RU2006115785A - Фармацевтический агент, содержащий стронций, аминокислоту и неорганический агент, и способ лечения рака - Google Patents
Фармацевтический агент, содержащий стронций, аминокислоту и неорганический агент, и способ лечения ракаInfo
- Publication number
- RU2006115785A RU2006115785A RU2006115785/15A RU2006115785A RU2006115785A RU 2006115785 A RU2006115785 A RU 2006115785A RU 2006115785/15 A RU2006115785/15 A RU 2006115785/15A RU 2006115785 A RU2006115785 A RU 2006115785A RU 2006115785 A RU2006115785 A RU 2006115785A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical agent
- agent according
- strontium
- vanadium
- amino acid
- Prior art date
Links
- 239000008177 pharmaceutical agent Substances 0.000 title claims abstract 12
- 229910052712 strontium Inorganic materials 0.000 title claims abstract 8
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 title claims abstract 8
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 6
- 201000011510 cancer Diseases 0.000 title claims abstract 6
- 238000011282 treatment Methods 0.000 title claims abstract 6
- 150000001413 amino acids Chemical class 0.000 title claims 3
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229910052720 vanadium Inorganic materials 0.000 claims 5
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 229910052804 chromium Inorganic materials 0.000 claims 3
- 239000011651 chromium Substances 0.000 claims 3
- 229910052718 tin Inorganic materials 0.000 claims 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 3
- 229910052721 tungsten Inorganic materials 0.000 claims 3
- 239000010937 tungsten Substances 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- -1 aspargin Chemical compound 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 229960000310 isoleucine Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 229910052711 selenium Inorganic materials 0.000 claims 2
- 239000011669 selenium Substances 0.000 claims 2
- IATRAKWUXMZMIY-UHFFFAOYSA-N strontium oxide Chemical compound [O-2].[Sr+2] IATRAKWUXMZMIY-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 150000008575 L-amino acids Chemical class 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 235000012041 food component Nutrition 0.000 claims 1
- 239000005428 food component Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910001427 strontium ion Inorganic materials 0.000 claims 1
- 239000011135 tin Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 235000013618 yogurt Nutrition 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 abstract 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (10)
1. Фармацевтический агент для лечения или профилактики рака, отличающийся тем, что содержит стронций, по меньшей мере одну аминокислоту, выбранную из группы, содержащей аргинин, серин, аспаргин, глицин, глутамин, лизин, изолейцин, и по меньшей мере один неорганический элемент, выбранный из группы, содержащей хром, олово, селен, ванадий и вольфрам, и витамины.
2. Фармацевтический агент по п.1, отличающийся тем, что содержит стронций в виде ионов стронция.
3. Фармацевтический агент по п.1, отличающийся тем, что содержит стронций в виде хлорида или оксида стронция.
4. Фармацевтический агент по п.1, отличающийся тем, что содержит 0,1-3 мг стронция, по меньшей мере одну L-аминокислоту, выбранную из группы, содержащей аргинин, серин, аспаргин, глицин, глутамин, лизин, в количестве 2-5 г каждой из выбранных аминокислот, по меньшей мере один неорганический элемент, выбранный из группы, содержащей хром, олово, ванадий и вольфрам в количестве 1-3 мг каждого из выбранных неорганических элементов, где количества рассчитаны на суточный прием.
5. Фармацевтический агент по п.1, отличающийся тем, что содержит стронций, серин и ванадий.
6. Фармацевтический агент по п.1, отличающийся тем, что содержит аргинин и ванадий.
7. Фармацевтический агент по п.1, отличающийся тем, что содержит стронций, изолейцин и по меньшей мере один неорганический элемент, выбранный из группы, содержащей хром, олово, ванадий, селен и вольфрам.
8. Фармацевтический агент по любому из пп.1-7, отличающийся тем, что представлен в виде пищевой добавки или компонента пищи.
9. Фармацевтический агент по п.8, отличающийся тем, что представлен в виде молочного продукта, предпочтительно йогурта.
10. Применение фармацевтического агента по любому из пп.1-7 для изготовления средства для лечения или профилактики рака.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03103850A EP1523985B1 (en) | 2003-10-17 | 2003-10-17 | Non-radioactive strontium agent for treating cancer |
| EP03103850.8 | 2003-10-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006115785A true RU2006115785A (ru) | 2007-11-27 |
| RU2363479C2 RU2363479C2 (ru) | 2009-08-10 |
Family
ID=34354592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006115785/15A RU2363479C2 (ru) | 2003-10-17 | 2004-10-15 | Фармацевтический агент, содержащий стронций, аминокислоту и неорганический агент, и способ лечения рака |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20070031476A1 (ru) |
| EP (1) | EP1523985B1 (ru) |
| CN (1) | CN1886143B (ru) |
| AT (1) | ATE460168T1 (ru) |
| AU (1) | AU2004281559B2 (ru) |
| DE (1) | DE60331654D1 (ru) |
| DK (1) | DK1523985T3 (ru) |
| ES (1) | ES2342461T3 (ru) |
| NO (1) | NO20062229L (ru) |
| RU (1) | RU2363479C2 (ru) |
| WO (1) | WO2005037295A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI122450B (fi) * | 2007-12-28 | 2012-01-31 | Neurofood Ab Oy | Koostumus steriilin inflammaation hoitoon |
| RU2570751C2 (ru) * | 2010-08-18 | 2015-12-10 | Колгейт-Палмолив Компани | Средство для ухода за полостью рта, способы его применения и производства |
| FI123756B (fi) * | 2010-09-21 | 2013-10-31 | Neurofood Ab Oy | Parannettu lisäravinne syövän hoitamiseksi tai ennaltaehkäisemiseksi |
| EP2530068A1 (en) | 2011-05-31 | 2012-12-05 | Lacer, S.A. | New strontium salts, synthesis and use thereof in the treatment of osteoporosis |
| WO2013013003A1 (en) * | 2011-07-21 | 2013-01-24 | Emory University | Methods for treating inflamatory conditions and states, and cancers by antagonizing nf-kb activation |
| RS64025B1 (sr) * | 2014-07-21 | 2023-03-31 | Oxolife Sl | Soli volframa (vi) za stimulaciju plodnosti i reprodukcije i za poboljšanje efikasnosti tehnika potpomognute reprodukcije |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB602029A (en) * | 1942-04-17 | 1948-05-19 | Western Condensing Co | Improvements in or relating to process of manufacturing a vitamin concentrate |
| GB602209A (en) * | 1945-06-13 | 1948-05-21 | Norton Co | Hydraulic table reciprocating mechanism |
| EP0366869A3 (en) * | 1988-10-17 | 1991-06-12 | Lycon Ag | Bacteriostatic, bactericidal and antifungal composition and methods of use thereof |
| CN1082845A (zh) | 1992-12-21 | 1994-03-02 | 颜怀玮 | 营养平衡强化型矿泉水及制造方法 |
| CN1053091C (zh) * | 1993-03-13 | 2000-06-07 | 彭建汉 | 天然竹汁保健饮料 |
| CN1113720A (zh) * | 1994-05-24 | 1995-12-27 | 云南智成科技实业公司 | 保健液及其生产方法 |
| US5650316A (en) * | 1994-06-06 | 1997-07-22 | Research Development Foundation | Uses of triplex forming oligonucleotides for the treatment of human diseases |
| EP0737471A3 (fr) * | 1995-04-10 | 2000-12-06 | L'oreal | Utilisation d'un sel d'une métal alcalino-terreux comme inhibiteur de TNF-alpha dans une composition unique et composition obtenue |
| FR2740341B1 (fr) * | 1995-10-26 | 1997-12-19 | Oreal | Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau |
| CN1153053A (zh) * | 1995-12-28 | 1997-07-02 | 汪贵昌 | 一种治疗肿瘤的克癌灵中药 |
| US5916143A (en) * | 1996-04-30 | 1999-06-29 | Apple; Marc G. | Brachytherapy catheter system |
| WO2000007607A1 (en) * | 1998-08-04 | 2000-02-17 | Kosbab, John, V. | Nutrient and therapeutic compositions for the treatment of cancer |
| EP1211955A1 (en) | 1999-08-30 | 2002-06-12 | Ocean Nutrition Canada Ltd. | A nutritional supplement for lowering serum triglyceride and cholesterol levels |
| EP1255576B1 (en) * | 1999-12-09 | 2003-08-20 | Biosyntech Canada Inc. | Mineral-polymer hybrid composition |
| US6456680B1 (en) * | 2000-03-29 | 2002-09-24 | Tci Incorporated | Method of strontium-89 radioisotope production |
| NO20014746D0 (no) * | 2001-09-28 | 2001-09-28 | Clas M Kjoelberg | Smertelindrende middel |
| CA2478239A1 (en) * | 2002-03-04 | 2003-09-18 | Medimmune, Inc. | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
-
2003
- 2003-10-17 EP EP03103850A patent/EP1523985B1/en not_active Expired - Lifetime
- 2003-10-17 DE DE60331654T patent/DE60331654D1/de not_active Expired - Lifetime
- 2003-10-17 ES ES03103850T patent/ES2342461T3/es not_active Expired - Lifetime
- 2003-10-17 AT AT03103850T patent/ATE460168T1/de not_active IP Right Cessation
- 2003-10-17 DK DK03103850.8T patent/DK1523985T3/da active
-
2004
- 2004-10-15 CN CN2004800350230A patent/CN1886143B/zh not_active Expired - Fee Related
- 2004-10-15 AU AU2004281559A patent/AU2004281559B2/en not_active Ceased
- 2004-10-15 RU RU2006115785/15A patent/RU2363479C2/ru not_active IP Right Cessation
- 2004-10-15 US US10/575,752 patent/US20070031476A1/en not_active Abandoned
- 2004-10-15 WO PCT/FI2004/000618 patent/WO2005037295A1/en active Application Filing
-
2006
- 2006-05-18 NO NO20062229A patent/NO20062229L/no not_active Application Discontinuation
-
2009
- 2009-11-30 US US12/626,980 patent/US8703211B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100074968A1 (en) | 2010-03-25 |
| CN1886143A (zh) | 2006-12-27 |
| DE60331654D1 (de) | 2010-04-22 |
| WO2005037295A1 (en) | 2005-04-28 |
| EP1523985B1 (en) | 2010-03-10 |
| AU2004281559A1 (en) | 2005-04-28 |
| ATE460168T1 (de) | 2010-03-15 |
| DK1523985T3 (da) | 2010-05-31 |
| EP1523985A1 (en) | 2005-04-20 |
| US8703211B2 (en) | 2014-04-22 |
| AU2004281559B2 (en) | 2010-04-01 |
| NO20062229L (no) | 2006-05-18 |
| CN1886143B (zh) | 2011-04-06 |
| ES2342461T3 (es) | 2010-07-07 |
| US20070031476A1 (en) | 2007-02-08 |
| RU2363479C2 (ru) | 2009-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Invention patent assignment |
Effective date: 20100531 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20151016 |