RU2006126779A - Фармацевтические композиции - Google Patents
Фармацевтические композиции Download PDFInfo
- Publication number
- RU2006126779A RU2006126779A RU2006126779/15A RU2006126779A RU2006126779A RU 2006126779 A RU2006126779 A RU 2006126779A RU 2006126779/15 A RU2006126779/15 A RU 2006126779/15A RU 2006126779 A RU2006126779 A RU 2006126779A RU 2006126779 A RU2006126779 A RU 2006126779A
- Authority
- RU
- Russia
- Prior art keywords
- ethylene carbonate
- active agent
- polymer
- tissue healing
- chloroform
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
- Laminated Bodies (AREA)
- Paints Or Removers (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Claims (13)
1. Устройство, содержащее биоразрушаемый полимер, включающий единицы этиленкарбоната формулы А
-(-С(O)-O-СН2-СН2-O-)- А,
в количестве 70-100 мол.%, обладающий внутренней вязкостью 0,4-4,0 дл/г при определении в хлороформе при 20°С в концентрации 1 г/дл и температурой стеклования 5-50°С, разрушаемый за счет поверхностной эрозии, которая контролируется по механизму негидролитического расщепления.
2. Устройство по п.1, поверхность которого покрыта полимером.
3. Устройство по п.1, дополнительно включающее фармацевтический действующий агент.
4. Устройство по п.3, в котором фармацевтический действующий агент растворен или диспергирован в полимере.
5. Устройство по п.3, содержащее иммунодепрессант или антипролиферативный агент в качестве фармацевтического действующего агента.
6. Устройство по п.1 в форме стента или катетера.
7. Устройство по п.6 в форме стента с вымываемым лекарственным средством.
8. Применение устройства по одному из предшествующих пунктов для контролируемого высвобождения фармакологического действующего агента.
9. Применение устройства по одному из предшествующих пп.1-7 для лечения или предупреждения неоинтимальной пролиферации и утолщения, повторного стеноза, окклюзии сосуда с последующим сосудистым повреждением и/или для активирования тканевого заживления.
10. Способ лечения или предупреждения неоинтимальной пролиферации и утолщения, повторного стеноза, окклюзии сосуда с последующим сосудистым повреждением, и/или активирования тканевого заживления в организме человека или животного, включающий имплантацию устройства по одному из пп.1-7 в то место, в котором такое лечение, профилактика или заживление ткани необходимо.
11. Способ получения устройства по одному из пп.1-7, включающий нанесение на устройство покрытия, содержащего полимер на основе этиленкарбоната.
12. Применение биоразрушаемого полимера, включающего единицы этиленкарбоната формулы А
-(-С(O)-O-СН2-СН2-O-)- А,
в количестве 70-100 мол.%, обладающего внутренней вязкостью 0,4-4,0 дл/г при определении в хлороформе при 20°С в концентрации 1 г/дл, и температурой стеклования 5-50°С, разрушаемый за счет поверхностной эрозии, которая контролируется по механизму негидролитического расщепления, для нанесения покрытия на устройство.
13. Применение биоразрушаемого полимера, включающего единицы этиленкарбоната формулы А
-(-С(O)-O-СН2-СН2-O-)- А,
в количестве 70-100 мол.%, обладающего внутренней вязкостью 0,4-4,0 дл/г при определении в хлороформе при 20°С в концентрации 1 г/дл, и температурой стеклования 5-50°С, разрушаемый за счет поверхностной эрозии, которая контролируется по механизму негидролитического расщепления, для получения устройства, предназначенного для лечения или предупреждения неоинтимальной пролиферации и утолщения, повторного стеноза, окклюзии сосуда с последующим сосудистым повреждением, и/или активирования тканевого заживления.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0330031.6 | 2003-12-24 | ||
GB0330031A GB0330031D0 (en) | 2003-12-24 | 2003-12-24 | Organic compounds |
GB0410261.2 | 2004-05-07 | ||
GB0410261A GB0410261D0 (en) | 2004-05-07 | 2004-05-07 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2006126779A true RU2006126779A (ru) | 2008-01-27 |
RU2363497C2 RU2363497C2 (ru) | 2009-08-10 |
Family
ID=34913647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006126779/15A RU2363497C2 (ru) | 2003-12-24 | 2004-12-23 | Фармацевтические композиции |
Country Status (13)
Country | Link |
---|---|
US (2) | US20070154520A1 (ru) |
EP (1) | EP1699503B8 (ru) |
JP (1) | JP4796506B2 (ru) |
KR (1) | KR20070015113A (ru) |
AT (1) | ATE549044T1 (ru) |
AU (1) | AU2004308654B2 (ru) |
BR (1) | BRPI0418167A (ru) |
CA (1) | CA2549601A1 (ru) |
ES (1) | ES2383374T3 (ru) |
PL (1) | PL1699503T3 (ru) |
PT (1) | PT1699503E (ru) |
RU (1) | RU2363497C2 (ru) |
WO (1) | WO2005063319A1 (ru) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
WO2007011707A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US8021678B2 (en) * | 2006-02-10 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics |
PL2019657T3 (pl) | 2006-04-26 | 2015-10-30 | Micell Technologies Inc | Powłoki zawierające wiele leków |
US9539593B2 (en) | 2006-10-23 | 2017-01-10 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
CA2679712C (en) | 2007-01-08 | 2016-11-15 | Micell Technologies, Inc. | Stents having biodegradable layers |
US8932345B2 (en) * | 2007-02-07 | 2015-01-13 | Cook Medical Technologies Llc | Medical device coatings for releasing a therapeutic agent at multiple rates |
KR101158981B1 (ko) * | 2007-04-17 | 2012-06-21 | 미셀 테크놀로지즈, 인코포레이티드 | 생체분해성 층을 갖는 스텐트 |
JP2010527746A (ja) | 2007-05-25 | 2010-08-19 | ミセル テクノロジーズ、インコーポレイテッド | メディカルデバイスコーティング用ポリマーフィルム |
CN102083397B (zh) | 2008-04-17 | 2013-12-25 | 米歇尔技术公司 | 具有生物可吸收层的支架 |
US9486431B2 (en) | 2008-07-17 | 2016-11-08 | Micell Technologies, Inc. | Drug delivery medical device |
KR20110074758A (ko) * | 2008-10-03 | 2011-07-01 | 엘릭서 메디컬 코포레이션 | 마크로사이클릭 락톤 화합물 및 이를 사용하는 방법 |
US9981072B2 (en) | 2009-04-01 | 2018-05-29 | Micell Technologies, Inc. | Coated stents |
WO2010121187A2 (en) | 2009-04-17 | 2010-10-21 | Micell Techologies, Inc. | Stents having controlled elution |
EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | MEDICAL DEVICE DISPENSING MEDICINE |
EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
CA2796307A1 (en) * | 2010-05-10 | 2011-11-17 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
WO2012034079A2 (en) | 2010-09-09 | 2012-03-15 | Micell Technologies, Inc. | Macrolide dosage forms |
US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
EP2967803B1 (en) | 2013-03-12 | 2023-12-27 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
WO2014186532A1 (en) | 2013-05-15 | 2014-11-20 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5145945A (en) * | 1987-12-17 | 1992-09-08 | Allied-Signal Inc. | Homopolymers and copolymers having recurring carbonate units |
US5376120A (en) * | 1992-10-21 | 1994-12-27 | Biomet, Inc. | Biocompatible implant and method of using same |
IL110787A0 (en) * | 1993-08-27 | 1994-11-11 | Sandoz Ag | Biodegradable polymer, its preparation and pharmaceutical composition containing it |
JP3476604B2 (ja) * | 1995-08-22 | 2003-12-10 | 鐘淵化学工業株式会社 | 薬剤を付着・コーティングしたステントの製造方法 |
US5703200A (en) * | 1996-03-15 | 1997-12-30 | Ethicon, Inc. | Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer |
WO2001047572A2 (en) * | 1999-12-29 | 2001-07-05 | Advanced Cardiovascular Systems, Inc. | Device and active component for inhibiting formation of thrombus-inflammatory cell matrix |
WO2003037397A2 (en) * | 2001-10-31 | 2003-05-08 | Edwards Lifesciences Corporation | Drug eluting radially expandable tubular stented grafts |
-
2004
- 2004-12-23 WO PCT/EP2004/014682 patent/WO2005063319A1/en active Application Filing
- 2004-12-23 AU AU2004308654A patent/AU2004308654B2/en not_active Ceased
- 2004-12-23 PL PL04804273T patent/PL1699503T3/pl unknown
- 2004-12-23 ES ES04804273T patent/ES2383374T3/es active Active
- 2004-12-23 RU RU2006126779/15A patent/RU2363497C2/ru not_active IP Right Cessation
- 2004-12-23 KR KR1020067012609A patent/KR20070015113A/ko active IP Right Grant
- 2004-12-23 JP JP2006546081A patent/JP4796506B2/ja not_active Expired - Fee Related
- 2004-12-23 CA CA002549601A patent/CA2549601A1/en not_active Abandoned
- 2004-12-23 EP EP04804273A patent/EP1699503B8/en not_active Not-in-force
- 2004-12-23 AT AT04804273T patent/ATE549044T1/de active
- 2004-12-23 PT PT04804273T patent/PT1699503E/pt unknown
- 2004-12-23 US US10/581,937 patent/US20070154520A1/en not_active Abandoned
- 2004-12-23 BR BRPI0418167-0A patent/BRPI0418167A/pt not_active IP Right Cessation
-
2011
- 2011-04-20 US US13/090,788 patent/US20110305742A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP4796506B2 (ja) | 2011-10-19 |
WO2005063319A1 (en) | 2005-07-14 |
KR20070015113A (ko) | 2007-02-01 |
ES2383374T3 (es) | 2012-06-20 |
RU2363497C2 (ru) | 2009-08-10 |
US20070154520A1 (en) | 2007-07-05 |
EP1699503A1 (en) | 2006-09-13 |
BRPI0418167A (pt) | 2007-06-19 |
PL1699503T3 (pl) | 2013-02-28 |
EP1699503B1 (en) | 2012-03-14 |
US20110305742A1 (en) | 2011-12-15 |
EP1699503B8 (en) | 2012-11-07 |
ATE549044T1 (de) | 2012-03-15 |
PT1699503E (pt) | 2012-06-06 |
JP2007516757A (ja) | 2007-06-28 |
CA2549601A1 (en) | 2005-07-14 |
AU2004308654A1 (en) | 2005-07-14 |
WO2005063319A8 (en) | 2005-09-09 |
AU2004308654B2 (en) | 2008-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20131224 |