AR043251A1 - Formulaciones de esteroides para tratar personas que sufren de transtornos oculares - Google Patents
Formulaciones de esteroides para tratar personas que sufren de transtornos ocularesInfo
- Publication number
- AR043251A1 AR043251A1 ARP040100544A ARP040100544A AR043251A1 AR 043251 A1 AR043251 A1 AR 043251A1 AR P040100544 A ARP040100544 A AR P040100544A AR P040100544 A ARP040100544 A AR P040100544A AR 043251 A1 AR043251 A1 AR 043251A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- triazol
- thio
- ethanone
- pyridin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1), caracterizado porque: R1, R2 y R4 se seleccionan, independientemente, del grupo H, alquilo C1-8, fenilo, fenilo sustituido, bencilo, bencilo sustituido, heteroarilo, heteroarilo sustituido, heteroarilmetileno y heteroarilmetileno sustituido; R3 es H, alquilo C1-8, heteroalquilo, cicloalquilo, arilo, heteroarilo; con la condición de que el compuesto no sea: 1-(4-metoxifenil)-2-[(4-fenil-5-piridin-4-il-4H-1,2,4-triazol-3-il)tio]etanona (6); 1-(4-clorofenil)-2-[(4-fenil-5-piridin-4-il-4H-1,2,4-triazol-3-il)tio]etanona (7); 1-(4-fluorofenil)-2-[(4-fenil-5-piridin-4-il-4H-1,2,4-triazol-3-il)tio]etanona (11); 1-fenil-2-[(4-fenil-5-piridin-4-il-4H-1,2,4-triazol-3-il)tio]etanona (12); 2-{[5-(4-metilfenil)-4-fenil-4H-1,2,4-triazol-3-il]tio}-1-feniletanona (21); 1-(4-metoxifenil)-2-{[5-(4-metoxifenil)-4-fenil-4H-1,2,4-triazol-3-il]tio}etanona (27); o 1-(4-metoxifenil)-2-{[4-(4-metifenil)-5-piridin-4-il-4H-1,2,4-triazol-3-il]tio}etanona (39).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44894303P | 2003-02-20 | 2003-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043251A1 true AR043251A1 (es) | 2005-07-20 |
Family
ID=32908674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100544A AR043251A1 (es) | 2003-02-20 | 2004-02-20 | Formulaciones de esteroides para tratar personas que sufren de transtornos oculares |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20040171598A1 (es) |
| EP (1) | EP1670480A4 (es) |
| JP (1) | JP2006518382A (es) |
| KR (1) | KR20050102652A (es) |
| CN (1) | CN1750828A (es) |
| AR (1) | AR043251A1 (es) |
| AU (1) | AU2004212895A1 (es) |
| BR (1) | BRPI0407693A (es) |
| CA (1) | CA2516782A1 (es) |
| MX (1) | MXPA05008561A (es) |
| PL (1) | PL378210A1 (es) |
| RU (1) | RU2005129276A (es) |
| TW (1) | TW200511996A (es) |
| UY (1) | UY28202A1 (es) |
| WO (1) | WO2004073607A2 (es) |
| ZA (1) | ZA200505989B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005032510A1 (en) * | 2003-09-23 | 2005-04-14 | Alcon, Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
| US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
| US20050101582A1 (en) * | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
| EP1755616B1 (en) * | 2004-04-08 | 2013-08-14 | Advanced Ocular Systems Limited | Treatment of exudative retinopathy with mineralcorticoids |
| MX339797B (es) * | 2005-10-18 | 2016-06-10 | Allergan Inc | Terapia ocular que usa derivados glucocorticoides que penetran selectivamente los tejidos del segmento posterior. |
| US20080076742A1 (en) * | 2005-10-31 | 2008-03-27 | Wisconsin Alumni Research Foundation | Methods and compositions for treating diseases associated with neovascualrization |
| ITRM20050547A1 (it) * | 2005-11-04 | 2007-05-05 | Sooft Italia S R L | Gel oftalmico composto da triamcinolone acetonide e da un polimero poliacrilico. |
| CN101959519B (zh) * | 2008-03-11 | 2013-03-20 | 爱尔康研究有限公司 | 用于玻璃体内注射的低粘度、高度絮凝的曲安奈德混悬液 |
| TW201105363A (en) | 2009-07-14 | 2011-02-16 | Univ Yamagata | Eye drop for macular edema treatment |
| JP6148175B2 (ja) * | 2010-05-10 | 2017-06-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 網膜中および／または網膜下における液体貯留の処置のための方法および組成物 |
| KR101106074B1 (ko) * | 2011-05-27 | 2012-01-18 | 김선미 | 교통 시설물 설치용 부착대 및 지주장치 |
| KR20170012480A (ko) | 2014-05-30 | 2017-02-02 | 오르후스 우니베르시테트 | 당뇨병을 치료하기 위한 카페스톨 |
| BR112017019025A2 (pt) | 2015-03-06 | 2018-07-31 | Envisia Therapeutics Inc | aplicadores de implante e métodos para administrar implantes. |
| CN108883070A (zh) | 2015-07-23 | 2018-11-23 | 爱瑞制药公司 | 用于治疗眼病的玻璃体内药物递送系统 |
| US11766421B2 (en) * | 2017-09-25 | 2023-09-26 | Surface Ophthalmics, Inc. | Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853224A (en) * | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| US5164188A (en) * | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| US5378475A (en) * | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5770592A (en) * | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
| US5869079A (en) * | 1995-06-02 | 1999-02-09 | Oculex Pharmaceuticals, Inc. | Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents |
| US6172054B1 (en) * | 1995-06-15 | 2001-01-09 | Alcon Laboratories, Inc. | Combination therapy for lowering and controlling intraocular pressure |
| US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US6011023A (en) * | 1997-08-27 | 2000-01-04 | Alcon Laboratories, Inc. | Angiostatic steroids |
| US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| MXPA02002376A (es) * | 1999-10-21 | 2002-08-28 | Alcon Universal Ltd | Entrega de droga al sub-tenon-. |
| ES2231257T3 (es) * | 1999-10-21 | 2005-05-16 | Alcon Inc. | Dispositivo para la administracion de farmacos. |
| US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
| US20030023228A1 (en) * | 2001-07-20 | 2003-01-30 | Parkinson Thomas M. | Ocular iontophoretic device and method for using the same |
-
2004
- 2004-02-04 US US10/771,829 patent/US20040171598A1/en not_active Abandoned
- 2004-02-04 RU RU2005129276/14A patent/RU2005129276A/ru not_active Application Discontinuation
- 2004-02-04 JP JP2006503303A patent/JP2006518382A/ja active Pending
- 2004-02-04 WO PCT/US2004/003138 patent/WO2004073607A2/en active Application Filing
- 2004-02-04 EP EP04708189A patent/EP1670480A4/en not_active Withdrawn
- 2004-02-04 CN CNA200480004350XA patent/CN1750828A/zh active Pending
- 2004-02-04 KR KR1020057015188A patent/KR20050102652A/ko not_active Application Discontinuation
- 2004-02-04 ZA ZA200505989A patent/ZA200505989B/xx unknown
- 2004-02-04 BR BRPI0407693-1A patent/BRPI0407693A/pt not_active IP Right Cessation
- 2004-02-04 MX MXPA05008561A patent/MXPA05008561A/es not_active Application Discontinuation
- 2004-02-04 CA CA002516782A patent/CA2516782A1/en not_active Abandoned
- 2004-02-04 US US10/545,055 patent/US20060154910A1/en not_active Abandoned
- 2004-02-04 AU AU2004212895A patent/AU2004212895A1/en not_active Abandoned
- 2004-02-04 PL PL378210A patent/PL378210A1/pl unknown
- 2004-02-19 TW TW093104084A patent/TW200511996A/zh unknown
- 2004-02-19 UY UY28202A patent/UY28202A1/es not_active Application Discontinuation
- 2004-02-20 AR ARP040100544A patent/AR043251A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1670480A2 (en) | 2006-06-21 |
| WO2004073607A3 (en) | 2004-11-25 |
| JP2006518382A (ja) | 2006-08-10 |
| PL378210A1 (pl) | 2006-03-20 |
| US20040171598A1 (en) | 2004-09-02 |
| MXPA05008561A (es) | 2005-11-04 |
| KR20050102652A (ko) | 2005-10-26 |
| UY28202A1 (es) | 2004-08-31 |
| ZA200505989B (en) | 2006-12-27 |
| RU2005129276A (ru) | 2006-01-27 |
| WO2004073607A2 (en) | 2004-09-02 |
| EP1670480A4 (en) | 2007-10-10 |
| CN1750828A (zh) | 2006-03-22 |
| CA2516782A1 (en) | 2004-09-02 |
| TW200511996A (en) | 2005-04-01 |
| AU2004212895A1 (en) | 2004-09-02 |
| BRPI0407693A (pt) | 2006-03-01 |
| US20060154910A1 (en) | 2006-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |