RU2006127040A - Антинейтрофильное средство - Google Patents
Антинейтрофильное средство Download PDFInfo
- Publication number
- RU2006127040A RU2006127040A RU2006127040/15A RU2006127040A RU2006127040A RU 2006127040 A RU2006127040 A RU 2006127040A RU 2006127040/15 A RU2006127040/15 A RU 2006127040/15A RU 2006127040 A RU2006127040 A RU 2006127040A RU 2006127040 A RU2006127040 A RU 2006127040A
- Authority
- RU
- Russia
- Prior art keywords
- antineutrophilic
- hydrogen atom
- halogen atom
- agent
- pyridazinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
1. Антинейтрофильное средство, содержащее соединение 3(2Н)-пиридазинона, представленное формулой (I), или его фармацевтически приемлемую соль
где каждый R1, R2 и R3 являются, независимо друг от друга, атомом водорода или С1-6 алкильной группой, Х является атомом галогена, циано или атомом водорода, Y является атомом галогена, трифторметилом или атомом водорода, и А является С1-8 алкиленом, в котором в качестве заместителя может присутствовать гидроксильная группа.
2. Антинейтрофильное средство по п.1, в котором в формуле (I) R1 и R2 являются атомами водорода, R3 является атомом водорода или С1-4 алкильной группой, Х является атомом галогена, Y является атомом галогена или атомом водорода, и А является С1-5 алкиленом, в котором в качестве заместителя может присутствовать гидроксильная группа.
3. Антинейтрофильное средство по п.1, в котором соединение, представленное формулой (I), представляет собой 4-бром-6-[3-(4-хлорфенил)пропокси]-5-(3-пиридилметиламино)-3(2Н)-пиридазинон или 4-бром-6-[3-(4-хлорфенил)-3-гидроксипропокси]-5-(3-пиридилметиламино)-3(2Н)-пиридазинон.
4. Антинейтрофильное средство по п.1, в котором фармацевтически приемлемой солью является соль органической кислоты или соль неорганической кислоты.
5. Антинейтрофильное средство по любому из пп.1-4, которое является профилактическим или терапевтическим средством в случае хронического обструктивного заболевания легких.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003433747 | 2003-12-26 | ||
| JP2003-433747 | 2003-12-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006127040A true RU2006127040A (ru) | 2008-02-10 |
| RU2356555C2 RU2356555C2 (ru) | 2009-05-27 |
Family
ID=34736527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006127040/15A RU2356555C2 (ru) | 2003-12-26 | 2004-12-22 | Антинейтрофильное средство |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070117806A1 (ru) |
| EP (1) | EP1698339A4 (ru) |
| JP (1) | JP4688681B2 (ru) |
| KR (2) | KR101293350B1 (ru) |
| CN (1) | CN1897952B (ru) |
| AU (1) | AU2004308806B9 (ru) |
| BR (1) | BRPI0417200A (ru) |
| CA (1) | CA2549672C (ru) |
| HK (1) | HK1098378A1 (ru) |
| IL (1) | IL176473A (ru) |
| RU (1) | RU2356555C2 (ru) |
| TW (1) | TW200522962A (ru) |
| WO (1) | WO2005063250A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101538245B (zh) * | 2008-03-18 | 2011-02-16 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和制备药物的用途 |
| CN102133217B (zh) * | 2010-01-27 | 2013-07-24 | 中国科学院上海药物研究所 | 一类以n为桥键的哒嗪酮类化合物在制备抗肿瘤的药物中的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA27031A1 (ru) * | 1990-04-25 | 2000-02-28 | Ніссан Кемікал Індастріз Лтд | ПРОИЗВОДНЫЕ 3(2Н)ПИРИДАЗИНОНА ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ОБЛАДАЮЩИЕ ПРОТИВОТРОБОтическим, ПОЗИТИВНЫМ ИНОТРОПНЫМ, СОСУДОРАСШИРЯЮЩИМ ДЕЙСТВИЕМ И АНТИАЛЛРГИЧЕСКУЮ АКТИВНОСТЬ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ |
| IL112695A (en) * | 1994-02-22 | 1999-04-11 | Green Cross Corp | Pharmaceutical compositions containing pyridazinone derivatives |
| DE69832089T2 (de) * | 1997-08-28 | 2006-07-20 | Nissan Chemical Industries, Ltd. | Mittel zur förderung und verstärkung der neovaskularisierung |
| US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| DK1123704T3 (da) * | 1998-09-01 | 2004-11-01 | Nissan Chemical Ind Ltd | Midler til spinalstenose |
| IL143530A0 (en) * | 1998-12-07 | 2002-04-21 | Nissan Chemical Ind Ltd | Pyridazinone derivatives |
| JP2001131088A (ja) * | 1999-11-02 | 2001-05-15 | Kyurin:Kk | シンドロームｘ症候群治療剤 |
-
2004
- 2004-12-22 CN CN2004800381582A patent/CN1897952B/zh not_active Expired - Fee Related
- 2004-12-22 EP EP04807556A patent/EP1698339A4/en not_active Withdrawn
- 2004-12-22 US US10/584,222 patent/US20070117806A1/en not_active Abandoned
- 2004-12-22 AU AU2004308806A patent/AU2004308806B9/en not_active Ceased
- 2004-12-22 JP JP2005516599A patent/JP4688681B2/ja not_active Expired - Fee Related
- 2004-12-22 CA CA2549672A patent/CA2549672C/en not_active Expired - Fee Related
- 2004-12-22 KR KR1020097027323A patent/KR101293350B1/ko not_active IP Right Cessation
- 2004-12-22 WO PCT/JP2004/019199 patent/WO2005063250A1/ja active Application Filing
- 2004-12-22 BR BRPI0417200-0A patent/BRPI0417200A/pt not_active Application Discontinuation
- 2004-12-22 RU RU2006127040/15A patent/RU2356555C2/ru not_active IP Right Cessation
- 2004-12-22 KR KR1020067012723A patent/KR20060125816A/ko not_active Application Discontinuation
- 2004-12-24 TW TW093140627A patent/TW200522962A/zh not_active IP Right Cessation
-
2006
- 2006-06-21 IL IL176473A patent/IL176473A/en not_active IP Right Cessation
-
2007
- 2007-05-09 HK HK07104941.5A patent/HK1098378A1/xx not_active IP Right Cessation
-
2008
- 2008-08-08 US US12/188,638 patent/US20080306080A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060125816A (ko) | 2006-12-06 |
| TWI341729B (ru) | 2011-05-11 |
| WO2005063250A1 (ja) | 2005-07-14 |
| TW200522962A (en) | 2005-07-16 |
| CA2549672A1 (en) | 2005-07-14 |
| AU2004308806B9 (en) | 2010-01-28 |
| AU2004308806B2 (en) | 2009-10-29 |
| RU2356555C2 (ru) | 2009-05-27 |
| US20080306080A1 (en) | 2008-12-11 |
| AU2004308806A1 (en) | 2005-07-14 |
| EP1698339A1 (en) | 2006-09-06 |
| IL176473A (en) | 2013-06-27 |
| EP1698339A4 (en) | 2009-06-17 |
| JP4688681B2 (ja) | 2011-05-25 |
| BRPI0417200A (pt) | 2007-02-06 |
| KR101293350B1 (ko) | 2013-08-05 |
| US20070117806A1 (en) | 2007-05-24 |
| HK1098378A1 (en) | 2007-07-20 |
| CN1897952A (zh) | 2007-01-17 |
| KR20100019542A (ko) | 2010-02-18 |
| JPWO2005063250A1 (ja) | 2007-07-19 |
| IL176473A0 (en) | 2006-10-05 |
| CN1897952B (zh) | 2010-12-08 |
| CA2549672C (en) | 2010-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002543183A5 (ru) | ||
| RU2361860C2 (ru) | Новые замещенные 3-сера-индолы | |
| JP2005539088A5 (ru) | ||
| JP2010504908A5 (ru) | ||
| JP2007508359A5 (ru) | ||
| JP2006508065A5 (ru) | ||
| JP2009515988A5 (ru) | ||
| JP2010510967A5 (ru) | ||
| JP2007500753A5 (ru) | ||
| RU2008119994A (ru) | Ингибиторы калиевых каналов | |
| JP2004002970A5 (ru) | ||
| JP2007519618A5 (ru) | ||
| RU2011147186A (ru) | 2, 5-дизамещенные арилсульфонамидные антагонисты ссr3 | |
| PL378201A1 (pl) | Sposób farmaceutyczny oraz związki wytwarzane tym sposobem | |
| RU2006132389A (ru) | Ингибитор гиперплазии интимы сосудов | |
| JP2005526773A5 (ru) | ||
| RU2006127040A (ru) | Антинейтрофильное средство | |
| JP2006527285A5 (ru) | ||
| JP2006509753A5 (ru) | ||
| RU2007124202A (ru) | Новые соединения, обладающие функцией антикоагулянтов, фармацевтические компании на их основе для лечения тромботических состояний и плазмозамещающий раствор для коррекции гиперкоагуляционных нарушений при гемодилюции | |
| JP2007513197A5 (ru) | ||
| JP2007507467A5 (ru) | ||
| DE602004031560D1 (de) | Diazaspiropiperidinderivate | |
| JP2006510659A5 (ru) | ||
| JP2019526593A5 (ru) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20161223 |