CA2464002C - Pacap compositions and methods for tumor imaging and therapy - Google Patents
Pacap compositions and methods for tumor imaging and therapy Download PDFInfo
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- CA2464002C CA2464002C CA2464002A CA2464002A CA2464002C CA 2464002 C CA2464002 C CA 2464002C CA 2464002 A CA2464002 A CA 2464002A CA 2464002 A CA2464002 A CA 2464002A CA 2464002 C CA2464002 C CA 2464002C
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- 229940056501 technetium 99m Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 210000001578 tight junction Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 229940073585 tromethamine hydrochloride Drugs 0.000 description 1
- 108010044292 tryptophyltyrosine Proteins 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 108010027345 wheylin-1 peptide Proteins 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34451101P | 2001-10-19 | 2001-10-19 | |
| US60/344,511 | 2001-10-19 | ||
| PCT/US2002/033904 WO2003033030A1 (en) | 2001-10-19 | 2002-10-21 | Pacap compositions and methods for tumor imaging and therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2464002A1 CA2464002A1 (en) | 2003-04-24 |
| CA2464002C true CA2464002C (en) | 2011-06-28 |
Family
ID=23350835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2464002A Expired - Lifetime CA2464002C (en) | 2001-10-19 | 2002-10-21 | Pacap compositions and methods for tumor imaging and therapy |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6855308B2 (enExample) |
| EP (1) | EP1441773A1 (enExample) |
| JP (1) | JP2005514335A (enExample) |
| KR (1) | KR20040055784A (enExample) |
| CN (1) | CN1571680A (enExample) |
| CA (1) | CA2464002C (enExample) |
| IL (1) | IL161332A0 (enExample) |
| RU (1) | RU2004115104A (enExample) |
| WO (1) | WO2003033030A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009739A1 (en) * | 2002-02-14 | 2005-01-13 | Wei Wang | Formulation strategies in stabilizing peptides in organic solvents and in dried states |
| US9006181B2 (en) | 2004-07-21 | 2015-04-14 | The Administrators Of The Tulane Educational Fund | Treatment of renal dysfunction and multiple myeloma using PACAP compounds |
| WO2011013703A1 (ja) * | 2009-07-31 | 2011-02-03 | 独立行政法人理化学研究所 | 膵臓内分泌細胞用指示薬、及びその利用 |
| JP5908406B2 (ja) | 2009-11-02 | 2016-04-26 | ジ アドミニストレーターズ オブ ザ トゥレーン エデュケーショナル ファンド | 下垂体アデニル酸シクラーゼ活性化ポリペプチド（ｐａｃａｐ）の類似体およびその使用方法 |
| ES2667119T3 (es) * | 2010-06-24 | 2018-05-09 | Genomictree, Inc. | Vector recombinante para suprimir la proliferación de células del papilomavirus humano que incluyen el gen del polipéptido activador de la adenilato ciclasa 1 (hipófisis) y composición farmacéutica para tratar el papilomavirus humano |
| KR20150143440A (ko) * | 2013-02-15 | 2015-12-23 | 토마스 제퍼슨 유니버시티 | 떨어져 나가거나 순환 중인 종양세포를 생물학적 유액 내에서 탐지하는 방법 |
| CA2901231C (en) * | 2013-02-15 | 2020-06-23 | Thomas Jefferson University | Kit comprising lyophilized compositions for tumor imaging |
| JP2016528299A (ja) * | 2013-08-22 | 2016-09-15 | ロバート・ドイルＲｏｂｅｒｔ ＤＯＹＬＥ | ビタミンｂ１２および内因子を含む組成物およびその使用方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US6165755A (en) * | 1997-01-23 | 2000-12-26 | University Of Victoria Innovation And Development Corporation | Chicken neuropeptide gene useful for improved poultry production |
| US6395255B1 (en) * | 1998-06-15 | 2002-05-28 | Thomas Jefferson University | Radiolabeled vasoactive intestinal peptide analogs for imaging and therapy |
-
2002
- 2002-10-21 JP JP2003535832A patent/JP2005514335A/ja active Pending
- 2002-10-21 WO PCT/US2002/033904 patent/WO2003033030A1/en not_active Ceased
- 2002-10-21 IL IL16133202A patent/IL161332A0/xx unknown
- 2002-10-21 US US10/279,554 patent/US6855308B2/en not_active Expired - Lifetime
- 2002-10-21 RU RU2004115104/14A patent/RU2004115104A/ru not_active Application Discontinuation
- 2002-10-21 KR KR10-2004-7005539A patent/KR20040055784A/ko not_active Withdrawn
- 2002-10-21 CA CA2464002A patent/CA2464002C/en not_active Expired - Lifetime
- 2002-10-21 CN CNA028206819A patent/CN1571680A/zh active Pending
- 2002-10-21 EP EP02776270A patent/EP1441773A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1441773A1 (en) | 2004-08-04 |
| KR20040055784A (ko) | 2004-06-26 |
| CA2464002A1 (en) | 2003-04-24 |
| US20030129133A1 (en) | 2003-07-10 |
| WO2003033030A1 (en) | 2003-04-24 |
| CN1571680A (zh) | 2005-01-26 |
| JP2005514335A (ja) | 2005-05-19 |
| US6855308B2 (en) | 2005-02-15 |
| RU2004115104A (ru) | 2005-02-20 |
| IL161332A0 (en) | 2004-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20221021 |