RU2000127088A - Photomatrix device - Google Patents

Photomatrix device

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Publication number
RU2000127088A
RU2000127088A RU2000127088/14A RU2000127088A RU2000127088A RU 2000127088 A RU2000127088 A RU 2000127088A RU 2000127088/14 A RU2000127088/14 A RU 2000127088/14A RU 2000127088 A RU2000127088 A RU 2000127088A RU 2000127088 A RU2000127088 A RU 2000127088A
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RU
Russia
Prior art keywords
emitters
radiation
substrate
biological object
range
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RU2000127088/14A
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Russian (ru)
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RU2195981C2 (en
Inventor
Владимир Павлович Жаров
Original Assignee
Владимир Павлович Жаров
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Priority claimed from RU98106764A external-priority patent/RU2145247C1/en
Application filed by Владимир Павлович Жаров filed Critical Владимир Павлович Жаров
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Publication of RU2195981C2 publication Critical patent/RU2195981C2/en
Publication of RU2000127088A publication Critical patent/RU2000127088A/en

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Claims (39)

1. Фотоматричное устройство, включающее в себя излучатели оптического диапазона спектра от ультрафиолетового до радиоволнового, соединенные с блоками управления и питания, отличающееся тем, что излучатели размещены в пространстве так, что индикатрисы излучения от каждого излучателя и их положение в пространстве вокруг или внутри биообъекта или его части ориентированы таким образом, чтобы обеспечивалось заданное распределение освещенности биообъекта в пределах заданной зоны, а длины волн излучателей выбираются, исходя из совпадения с максимумами спектров биодействия или полос поглощения биомолекул, как экзогенного, так и эндогенного происхождения, включая лекарственные препараты и фотосенсибилизаторы.1. Photomatrix device, including emitters of the optical spectrum from ultraviolet to radio wave, connected to control units and power, characterized in that the emitters are placed in space so that the indicatrix of radiation from each emitter and their position in the space around or inside the biological object or its parts are oriented in such a way as to ensure a given distribution of the illumination of the biological object within the specified zone, and the wavelengths of the emitters are selected based on coincidence with maxima of the bio-action spectra or absorption bands of biomolecules, both exogenous and endogenous, including drugs and photosensitizers. 2. Устройство по п.1, отличающееся тем, что излучатели размещены на жесткой подложке, выполненной из металла, пластмассы, пластики, стекла, керамики или ситаллов, путем их механического закрепления, приклеивания, припаивания или в виде монолитного чипа с микрокристаллическими излучателями на его поверхности.2. The device according to claim 1, characterized in that the emitters are placed on a rigid substrate made of metal, plastic, plastic, glass, ceramic or ceramic, by mechanical fixing, gluing, soldering or in the form of a monolithic chip with microcrystalline emitters on it surface. 3. Устройство по п.1, отличающееся тем, что излучатели размещены на подложке, выполненной из отдельных жестких сегментов, излучатели в пределах каждого сегмента расположены равномерно, а отдельные сегменты или зафиксированы в пространстве независимо в виде выносных головок от одного блока питания, или соединены между собой жесткой связью, так чтобы в сборе их общая поверхность следовала за рельефом поверхности биообъекта, или гибкой связью, так чтобы они путем изменения угла и расстояния между ними и их размеров могли быть адаптированы к любой сложной поверхности биообъекта.3. The device according to claim 1, characterized in that the emitters are placed on a substrate made of separate hard segments, the emitters within each segment are evenly spaced, and the individual segments are either fixed in space independently in the form of remote heads from one power supply, or connected between each other by a rigid connection, so that in assembly their common surface follows the relief of the surface of the biological object, or by a flexible connection, so that by changing the angle and distance between them and their sizes they can be adapted to any complex surface of a bioobject. 4. Устройство по п.1, отличающееся тем, что излучатели размещены на гибкой подложке, которая при поджатии или охвате биообъекта принимает форму поверхности биообъекта.4. The device according to claim 1, characterized in that the emitters are placed on a flexible substrate, which, when pressed or covered by a biological object, takes the form of the surface of a biological object. 5. Устройство по пп.2, 3 или 4, отличающееся тем, что излучатели размещены с тыльной стороны нерабочей поверхности подложки, непосредственно в которой находятся выходные окна источников или согласующие линзы.5. The device according to claims 2, 3 or 4, characterized in that the emitters are located on the back side of the non-working surface of the substrate, directly in which there are output windows of sources or matching lenses. 6. Устройство по п.1, отличающееся тем, что равномерная освещенность протяженной зоны достигается путем введения системы оптических делителей пучков.6. The device according to claim 1, characterized in that the uniform illumination of the extended zone is achieved by introducing a system of optical beam dividers. 7. Устройство по пп.2, 3 или 4, отличающееся тем, что между рабочей поверхностью подложки с излучателями и биообъектом введены дополнительные оптические элементы в виде защитной прозрачной пластины или пленки, диффузного рассеивающего экрана, или в виде отдельных для каждого излучателя собирающих или рассеивающих линз, или в виде комбинации указанных оптических элементов.7. The device according to claims 2, 3 or 4, characterized in that between the working surface of the substrate with emitters and a biological object, additional optical elements are introduced in the form of a protective transparent plate or film, a diffuse scattering screen, or in the form of collecting or scattering separate for each emitter lenses, or in the form of a combination of these optical elements. 8. Устройство по п.1, отличающееся тем, что в качестве излучателей используются полупроводниковые гибридные лазеры, работающие, как в непрерывном, так и в импульсном режиме с частотой повторения от 1 Гц до 104 Гц в диапазоне длительностей импульсов от 0,1 до 10-9 с.8. The device according to claim 1, characterized in that the semiconductor hybrid lasers are used as emitters, operating both in continuous and in pulsed mode with a repetition frequency from 1 Hz to 10 4 Hz in the range of pulse durations from 0.1 to 10 -9 p. 9. Устройство по п.1, отличающееся тем, что в качестве излучателей используются, как широкополостные со спектральной шириной до 0,3 мкм, так и узкополосные гибридные светодиоды в диапазоне от 200 до 2000 нм с шириной линии излучения от 5 до 40 нм, мощностью излучения от 0,1 мВт до 1 Вт, и с индикатрисой излучения от 10 до 180°, обеспечиваемой нанесением на поверхность светодиодов оптического покрытия в виде линзы или диффузного рассеивателя.9. The device according to claim 1, characterized in that the emitters are used as wide-band with a spectral width of up to 0.3 μm, and narrow-band hybrid LEDs in the range from 200 to 2000 nm with a radiation line width from 5 to 40 nm, radiation power from 0.1 mW to 1 W, and with an indicatrix of radiation from 10 to 180 °, provided by applying an optical coating on the surface of the LEDs in the form of a lens or a diffuse diffuser. 10. Устройство по п.1, отличающееся тем, что в качестве излучателя используется множество компактных ламп накаливания, газоразрядных или люминесцентных ламп совместно со светофильтрами, выделяющими требуемую область спектра.10. The device according to claim 1, characterized in that the emitter uses many compact incandescent lamps, gas discharge or fluorescent lamps in conjunction with filters that highlight the desired region of the spectrum. 11. Устройство по п.1, отличающееся тем, что в качестве излучателей используются источники миллиметрового и/или радиодиапазона в виде ламп обратной волны, лавинно-пролетных диодов, диодов Ганна, специальных транзисторов, клистронов или магнетронов.11. The device according to claim 1, characterized in that the sources of millimeter and / or radio range in the form of backward wave tubes, avalanche-span diodes, Gunn diodes, special transistors, klystrons or magnetrons are used as emitters. 12. Устройство по п.1, отличающееся тем, что для лечения инфицированных процессов, излучатели размещены на подложке, с формой рабочей поверхности, обеспечивающей как равномерное облучение патологической зоны, затронутой инфекцией, так и соседних зон, где могут локализоваться микроорганизмы, включая облучение крови в перифирических сосудах по всему телу, а длина волны излучения выбрана совпадающей с полосой поглощения фотосенсибилизатора, наиболее эффективно поражающих большинство микроорганизмов.12. The device according to claim 1, characterized in that for the treatment of infected processes, the emitters are placed on a substrate, with the shape of the working surface, providing both uniform irradiation of the pathological zone affected by the infection, and neighboring areas where microorganisms can be localized, including blood irradiation in peripheral vessels throughout the body, and the radiation wavelength is chosen to coincide with the absorption band of the photosensitizer, which most effectively affects most microorganisms. 13. Устройство по п.1, отличающееся тем, что длины волн нескольких источников излучения совпадают с максимумом поглощения смеси из нескольких отдельных фотосенсибилизаторов использующихся, например, в фотодинамической терапии рака, при лечении дерматологических заболеваний, инфицированных микроорганизмами процессов.13. The device according to claim 1, characterized in that the wavelengths of several radiation sources coincide with the maximum absorption of a mixture of several separate photosensitizers used, for example, in the photodynamic therapy of cancer, in the treatment of dermatological diseases infected with microorganisms of processes. 14. Устройство по п.13, отличающееся тем, что в качестве излучателей используются полупроводниковые лазеры или матрицы светодиодов с длинами волн вблизи 0,63 мкм, 0,67 мкм, 0,69 мкм, 0,75 мкм, 1,26 мкм, со спектральной шириной не более 30 нм и мощностью в диапазоне от 1 мВт до 1 Вт, каждый для работы соответственно с фотосенсибилизаторами: производные гематопорфирина (0,63 мкм), хлоринами и соединениями фталоцианина (0,67 мкм), производными бензопорфирина (0,69 мкм), индоцианином зеленым (0,75 мкм), растворенным кислородом (1,26 мкм).14. The device according to item 13, characterized in that the emitters used are semiconductor lasers or matrix LEDs with wavelengths near 0.63 μm, 0.67 μm, 0.69 μm, 0.75 μm, 1.26 μm, with a spectral width of not more than 30 nm and a power in the range from 1 mW to 1 W, each for working with photosensitizers respectively: hematoporphyrin derivatives (0.63 μm), chlorins and phthalocyanine compounds (0.67 μm), benzoporphyrin derivatives (0, 69 microns), indocyanine green (0.75 microns), dissolved oxygen (1.26 microns). 15. Устройство по п.1, отличающееся тем, что используют одновременно излучатели видимого и инфракрасного диапазона повышенной мощности до 5 Вт для реализации фото и тепловой терапии суставов при лечении артритов.15. The device according to claim 1, characterized in that they use simultaneously emitters of the visible and infrared range of increased power up to 5 W for the implementation of photo and thermal therapy of joints in the treatment of arthritis. 16. Устройство по п.1, отличающееся тем, что используют дополнительный физиотерапевтический модуль в виде электростимулятора с двумя или большим количеством электродов, расположенных или непосредственно на подложке или по ее краям и находящихся в контакте с поверхностью биообъекта.16. The device according to claim 1, characterized in that they use an additional physiotherapeutic module in the form of an electrical stimulator with two or more electrodes located either directly on the substrate or along its edges and in contact with the surface of the biological object. 17. Устройство по п.1, отличающееся тем, что используют дополнительный физиотерапевтический модуль в виде источников вибрации, акустических или ультразвуковых колебаний в виде магнитострикционных или пьезоэлектрических преобразователей, рабочие окончания которых находятся в контакте или непосредственно с биообъектом или через промежуточную среду в виде физиологического раствора, находящегося в контакте с патологической зоной.17. The device according to claim 1, characterized in that they use an additional physiotherapeutic module in the form of vibration sources, acoustic or ultrasonic vibrations in the form of magnetostrictive or piezoelectric transducers, the working ends of which are in contact either directly with the biological object or through an intermediate medium in the form of physiological saline in contact with the pathological zone. 18. Устройство по п.17, отличающееся тем, что для реализации сочетанной фотосонодинамической терапии рака, инфицированных и дерматологических заболеваний, раствор содержит дополнительно лекарственные препараты и фотосенсибилизатор, длина волны излучателя совпадает с полосой поглощения фотосенсибилизатора, параметры ультразвука выбраны такими, при которых эффекты кавитации активизируют вещества в растворе, а форма матрицы и расположение излучателей на ней обеспечивают равномерную освещенность раствора над областью патологии.18. The device according to p. 17, characterized in that for the implementation of the combined photonodynamic therapy of cancer, infected and dermatological diseases, the solution additionally contains drugs and a photosensitizer, the emitter wavelength coincides with the absorption band of the photosensitizer, the ultrasound parameters are selected such that cavitation effects they activate substances in the solution, and the shape of the matrix and the location of the emitters on it provide uniform illumination of the solution over the pathology area. 19. Устройство по п.1, отличающееся тем, что введен прозрачный колпак полусферической или конической формы с размещенными на внешней поверхности излучателями, примыкающий к краям и к поверхности биообъекта или охватывающий его.19. The device according to claim 1, characterized in that a transparent cap of a hemispherical or conical shape with emitters placed on the outer surface is inserted, adjacent to the edges and to the surface of the biological object or covering it. 20. Устройство по п.1, отличающееся тем, что все устройство выполнено автономным в виде замкнутой капсулы со стенками или частью их, прозрачными для излучения, на внутренней поверхности которой размещены излучатели, ориентированные излучающими поверхностями наружу капсулы.20. The device according to claim 1, characterized in that the entire device is autonomous in the form of a closed capsule with walls or part of them transparent to radiation, on the inner surface of which are emitters oriented by the radiating surfaces to the outside of the capsule. 21. Устройство по п.1, отличающееся тем, что в целях равномерного облучения объемной патологической зоны внутри организма излучатели выполнены в виде химического вещества, равномерно распределенного по объему патологической зоны в результате его селективного накопления при введении в кровь или принудительной импрегнации и флюоресцирующего под влиянием внешних физических факторов, например, высокочастотного электрического поля, рентгеновского излучения или ультразвуковых колебаний.21. The device according to claim 1, characterized in that in order to uniformly irradiate the volumetric pathological zone inside the body, the emitters are made in the form of a chemical substance uniformly distributed over the volume of the pathological zone as a result of its selective accumulation when introduced into the blood or forced impregnation and fluorescent under the influence external physical factors, for example, a high-frequency electric field, x-rays or ultrasonic vibrations. 22. Устройство по п.1, отличающееся тем, что оно выполнено в виде отдельных прямоугольных матричных сегментов с высокой плотностью размещения светодиодов на монолитных интегральных чипах, обеспечивающей плотность мощности на уровне 100-300 мВт/см2, соединенных между собой гибкой связью и равномерно охватывающих область патологии.22. The device according to claim 1, characterized in that it is made in the form of separate rectangular matrix segments with a high density of LEDs on monolithic integrated chips, providing a power density of 100-300 mW / cm 2 , interconnected by a flexible connection and evenly covering the field of pathology. 23. Устройство по п.1, отличающееся тем, что оно выполнено в виде полого цилиндра, помещаемого во внутренние полости организма непосредственно или через соответствующий катетер (трансуретральный, трансректальный, вагинальный и др.) или полую иглу с излучателями, обращенными наружу и размещаемыми или на внешней поверхности цилиндра или на внутренней поверхности цилиндра с оптически прозрачными или диффузными стенками.23. The device according to claim 1, characterized in that it is made in the form of a hollow cylinder placed in the internal cavity of the body directly or through an appropriate catheter (transurethral, transrectal, vaginal, etc.) or a hollow needle with emitters facing out and placed or on the outer surface of the cylinder or on the inner surface of the cylinder with optically transparent or diffuse walls. 24. Устройство по п.1 или 23, отличающееся тем, что излучатели выполнены в виде параллельных линеек, размещены на узких прямоугольных сегментах, фиксируемых на мягкой подложке, или на внутренней, или внешней поверхности цилиндра, параллельно его оси.24. The device according to claim 1 or 23, characterized in that the emitters are made in the form of parallel rulers, placed on narrow rectangular segments fixed on a soft substrate, or on the inner or outer surface of the cylinder, parallel to its axis. 25. Устройство по п.23, отличающееся тем, что компактные излучатели размещены в виде линейки вдоль оси полого цилиндра с прозрачными или диффузными стенками, причем направление максимума диаграммы направленности выбирается в пределах от 0 до 90° по отношению к оси цилиндра.25. The device according to item 23, wherein the compact emitters are placed in a ruler along the axis of the hollow cylinder with transparent or diffuse walls, and the direction of the maximum radiation pattern is selected in the range from 0 to 90 ° with respect to the axis of the cylinder. 26. Устройство по п.1 или 2, отличающееся тем, что содержит системы охлаждения излучателей и/или подложки, размещенные на тыльной стороне, соответственно, излучателей и/или подложки.26. The device according to claim 1 or 2, characterized in that it contains cooling systems for emitters and / or substrates located on the back side, respectively, of emitters and / or substrates. 27. Устройство по п.24, отличающееся тем, что применительно к косметологии, излучатели вместе с гибкими постоянными магнитами и/или электродами электростимулятора встроены в маску, охватывающую лицо пациента.27. The device according to paragraph 24, wherein in relation to cosmetology, the emitters, along with flexible permanent magnets and / or electrostimulator electrodes, are built into the mask covering the patient's face. 28. Устройство по п.1, отличающееся тем, что излучатели встроены в оправу очков, облучающие, как сам глаз, так и примыкающие к нему зоны, причем для индивидуального управления настроением человека, длины волн выбираются и переключаются по заданной программе.28. The device according to claim 1, characterized in that the emitters are built into the frame of the glasses, irradiating both the eye itself and the adjacent areas, moreover, for individual control of a person’s mood, the wavelengths are selected and switched according to a predetermined program. 29. Устройство по п.1, отличающееся тем, что для регулирования веса пациента гибкая матрица закрепляется в местах скопления жировой ткани: на животе, шее, подбородке, бедрах, и/или в местах наибольшей концентрации сосудов крови, причем длина волны в первом случае выбирается исходя из максимальной активации фотохимических процессов, приводящих к рассасыванию жира, в том числе при участии фотосенсибилизаторов, а во втором случае исходя из активации выработки биологических активных веществ, в частности, серотонина, ответственных за регуляцию веса.29. The device according to claim 1, characterized in that for regulating the weight of the patient a flexible matrix is fixed in places of accumulation of adipose tissue: on the abdomen, neck, chin, hips, and / or in places of the highest concentration of blood vessels, the wavelength in the first case is selected based on the maximum activation of photochemical processes leading to the absorption of fat, including with the participation of photosensitizers, and in the second case, based on the activation of the production of biological active substances, in particular, serotonin, responsible for regulation ENA. 30. Устройство по п.29, отличающееся тем, что дополнительно содержит матрицу инфракрасных источников, обеспечивающих нагрев жировой ткани.30. The device according to clause 29, characterized in that it further comprises a matrix of infrared sources, providing heating of adipose tissue. 31. Устройство по пп.29-30, отличающееся тем, что дополнительно содержит модули электростимуляции, ультразвуковой и вакуумной терапии.31. The device according to PP.29-30, characterized in that it further comprises modules of electrical stimulation, ultrasonic and vacuum therapy. 32. Устройство по п.1, отличающееся тем, что для терапии крови излучатели в виде матрицы светодиодов встроены в браслет, охватывающий запястье, или встроенные в часы, и/или ремень для часов.32. The device according to claim 1, characterized in that for the treatment of blood, emitters in the form of a matrix of LEDs are embedded in a bracelet covering the wrist, or integrated in the watch, and / or watch strap. 33. Устройство по п.1, отличающееся тем, что для управления биологическими ритмами, в частности, сном человека и его быстрой временной адаптацией при пересечении им часовых поясов, оно дополнительно содержит таймер, соединенный с блоком управления и включающий излучатели в определенные моменты, согласованные со временем и скоростью пересечения часовых поясов.33. The device according to claim 1, characterized in that for controlling biological rhythms, in particular, a person’s sleep and his quick time adaptation when crossing time zones, it further comprises a timer connected to the control unit and turning on the emitters at certain points agreed upon with the time and speed of crossing time zones. 34. Устройство по п.1, отличающееся тем, что для активизации иммунной системы путем перевода антител из неактивной формы в активную (авидную), излучатели равномерно охватывают тело пациента в зонах, ответственных за формирование иммунного ответа, длина волны излучения выбирается вблизи 0,66 мкм, плотность мощности в диапазоне от 2 до 20 мВт/см2, а время экспозиции от 10 до 50 мин.34. The device according to claim 1, characterized in that to activate the immune system by transferring antibodies from an inactive form to an active (avid) form, the emitters evenly cover the patient’s body in the areas responsible for the formation of the immune response, the radiation wavelength is selected near 0.66 microns, power density in the range from 2 to 20 mW / cm 2 and the exposure time from 10 to 50 minutes 35. Устройство по п.1, отличающееся тем, что для применения в пульмонологии и для лечения туберкулеза, излучатели в виде матрицы светодиодов размещены на гибкой полосе, равномерно охватывающей тело пациента в области легких со стороны груди и/или спины, а длина волны излучения выбрана из диапазона наибольшей прозрачности биоткани 0,7-0,95 мкм и совпадает с полосой поглощения фотосенсибилизатора.35. The device according to claim 1, characterized in that for use in pulmonology and for the treatment of tuberculosis, emitters in the form of a matrix of LEDs are placed on a flexible strip that uniformly covers the patient’s body in the lung region from the chest and / or back, and the radiation wavelength selected from the range of maximum transparency of the biological tissue of 0.7-0.95 μm and coincides with the absorption band of the photosensitizer. 36. Устройство по п.1, отличающееся тем, что для лечения постмастектомических осложнений введен дополнительно модуль механотерапии в виде управляемого давлением воздуха компрессионного бандажа, излучатели размещены на внутренней поверхности бандажа и/или на подложке цилиндрической формы, охватывающей бандаж, который выполнен прозрачным или частично прозрачным для используемого излучения, используются излучатели видимого диапазона длин волн, в сочетании с инфракрасными, как для прогрева патологической зоны, так и фотодинамической терапии в сочетании с фотосенсибилизаторами и/или лекарствами типа кумарина, в том числе для активации иммунной системы.36. The device according to claim 1, characterized in that for the treatment of post-mastectomy complications an additional mechanotherapy module is introduced in the form of an air pressure compression bandage, emitters are placed on the inner surface of the bandage and / or on a cylindrical substrate covering the bandage, which is made transparent or partially transparent to the radiation used, emitters of the visible wavelength range are used, in combination with infrared, both for heating the pathological zone and the photodynamic ter FDI in conjunction with photosensitizers and / or drugs such as coumarin, including the activation of the immune system. 37. Устройство по пп.1, 2, 3 или 4, отличающееся тем, что, с целью повышения эффективности фотофореза, оно снабжено механическими иголками длиной от 5 до 10 мкм, равномерно распределенными по площади подложки, находящимися в контакте с поверхностью биообъекта, а подложка снабжена дополнительно механизмом поджатия иголок к биообъекту.37. The device according to claims 1, 2, 3 or 4, characterized in that, in order to increase the efficiency of photophoresis, it is equipped with mechanical needles from 5 to 10 μm in length, uniformly distributed over the substrate, in contact with the surface of the biological object, and the substrate is additionally equipped with a mechanism for preloading the needles to the bioobject. 38. Устройство по п.1, отличающееся тем, что оно дополнительно содержит модуль электрофореза.38. The device according to claim 1, characterized in that it further comprises an electrophoresis module. 39. Устройство по п.1, отличающееся тем, что заданное распределение освещенности обеспечивается за счет заданного распределения излучателей и/или изменения их мощности, и/или введения масок или фильтров между излучателями и поверхностью биообъекта.39. The device according to claim 1, characterized in that a predetermined distribution of illumination is provided due to a predetermined distribution of emitters and / or changes in their power, and / or the introduction of masks or filters between the emitters and the surface of the biological object.
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