TWI400104B - Body temperature measurement device and method - Google Patents

Description

Body temperature measuring device and method

The present invention relates to a medical device, and more particularly to a photobiochemical reaction excitation device which is easy to perform and which can alleviate the pain of a living body, and a magnetic induction light-emitting element thereof, and an energy application using the foregoing magnetic induction light-emitting element A device and method for measuring body temperature of a living body of a living body.

According to the Department of Health's investigation of the top ten causes of death among residents in Taiwan, malignant tumors and cerebrovascular diseases have ranked first and second among consecutive years. Stroke has become the third most deadly disease in most developing countries, and patients who survived a stroke face a huge physical, mental and economic burden.

In the treatment of cancer, the conventional method is to treat the tumor by radiotherapy, chemotherapy, photodynamic therapy (PDT), etc. In the study of stroke, the conventional methods include ligation, embolization, and chlorine. Iron-induced, photothrombotic (Photothrombotic) and other methods to establish a rat carotid artery thrombosis model.

The conventional PDT is a method in which a human body applies a photo-sensing drug and then stimulates a tumor site by light to achieve a therapeutic effect by a photobiochemical reaction; a conventional light-induced thrombus cuts the rat neck tissue to The light-sensing drug was injected into the rat body, and then the rat carotid artery was irradiated to generate a thrombus.

However, PDT is easier to treat on the surface of the tumor, but for the tumor in the body, it is not only time-consuming and labor-intensive to introduce the fiber into the body, and it is necessary to repeatedly perform the minimally invasive surgery of the fiber into the body for each course of treatment, so that the patient still has to repeatedly Endure the pain of treatment; photo-induced thrombosis or endothelial cell proliferation, need to be large When the rat carotid artery shines, it will be accompanied by the wound of the neck when it is illuminated, and even after the wound is restored, it can no longer be irradiated. The above two disposal methods are necessary for further improvement.

In addition, in the diagnosis process of the disease, the measurement of body temperature is usually one of the most basic factors of the physician's consideration. It can be seen that the operation of measuring the body temperature of the patient has an unspeakable importance in the whole process of treatment of the disease.

There are many different body temperature measuring devices and methods, such as contact mercury thermometers, alcohol thermometers, and non-contact ear thermometers. The body temperature of the body parts measured by these thermometers is nothing more than the oral temperature, the temperature of the armpits, the temperature of the anus or the temperature inside the ear. Although the operation modes are different, the accuracy of the measured body temperature is also different. However, it does not lose its simple needs. However, the body parts measured by the conventional body temperature measuring device and method are generally limited to the body surface or the parts such as the mouth or anus which are easily accessible to the body surface, and cannot measure the temperature in the body. This is clearly lacking and should be complemented by diseases that require in vivo temperature data to aid diagnosis.

In view of the above, an object of the present invention is to provide a photobiochemical reaction excitation device and a magnetic induction light-emitting device thereof, which can be implanted into a living body for a long time or a semi-long time, and is particularly suitable for applications requiring frequent or multiple photoexcitation. In order to reduce the number of operations, and effectively achieve the desired performance of photoexcitation. It does not require repeated experiments or treatments required for treatment, which not only makes the experimental or therapeutic work easier to perform, but also effectively reduces the pain and reduces the risk of infection in the treated organism.

Another object of the present invention is to provide a body temperature measuring device and method for measuring the temperature of a body part of a living body to assist the physician in performing more Precise disease diagnosis.

To achieve the above and other objects, the present invention provides a photobiochemical reaction excitation device suitable for performing an experiment or treatment of an organism and a magnetic induction light-emitting element therefor. The photobiochemical reaction excitation device comprises: a magnetic induction illuminating element and a magnetic field generating unit, wherein the magnetic induction illuminating element is used for implanting in the living body, so that when the magnetic field passing through the magnetic induction illuminating element is sensed, The light beam required for the photobiochemical reaction process is generated, and the magnetic field generating unit is used to provide a varying magnetic field, so that the magnetic induction light-emitting element implanted in the living body can emit light due to the change of the induced magnetic field.

The magnetic induction light-emitting element comprises: a magnetic conductive base, a wire, an illumination source, and a coating layer for covering the magnetic base, the wire and the light source. The magnetic base has magnetic conductive characteristics, and the wire surrounds the magnetic base so that when the magnetic field passing through the magnetic base changes, an induced voltage is generated at both ends of the wire, and the induced voltage is driven to be configured. The light source on the magnetic base emits a light beam. Since the cladding layer is made of a light transmissive material, the light beam generated by the illumination source can be penetrated to the outside to be used as a light beam of the photobiochemical reaction process.

In one embodiment, the magnetic conductive base is composed of an iron powder core or a silicon steel sheet, the conductive wire is an enamel wire, the light transmissive material for forming the coating layer is silicone or glass, and the light source is a wafer type light emitting diode. The body or the laser diode, and the outer surface of the cladding layer is formed into a capsule shape or an ellipsoidal shape to facilitate implantation into the living body.

In an embodiment, in order to enable the light source to emit light more efficiently, the magnetic induction light-emitting element further includes a driving circuit for applying the induced voltage across the wire to efficiently drive the light source to emit light.

In an embodiment, the magnetic field generating unit includes: a magnetic conductive core and a wire surrounding the magnetic conductive core. Both ends of the wire can be connected to a power source to generate a varying magnetic field.

The present invention further provides a body temperature measuring device for measuring body temperature of various living organisms including humans. The body temperature measuring device includes: a magnetic induction light emitting element, a magnetic field generating unit, a light sensing unit, and a temperature conversion unit.

Wherein, the magnetic field generating unit can provide a magnetic field of change, and the magnetic induction light-emitting element is used for implanting the body part of the living body to be measured, so as to generate a body temperature when the magnetic induction light-emitting element senses a change in the magnetic field. Measure the required beam. The light sensing unit is configured to receive the light beam emitted by the magnetic induction light emitting element to induce the wavelength value thereof. The temperature conversion unit is coupled to the light sensing unit for converting the wavelength value outputted by the light sensing unit to the internal part of the living body according to the wavelength temperature curve of the light beam emitted by the magnetic induction light emitting element. The output value of body temperature.

In one embodiment, the magnetic induction light-emitting element of the body temperature measuring device comprises: a magnetic conductive base, a wire, a light source, and a coating layer for covering the magnetic base, the wire and the light source. The magnetic base has magnetic conductive characteristics, and the wire surrounds the magnetic base so that when the magnetic field passing through the magnetic base changes, an induced voltage is generated at both ends of the wire, and the induced voltage is driven to be configured. The light source on the magnetic base emits a light beam. Since the cladding layer is made of a light transmissive material, the light beam generated by the illumination source can be penetrated to the outside to be used as a light beam required for body temperature measurement.

In one embodiment, the magnetic conductive base is composed of an iron powder core or a silicon steel sheet, the conductive wire is an enamel wire, the light transmissive material for forming the coating layer is silicone or glass, and the light source is a wafer type light emitting diode. Body or laser diode, and The outer surface of the coating layer is formed into a capsule shape or an ellipsoidal shape to facilitate implantation into a living body.

In an embodiment, in order to enable the light source to emit light more efficiently, the magnetic induction light-emitting element further includes a driving circuit for applying the induced voltage across the wire to efficiently drive the light source to emit light.

In an embodiment, the magnetic field generating unit of the body temperature measuring device comprises: a magnetic conductive core and a wire surrounding the magnetic conductive core. Both ends of the wire can be connected to a power source to generate a varying magnetic field.

In one embodiment, the light sensing unit of the body temperature measuring device comprises: a first photosensitive diode, a first resistor, a second photosensitive diode, a second resistor and a wavelength conversion circuit. The first photodiode system is configured to output a first induced current according to the induced light beam. The first resistor is connected in series with the first photodiode to convert the first induced current into the first induced voltage. The second photosensitive diode has a spectral sensing sensitivity curve different from the first photosensitive diode for outputting the second induced current according to the induced light beam. The second resistor is connected in series with the second photosensitive diode for converting the second induced current into the second induced voltage. The wavelength conversion circuit is configured to receive the first induced voltage and the second induced voltage, and convert the wavelength value of the obtained light beam according to a ratio calculation formula of the first induced voltage and the second induced voltage.

The invention further provides a body temperature measuring method suitable for measuring body temperature of various organisms including humans. The body temperature measuring method comprises the steps of first providing a magnetic induction light-emitting element suitable for implantation in a living body, so that when the magnetic induction light-emitting element senses a change in a magnetic field, a light beam required for body temperature measurement is generated. And secondly, providing a magnetic field of change; after that, inducing the light beam emitted by the magnetic induction light-emitting element to obtain the wave of the induced beam The long value; and the wavelength value of the light beam emitted by the magnetic induction light-emitting element is converted into an output value representing the body temperature of the living body.

The step of obtaining the wavelength value includes: sensing the light beam by the photosensitive diode, and outputting the first induced current; converting the first induced current into the first induced voltage; and having a spectral sensation different from the photosensitive diode Measuring another light-sensitive diode of the sensitivity curve to sense the light beam, and outputting a second induced current; converting the second induced current into a second induced voltage; and receiving the first induced voltage and the second induced voltage to be based on the first sensing The ratio of the voltage to the second induced voltage is calculated by converting the wavelength value.

In summary, since the photo-biochemical reaction excitation device of the present invention is used for the experiment or treatment, the magnetic induction illuminating element can be implanted into the living body by injection needle or minimally invasive surgery, and the subsequent operation can be repeated. The photobiochemical reaction experiment or treatment can not only make the experiment or treatment work easier to perform, but also effectively reduce the suffering of the organism due to repeated surgery. In addition, due to the body temperature measuring device and method provided by the present invention, the magnetic induction light-emitting element can be implanted into the body by using an injection needle or a minimally invasive surgery, and converted by the relationship between the wavelength of the generated light beam and the body temperature. By obtaining its temperature output value, it can measure the temperature of the body parts of various organisms including humans, as a reference for assisting physicians to diagnose more accurate diseases.

The above and other objects, features, and advantages of the present invention will become more apparent and understood.

Please refer to FIG. 1, which is a schematic diagram of a photobiochemical reaction excitation device according to a preferred embodiment of the present invention. The photobiochemical reaction excitation device 10 can be used as an auxiliary device for performing photodynamic therapy of an organism, and when the auxiliary device is used for photodynamic therapy, the procedure of repeating minimally invasive surgery can be eliminated, except that the treatment work is easier to perform. In addition, it can effectively alleviate the suffering of patients receiving treatment.

In addition, when the photobiochemical reaction excitation device 10 is used for the experiment of rat carotid endothelial cell proliferation, it is also convenient to administer Rosebengal dye to the rats, and then the photobiochemical reaction is carried out. The magnetic induction illuminating element 11 of the excitation device 10 is placed beside the rat carotid artery to provide the light required for the irradiation, so that the rose red dye is caused by the light to produce the toxin, which gradually causes the proliferation of the carotid artery endothelial cells of the rat. The experimental process is very easy to perform and has outstanding utility.

In FIG. 1, the photobiochemical reaction excitation device 10 includes a magnetic induction light-emitting element 11 and a magnetic field generating unit 12. The magnetic induction light-emitting element 11 includes, for example, a magnetic conductive base 111 composed of an iron powder core or a silicon steel sheet, a wire 112 such as an enameled wire, and a wafer-type light-emitting diode or a laser diode. The body light source 113 and a coating layer 115 made of a light transmissive material such as silicone or glass. The magnetic field generating unit 12 includes, for example, a magnetic core 121 composed of an iron powder core or a silicon steel sheet, and a wire 122 such as an enameled wire surrounding the magnetic core 121.

When the magnetic induction light-emitting element 11 is fabricated, the wire 112 is wound around the magnetic conductive base 111 in a certain direction, and the two ends of the wire 112 are respectively connected to the light-emitting source 113 disposed on the magnetic conductive base 111, and finally, Light transmissive material The magnetic conductive base 111, the wire 112 and the light source 113 are coated to form a coating layer 115 having an outer surface of a capsule shape or an elliptical shape.

In Fig. 1, although the magnetic induction light-emitting element 11 has two wafer-type light-emitting diodes or a light-emitting source 113 of a laser diode, it is known to those skilled in the art that magnetic induction light having a single light-emitting source 113 Element 11 can also achieve the purpose of inductive illumination. In addition, the outer surface of the coating layer 115 is formed into a capsule shape or an ellipsoidal shape, and the magnetic induction light-emitting element 11 is implanted by an injection needle or a minimally invasive surgery only for the purpose of facilitating photobiochemical reaction experiments or treatments. Execution of work in the body.

Please refer to FIG. 2 , which is a schematic diagram of the circuit of FIG. 1 . The principle of the induced light emission of the photobiochemical reaction excitation device 10 will be described below with reference to FIG. 1 and FIG. 2 . First, the two ends of the wire 122 of the magnetic field generating unit 12 are connected to an alternating power source 13 to cause the magnetic field generating unit 12 to generate a varying magnetic field, which is coupled via the magnetic core 121 to a magnetically conductive magnetic field. The susceptor 111 also changes the magnetic field passing through the magnetic susceptor 111. At this time, the two ends of the wire 112 surrounding the magnetic susceptor 111 will generate an induced voltage due to the change of the magnetic field passing through the magnetic susceptor 111, and the induced voltage can alternately drive the illuminating source 113 to emit a light beam. . Since the cladding layer 115 is made of a light-transmitting material, the light beam generated by the light-emitting source 113 can be penetrated to the outside to achieve a photobiochemical reaction function.

Please refer to FIG. 3, which is a circuit diagram of another embodiment of the photobiochemical reaction excitation device according to the present invention. As shown in the figure, the configuration of this embodiment is substantially the same as that shown in FIG. 2. However, in order to enable the light source 313 to emit light more efficiently, the ends of the wires 312 of the magnetic induction light-emitting element 31 in the figure are not Directly connected to the light source 313, but input to the driving circuit 316 is further driven by the output of drive circuit 316. The driving circuit 316 may be a circuit having functions of energy storage, rectification, etc., so that the induced voltage across the wire 312 can be applied to efficiently drive the light source 313 to emit light.

Please refer to FIG. 4, which is a schematic diagram of a body temperature measuring device according to a preferred embodiment of the present invention. The body temperature measuring device 40 can be used to measure the temperature in various living organisms including humans as a reference for assisting the physician in more accurate disease diagnosis.

In the figure, the body temperature measuring device 40 includes a magnetic induction light emitting element 41, a magnetic field generating unit 42, a light sensing unit 43, and a temperature converting unit 44. The structure and manufacturing method of the magnetic induction light-emitting element 41 may be the same as that of the magnetic induction light-emitting element 11 of FIG. 1, or a magnetic induction light-emitting element 31 as shown in FIG. 3 may be used, and the magnetic field generating unit 42 may be used. It is the same as or similar to the magnetic field generating unit 12 of FIG.

The light sensing unit 43 may be any circuit or instrument for measuring the wavelength value of the light beam generated by the magnetic induction light-emitting element 41 to transmit the measured wavelength value to the temperature conversion unit 44 coupled to the light sensing unit 43. The wavelength value outputted by the light sensing unit 43 is converted into an output representing the temperature of the body part of the living body to be measured according to the wavelength temperature curve of the light beam emitted from the magnetic induction light-emitting element 41 (as shown in FIG. 6). value. As shown in the figure, the wavelength of the light beam emitted from the magnetic induction light-emitting element 41 is measured by a light-sensing unit 43 including a photodiode 431, 433, a resistor 432, 434, and a wavelength conversion circuit 435. The principle of induction luminescence and temperature measurement of the body temperature measuring device 40 will be described below with reference to FIG.

First, the magnetic induction light-emitting element 41 suitable for implantation in an organism is implanted into the body part of the living body to be measured by an injection needle or a minimally invasive surgery. The two ends of the wire 422 of the magnetic field generating unit 42 are connected to an alternating power source (please refer to FIG. 2) to cause the magnetic field generating unit 42 to generate a varying magnetic field. This varying magnetic field will be coupled via a magnetically permeable core 421 to a magnetically permeable base 411 that also has magnetically conductive properties, such that the magnetic field passing through the magnetically permeable base 411 also changes.

At this time, the two ends of the wire 412 surrounding the magnetic base 411 will generate an induced voltage due to the change of the magnetic field passing through the magnetic base 411, and the induced voltage can alternately drive the light source 413 to emit a light beam. . Since the cladding layer 415 is made of a light-transmitting material, the light beam generated by the light-emitting source 413 is allowed to penetrate to the outside and is incident on the photosensitive diodes 431 and 433 of the light-sensing unit 43.

In the present embodiment, the photodiode 431, 433 is exemplified by a solar cell and a photodiode, which respectively have different spectral sensing sensitivity curves 501, 502 as shown in FIG. 5, and thus, Under the illumination of the same beam, different induced currents are respectively induced and outputted. The induced currents generated by the light-sensing diodes 431 and 433 are converted into two induced voltages via the series connected resistors 432 and 434, respectively. The two induced voltages are received by the wavelength conversion circuit 435 to calculate the wavelength value of the sensed light beam according to the ratio of the two induced voltages. The wavelength value is further transmitted to the temperature conversion unit 44 to be converted into an internal part of the living body representing the desired measurement according to the wavelength temperature curve of the light beam emitted from the magnetic induction light-emitting element 41 (as shown in FIG. 6). The output value of the temperature.

In Fig. 5, the ratio calculation formula 503 is calculated by the following equation: PD = (PD1 - PD2) / (PD1 + PD2). Wherein, PD1 represents the spectral sensing sensitivity value of the spectral sensing sensitivity curve 501, and PD2 represents the spectral sensing sensitivity. The spectral sensing sensitivity value of the sensitivity curve 502, and PD represents the calculated ratio of the ratio calculation curve 503.

Since the spectral sensing sensitivity curves 501 and 502 are the relationship between the wavelength and the sensing sensitivity, the magnitude of the current or voltage induced by the photosensitive diodes 431 and 433 is determined by the intensity of the light beam generated by the light source 413. Since it changes, it is impossible to directly obtain the wavelength value of the induced beam by the current or voltage induced by the single photodiode 431 or 433. Therefore, the ratio calculation formula 503 corresponding to the calculation ratio and the wavelength value of the current or voltage induced by the photodiode 431, 433 is calculated by the ratio calculation formula as described above, and the photodiode is used. The current or voltage induced by 431 and 433 is substituted into the ratio calculated by the same calculation formula to obtain the wavelength value of the induced beam.

In the embodiment, the reason for using the above calculation formula is that it is possible to obtain a better linearity of the global wavelengths in FIG. However, those skilled in the art are aware that different calculation formulas such as PD=PD1/PD2 can be used to calculate different ratio calculation formulas, thereby using the wavelength conversion circuit 435 to convert the wavelength value of the induced beam. curve.

In the above description, the steps of a body temperature measurement method can be summarized as follows: First, a magnetic induction light-emitting element 41 suitable for implantation in a living body is provided, so that when the magnetic induction light-emitting element 41 senses a change in a magnetic field, A light beam required for body temperature measurement is generated; secondly, a magnetic field is provided; and then the light beam emitted from the magnetic induction light-emitting element 41 is induced to obtain a wavelength value of the induced light beam; and the magnetic induction light-emitting element 41 is used. The wavelength temperature profile of the emitted beam is used to convert the aforementioned wavelength value into an output value representative of the body temperature of the living body.

The step of obtaining the wavelength value includes: sensing the light beam by the photosensitive diode 431, and outputting the first induced current; converting the first induced current into the first induced voltage; and having the difference from the photosensitive diode 431 The other photosensitive diode 433 of the spectral sensing sensitivity curve 501 senses the light beam and outputs a second induced current; converts the second induced current into a second induced voltage; and receives the first induced voltage and the second induced voltage to The wavelength value is converted according to the ratio of the first induced voltage and the second induced voltage.

While the invention has been described above by way of a preferred embodiment, it is not intended to limit the invention, and it is intended to be within the scope of the invention. . Therefore, the scope of the invention is defined by the scope of the appended claims.

10‧‧‧Photobiochemical reaction excitation device

11, 31, 41‧‧‧ Magnetic Induction Light-emitting Elements

111,411‧‧‧magnetic base

112, 122, 312, 412, 422‧‧‧ wires

113, 313, 413 ‧ ‧ illumination source

115, 415‧‧ ‧ coating

12. 42‧‧‧ Magnetic field generating unit

121, 421‧‧‧ magnetic core

13‧‧‧Power supply

316‧‧‧ drive circuit

40‧‧‧ body temperature measuring device

43‧‧‧Light sensing unit

431, 433‧‧‧Photosensitive diode

432, 434‧‧‧ resistance

435‧‧‧wavelength conversion circuit

44‧‧‧Temperature conversion unit

501, 502‧‧ ‧ split light sensing sensitivity curve

503‧‧‧ ratio calculation curve

1 is a schematic view showing a photobiochemical reaction excitation device according to a preferred embodiment of the present invention.

2 is a circuit diagram showing the circuit of FIG. 1.

Fig. 3 is a circuit diagram showing another embodiment of the photobiochemical reaction excitation device according to the present invention.

4 is a schematic view showing a body temperature measuring device according to a preferred embodiment of the present invention.

Fig. 5 is a graph showing the spectral sensitivity of the photosensitive diode of Fig. 4.

Fig. 6 is a graph showing the wavelength temperature of the light source of Fig. 4.

10‧‧‧Photobiochemical reaction excitation device

11‧‧‧Magnetic Inductive Light-Emitting Elements

111‧‧‧magnetic base

112, 122‧‧‧ wires

113‧‧‧Light source

115‧‧‧Cladding

12‧‧‧Magnetic field generating unit

121‧‧‧ magnetic core

Claims (8)

A body temperature measuring device adapted to measure a body temperature of a living body, comprising: a magnetic induction light-emitting element adapted to be implanted into the living body to generate a light beam when a magnetic field is induced to change; a magnetic field generating unit The light sensing unit is configured to receive the light beam to induce a wavelength value of the light beam; and a temperature conversion unit coupled to the light sensing unit for using the magnetic induction light emitting element A wavelength temperature profile of the beam is generated to convert the wavelength value to an output value representative of the body temperature of the organism. The body temperature measuring device of claim 1, wherein the magnetic induction light-emitting element comprises: a magnetic conductive base; a wire surrounding the magnetic conductive base to pass the changed magnetic field When the magnetic base is used, an induced voltage is generated at both ends of the wire; a light source is disposed on the magnetic base to receive the light by driving the induced voltage; and a cladding layer is A light transmissive material is formed to cover the magnetic base, the wire and the light source. The body temperature measuring device according to claim 2, wherein the magnetic conductive base is composed of an iron powder core or a silicon steel sheet, the wire is an enameled wire, and the light transmitting material is silicone or glass, and the light is emitted. The source is a light-emitting diode or a laser diode, and the outer surface of the coating layer is in the form of a capsule or an elliptical sphere. The body temperature measuring device according to claim 2, further comprising a driving circuit for applying the induced voltage to efficiently drive the light source. The body temperature measuring device according to claim 1, wherein the magnetic field generating unit comprises: a magnetic core; and a wire surrounding the magnetic core to generate a magnetic field when the power is connected . The body temperature measuring device of claim 1, wherein the light sensing unit comprises: a first photosensitive diode for outputting a first induced current according to the induced light beam; a first resistor The first photosensitive diode is connected in series to convert the first induced current into a first induced voltage; and the second photosensitive diode has a spectral sensing different from the first photosensitive diode a sensitivity curve for outputting a second induced current according to the induced light beam; a second resistor connected in series with the second photosensitive diode for converting the second induced current into a second induced voltage; And a wavelength conversion circuit for receiving the first induced voltage and the second induced voltage, and converting the obtained wavelength value according to a ratio calculation formula of the first induced voltage and the second induced voltage. A body temperature measuring method suitable for measuring a body temperature of a living body, comprising the steps of: providing a magnetic induction light-emitting element suitable for implanting the living body, when When the magnetic induction light-emitting element senses a magnetic field change, a light beam is generated; the magnetic field is changed; the light beam is induced to obtain a wavelength value of the light beam; and the wavelength value is converted according to the wavelength temperature curve of the light beam. A value is output to represent one of the body temperatures of the organism. The method for measuring body temperature according to claim 7, wherein the step of obtaining the wavelength value comprises: sensing the light beam with a photosensitive diode to output a first induced current; converting the first induced current a first induced voltage; sensing the light beam with another photosensitive diode having a spectral sensitivity sensitivity curve different from the photosensitive diode to output a second induced current; converting the second induced current And a second induced voltage; and receiving the first induced voltage and the second induced voltage to convert the obtained wavelength value according to a ratio calculation formula of the first induced voltage and the second induced voltage.