RU2005116983A - Меченые антагонисты фагоцитарных рецепторов макрофагов для визуализации сердечно-сосудистых заболеваний - Google Patents
Меченые антагонисты фагоцитарных рецепторов макрофагов для визуализации сердечно-сосудистых заболеваний Download PDFInfo
- Publication number
- RU2005116983A RU2005116983A RU2005116983/15A RU2005116983A RU2005116983A RU 2005116983 A RU2005116983 A RU 2005116983A RU 2005116983/15 A RU2005116983/15 A RU 2005116983/15A RU 2005116983 A RU2005116983 A RU 2005116983A RU 2005116983 A RU2005116983 A RU 2005116983A
- Authority
- RU
- Russia
- Prior art keywords
- agent according
- metal ion
- visualization agent
- radioactive
- imaging
- Prior art date
Links
- 208000024172 Cardiovascular disease Diseases 0.000 title claims 4
- 239000005557 antagonist Substances 0.000 title claims 4
- 210000002540 macrophage Anatomy 0.000 title claims 2
- 230000000242 pagocytic effect Effects 0.000 title claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 19
- 238000012800 visualization Methods 0.000 claims 19
- 229910021645 metal ion Inorganic materials 0.000 claims 16
- 230000002285 radioactive effect Effects 0.000 claims 15
- 230000005298 paramagnetic effect Effects 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 238000002059 diagnostic imaging Methods 0.000 claims 5
- 239000002243 precursor Substances 0.000 claims 5
- 101001013832 Homo sapiens Mitochondrial peptide methionine sulfoxide reductase Proteins 0.000 claims 4
- 102100031767 Mitochondrial peptide methionine sulfoxide reductase Human genes 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000012216 imaging agent Substances 0.000 claims 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 3
- 150000004696 coordination complex Chemical class 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- -1 hydroxy, carboxy Chemical group 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 239000011630 iodine Substances 0.000 claims 3
- 229910052755 nonmetal Inorganic materials 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000005422 alkyl sulfonamido group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000005140 aralkylsulfonyl group Chemical group 0.000 claims 1
- 125000003435 aroyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims 1
- 125000005421 aryl sulfonamido group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0228490.9 | 2002-12-06 | ||
| GBGB0228490.9A GB0228490D0 (en) | 2002-12-06 | 2002-12-06 | Novel imaging compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005116983A true RU2005116983A (ru) | 2006-02-27 |
Family
ID=9949200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005116983/15A RU2005116983A (ru) | 2002-12-06 | 2003-12-05 | Меченые антагонисты фагоцитарных рецепторов макрофагов для визуализации сердечно-сосудистых заболеваний |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060239915A1 (https=) |
| EP (1) | EP1567141A1 (https=) |
| JP (1) | JP2006514945A (https=) |
| CN (1) | CN1744890A (https=) |
| AU (1) | AU2003292384B2 (https=) |
| CA (1) | CA2508663A1 (https=) |
| GB (1) | GB0228490D0 (https=) |
| NO (1) | NO20052633L (https=) |
| RU (1) | RU2005116983A (https=) |
| WO (1) | WO2004052357A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7886497B2 (en) | 2003-12-02 | 2011-02-15 | Valinge Innovation Ab | Floorboard, system and method for forming a flooring, and a flooring formed thereof |
| GB0428020D0 (en) | 2004-12-22 | 2005-01-26 | Amersham Health As | Stabilisation of radiopharmaceutical precursors |
| WO2006077901A1 (ja) * | 2005-01-20 | 2006-07-27 | Shionogi & Co., Ltd. | Ctgf発現阻害剤 |
| RU2474435C2 (ru) * | 2007-11-07 | 2013-02-10 | Джи-И Хелткер БВ | Стабилизация радиофармацевтических композиций |
| US11725395B2 (en) | 2009-09-04 | 2023-08-15 | Välinge Innovation AB | Resilient floor |
| EP2473687B1 (en) | 2009-09-04 | 2019-04-24 | Välinge Innovation AB | A method of assembling resilient floorboards which are provided with a mechanical locking system |
| PT3115161T (pt) | 2011-08-29 | 2020-02-06 | Ceraloc Innovation Ab | Sistema de encaixe mecânico para painéis de pavimento |
| PT3358101T (pt) | 2013-03-25 | 2020-01-21 | Vaelinge Innovation Ab | Tábuas de piso providas de um sistema de bloqueio mecânico e método para produzir um sistema de bloqueio deste tipo |
| EP3802514B1 (en) * | 2018-06-01 | 2022-08-03 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5820873A (en) * | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| MXPA02000123A (es) * | 1999-06-24 | 2002-07-02 | Smithkline Beecham Corp | Antagonistas de receptor depurador de macrofago. |
| WO2001098264A1 (en) * | 2000-06-21 | 2001-12-27 | Smithkline Beecham Corporation | Macrophage scavenger receptor antagonists |
| EP1377321A4 (en) * | 2001-02-23 | 2006-01-11 | Bristol Myers Squibb Co | RECOVERY ANTAGONISTS RECEIVING DETECTABLE MACROPHAGE RECEPTORS FOR THE IDENTIFICATION OF ATHEROSCLEROSIS AND VULNERABLE PLAQUE BY IMAGING |
-
2002
- 2002-12-06 GB GBGB0228490.9A patent/GB0228490D0/en not_active Ceased
-
2003
- 2003-12-05 CN CNA2003801095526A patent/CN1744890A/zh active Pending
- 2003-12-05 US US10/537,103 patent/US20060239915A1/en not_active Abandoned
- 2003-12-05 CA CA002508663A patent/CA2508663A1/en not_active Abandoned
- 2003-12-05 RU RU2005116983/15A patent/RU2005116983A/ru not_active Application Discontinuation
- 2003-12-05 EP EP03767961A patent/EP1567141A1/en not_active Withdrawn
- 2003-12-05 WO PCT/GB2003/005319 patent/WO2004052357A1/en not_active Ceased
- 2003-12-05 JP JP2004558793A patent/JP2006514945A/ja active Pending
- 2003-12-05 AU AU2003292384A patent/AU2003292384B2/en not_active Ceased
-
2005
- 2005-06-01 NO NO20052633A patent/NO20052633L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006514945A (ja) | 2006-05-18 |
| NO20052633D0 (no) | 2005-06-01 |
| EP1567141A1 (en) | 2005-08-31 |
| CA2508663A1 (en) | 2004-06-24 |
| NO20052633L (no) | 2005-07-06 |
| US20060239915A1 (en) | 2006-10-26 |
| AU2003292384A1 (en) | 2004-06-30 |
| AU2003292384B2 (en) | 2007-04-19 |
| GB0228490D0 (en) | 2003-01-08 |
| CN1744890A (zh) | 2006-03-08 |
| WO2004052357A1 (en) | 2004-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20080424 |