RU2004115104A - Расар-композиции и способы визуализации злокачественных опухолей, а также их терапия - Google Patents
Расар-композиции и способы визуализации злокачественных опухолей, а также их терапия Download PDFInfo
- Publication number
- RU2004115104A RU2004115104A RU2004115104/14A RU2004115104A RU2004115104A RU 2004115104 A RU2004115104 A RU 2004115104A RU 2004115104/14 A RU2004115104/14 A RU 2004115104/14A RU 2004115104 A RU2004115104 A RU 2004115104A RU 2004115104 A RU2004115104 A RU 2004115104A
- Authority
- RU
- Russia
- Prior art keywords
- patient
- compound
- spacer
- imaging
- nxsy
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 34
- 206010028980 Neoplasm Diseases 0.000 title claims 3
- 239000000203 mixture Substances 0.000 title claims 2
- 230000003211 malignant effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000002738 chelating agent Substances 0.000 claims 12
- 238000003384 imaging method Methods 0.000 claims 9
- 125000006850 spacer group Chemical group 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 6
- 102000002808 Pituitary adenylate cyclase-activating polypeptide Human genes 0.000 claims 5
- 108010004684 Pituitary adenylate cyclase-activating polypeptide Proteins 0.000 claims 5
- 230000037396 body weight Effects 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 4
- 210000003734 kidney Anatomy 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- RXACEEPNTRHYBQ-UHFFFAOYSA-N 2-[[2-[[2-[(2-sulfanylacetyl)amino]acetyl]amino]acetyl]amino]acetic acid Chemical compound OC(=O)CNC(=O)CNC(=O)CNC(=O)CS RXACEEPNTRHYBQ-UHFFFAOYSA-N 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 230000004071 biological effect Effects 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 210000003679 cervix uteri Anatomy 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 210000004696 endometrium Anatomy 0.000 claims 2
- 210000003238 esophagus Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 2
- 210000000867 larynx Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 210000005075 mammary gland Anatomy 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 210000001672 ovary Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 210000003681 parotid gland Anatomy 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 210000000664 rectum Anatomy 0.000 claims 2
- 208000000649 small cell carcinoma Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 210000004291 uterus Anatomy 0.000 claims 2
- VGPWRRFOPXVGOH-BYPYZUCNSA-N Ala-Gly-Gly Chemical compound C[C@H](N)C(=O)NCC(=O)NCC(O)=O VGPWRRFOPXVGOH-BYPYZUCNSA-N 0.000 claims 1
- 108010076324 alanyl-glycyl-glycine Proteins 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 210000003445 biliary tract Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34451101P | 2001-10-19 | 2001-10-19 | |
| US60/344,511 | 2001-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004115104A true RU2004115104A (ru) | 2005-02-20 |
Family
ID=23350835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004115104/14A RU2004115104A (ru) | 2001-10-19 | 2002-10-21 | Расар-композиции и способы визуализации злокачественных опухолей, а также их терапия |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6855308B2 (enExample) |
| EP (1) | EP1441773A1 (enExample) |
| JP (1) | JP2005514335A (enExample) |
| KR (1) | KR20040055784A (enExample) |
| CN (1) | CN1571680A (enExample) |
| CA (1) | CA2464002C (enExample) |
| IL (1) | IL161332A0 (enExample) |
| RU (1) | RU2004115104A (enExample) |
| WO (1) | WO2003033030A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009739A1 (en) * | 2002-02-14 | 2005-01-13 | Wei Wang | Formulation strategies in stabilizing peptides in organic solvents and in dried states |
| US9006181B2 (en) | 2004-07-21 | 2015-04-14 | The Administrators Of The Tulane Educational Fund | Treatment of renal dysfunction and multiple myeloma using PACAP compounds |
| WO2011013703A1 (ja) * | 2009-07-31 | 2011-02-03 | 独立行政法人理化学研究所 | 膵臓内分泌細胞用指示薬、及びその利用 |
| JP5908406B2 (ja) | 2009-11-02 | 2016-04-26 | ジ アドミニストレーターズ オブ ザ トゥレーン エデュケーショナル ファンド | 下垂体アデニル酸シクラーゼ活性化ポリペプチド（ｐａｃａｐ）の類似体およびその使用方法 |
| ES2667119T3 (es) * | 2010-06-24 | 2018-05-09 | Genomictree, Inc. | Vector recombinante para suprimir la proliferación de células del papilomavirus humano que incluyen el gen del polipéptido activador de la adenilato ciclasa 1 (hipófisis) y composición farmacéutica para tratar el papilomavirus humano |
| KR20150143440A (ko) * | 2013-02-15 | 2015-12-23 | 토마스 제퍼슨 유니버시티 | 떨어져 나가거나 순환 중인 종양세포를 생물학적 유액 내에서 탐지하는 방법 |
| CA2901231C (en) * | 2013-02-15 | 2020-06-23 | Thomas Jefferson University | Kit comprising lyophilized compositions for tumor imaging |
| JP2016528299A (ja) * | 2013-08-22 | 2016-09-15 | ロバート・ドイルＲｏｂｅｒｔ ＤＯＹＬＥ | ビタミンｂ１２および内因子を含む組成物およびその使用方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US6165755A (en) * | 1997-01-23 | 2000-12-26 | University Of Victoria Innovation And Development Corporation | Chicken neuropeptide gene useful for improved poultry production |
| US6395255B1 (en) * | 1998-06-15 | 2002-05-28 | Thomas Jefferson University | Radiolabeled vasoactive intestinal peptide analogs for imaging and therapy |
-
2002
- 2002-10-21 JP JP2003535832A patent/JP2005514335A/ja active Pending
- 2002-10-21 WO PCT/US2002/033904 patent/WO2003033030A1/en not_active Ceased
- 2002-10-21 IL IL16133202A patent/IL161332A0/xx unknown
- 2002-10-21 US US10/279,554 patent/US6855308B2/en not_active Expired - Lifetime
- 2002-10-21 RU RU2004115104/14A patent/RU2004115104A/ru not_active Application Discontinuation
- 2002-10-21 KR KR10-2004-7005539A patent/KR20040055784A/ko not_active Withdrawn
- 2002-10-21 CA CA2464002A patent/CA2464002C/en not_active Expired - Lifetime
- 2002-10-21 CN CNA028206819A patent/CN1571680A/zh active Pending
- 2002-10-21 EP EP02776270A patent/EP1441773A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1441773A1 (en) | 2004-08-04 |
| KR20040055784A (ko) | 2004-06-26 |
| CA2464002A1 (en) | 2003-04-24 |
| US20030129133A1 (en) | 2003-07-10 |
| WO2003033030A1 (en) | 2003-04-24 |
| CN1571680A (zh) | 2005-01-26 |
| CA2464002C (en) | 2011-06-28 |
| JP2005514335A (ja) | 2005-05-19 |
| US6855308B2 (en) | 2005-02-15 |
| IL161332A0 (en) | 2004-09-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3445796B2 (ja) | ソマトスタチンペプチド | |
| JP3918157B2 (ja) | ソマトスタチン結合性ペプチド−金属キレートコンジュゲート | |
| AU703057B2 (en) | Improvements in or relating to organic compounds | |
| Ruserb et al. | Somatostatin analogues for somatostatin-receptor-mediated radiotherapy of cancer | |
| ES2308778T3 (es) | Composiciones de peptidos radiomarcados para dirigir a un sitio especifico. | |
| JPH08503924A (ja) | 造影および治療用途の放射性標識ソマトスタチン誘導ペプチド | |
| CN110743017B (zh) | 一种靶向半乳糖凝集素-1的放射性药物及其制备方法 | |
| TWI893557B (zh) | 一種靶向sstr2的化合物及其製備方法和應用 | |
| EP4474379A1 (en) | Peptide urea derivative, pharmaceutical composition containing peptide urea derivative, and application of peptide urea derivative | |
| US12458710B2 (en) | Astatine solution and method for producing same | |
| JP2014500262A (ja) | 放射線治療のための１７７ルテチウム標識されたボンベシン類似体 | |
| AU650944B2 (en) | Method of treating and/or diagnosing soft tissue tumors | |
| WO2024099245A1 (zh) | 一种rgd二聚体化合物及其制备方法和应用 | |
| JP7824281B2 (ja) | ガストリン放出ペプチド受容体アンタゴニストを含むコンジュゲートまたはその塩およびそれらの使用 | |
| CA2464002A1 (en) | Pacap compositions and methods for tumor imaging and therapy | |
| US20230097381A1 (en) | Composition, kit and method for diagnosis and treatment of prostate cancer | |
| EP0700930B1 (en) | Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide | |
| TWI726368B (zh) | 多型態的乳癌診療神經胜肽藥物 | |
| Jin et al. | Radioiodine gene therapy of hepatocellular carcinoma targeted human alpha fetoprotein | |
| EP2873676A1 (en) | Small molecular peptide and use thereof | |
| CN111375072A (zh) | 可靶向葡萄糖调节蛋白grp78高表达肿瘤的放射性核素药物及其应用 | |
| CN120349373A (zh) | 一种含氮化合物及其制备方法与用途 | |
| TW202313120A (zh) | 膽囊收縮素b受體靶向複合體及其造影劑 | |
| Thakur et al. | 99mTechnetium labelled vasoactive intestinal peptide analogue for rapid localization of tumours in humans |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20060719 |