230C/zh not_active Expired - Fee Related
- 2005-02-02 AU AU2005210326A patent/AU2005210326B2/en not_active Ceased
- 2005-02-02 US US10/585,949 patent/US20070161642A1/en not_active Abandoned
- 2005-02-02 BR BRPI0507518A patent/BRPI0507518A8/pt active Search and Examination
- 2005-02-02 CA CA2553915A patent/CA2553915C/en not_active Expired - Fee Related
- 2005-02-02 RU RU2006132389/15A patent/RU2339381C2/ru not_active IP Right Cessation
- 2005-02-02 EP EP05709638A patent/EP1714654A4/en not_active Withdrawn
- 2005-02-03 TW TW094103407A patent/TWI357409B/zh not_active IP Right Cessation
-
2006
- 2006-07-11 IL IL176795A patent/IL176795A/en not_active IP Right Cessation
-
2007
- 2007-05-09 HK HK07104940.6A patent/HK1098377A1/xx not_active IP Right Cessation
-
2009
- 2009-01-14 US US12/353,646 patent/US20090155187A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2005074938A1 (ja) | 2007-09-13 |
| IL176795A (en) | 2013-01-31 |
| CN100506230C (zh) | 2009-07-01 |
| IL176795A0 (en) | 2006-10-31 |
| CN1905882A (zh) | 2007-01-31 |
| BRPI0507518A (pt) | 2007-07-03 |
| AU2005210326A1 (en) | 2005-08-18 |
| TW200530218A (en) | 2005-09-16 |
| WO2005074938A1 (ja) | 2005-08-18 |
| BRPI0507518A8 (pt) | 2015-12-01 |
| CA2553915A1 (en) | 2005-08-18 |
| EP1714654A4 (en) | 2011-02-16 |
| CA2553915C (en) | 2010-06-01 |
| AU2005210326B2 (en) | 2009-10-22 |
| RU2339381C2 (ru) | 2008-11-27 |
| JP4783152B2 (ja) | 2011-09-28 |
| EP1714654A1 (en) | 2006-10-25 |
| US20070161642A1 (en) | 2007-07-12 |
| US20090155187A1 (en) | 2009-06-18 |
| TWI357409B (en) | 2012-02-01 |
| KR20070029133A (ko) | 2007-03-13 |
| HK1098377A1 (en) | 2007-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20170203 |