RU2005129276A - Применение стероидов для лечения субъектов, страдающих заболеванием глаз - Google Patents
Применение стероидов для лечения субъектов, страдающих заболеванием глаз Download PDFInfo
- Publication number
- RU2005129276A RU2005129276A RU2005129276/14A RU2005129276A RU2005129276A RU 2005129276 A RU2005129276 A RU 2005129276A RU 2005129276/14 A RU2005129276/14 A RU 2005129276/14A RU 2005129276 A RU2005129276 A RU 2005129276A RU 2005129276 A RU2005129276 A RU 2005129276A
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- Russia
- Prior art keywords
- composition
- acetate
- concentration
- glucocorticoid
- anecortava
- Prior art date
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- 208000030533 eye disease Diseases 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 8
- 239000003862 glucocorticoid Substances 0.000 claims 7
- 229960002117 triamcinolone acetonide Drugs 0.000 claims 4
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims 4
- -1 flucortin-butyl Chemical compound 0.000 claims 3
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 2
- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 claims 2
- 229940022663 acetate Drugs 0.000 claims 2
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- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 229960002800 prednisolone acetate Drugs 0.000 claims 2
- 229960001487 rimexolone Drugs 0.000 claims 2
- QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 claims 2
- IXJKSIRTUSUXQC-ZXYIWLIBSA-N (8s,9s,10r,11s,13s,14s,17s)-11,17-dihydroxy-10,13-dimethyl-17-prop-1-ynyl-9,11,12,14,15,16-hexahydro-8h-cyclopenta[a]phenanthren-3-one Chemical compound C1=CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C#CC)(O)[C@@]1(C)C[C@@H]2O IXJKSIRTUSUXQC-ZXYIWLIBSA-N 0.000 claims 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- MYYIMZRZXIQBGI-HVIRSNARSA-N 6alpha-Fluoroprednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3C[C@H](F)C2=C1 MYYIMZRZXIQBGI-HVIRSNARSA-N 0.000 claims 1
- ZOCUOMKMBMEYQV-GSLJADNHSA-N 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ZOCUOMKMBMEYQV-GSLJADNHSA-N 0.000 claims 1
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- WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 claims 1
- POPFMWWJOGLOIF-XWCQMRHXSA-N Flurandrenolide Chemical compound C1([C@@H](F)C2)=CC(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O POPFMWWJOGLOIF-XWCQMRHXSA-N 0.000 claims 1
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- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 1
- 201000010183 Papilledema Diseases 0.000 claims 1
- MKPDWECBUAZOHP-AFYJWTTESA-N Paramethasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O MKPDWECBUAZOHP-AFYJWTTESA-N 0.000 claims 1
- 206010038886 Retinal oedema Diseases 0.000 claims 1
- 201000007917 background diabetic retinopathy Diseases 0.000 claims 1
- 229940092705 beclomethasone Drugs 0.000 claims 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims 1
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- YTJIBEDMAQUYSZ-FDNPDPBUSA-N cloprednol Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3C=C(Cl)C2=C1 YTJIBEDMAQUYSZ-FDNPDPBUSA-N 0.000 claims 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- FKAINCOIINXAOK-UFVJYOHBSA-N deacylcortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)CO)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 FKAINCOIINXAOK-UFVJYOHBSA-N 0.000 claims 1
- 229960001145 deflazacort Drugs 0.000 claims 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44894303P | 2003-02-20 | 2003-02-20 | |
| US60/448,943 | 2003-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005129276A true RU2005129276A (ru) | 2006-01-27 |
Family
ID=32908674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005129276/14A RU2005129276A (ru) | 2003-02-20 | 2004-02-04 | Применение стероидов для лечения субъектов, страдающих заболеванием глаз |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20060154910A1 (enExample) |
| EP (1) | EP1670480A4 (enExample) |
| JP (1) | JP2006518382A (enExample) |
| KR (1) | KR20050102652A (enExample) |
| CN (1) | CN1750828A (enExample) |
| AR (1) | AR043251A1 (enExample) |
| AU (1) | AU2004212895A1 (enExample) |
| BR (1) | BRPI0407693A (enExample) |
| CA (1) | CA2516782A1 (enExample) |
| MX (1) | MXPA05008561A (enExample) |
| PL (1) | PL378210A1 (enExample) |
| RU (1) | RU2005129276A (enExample) |
| TW (1) | TW200511996A (enExample) |
| UY (1) | UY28202A1 (enExample) |
| WO (1) | WO2004073607A2 (enExample) |
| ZA (1) | ZA200505989B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1663144A1 (en) * | 2003-09-23 | 2006-06-07 | Alcon, Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
| US20050101582A1 (en) * | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
| US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
| CA2562356A1 (en) * | 2004-04-08 | 2005-10-27 | Retmed Pty Ltd | Treatment of ophthalmic conditions with mineralcorticoids |
| EP1937210B1 (en) | 2005-10-18 | 2017-05-31 | Allergan, Inc. | Ocular therapy using glucocorticoid derivatives selectively penetrating posterior segment tissues |
| US20080076742A1 (en) * | 2005-10-31 | 2008-03-27 | Wisconsin Alumni Research Foundation | Methods and compositions for treating diseases associated with neovascualrization |
| ITRM20050547A1 (it) * | 2005-11-04 | 2007-05-05 | Sooft Italia S R L | Gel oftalmico composto da triamcinolone acetonide e da un polimero poliacrilico. |
| SI2262506T1 (sl) | 2008-03-11 | 2014-07-31 | Alcon Research, Ltd. | Močno flokulirane suspenzije triamcinolon acetonida z nizko viskoznostjo za intravitrealno injekcijo |
| TW201105363A (en) * | 2009-07-14 | 2011-02-16 | Univ Yamagata | Eye drop for macular edema treatment |
| US8957052B2 (en) * | 2010-05-10 | 2015-02-17 | Universite Paris Descartes | Methods and compositions for the treatment of fluid accumulation in and/or under the retina |
| KR101106074B1 (ko) * | 2011-05-27 | 2012-01-18 | 김선미 | 교통 시설물 설치용 부착대 및 지주장치 |
| US10328048B2 (en) | 2014-05-30 | 2019-06-25 | Aarhus Universitet | Cafestol for treating diabetes |
| HK1249460A1 (zh) | 2015-03-06 | 2018-11-02 | Aerie Pharmaceuticals, Inc. | 植入物施用器和植入物的施用方法 |
| JP6914931B2 (ja) * | 2015-07-23 | 2021-08-04 | アエリエ ファーマシューティカルズ インコーポレイテッド | 眼の症状の治療のための医薬組成物、硝子体内インプラント及び医薬品の製造におけるそれらの使用 |
| JP2019534063A (ja) | 2016-09-02 | 2019-11-28 | エンビシャ セラピューティクス インコーポレイテッド | インプラントアプリケータ |
| US11766421B2 (en) * | 2017-09-25 | 2023-09-26 | Surface Ophthalmics, Inc. | Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853224A (en) * | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| US5164188A (en) * | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5770592A (en) * | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
| US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6172054B1 (en) * | 1995-06-15 | 2001-01-09 | Alcon Laboratories, Inc. | Combination therapy for lowering and controlling intraocular pressure |
| US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US6011023A (en) * | 1997-08-27 | 2000-01-04 | Alcon Laboratories, Inc. | Angiostatic steroids |
| US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6413245B1 (en) * | 1999-10-21 | 2002-07-02 | Alcon Universal Ltd. | Sub-tenon drug delivery |
| ES2231257T3 (es) * | 1999-10-21 | 2005-05-16 | Alcon Inc. | Dispositivo para la administracion de farmacos. |
| US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| IL180679A0 (en) * | 2000-10-27 | 2009-02-11 | Pfizer Prod Inc | Process for the preparation of non-steroidal glucocorticoid receptor modulators |
| US20030023228A1 (en) * | 2001-07-20 | 2003-01-30 | Parkinson Thomas M. | Ocular iontophoretic device and method for using the same |
-
2004
- 2004-02-04 MX MXPA05008561A patent/MXPA05008561A/es not_active Application Discontinuation
- 2004-02-04 US US10/545,055 patent/US20060154910A1/en not_active Abandoned
- 2004-02-04 ZA ZA200505989A patent/ZA200505989B/xx unknown
- 2004-02-04 AU AU2004212895A patent/AU2004212895A1/en not_active Abandoned
- 2004-02-04 EP EP04708189A patent/EP1670480A4/en not_active Withdrawn
- 2004-02-04 US US10/771,829 patent/US20040171598A1/en not_active Abandoned
- 2004-02-04 KR KR1020057015188A patent/KR20050102652A/ko not_active Withdrawn
- 2004-02-04 CA CA002516782A patent/CA2516782A1/en not_active Abandoned
- 2004-02-04 WO PCT/US2004/003138 patent/WO2004073607A2/en not_active Ceased
- 2004-02-04 BR BRPI0407693-1A patent/BRPI0407693A/pt not_active IP Right Cessation
- 2004-02-04 RU RU2005129276/14A patent/RU2005129276A/ru not_active Application Discontinuation
- 2004-02-04 JP JP2006503303A patent/JP2006518382A/ja active Pending
- 2004-02-04 PL PL378210A patent/PL378210A1/pl unknown
- 2004-02-04 CN CNA200480004350XA patent/CN1750828A/zh active Pending
- 2004-02-19 UY UY28202A patent/UY28202A1/es not_active Application Discontinuation
- 2004-02-19 TW TW093104084A patent/TW200511996A/zh unknown
- 2004-02-20 AR ARP040100544A patent/AR043251A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2516782A1 (en) | 2004-09-02 |
| WO2004073607A3 (en) | 2004-11-25 |
| EP1670480A4 (en) | 2007-10-10 |
| BRPI0407693A (pt) | 2006-03-01 |
| UY28202A1 (es) | 2004-08-31 |
| ZA200505989B (en) | 2006-12-27 |
| US20040171598A1 (en) | 2004-09-02 |
| PL378210A1 (pl) | 2006-03-20 |
| MXPA05008561A (es) | 2005-11-04 |
| KR20050102652A (ko) | 2005-10-26 |
| JP2006518382A (ja) | 2006-08-10 |
| WO2004073607A2 (en) | 2004-09-02 |
| CN1750828A (zh) | 2006-03-22 |
| AR043251A1 (es) | 2005-07-20 |
| AU2004212895A1 (en) | 2004-09-02 |
| EP1670480A2 (en) | 2006-06-21 |
| TW200511996A (en) | 2005-04-01 |
| US20060154910A1 (en) | 2006-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080910 |