CA2432568C - Benzoylpyridazines - Google Patents
Benzoylpyridazines Download PDFInfo
- Publication number
- CA2432568C CA2432568C CA2432568A CA2432568A CA2432568C CA 2432568 C CA2432568 C CA 2432568C CA 2432568 A CA2432568 A CA 2432568A CA 2432568 A CA2432568 A CA 2432568A CA 2432568 C CA2432568 C CA 2432568C
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- Prior art keywords
- compound
- och3
- solvate
- medicament
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- VDWSVBMVZLRATD-UHFFFAOYSA-N phenyl(pyridazin-3-yl)methanone Chemical class C=1C=CN=NC=1C(=O)C1=CC=CC=C1 VDWSVBMVZLRATD-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 223
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims abstract description 12
- -1 COOA1 Chemical group 0.000 claims description 121
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- 150000003839 salts Chemical class 0.000 claims description 90
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- 239000012453 solvate Substances 0.000 claims description 72
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10064997.1 | 2000-12-23 | ||
| DE10064997A DE10064997A1 (de) | 2000-12-23 | 2000-12-23 | Benzoylpyridazine |
| PCT/EP2001/015070 WO2002051814A1 (en) | 2000-12-23 | 2001-12-19 | Benzoylpyridazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2432568A1 CA2432568A1 (en) | 2002-07-04 |
| CA2432568C true CA2432568C (en) | 2011-08-09 |
Family
ID=7668970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2432568A Expired - Fee Related CA2432568C (en) | 2000-12-23 | 2001-12-19 | Benzoylpyridazines |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7312328B2 (enExample) |
| EP (1) | EP1343769B1 (enExample) |
| JP (1) | JP4532071B2 (enExample) |
| KR (1) | KR20030065564A (enExample) |
| CN (1) | CN1483026A (enExample) |
| AR (1) | AR032010A1 (enExample) |
| AT (1) | ATE476423T1 (enExample) |
| BR (1) | BR0116304A (enExample) |
| CA (1) | CA2432568C (enExample) |
| CZ (1) | CZ20031860A3 (enExample) |
| DE (2) | DE10064997A1 (enExample) |
| ES (1) | ES2349622T3 (enExample) |
| HU (1) | HUP0302562A2 (enExample) |
| MX (1) | MXPA03005494A (enExample) |
| NO (1) | NO20032862L (enExample) |
| PL (1) | PL364229A1 (enExample) |
| RU (1) | RU2003122188A (enExample) |
| SK (1) | SK8662003A3 (enExample) |
| WO (1) | WO2002051814A1 (enExample) |
| ZA (1) | ZA200305661B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| PE20060272A1 (es) * | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| EP2433124B1 (en) * | 2009-05-19 | 2017-03-01 | Vivia Biotech S.L. | Methods for providing personalized medicine tests ex vivo for hematological neoplasms |
| US10806711B2 (en) | 2011-08-12 | 2020-10-20 | University Of Cincinnati | Method of treating acute decompensated heart failure with probenecid |
| MX376077B (es) | 2013-03-13 | 2025-03-07 | Univ Cincinnati | Tratamiento de una disfuncion cardiaca diastolica con un agonista del receptor trpv2. |
| WO2016149126A1 (en) | 2015-03-13 | 2016-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Ltb4 inhibition to prevent and treat human lymphedema |
| CN105175283A (zh) * | 2015-09-23 | 2015-12-23 | 蚌埠中实化学技术有限公司 | 一种3-乙氧基-4-甲氧基苯腈的制备方法 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2168276T3 (es) * | 1992-07-01 | 2002-06-16 | Ortho Pharma Corp | 1-arilsulfonil-3-fenil-1,4,5,6-tetrahidropiridazinas. |
| EP0738268B1 (en) | 1993-12-22 | 2004-03-03 | Celltech R&D Limited | Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412672D0 (en) | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| DE19514568A1 (de) * | 1995-04-20 | 1996-10-24 | Merck Patent Gmbh | Arylalkyl-pyridazinone |
| DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| GB9525262D0 (en) | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
| DE19632549A1 (de) * | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19826841A1 (de) * | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE19850701A1 (de) * | 1998-11-04 | 2000-05-11 | Merck Patent Gmbh | Benzoylpyridazine |
-
2000
- 2000-12-23 DE DE10064997A patent/DE10064997A1/de not_active Withdrawn
-
2001
- 2001-12-19 US US10/451,393 patent/US7312328B2/en not_active Expired - Fee Related
- 2001-12-19 WO PCT/EP2001/015070 patent/WO2002051814A1/en not_active Ceased
- 2001-12-19 RU RU2003122188/04A patent/RU2003122188A/ru not_active Application Discontinuation
- 2001-12-19 ES ES01272031T patent/ES2349622T3/es not_active Expired - Lifetime
- 2001-12-19 BR BR0116304-3A patent/BR0116304A/pt not_active Application Discontinuation
- 2001-12-19 JP JP2002552911A patent/JP4532071B2/ja not_active Expired - Fee Related
- 2001-12-19 AR ARP010105890A patent/AR032010A1/es unknown
- 2001-12-19 DE DE60142749T patent/DE60142749D1/de not_active Expired - Lifetime
- 2001-12-19 MX MXPA03005494A patent/MXPA03005494A/es unknown
- 2001-12-19 AT AT01272031T patent/ATE476423T1/de not_active IP Right Cessation
- 2001-12-19 PL PL01364229A patent/PL364229A1/xx unknown
- 2001-12-19 SK SK866-2003A patent/SK8662003A3/sk unknown
- 2001-12-19 CZ CZ20031860A patent/CZ20031860A3/cs unknown
- 2001-12-19 KR KR10-2003-7008423A patent/KR20030065564A/ko not_active Withdrawn
- 2001-12-19 HU HU0302562A patent/HUP0302562A2/hu unknown
- 2001-12-19 EP EP01272031A patent/EP1343769B1/en not_active Expired - Lifetime
- 2001-12-19 CA CA2432568A patent/CA2432568C/en not_active Expired - Fee Related
- 2001-12-19 CN CNA018211763A patent/CN1483026A/zh active Pending
-
2003
- 2003-06-20 NO NO20032862A patent/NO20032862L/no not_active Application Discontinuation
- 2003-07-22 ZA ZA200305661A patent/ZA200305661B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR032010A1 (es) | 2003-10-22 |
| US20040067954A1 (en) | 2004-04-08 |
| EP1343769B1 (en) | 2010-08-04 |
| BR0116304A (pt) | 2003-09-30 |
| CN1483026A (zh) | 2004-03-17 |
| WO2002051814A1 (en) | 2002-07-04 |
| NO20032862D0 (no) | 2003-06-20 |
| ATE476423T1 (de) | 2010-08-15 |
| JP4532071B2 (ja) | 2010-08-25 |
| MXPA03005494A (es) | 2003-10-06 |
| HUP0302562A2 (hu) | 2003-11-28 |
| US7312328B2 (en) | 2007-12-25 |
| ZA200305661B (en) | 2004-10-22 |
| ES2349622T3 (es) | 2011-01-07 |
| EP1343769A1 (en) | 2003-09-17 |
| CZ20031860A3 (cs) | 2003-10-15 |
| RU2003122188A (ru) | 2005-02-27 |
| KR20030065564A (ko) | 2003-08-06 |
| CA2432568A1 (en) | 2002-07-04 |
| DE60142749D1 (de) | 2010-09-16 |
| SK8662003A3 (en) | 2003-12-02 |
| DE10064997A1 (de) | 2002-06-27 |
| NO20032862L (no) | 2003-06-20 |
| PL364229A1 (en) | 2004-12-13 |
| JP2004519450A (ja) | 2004-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20161219 |