RU2002115713A - Устройства и способы для подкожного отбора проб биологической жидкости и измерения анлизируемого вещества - Google Patents

Устройства и способы для подкожного отбора проб биологической жидкости и измерения анлизируемого вещества Download PDF

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Publication number
RU2002115713A
RU2002115713A RU2002115713/14A RU2002115713A RU2002115713A RU 2002115713 A RU2002115713 A RU 2002115713A RU 2002115713/14 A RU2002115713/14 A RU 2002115713/14A RU 2002115713 A RU2002115713 A RU 2002115713A RU 2002115713 A RU2002115713 A RU 2002115713A
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RU
Russia
Prior art keywords
biological fluid
electrode
sampling
microneedle
concentration
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RU2002115713/14A
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English (en)
Inventor
Борзу СОХРАБ (US)
Борзу СОХРАБ
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Лайфскен, Инк. (Us)
Лайфскен, Инк.
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Publication of RU2002115713A publication Critical patent/RU2002115713A/ru

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood

Claims (10)

1. Устройство для отбора проб биологической жидкости и измерения концентрации анализируемого вещества, содержащее удлиненное средство для отбора проб, выполненное с возможностью прокола поверхности кожи для обеспечения доступа к биологической жидкости, концентрично расположенные электроды внутри удлиненного средства для отбора проб, образующие гальванический элемент для измерения концентрации анализируемого вещества в биологической жидкости.
2. Устройство по п.1, отличающееся тем, что дополнительно содержит изоляционный материал между концентрично расположенными электродами.
3. Устройство по п.1, отличающееся тем, что средство для отбора проб содержит полость и открытый дистальный конец, обеспечивающий проход в полость.
4. Устройство по п.3, отличающееся тем, что полость выполнена с возможностью создания капиллярной силы, достаточной для втягивания пробы биологической жидкости в эту полость.
5. Устройство для отбора проб биологической жидкости и измерения концентрации целевого компонента в биологической жидкости, содержащее первый электрод, второй электрод, размещенный концентрично вокруг первого электрода и на расстоянии от него, пористый материал, размещенный в пространстве между электродами, при этом устройство имеет конфигурацию, обеспечивающую прокол кожи.
6. Устройство по п.5, отличающееся тем, что второй электрод имеет конфигурацию, обеспечивающую прокол кожи.
7. Устройство по п.6, отличающееся тем, что второй электрод имеет открытый дистальный конец и образует в устройстве полость, имеющую конфигурацию, создающую капиллярную силу, достаточную для втягивания биологической жидкости через открытый дистальный конец.
8. Микроигла для отбора проб биологической жидкости и измерения концентрации целевого компонента в биологической жидкости, содержащая сердечник, имеющий длину, первый электрод, соосно размещенный вокруг сердечника, пористый материал, соосно размещенный вокруг первого электрода, второй электрод, соосно размещенный вокруг пористого материала и имеющий длину, больше длины сердечника и заканчивающийся у открытого конца, реагент, выбранный в соответствии с требуемым компонентом и размещенный в микроигле.
9. Система для отбор проб биологической жидкости из кожи пациента и измерения требуемого компонента в биологической жидкости, содержащая по меньшей мере, одну микроиглу, содержащую средство для отбора проб, реагент и гальванический элемент, размещенные в микроигле, при этом гальванический элемент содержит опорный электрод, рабочий электрод и изоляционный материал между ними, и реагент находится в контакте, по меньшей мере, с одним или несколькими элементами из опорного электрода, рабочего электрода и изоляционного материала, при этом средство для отбора проб содержит дистальное отверстие и, по меньшей мере, одну полость в микроигле, конфигурация которой обеспечивает впитывание биологической жидкости в микроиглу, блок управления, электрически связанный с, по меньшей мере, одной микроиглой и содержащий средство для подачи электрического опорного сигнала в опорный электрод и приема электрического выходного сигнала из рабочего электрода и программно-реализованный алгоритм для вычисления и определения концентрации целевого компонента в биологической пробе после приема электрического выходного сигнала.
10. Способ анализа биологической жидкости в коже пациента и определения концентрации целевого компонента, содержащегося в ней, заключающийся в том, что используют, по меньшей мере, одну микроиглу, содержащую открытый дистальный конец и гальванический элемент в ней, причем гальванический элемент содержит реагент и расположенную концентричными слоями систему электродов, вводят, по меньшей мере, одну микроиглу в кожу на выбранную глубину, обеспечивают впитывание пробы биологической жидкости, присутствующей в открытом дистальном конце, в гальванический элемент, дают пробе вступить с реагентом в реакцию, в результате которой в гальваническом элементе образуется вещество, подают первый электрический сигнал в упомянутое вещество и принимают второй электрический сигнал, выработанный веществом и представляющий концентрацию компонента в пробе.
RU2002115713/14A 2001-06-12 2002-06-11 Устройства и способы для подкожного отбора проб биологической жидкости и измерения анлизируемого вещества RU2002115713A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/879,106 US6501976B1 (en) 2001-06-12 2001-06-12 Percutaneous biological fluid sampling and analyte measurement devices and methods
US09/879,106 2001-06-12

Publications (1)

Publication Number Publication Date
RU2002115713A true RU2002115713A (ru) 2003-12-27

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Country Link
US (2) US6501976B1 (ru)
EP (1) EP1266625A3 (ru)
JP (1) JP2003038464A (ru)
KR (1) KR20020094899A (ru)
CN (1) CN1273833C (ru)
AR (1) AR034379A1 (ru)
AU (1) AU784464B2 (ru)
CA (1) CA2390332A1 (ru)
CZ (1) CZ20022024A3 (ru)
HK (1) HK1049593A1 (ru)
IL (1) IL150097A (ru)
MX (1) MXPA02005619A (ru)
PL (1) PL354419A1 (ru)
RU (1) RU2002115713A (ru)
TW (1) TWI234451B (ru)

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