RU2003122188A - Бензоилпиридазины - Google Patents
Бензоилпиридазины Download PDFInfo
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- RU2003122188A RU2003122188A RU2003122188/04A RU2003122188A RU2003122188A RU 2003122188 A RU2003122188 A RU 2003122188A RU 2003122188/04 A RU2003122188/04 A RU 2003122188/04A RU 2003122188 A RU2003122188 A RU 2003122188A RU 2003122188 A RU2003122188 A RU 2003122188A
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- VDWSVBMVZLRATD-UHFFFAOYSA-N phenyl(pyridazin-3-yl)methanone Chemical class C=1C=CN=NC=1C(=O)C1=CC=CC=C1 VDWSVBMVZLRATD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 34
- 208000006673 asthma Diseases 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 22
- 239000012453 solvate Substances 0.000 claims 22
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 13
- 125000004432 carbon atom Chemical group C* 0.000 claims 12
- -1 COOA 1 Chemical group 0.000 claims 10
- 206010006895 Cachexia Diseases 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 10
- 208000024780 Urticaria Diseases 0.000 claims 9
- 206010046851 Uveitis Diseases 0.000 claims 9
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- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 8
- 239000005557 antagonist Substances 0.000 claims 8
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- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 claims 6
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 claims 6
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
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- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 claims 3
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- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 2
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims 2
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
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- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 2
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- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 2
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- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims 2
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- GEYMMMXKROUBAI-UHFFFAOYSA-N chlorane Chemical compound Cl.Cl.Cl.Cl.Cl GEYMMMXKROUBAI-UHFFFAOYSA-N 0.000 claims 2
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- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
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- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims 1
- OLZHFFKRBCZHHT-SNVBAGLBSA-N 1-[(2r)-4-[5-(4-fluorophenoxy)furan-2-yl]but-3-yn-2-yl]-1-hydroxyurea Chemical compound O1C(C#C[C@@H](C)N(O)C(N)=O)=CC=C1OC1=CC=C(F)C=C1 OLZHFFKRBCZHHT-SNVBAGLBSA-N 0.000 claims 1
- MMSNEKOTSJRTRI-LLVKDONJSA-N 1-[(2r)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea Chemical compound S1C(C#C[C@@H](C)N(O)C(N)=O)=CC=C1CC1=CC=C(F)C=C1 MMSNEKOTSJRTRI-LLVKDONJSA-N 0.000 claims 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 claims 1
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 1
- AXUZQJFHDNNPFG-LHAVAQOQSA-N 3-[(r)-[3-[(e)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-[3-(dimethylamino)-3-oxopropyl]sulfanylmethyl]sulfanylpropanoic acid Chemical compound CN(C)C(=O)CCS[C@H](SCCC(O)=O)C1=CC=CC(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)=C1 AXUZQJFHDNNPFG-LHAVAQOQSA-N 0.000 claims 1
- MBLJFKQACMILLC-UHFFFAOYSA-N 4-[[3-[[4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy]methyl]phenyl]methoxy]benzenecarboximidamide Chemical compound C=1C=C(OCC=2C=C(COC=3C=CC(=CC=3)C(N)=N)C=CC=2)C=CC=1C(C)(C)C1=CC=C(O)C=C1 MBLJFKQACMILLC-UHFFFAOYSA-N 0.000 claims 1
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- IXJCHVMUTFCRBH-SDUHDBOFSA-N 7-[(1r,2s,3e,5z)-10-(4-acetyl-3-hydroxy-2-propylphenoxy)-1-hydroxy-1-[3-(trifluoromethyl)phenyl]deca-3,5-dien-2-yl]sulfanyl-4-oxochromene-2-carboxylic acid Chemical compound CCCC1=C(O)C(C(C)=O)=CC=C1OCCCC\C=C/C=C/[C@@H]([C@H](O)C=1C=C(C=CC=1)C(F)(F)F)SC1=CC=C2C(=O)C=C(C(O)=O)OC2=C1 IXJCHVMUTFCRBH-SDUHDBOFSA-N 0.000 claims 1
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| DE10064997.1 | 2000-12-23 | ||
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| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| EP2433124B1 (en) * | 2009-05-19 | 2017-03-01 | Vivia Biotech S.L. | Methods for providing personalized medicine tests ex vivo for hematological neoplasms |
| US10806711B2 (en) | 2011-08-12 | 2020-10-20 | University Of Cincinnati | Method of treating acute decompensated heart failure with probenecid |
| MX376077B (es) | 2013-03-13 | 2025-03-07 | Univ Cincinnati | Tratamiento de una disfuncion cardiaca diastolica con un agonista del receptor trpv2. |
| WO2016149126A1 (en) | 2015-03-13 | 2016-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
| CN105175283A (zh) * | 2015-09-23 | 2015-12-23 | 蚌埠中实化学技术有限公司 | 一种3-乙氧基-4-甲氧基苯腈的制备方法 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
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|---|---|---|---|---|
| ES2168276T3 (es) * | 1992-07-01 | 2002-06-16 | Ortho Pharma Corp | 1-arilsulfonil-3-fenil-1,4,5,6-tetrahidropiridazinas. |
| EP0738268B1 (en) | 1993-12-22 | 2004-03-03 | Celltech R&D Limited | Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412672D0 (en) | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
| DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| GB9525262D0 (en) | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
| DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19826841A1 (de) * | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19850701A1 (de) * | 1998-11-04 | 2000-05-11 | Merck Patent Gmbh | Benzoylpyridazine |
-
2000
- 2000-12-23 DE DE10064997A patent/DE10064997A1/de not_active Withdrawn
-
2001
- 2001-12-19 US US10/451,393 patent/US7312328B2/en not_active Expired - Fee Related
- 2001-12-19 WO PCT/EP2001/015070 patent/WO2002051814A1/en not_active Ceased
- 2001-12-19 RU RU2003122188/04A patent/RU2003122188A/ru not_active Application Discontinuation
- 2001-12-19 ES ES01272031T patent/ES2349622T3/es not_active Expired - Lifetime
- 2001-12-19 BR BR0116304-3A patent/BR0116304A/pt not_active Application Discontinuation
- 2001-12-19 JP JP2002552911A patent/JP4532071B2/ja not_active Expired - Fee Related
- 2001-12-19 AR ARP010105890A patent/AR032010A1/es unknown
- 2001-12-19 DE DE60142749T patent/DE60142749D1/de not_active Expired - Lifetime
- 2001-12-19 MX MXPA03005494A patent/MXPA03005494A/es unknown
- 2001-12-19 AT AT01272031T patent/ATE476423T1/de not_active IP Right Cessation
- 2001-12-19 PL PL01364229A patent/PL364229A1/xx unknown
- 2001-12-19 SK SK866-2003A patent/SK8662003A3/sk unknown
- 2001-12-19 CZ CZ20031860A patent/CZ20031860A3/cs unknown
- 2001-12-19 KR KR10-2003-7008423A patent/KR20030065564A/ko not_active Withdrawn
- 2001-12-19 HU HU0302562A patent/HUP0302562A2/hu unknown
- 2001-12-19 EP EP01272031A patent/EP1343769B1/en not_active Expired - Lifetime
- 2001-12-19 CA CA2432568A patent/CA2432568C/en not_active Expired - Fee Related
- 2001-12-19 CN CNA018211763A patent/CN1483026A/zh active Pending
-
2003
- 2003-06-20 NO NO20032862A patent/NO20032862L/no not_active Application Discontinuation
- 2003-07-22 ZA ZA200305661A patent/ZA200305661B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR032010A1 (es) | 2003-10-22 |
| US20040067954A1 (en) | 2004-04-08 |
| EP1343769B1 (en) | 2010-08-04 |
| BR0116304A (pt) | 2003-09-30 |
| CN1483026A (zh) | 2004-03-17 |
| WO2002051814A1 (en) | 2002-07-04 |
| NO20032862D0 (no) | 2003-06-20 |
| ATE476423T1 (de) | 2010-08-15 |
| JP4532071B2 (ja) | 2010-08-25 |
| MXPA03005494A (es) | 2003-10-06 |
| HUP0302562A2 (hu) | 2003-11-28 |
| US7312328B2 (en) | 2007-12-25 |
| ZA200305661B (en) | 2004-10-22 |
| ES2349622T3 (es) | 2011-01-07 |
| EP1343769A1 (en) | 2003-09-17 |
| CZ20031860A3 (cs) | 2003-10-15 |
| CA2432568C (en) | 2011-08-09 |
| KR20030065564A (ko) | 2003-08-06 |
| CA2432568A1 (en) | 2002-07-04 |
| DE60142749D1 (de) | 2010-09-16 |
| SK8662003A3 (en) | 2003-12-02 |
| DE10064997A1 (de) | 2002-06-27 |
| NO20032862L (no) | 2003-06-20 |
| PL364229A1 (en) | 2004-12-13 |
| JP2004519450A (ja) | 2004-07-02 |
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