CN1744890A - 用于心血管疾病成像的标记的巨噬细胞清除剂受体拮抗剂 - Google Patents

用于心血管疾病成像的标记的巨噬细胞清除剂受体拮抗剂 Download PDF

Info

Publication number
CN1744890A
CN1744890A CNA2003801095526A CN200380109552A CN1744890A CN 1744890 A CN1744890 A CN 1744890A CN A2003801095526 A CNA2003801095526 A CN A2003801095526A CN 200380109552 A CN200380109552 A CN 200380109552A CN 1744890 A CN1744890 A CN 1744890A
Authority
CN
China
Prior art keywords
preparation
metal ion
imaging
alkyl
msra
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2003801095526A
Other languages
English (en)
Chinese (zh)
Inventor
I·威尔逊
D·怀恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN1744890A publication Critical patent/CN1744890A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2003801095526A 2002-12-06 2003-12-05 用于心血管疾病成像的标记的巨噬细胞清除剂受体拮抗剂 Pending CN1744890A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0228490.9A GB0228490D0 (en) 2002-12-06 2002-12-06 Novel imaging compounds
GB0228490.9 2002-12-06

Publications (1)

Publication Number Publication Date
CN1744890A true CN1744890A (zh) 2006-03-08

Family

ID=9949200

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2003801095526A Pending CN1744890A (zh) 2002-12-06 2003-12-05 用于心血管疾病成像的标记的巨噬细胞清除剂受体拮抗剂

Country Status (10)

Country Link
US (1) US20060239915A1 (https=)
EP (1) EP1567141A1 (https=)
JP (1) JP2006514945A (https=)
CN (1) CN1744890A (https=)
AU (1) AU2003292384B2 (https=)
CA (1) CA2508663A1 (https=)
GB (1) GB0228490D0 (https=)
NO (1) NO20052633L (https=)
RU (1) RU2005116983A (https=)
WO (1) WO2004052357A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7886497B2 (en) 2003-12-02 2011-02-15 Valinge Innovation Ab Floorboard, system and method for forming a flooring, and a flooring formed thereof
GB0428020D0 (en) 2004-12-22 2005-01-26 Amersham Health As Stabilisation of radiopharmaceutical precursors
WO2006077901A1 (ja) * 2005-01-20 2006-07-27 Shionogi & Co., Ltd. Ctgf発現阻害剤
MX2010005122A (es) * 2007-11-07 2010-08-18 Ge Healthcare Bv Estabilizacion de radiofarmaceuticos.
US11725395B2 (en) 2009-09-04 2023-08-15 Välinge Innovation AB Resilient floor
ES2985671T3 (es) 2009-09-04 2024-11-06 Vaelinge Innovation Ab Suelo elástico
JP6105587B2 (ja) 2011-08-29 2017-04-05 セラロック、イノベーション、アクチボラグ フロアパネル用機械式係止システム
EP3656944A1 (en) 2013-03-25 2020-05-27 Välinge Innovation AB Floorboards provided with a mechanical locking system and a method to produce such a locking system
EP4140991B1 (en) * 2018-06-01 2024-05-15 Promega Corporation Inhibitors of oplophorus luciferase-derived bioluminescent complexes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820873A (en) * 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
WO2000078145A1 (en) * 1999-06-24 2000-12-28 Smithkline Beecham Corporation Macrophage scavenger receptor antagonists
WO2001098264A1 (en) * 2000-06-21 2001-12-27 Smithkline Beecham Corporation Macrophage scavenger receptor antagonists
AU2002254000A1 (en) * 2001-02-23 2002-09-12 Bristol-Myers Squibb Pharma Company Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque

Also Published As

Publication number Publication date
GB0228490D0 (en) 2003-01-08
NO20052633D0 (no) 2005-06-01
JP2006514945A (ja) 2006-05-18
WO2004052357A1 (en) 2004-06-24
US20060239915A1 (en) 2006-10-26
RU2005116983A (ru) 2006-02-27
AU2003292384A1 (en) 2004-06-30
CA2508663A1 (en) 2004-06-24
EP1567141A1 (en) 2005-08-31
AU2003292384B2 (en) 2007-04-19
NO20052633L (no) 2005-07-06

Similar Documents

Publication Publication Date Title
CN1622832A (zh) 用于动脉粥样硬化和易病变性斑块成像的标记的巨噬细胞清除剂受体拮抗剂
TW201034689A (en) CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer
JP5043438B2 (ja) 阻害剤造影剤
JP2021513979A (ja) エバンスブルー誘導体の化学結合体ならびに前立腺癌を標的とするための放射線療法および造影剤としてのその使用
EP4116306A1 (en) Compound and radioactive labeling compound
JP2013514326A (ja) 標識インテグリン結合剤
CN1744890A (zh) 用于心血管疾病成像的标记的巨噬细胞清除剂受体拮抗剂
JP2009515940A (ja) 末梢ベンゾジアゼピンレセプター（ｐｂｒ）親和性を有するインビボイメージング剤としての四環式インドール誘導体
JP7213493B2 (ja) ニューロテンシン受容体関連病態の診断、治療及び予防
EP2618850A1 (en) In vivo imaging method of mood disorders
CN1298390C (zh) 心脏灌注和玻连蛋白受体靶向成像剂的同时成像
JP2006519216A (ja) Ｍｍｐ阻害活性を有する画像診断剤
JP2008514580A (ja) 酵素阻害剤造影剤
US20080292547A1 (en) Novel Imaging Agents for Fibrosis
KR101861025B1 (ko) 영상화 제제로서의 ｎ-알콕시아미드 접합체
AU2003273505B2 (en) Improved imaging agents comprising barbituric acid derivatives
CN101039702A (zh) 作为靶向试剂用于内皮－特异性体内转导的热激蛋白
US20080279771A1 (en) Novel Imaging Agents for Cancer
WO2025226524A1 (en) Granzyme b pet imaging agents
CN1747749A (zh) 具有mmp抑制活性的诊断造影剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication