RU2005136864A - Применение соединений оксикама - Google Patents
Применение соединений оксикама Download PDFInfo
- Publication number
- RU2005136864A RU2005136864A RU2005136864/15A RU2005136864A RU2005136864A RU 2005136864 A RU2005136864 A RU 2005136864A RU 2005136864/15 A RU2005136864/15 A RU 2005136864/15A RU 2005136864 A RU2005136864 A RU 2005136864A RU 2005136864 A RU2005136864 A RU 2005136864A
- Authority
- RU
- Russia
- Prior art keywords
- lornoxicam
- cox
- induction
- thiazine
- thieno
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (3)
1. Применение лорноксикама или аналогов лорноксикама, которые ингибируют циклооксигеназу 1 и циклооксигеназу 2 (СОХ 1 и СОХ 2), не могут преодолевать гематоэнцефалический барьер при физиологических условиях, и сокращают индуцированную простогландином Е2 индукцию белка-предшественника амилоидов (АРР), для получения фармацевтической композиции для лечения или предотвращения болезни Альцгеймера (БА) или артериосклероза.
2. Применение по п.1, отличающееся тем, что введение вещества сопровождается тяжелыми нежелательными побочными действиями на уровне ниже 1%, предпочтительно ниже 0,5%, более предпочтительно ниже 0,1%, в особенности ниже 0,05% пациентов.
3. Применение по п.1 или 2, отличающееся тем, что аналог лорноксикама выбран из группы включающей 6-хлор-4-(1-(этоксикарбамоилокси)этокси)-2-метил-N-(2-пиридил)-2Н-тиено-(2,3-е)-1,2-тиазин-3-карбоновой кислоты амид-1,1-диоксид, 6-хлор-4-гидрокси-2-метил-3-(2-пиридил-карбамоил)-2Н-тиено[3,2-е]1,2-тиазин-1,1-диоксид.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA819/2003 | 2003-05-27 | ||
| AT0081903A AT413944B (de) | 2003-05-27 | 2003-05-27 | Verwendung von oxicam-verbindungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005136864A true RU2005136864A (ru) | 2006-06-10 |
| RU2366425C2 RU2366425C2 (ru) | 2009-09-10 |
Family
ID=33479909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005136864/15A RU2366425C2 (ru) | 2003-05-27 | 2004-05-27 | Применение соединений оксикама |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8129370B2 (ru) |
| EP (1) | EP1626726B1 (ru) |
| JP (1) | JP5597339B2 (ru) |
| KR (1) | KR101134244B1 (ru) |
| CN (3) | CN102218067A (ru) |
| AT (2) | AT413944B (ru) |
| CA (1) | CA2526816C (ru) |
| DE (1) | DE502004001499D1 (ru) |
| DK (1) | DK1626726T3 (ru) |
| ES (1) | ES2271893T3 (ru) |
| PL (1) | PL1626726T3 (ru) |
| RU (1) | RU2366425C2 (ru) |
| WO (1) | WO2004105766A2 (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2563575C (en) * | 2004-04-29 | 2012-12-18 | Binder, Eva | Enantiomerically pure hexahydropyrrolocyclopentapyridine derivatives |
| WO2010057020A2 (en) * | 2008-11-13 | 2010-05-20 | Modgene, Llc | Modification of amyloid-beta load in non-brain tissue |
| EP2776035B1 (en) | 2011-11-01 | 2016-08-10 | Modgene, Llc | Compositions and methods for reduction of amyloid-beta load |
| CN115227655A (zh) * | 2022-08-17 | 2022-10-25 | 海南锦瑞制药有限公司 | 注射用氯诺昔康的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU518216B2 (en) | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
| JPS58146040A (ja) * | 1982-02-24 | 1983-08-31 | Pioneer Video Kk | 光学式情報記録原盤 |
| ATE26720T1 (de) | 1982-09-09 | 1987-05-15 | Hoffmann La Roche | Thieno(2,3-e)-1,2-thiazin-derivate. |
| IL87951A (en) | 1987-10-29 | 1992-03-29 | Chem Pharm Forsch Gmbh | Carbonic acid esters of 6-chloro-4-(1-hydroxyethoxy)-2-methyl-n-(2-pyridyl)-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide,their preparation and pharmaceutical compositions containing them |
| US5192753A (en) * | 1991-04-23 | 1993-03-09 | Mcgeer Patrick L | Anti-rheumatoid arthritic drugs in the treatment of dementia |
| AT400437B (de) * | 1993-12-14 | 1995-12-27 | Chem Pharm Forsch Gmbh | Neue n-heterocyclische thienothiazincarboxamide, verfahren zu ihrer herstellung und ihre verwendung |
| US5643960A (en) * | 1994-04-15 | 1997-07-01 | Duke University | Method of delaying onset of alzheimer's disease symptoms |
| US6043224A (en) | 1996-09-05 | 2000-03-28 | The Massachusetts Institute Of Technology | Compositions and methods for treatment of neurological disorders and neurodegenerative diseases |
| US6184248B1 (en) * | 1996-09-05 | 2001-02-06 | Robert K. K. Lee | Compositions and methods for treatment of neurological disorders and neurodegenerative diseases |
| AU3885901A (en) * | 1999-09-21 | 2001-04-24 | Emory University | Methods and compositions for treating platelet-related disorders |
| AU2001257022B2 (en) * | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
| US6429223B1 (en) | 2000-06-23 | 2002-08-06 | Medinox, Inc. | Modified forms of pharmacologically active agents and uses therefor |
| TWI256305B (en) * | 2000-08-18 | 2006-06-11 | Pharmacia Corp | Oral fast-melt pharmaceutical composition of a cyclooxygenase-2 inhibitor and process for preparing the same |
| JP2002363104A (ja) | 2001-04-04 | 2002-12-18 | Sankyo Co Ltd | 炎症性サイトカイン産生抑制剤の新規医薬用途 |
| US7008614B2 (en) * | 2001-08-20 | 2006-03-07 | Fuji Photo Film Co., Ltd. | Liposome containing hydrophobic iodine compound and X-ray contrast medium for radiograph comprising the liposome |
| US20030225054A1 (en) * | 2002-06-03 | 2003-12-04 | Jingwu Duan | Combined use of tace inhibitors and COX2 inhibitors as anti-inflammatory agents |
-
2003
- 2003-05-27 AT AT0081903A patent/AT413944B/de not_active IP Right Cessation
-
2004
- 2004-05-27 KR KR1020057022636A patent/KR101134244B1/ko active IP Right Grant
- 2004-05-27 CN CN2011100997401A patent/CN102218067A/zh active Pending
- 2004-05-27 ES ES04734972T patent/ES2271893T3/es not_active Expired - Lifetime
- 2004-05-27 PL PL04734972T patent/PL1626726T3/pl unknown
- 2004-05-27 DK DK04734972T patent/DK1626726T3/da active
- 2004-05-27 EP EP04734972A patent/EP1626726B1/de not_active Expired - Fee Related
- 2004-05-27 JP JP2006529424A patent/JP5597339B2/ja not_active Expired - Fee Related
- 2004-05-27 CN CNA2008101754015A patent/CN101450057A/zh active Pending
- 2004-05-27 RU RU2005136864/15A patent/RU2366425C2/ru not_active IP Right Cessation
- 2004-05-27 DE DE502004001499T patent/DE502004001499D1/de not_active Expired - Lifetime
- 2004-05-27 CN CNA2004800143442A patent/CN1842338A/zh active Pending
- 2004-05-27 WO PCT/AT2004/000185 patent/WO2004105766A2/de active Application Filing
- 2004-05-27 CA CA2526816A patent/CA2526816C/en not_active Expired - Fee Related
- 2004-05-27 US US10/558,117 patent/US8129370B2/en not_active Expired - Fee Related
- 2004-05-27 AT AT04734972T patent/ATE339206T1/de active
-
2009
- 2009-04-03 US US12/418,339 patent/US20090239852A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2271893T3 (es) | 2007-04-16 |
| ATE339206T1 (de) | 2006-10-15 |
| CA2526816C (en) | 2012-11-27 |
| CN102218067A (zh) | 2011-10-19 |
| KR101134244B1 (ko) | 2012-04-09 |
| CA2526816A1 (en) | 2004-12-09 |
| EP1626726A2 (de) | 2006-02-22 |
| KR20060017618A (ko) | 2006-02-24 |
| JP5597339B2 (ja) | 2014-10-01 |
| CN101450057A (zh) | 2009-06-10 |
| US8129370B2 (en) | 2012-03-06 |
| US20070275958A1 (en) | 2007-11-29 |
| EP1626726B1 (de) | 2006-09-13 |
| PL1626726T3 (pl) | 2007-02-28 |
| WO2004105766A3 (de) | 2005-03-03 |
| WO2004105766A2 (de) | 2004-12-09 |
| JP2006528206A (ja) | 2006-12-14 |
| DE502004001499D1 (de) | 2006-10-26 |
| CN1842338A (zh) | 2006-10-04 |
| US20090239852A1 (en) | 2009-09-24 |
| ATA8192003A (de) | 2005-11-15 |
| AT413944B (de) | 2006-07-15 |
| RU2366425C2 (ru) | 2009-09-10 |
| DK1626726T3 (da) | 2006-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20110928 |
|
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20131122 |
|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20200528 |