RU2006126779A - Фармацевтические композиции - Google Patents

Фармацевтические композиции Download PDF

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Publication number
RU2006126779A
RU2006126779A RU2006126779/15A RU2006126779A RU2006126779A RU 2006126779 A RU2006126779 A RU 2006126779A RU 2006126779/15 A RU2006126779/15 A RU 2006126779/15A RU 2006126779 A RU2006126779 A RU 2006126779A RU 2006126779 A RU2006126779 A RU 2006126779A
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RU
Russia
Prior art keywords
ethylene carbonate
active agent
polymer
tissue healing
chloroform
Prior art date
Application number
RU2006126779/15A
Other languages
English (en)
Other versions
RU2363497C2 (ru
Inventor
Михаэль АУСБОРН (DE)
Михаэль АУСБОРН
Томас КИССЕЛЬ (DE)
Томас КИССЕЛЬ
Original Assignee
Новартис АГ (CH)
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0330031A external-priority patent/GB0330031D0/en
Priority claimed from GB0410261A external-priority patent/GB0410261D0/en
Application filed by Новартис АГ (CH), Новартис Аг filed Critical Новартис АГ (CH)
Publication of RU2006126779A publication Critical patent/RU2006126779A/ru
Application granted granted Critical
Publication of RU2363497C2 publication Critical patent/RU2363497C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Laminated Bodies (AREA)
  • Paints Or Removers (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Claims (13)

1. Устройство, содержащее биоразрушаемый полимер, включающий единицы этиленкарбоната формулы А
-(-С(O)-O-СН2-СН2-O-)- А,
в количестве 70-100 мол.%, обладающий внутренней вязкостью 0,4-4,0 дл/г при определении в хлороформе при 20°С в концентрации 1 г/дл и температурой стеклования 5-50°С, разрушаемый за счет поверхностной эрозии, которая контролируется по механизму негидролитического расщепления.
2. Устройство по п.1, поверхность которого покрыта полимером.
3. Устройство по п.1, дополнительно включающее фармацевтический действующий агент.
4. Устройство по п.3, в котором фармацевтический действующий агент растворен или диспергирован в полимере.
5. Устройство по п.3, содержащее иммунодепрессант или антипролиферативный агент в качестве фармацевтического действующего агента.
6. Устройство по п.1 в форме стента или катетера.
7. Устройство по п.6 в форме стента с вымываемым лекарственным средством.
8. Применение устройства по одному из предшествующих пунктов для контролируемого высвобождения фармакологического действующего агента.
9. Применение устройства по одному из предшествующих пп.1-7 для лечения или предупреждения неоинтимальной пролиферации и утолщения, повторного стеноза, окклюзии сосуда с последующим сосудистым повреждением и/или для активирования тканевого заживления.
10. Способ лечения или предупреждения неоинтимальной пролиферации и утолщения, повторного стеноза, окклюзии сосуда с последующим сосудистым повреждением, и/или активирования тканевого заживления в организме человека или животного, включающий имплантацию устройства по одному из пп.1-7 в то место, в котором такое лечение, профилактика или заживление ткани необходимо.
11. Способ получения устройства по одному из пп.1-7, включающий нанесение на устройство покрытия, содержащего полимер на основе этиленкарбоната.
12. Применение биоразрушаемого полимера, включающего единицы этиленкарбоната формулы А
-(-С(O)-O-СН2-СН2-O-)- А,
в количестве 70-100 мол.%, обладающего внутренней вязкостью 0,4-4,0 дл/г при определении в хлороформе при 20°С в концентрации 1 г/дл, и температурой стеклования 5-50°С, разрушаемый за счет поверхностной эрозии, которая контролируется по механизму негидролитического расщепления, для нанесения покрытия на устройство.
13. Применение биоразрушаемого полимера, включающего единицы этиленкарбоната формулы А
-(-С(O)-O-СН2-СН2-O-)- А,
в количестве 70-100 мол.%, обладающего внутренней вязкостью 0,4-4,0 дл/г при определении в хлороформе при 20°С в концентрации 1 г/дл, и температурой стеклования 5-50°С, разрушаемый за счет поверхностной эрозии, которая контролируется по механизму негидролитического расщепления, для получения устройства, предназначенного для лечения или предупреждения неоинтимальной пролиферации и утолщения, повторного стеноза, окклюзии сосуда с последующим сосудистым повреждением, и/или активирования тканевого заживления.
RU2006126779/15A 2003-12-24 2004-12-23 Фармацевтические композиции RU2363497C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0330031.6 2003-12-24
GB0330031A GB0330031D0 (en) 2003-12-24 2003-12-24 Organic compounds
GB0410261.2 2004-05-07
GB0410261A GB0410261D0 (en) 2004-05-07 2004-05-07 Organic compounds

Publications (2)

Publication Number Publication Date
RU2006126779A true RU2006126779A (ru) 2008-01-27
RU2363497C2 RU2363497C2 (ru) 2009-08-10

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RU2006126779/15A RU2363497C2 (ru) 2003-12-24 2004-12-23 Фармацевтические композиции

Country Status (13)

Country Link
US (2) US20070154520A1 (ru)
EP (1) EP1699503B8 (ru)
JP (1) JP4796506B2 (ru)
KR (1) KR20070015113A (ru)
AT (1) ATE549044T1 (ru)
AU (1) AU2004308654B2 (ru)
BR (1) BRPI0418167A (ru)
CA (1) CA2549601A1 (ru)
ES (1) ES2383374T3 (ru)
PL (1) PL1699503T3 (ru)
PT (1) PT1699503E (ru)
RU (1) RU2363497C2 (ru)
WO (1) WO2005063319A1 (ru)

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Also Published As

Publication number Publication date
JP4796506B2 (ja) 2011-10-19
WO2005063319A1 (en) 2005-07-14
KR20070015113A (ko) 2007-02-01
ES2383374T3 (es) 2012-06-20
RU2363497C2 (ru) 2009-08-10
US20070154520A1 (en) 2007-07-05
EP1699503A1 (en) 2006-09-13
BRPI0418167A (pt) 2007-06-19
PL1699503T3 (pl) 2013-02-28
EP1699503B1 (en) 2012-03-14
US20110305742A1 (en) 2011-12-15
EP1699503B8 (en) 2012-11-07
ATE549044T1 (de) 2012-03-15
PT1699503E (pt) 2012-06-06
JP2007516757A (ja) 2007-06-28
CA2549601A1 (en) 2005-07-14
AU2004308654A1 (en) 2005-07-14
WO2005063319A8 (en) 2005-09-09
AU2004308654B2 (en) 2008-11-20

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Effective date: 20131224