IL84367A

IL84367A - Apparatus for use in radiation therapy

Info

Publication number: IL84367A
Application number: IL8436787A
Authority: IL
Inventors: Lison Jonathan; Mendes Emanuel
Original assignee: Amcor Ltd
Priority date: 1987-11-04
Filing date: 1987-11-04
Publication date: 1994-02-27
Also published as: GB8818809D0; IL102125A; GB2212010A; IL84367A0

Description

84367/ 3 MJ'lp-l lD'Oi WlWWi? BDO apparatus for use in radiation therap The inventors are: Jonathan LISON Emanuel ENDES AMCOR LTD. 13") TlpttK C. 13382 An Apparatus for Use in Radiation Therapy BACKGROUND OF THE IMVEMTIOM This invention relates to an apparatus for use in radiation therapy, and in particular to an apparatus which may effectively be used as a substitute for certain laser radiation devices.

Laser therapy using helium neon lasers, in particular, has existed for many years and, more recently, has been integrated with infrared lasers which has extended the limits of the technique. Among the wide range of laser therapy applications, low power helium neon and minimum power infrared lasers are used in order to effect treatment either to the surface of the body so as to heal wounds, burns and so on, or, alternatively, for the treatment of inflammatory rheumatoid diseases, diseases of the locomotor system, and so on, depending on the depth of penetration of the laser being employed.

Such lasers are not surgical lasers, and are therefore not used in order to cut body tissue. Moreover, they produce no heating effect on the body tissue, and the exact mechanism by which they achieve their therapeutic results is not precisely known. It has been suggested that the specific wavelength associated with laser light, and a cha acteristic of the lasing medium being employed, determines the depth to which it will penetrate body tissue, and be absorbed, reflected and scatte ed thereby. It has also been suggested that the energy of the laser beam excites molecules within the cells of damaged tissue, and thereby accelerates their repair.

Conventional laser therapy is expensive. Helium neon lasers, which utilize a conventional lasing medium, are large and highly expensive. They provide a continuous, relatively low power (approximately 10 mW) beam of coherent radiation having a sharply defined wavelength which remains stable to within ± 1 nm.

Infrared lasers, on the other hand, are based on semi-conductor diode technology, and are very much less expensive than their helium neon counterparts. The output from a laser diode is a sharply diverted cone which is difficult to couple efficiently to an optical system. The output is also highly coherent, resulting from the physics of the laser action, thus dictating the need for diffraction limited collection, focusing and coupling optics. These add significantly to the cost of the resulting system. Laser diodes are, essentially, light emitting diodes (LEDs), wherein the stimulated emission occurs at the same wavelength a corresponding LED would be most likely to emit. However, a higher operating current is required in a laser diode in order to maintain an adequate population inversion by producing a high density of electron-hole pairs. Consequently, the output of a laser diode is essentially monochromatic whilst a comparable LED emits radiation within a somewhat broader spectral bandwidth.

The population inversion in laser diodes is achieved by passing a relatively high current through the diode. However, on account of the relatively high current density through the laser diode, such lasers may only be used in a pulsed mode, wherein a current sufficient to cause population inversion is passed through the diode as a pulse train consisting of pulses of very short duration (in the order nanoseconds). Consequently, the switching frequency of the laser diode needs to be very fast and a powe supply must be provided which can generate such pulses. The electronics required in such a power supply is complex and correspondingly expensive.

In spite of this drawback, laser diodes have many advantages over conventional helium neon lasers for use in medical therapy. They are not only substantially less expensive than conventional helium neon lasers, but are also available with a range of different frequency characte istics, currently in the infrared range. Moreover, on account of their very small size they can be easily manually manipulated, whereas conventional helium neon lasers of equivalent power rating are unmanageably large and require cooling when providing high power output (e.g. 10 W).

It would be desirable to combine the continuous operating characteristics of helium neon lasers with the low cost convenience and high powered pulsed output of laser diodes. It has already been explained that the properties of laser light which are thought to be * 84367/3 responsible tor its therapeutic etfect, are its monochromacity and its coherence; properties that standard LEDs do not exhibit. However, recent research seems to suggest that such LEDs may indeed be used in irradiation equipment to provide effective therapeutic treatment of a wide range of ailments.

Related apparatus in the prior art include U.S. Patent 4,535,784 which shows use of a single LED for stimulating acupuncture points.

U.S. Patent 4,646,743 shows the use of a plurality of LEDs fo'. Eradiating a larger area than a single diode can effectively irradiate.

Summary of the Invention It is an object of the present invention to provide an apparatus for use in radiation therapy. It is a further object of the invention to provide an apparatus for use in radiation therapy wherein the energy from a plurality of radiation sources is concentrated over a zone for biostimulative treatment thereof.

The apparatus comprises: a plurality of light emitting diodes (LEDs) each diode including means for emitting non-coherent light radiation in a narrow bandwidth centered at a designated wavelength and means for concentrating the light radiation of the plurality of diodes and projecting the light radiation to a zone on an area for biostimulative treatment of said zone. 84367/2 The light emitting diodes used in the present invention are standard, lew cost components which are provided with none of the complex optics associated with laser diodes. The diodes of the present invention may be used in either a continuous or pulsed mode, and a control circuit is provided with a selector switch in order to select which mode is to be employed.

The wavelength of the radiation is a function of. the particular type of LED selected and nay be in the. red or infra- red range of the spectrum. Thus, the quality of radiation may easily be predetermined to correspond to that of conventional helium neon cr infra-red lasers without changing the configuration of the radiation source itself.

Preferably, the diodes are connected; in a matrix comprising several parallel banks each of which includes a number of series-connected diodes. The current flowing through each individual bank of diodes is limited by means of a resistor, and the total current flowing through all the parallel banks of diodes is limited by means of a HEXFET. By employing a large number of diodes, a relatively high power radiation source may be constructed with a reasonably sharply defined, predetermined wavelength and a bandwidth of * 25 nm.

When using the system in the continuous mode, a voltage applied across the diode matrix is varied in order to adjust the current flowing through the diodes, and thereby the net power output. When the system is used in the pulsed mode, a pulse chain is applied to the gate of the HEXFET and the total current flowing through the diode matrix and also through the HEXFET may then be varied by changing the frequency and/or the duty cycle of the pulses.

BRIEF DESCRIPTION OF THE DRAWINGS The invention will now be described with regard to an apparatus for use in radiation therapy, employing low cost LEDs, with reference to the accompanying drawings, in which: Fig. 1 is a block diagram showing functionally the apparatus according to the invention; Fig. 2 shows a preferred arrangement for connecting the LEDs shown functionally in Fig. 1; and Fig. 3 shows an arrangement for connecting the LEDs shown in Fig. 2.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENT Referring to Fig. 1, there is shown a compact radiation source 1 and an associated control unit 2. The radiation source 1 comprises a plurality of LEDs which receive power via a driver circuit 6. The control unit 2 contains a power supply 7 coupled to a selector switch 9 whose function is to determine the mode of operation (pulsed or continuous) of the control unit 2. The selector switch 9 is energized via a timer 10 which can be constituted by a standard clock circuit provided with "set time" switches, and whose function is to disable the control circuit 2 after a preset time has elapsed.

One output from the selector switch 9 is fed to an amplitude variation circuit 12 whose output is a variable amplitude d.c. signal which is fed to the driver 6 of the radiation source 1. A second output from the selector switch 9 is fed to a pulse shaper circuit 1 whose output is a square wave pulse of a predetermined amplitude. The output from the pulse shaper circuit 1 t is fed to a duty cycle and frequency variation circuit 16 whose output is fed to the driver 6 of the radiation source 1.

Thus, depending on the position of the selector switch 9, a variable amplitude d.c. signal or, alternatively, a constant amplitude square wave pulse of variable frequency and duty cycle is fed to the driver circuit 6 of the radiation source 1.

Fig. 2 shows the radiation source 1 in greater detail. The LEDs 4 are arranged in the form of a LED matrix 20 comprising a plurality of parallel branches each of which contains a predetermined number of LEDs connected in series. Thus, in Fig. 2 three LEDs 22a, 23a and 24a are connected in series and constitute one parallel branch of the diode matrix 20. The current flowing through this branch is limited by means of- a series resistor ' 26a, and the esulting branch is connected between a high voltage d.c. rail 28 and a low voltage d.c. rail 30. Thus, one terminal of the series connected current-limiting resistor is connected to the high voltage rail 28 whilst the cathode of LED 24a is connected to the low voltage rail 30. The connection of all other branches of the LED matrix 20 is identical.

Connected between the low voltage rail 3 0 of the LED matrix 20 and the ground rail 3 1 is a HEXFET 3 3 which constitutes the driver circuit 6 shown in Fig. 1 . The HEXFET 33 is provided with drain and source terminals connected to supply rails 30 and 3 1 . respectively, and a gate terminal 3 ^ which is coupled, via a series resistor 3 6 , either to the duty cycle and frequency variation circuit 16 or, alternatively, to the amplitude variation circuit 1 2 , depending on the position of the selector switch 9 shown in Fig. 1 , Also connected between the gate terminal 3 ^ of the HEXFET 3 3 and the ground rail 3 1 is a high value shunt resistor 37 . The HEXFET is a field effect transistor which is specially adapted to pass a high current from its drain to source terminals when a voltage is applied at its gate te m i nal .

When the selector switch 9 (Fig. 1 ) is set to "continuous" mode, a variable amplitude d.c. signal is applied to the high voltage rail 28, and a sufficiently high d.c. voltage is applied to the gate 3 ^ of the HEXFET 33 such that the HEXFET 33 acts, effectively, as a closed switch. Under these circumstances, the total current flowing through the LED matrix 20 flows through the HEXFET 3 3 to ground, and this current is limited only by the setting of the amplitude variation circuit 1 2 .

On the other hand, when the selector switch 9 is set to the "pulsed" mode, the signal applied to the gate 3 4 of the HEXFET 3 3 , via the series resistor 3 6 , is a square wave pulse of variable duty cycle and frequency. The amplitude of this, pulse is constant and is such that the HEXFET 33 passes current in response to a non-zero signal on its gate 34. In effect, the HEXFET 33 operates as a switch wherein the current flowing between its drain and source terminals is a function of the d.c. voltage pulse applied to its gate terminal. Thus, in this configuration, the HEXFET 33 acts as a buffer which permits a high amplitude current pulse to pass through the LED matrix 20 in response to a pulse applied to its gate 34.

Fig. 3 shows a preferred arrangement for the physical connections of the LEDs shown schematically in Fig. 2. The LEDs are arranged such that their light output is focused over a sharply defined area. In a preferred embodiment, the area over which the LEDs are focused is substantiall circular with a diameter of 1.2 cm, and this has been found to have beneficial therapeutic results. It will be understood that the greater the number of LEDs connected within the LED matrix 20 of Fig. 2, the greater will be the intensity of the light output by the radiation source 1 (Fig. 1).

The operation of the system is as follows. When the selector switch 9 is set to the "continuous" mode, the amplitude variation circuit 12 operates so as to provide a variable ampl it ude d.c. voltage between the high voltage supply rail 28 and the ground terminal 31 via the HEXFET 33 which, as explained above, fun- ctions as a short circuit. Thus, by varying the setting of the amplitude variation circuit 12, the overall current flowing through the LED matrix 20 may be varied and, therefore, the light intensity of the radiation so ur c e 1.

When the selector switch 9 is set to the "pulsed" mode, a predetermined voltage is applied to the high voltage rail 28, and a square wave pulse of predetermined amplitude is applied to the gate 3^ of the HEXFET 33 via the series resistor 36. Current will only flow through the HEXFET 33 when its gate voltage is greater than a predetermined value (i.e. the pinch-off voltage), or when the pulsed voltage applied to the gate is non-zero. Under these circumstances, the current flowing through the HEXFET 33, and thus through the- LED matrix 20, is a function of the potential difference between the high voltage rail 28 and the ground rail 31. The average current flowing through the HEXFET 33 may thus be varied by varying either the frequency or, alternati ely, the duty cycle of the pulse appearing at its gate 3^· The operator of the system is therefore able to choose two modes of operation by means of the selector switch 9. In the "continuous" mode, the radiation source 1 emits radiation continuously with a magnitude determined by the amplitude variation circuit 12. In the "pulsed" mode, the radiation source 1 emits pulses of radiation whose average intensity may be varied either by varying the duty cycle or, alternatively, the frequency of the pulses produced by the pulse shaper circuit 14.

Although in the preferred embodiment the HEXFET is used as an on-off switch, it is also possible to employ the HEXFET as a current limiter wherein the current flowing from its drain to source terminals is a function of the voltage applied to its gate.

Thus, the invention affords a low cost radiation therapy apparatus producing a non-coherent source of radiation focused over a small area. The exact wavelength of the radiation is confined within a relatively narrow bandwidth (± 25 nm) and its central value may be predetermined by suitable selection of the LEDs in the LED matrix 20. In both the "continuous" and "pulsed" modes of operation, the average intensity of the emitted radiation may easily be varied by the operator, and the therapy time may be preset by means of the integral timer circuit provided. Although the radiation emitted by the radiation source of the invention is neither coherent nor monochromatic, successful therapeutic results have nevertheless been observed. - 10 -

Claims

1. Apparatus for radiation therapy comprising: a plurality of light emitting diodes (LEDs) each diode including means for emitting non-coherent light radiation in a narrow bandwidth centered at a designated wavelength; means for concentrating the light radiation of the plurality of diodes and projecting the light radiation to a zone on a area for biostimulative treatment of said zone.

2. Apparatus according to claim 1 wherein the diodes are activated by application of a voltage differential across the diodes and wherein the apparatus includes means for applying a voltage differential across each of the diodes of said plurality of diodes .

3. Apparatus according to claim 2 wherein the means for applying is operative to apply a constant voltage differential across the diodes for the duration of the biostimulative session. .

4. Apparatus according to claim 2 wherein the means for applying includes means for controlling the current flow through the diodes.

5. , Apparatus according to claim 2 or claim 4 wherein the voltage across the diodes is pulsed during the course of the biostimulative treatment.

6. Apparatus according to claim 6 and including means for varying the frequency of said pulsed voltage.

7. Apparatus according to claim 5 or claim 6 and including means for varying the duty cycle of said pulsed voltage.

8. Apparatus according to any of the preceding claims wherein the zone has an extent of about 1.2 cm. - 11 - 9 .

9. Apparatus according to any of the preceding claims wherein the plurality of LEDs comprises at least 9 LEDs . 1G.

10. Apparatus according to any of the preceding claims and including means for timing the duration of the biostimulative treatment .

11. Apparatus according to any of the preceding claims wherein the means for concentrating is free of lenses.

12. Apparatus according to any of the preceding claims wherein the means for concentrating the light radiation comprises a base, means for mounting each diode to the base and means for orienting the light radiation from each diode toward the zone.

13. · Apparatus according to claim 12 wherein the base is formed in accordance with a convex contour, the means for orienting the light radiation comprising the convex contour.

14. l4. Apparatus according to any of the preceding claims wherein said LEDS are adapted to emit radiation having a predetermined frequency bandwidth.

15. » Apparatus according to claim 14 wherein said frequency bandwidth is approximately +25 nm .

16. Apparatus according to any of , the preceding claims wherein each of the LEDs emits a cone of light, said cones of light being adapted to intersect over said zone. For the applicant, Sanford T. Colb & Co. C: 13382