RU2000100756A - Способы и составы для модулирования сексуальной реакции человека - Google Patents
Способы и составы для модулирования сексуальной реакции человекаInfo
- Publication number
- RU2000100756A RU2000100756A RU2000100756/14A RU2000100756A RU2000100756A RU 2000100756 A RU2000100756 A RU 2000100756A RU 2000100756/14 A RU2000100756/14 A RU 2000100756/14A RU 2000100756 A RU2000100756 A RU 2000100756A RU 2000100756 A RU2000100756 A RU 2000100756A
- Authority
- RU
- Russia
- Prior art keywords
- composition
- composition according
- phentolamine
- vasodilator
- hydrochloride
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 22
- 230000000051 modifying Effects 0.000 title 1
- 230000001568 sexual Effects 0.000 title 1
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical group C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 claims 9
- 229960001999 Phentolamine Drugs 0.000 claims 5
- 229960003056 Phentolamine Mesylate Drugs 0.000 claims 4
- 230000000261 vasodilator Effects 0.000 claims 4
- 239000003071 vasodilator agent Substances 0.000 claims 4
- 239000007937 lozenge Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- SNIOPGDIGTZGOP-UHFFFAOYSA-N 1,2,3-propanetrioltrinitrate Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 claims 1
- 229940068682 Chewable Tablet Drugs 0.000 claims 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N Imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 claims 1
- 229960003509 Moxisylyte Drugs 0.000 claims 1
- VRYMTAVOXVTQEF-UHFFFAOYSA-N Moxisylyte Chemical compound CC(C)C1=CC(OC(C)=O)=C(C)C=C1OCCN(C)C VRYMTAVOXVTQEF-UHFFFAOYSA-N 0.000 claims 1
- 229960004738 Nicotinyl Alcohol Drugs 0.000 claims 1
- MVQVNTPHUGQQHK-UHFFFAOYSA-N Nicotinyl alcohol Chemical compound OCC1=CC=CN=C1 MVQVNTPHUGQQHK-UHFFFAOYSA-N 0.000 claims 1
- 229940014995 Nitroglycerin Drugs 0.000 claims 1
- 239000000006 Nitroglycerin Substances 0.000 claims 1
- XQYZDYMELSJDRZ-UHFFFAOYSA-N Papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 claims 1
- 229960003418 Phenoxybenzamine Drugs 0.000 claims 1
- QZVCTJOXCFMACW-UHFFFAOYSA-N Phenoxybenzamine Chemical compound C=1C=CC=CC=1CN(CCCl)C(C)COC1=CC=CC=C1 QZVCTJOXCFMACW-UHFFFAOYSA-N 0.000 claims 1
- JIVZKJJQOZQXQB-UHFFFAOYSA-N Tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 claims 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N Verapamil Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000007911 effervescent powder Substances 0.000 claims 1
- 239000007938 effervescent tablet Substances 0.000 claims 1
- 229960003711 glyceryl trinitrate Drugs 0.000 claims 1
- 229960004801 imipramine Drugs 0.000 claims 1
- 229960001789 papaverine Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 229960002312 tolazoline Drugs 0.000 claims 1
- 229960001722 verapamil Drugs 0.000 claims 1
Claims (12)
1. Композиция, составляющая перорально вводимые быстрорастворимый порошок, таблетку, жевательную таблетку, шипучую таблетку, шипучий порошок, инкапсулированный порошок, лепешку, пастилку, суспензию и/или раствор, содержащая сосудорасширяющее средство и фармацевтически приемлемый носитель, причем указанная композиция имеет время распадаемости двадцать минут или меньше.
2. Композиция по п. 1, отличающаяся тем, что эта композиция имеет время распадаемости от примерно одной минуты до примерно десяти минут.
3. Композиция по п. 1, отличающаяся тем, что эта композиция имеет время распадаемости менее одной мин.
4. Композиция по любому из пп. 1-3, отличающаяся тем, что сосудорасширяющее средство представляет собой фентоламин, феноксибензамин, нитроглицерин, тимоксамин, никотиниловый спирт, имипрамин, верапамил, изоксуприн, нафтидрофурил, толазолин или папаверин или их производное.
5. Композиция по любому из пп. 1-4, отличающаяся тем, что сосудорасширяющее средство представляет собой мезилат фентоламина.
6. Композиция по п. 5, отличающаяся тем, что эта композиция содержит примерно от 5 до 80 мг мезилата фентоламина.
7. Композиция по п. 5, отличающаяся тем, что эта композиция содержит 40 мг мезилата фентоламина.
8. Композиция по п. 5, отличающаяся тем, что эта композиция содержит 80 мг мезилата фентоламина.
9. Композиция по любому из пп. 1-8, отличающаяся тем, что сосудорасширяющее средство представляет собой гидрохлорид фентоламина.
10. Композиция по п. 9, отличающаяся тем, что эта композиция содержит примерно от 5 до 80 мг гидрохлорида фентоламина.
11. Композиция по п. 9, отличающаяся тем, что эта композиция содержит примерно 40 мг гидрохлорида фентоламина.
12. Композиция по п. 9, отличающаяся тем, что эта композиция содержит примерно 80 мг гидрохлорида фентоламина.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/431,145 | 1995-04-28 | ||
| US08/431,145 US5731339A (en) | 1995-04-28 | 1995-04-28 | Methods and formulations for modulating the human sexual response |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97119646/14A Division RU2177786C2 (ru) | 1995-04-28 | 1996-04-26 | Составы для модулирования сексуальной реакции человека |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000100756A true RU2000100756A (ru) | 2002-01-10 |
| RU2239424C2 RU2239424C2 (ru) | 2004-11-10 |
Family
ID=23710676
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000100756/15A RU2239424C2 (ru) | 1995-04-28 | 1996-04-26 | Композиция для модулирования сексуальной реакции человека |
| RU97119646/14A RU2177786C2 (ru) | 1995-04-28 | 1996-04-26 | Составы для модулирования сексуальной реакции человека |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97119646/14A RU2177786C2 (ru) | 1995-04-28 | 1996-04-26 | Составы для модулирования сексуальной реакции человека |
Country Status (35)
| Country | Link |
|---|---|
| US (6) | US5731339A (ru) |
| EP (2) | EP0767660B1 (ru) |
| JP (2) | JP3469901B2 (ru) |
| KR (1) | KR100363056B1 (ru) |
| CN (1) | CN101816638A (ru) |
| AR (1) | AR001739A1 (ru) |
| AT (1) | ATE185695T1 (ru) |
| AU (1) | AU710111B2 (ru) |
| BG (1) | BG63071B1 (ru) |
| BR (1) | BR9604983A (ru) |
| CA (1) | CA2219502C (ru) |
| CZ (1) | CZ294350B6 (ru) |
| DE (1) | DE69604762T2 (ru) |
| DK (1) | DK0767660T3 (ru) |
| EE (1) | EE03472B1 (ru) |
| ES (1) | ES2140847T3 (ru) |
| GR (1) | GR3032182T3 (ru) |
| HU (1) | HU222044B1 (ru) |
| IL (1) | IL117871A (ru) |
| IS (1) | IS4598A (ru) |
| LT (1) | LT4404B (ru) |
| LV (1) | LV12038B (ru) |
| MD (1) | MD1663C2 (ru) |
| NO (1) | NO314746B1 (ru) |
| NZ (1) | NZ307020A (ru) |
| PL (1) | PL185528B1 (ru) |
| PT (1) | PT767660E (ru) |
| RO (1) | RO116866B1 (ru) |
| RU (2) | RU2239424C2 (ru) |
| SI (1) | SI9620058A (ru) |
| SK (1) | SK283847B6 (ru) |
| TR (2) | TR199701260T1 (ru) |
| UA (1) | UA70277C2 (ru) |
| WO (1) | WO1996033705A1 (ru) |
| ZA (1) | ZA963380B (ru) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731339A (en) * | 1995-04-28 | 1998-03-24 | Zonagen, Inc. | Methods and formulations for modulating the human sexual response |
| US6387407B1 (en) | 1995-09-29 | 2002-05-14 | L.A.M. Pharmaceutical Corporation | Topical drug preparations |
| US5897880A (en) | 1995-09-29 | 1999-04-27 | Lam Pharmaceuticals, Llc. | Topical drug preparations |
| US6251436B1 (en) | 1995-09-29 | 2001-06-26 | L.A.M. Pharmaceutical Corporation | Drug preparations for treating sexual dysfunction |
| US6036977A (en) * | 1995-09-29 | 2000-03-14 | L.A.M. Pharmaceutical Corp. | Drug preparations for treating sexual dysfunction |
| US6258032B1 (en) * | 1997-01-29 | 2001-07-10 | William M. Hammesfahr | Method of diagnosis and treatment and related compositions and apparatus |
| US6323211B1 (en) * | 1996-02-02 | 2001-11-27 | Nitromed, Inc. | Compositions and methods for treating sexual dysfunctions |
| US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
| US20020143007A1 (en) * | 1996-02-02 | 2002-10-03 | Garvey David S. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
| US6469065B1 (en) | 1996-02-02 | 2002-10-22 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use |
| US6294517B1 (en) | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
| US6432401B2 (en) * | 2000-05-12 | 2002-08-13 | Novalar Pharmaceuticals, Inc. | Local anesthetic methods and kits |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| GR1002847B (el) | 1997-05-06 | 1998-01-27 | Χρηση της μισοπροστολης ή/και της μισοπροστολης οξυ για την παρασκευη φαρμακευτικου προιοντος για τη θεραπευτικη αντιμετωπιση των δυσλειτουργιων της στυσεως | |
| ATE333279T1 (de) * | 1997-05-19 | 2006-08-15 | Zonagen Inc | Kombinationstherapie zur modulation der humanen sexualreaktion |
| US20030004170A1 (en) * | 1997-05-19 | 2003-01-02 | Zonagen, Inc. | Combination therapy for modulating the human sexual response |
| ATE315931T1 (de) * | 1997-06-23 | 2006-02-15 | Cellegy Pharma Inc | Microdosistherapie von gefässbedingten erscheinungen durch no-donoren |
| US6399618B1 (en) | 1997-07-09 | 2002-06-04 | Cardiome Pharma Corp | Compositions and methods for modulating sexual activity |
| US6103765A (en) | 1997-07-09 | 2000-08-15 | Androsolutions, Inc. | Methods for treating male erectile dysfunction |
| CA2295595A1 (en) | 1997-07-09 | 1999-01-21 | Androsolutions, Inc. | Improved methods and compositions for treating male erectile dysfunction |
| US5947901A (en) | 1997-09-09 | 1999-09-07 | Redano; Richard T. | Method for hemodynamic stimulation and monitoring |
| US6593369B2 (en) | 1997-10-20 | 2003-07-15 | Vivus, Inc. | Methods, compositions, and kits for enhancing female sexual desire and responsiveness |
| WO1999021562A1 (en) * | 1997-10-28 | 1999-05-06 | Asivi, Llc | Treatment of female sexual dysfunction |
| US5877216A (en) * | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
| US20050070516A1 (en) * | 1997-10-28 | 2005-03-31 | Vivus Inc. | As-needed administration of an androgenic agent to enhance female desire and responsiveness |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| TW380045B (en) | 1998-01-13 | 2000-01-21 | Urometrics Inc | Devices and methods for monitoring female arousal |
| FR2774593B1 (fr) * | 1998-02-12 | 2000-05-05 | Philippe Gorny | Obtention d'un medicament destine a combattre les dysfonctions sexuelles feminines |
| AU4068599A (en) * | 1998-05-20 | 1999-12-06 | Schering Corporation | Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction |
| US6011043A (en) * | 1998-06-19 | 2000-01-04 | Schering Corporation | Combination of phentolamine and apomorphine for the treatment of human sexual function and dysfunction |
| US6031005A (en) | 1998-08-03 | 2000-02-29 | Easterling; W. Jerry | Composition and method for treating Peyronie's disease and related connective tissue disorders |
| US6627663B2 (en) | 1998-08-03 | 2003-09-30 | W. Jerry Easterling | Noninvasive method for treating hemangiomas through transdermal delivery of calcium channel blocker agents and medicament for use in such method |
| US6525100B1 (en) | 1998-08-03 | 2003-02-25 | W. Jerry Easterling | Composition and method for treating peyronie's disease and related fibrotic tissue disorders |
| US20040170675A1 (en) * | 1998-08-03 | 2004-09-02 | Easterling W. Jerry | Noninvasive method for treating cellulite through transdermal delivery of calcium channel blocker agents and medicament for use in such method |
| GR1003199B (el) * | 1998-08-14 | 1999-09-01 | Χρηση της μισοπροστολης ή και της μισοπροστολης οξυ για την παρασκευη φαρμακευτικου προιοντος για τη θεραπευτικη αντιμετωπιση της σεξουαλικης δυσλειτουργιας στις γυναικες | |
| US6284763B1 (en) * | 1998-08-26 | 2001-09-04 | Queen's University At Kingston | Methods for remodeling neuronal and cardiovascular pathways |
| US6482426B1 (en) * | 1998-09-17 | 2002-11-19 | Zonagen, Inc. | Compositions for the treatment of male erectile dysfunction |
| US6706682B2 (en) * | 1999-01-21 | 2004-03-16 | The Trustees Of Columbia University In The City Of New York | Uses of vascular endothelial growth factor in the treatment of erectile dysfunction |
| US6552024B1 (en) | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
| AU3724400A (en) * | 1999-03-08 | 2000-09-28 | Merck & Co., Inc. | Methods and compositions for treating erectile dysfunction |
| JP2002541100A (ja) * | 1999-04-06 | 2002-12-03 | ゾナジェン， インコーポレイテッド | ヒトの性的応答を調節するための方法 |
| AU4663100A (en) | 1999-04-30 | 2000-11-17 | Lilly Icos Llc | Treatment of female arousal disorder |
| IT1312310B1 (it) | 1999-05-07 | 2002-04-15 | Recordati Ind Chimica E Farma | Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale |
| US20010003120A1 (en) * | 1999-05-14 | 2001-06-07 | M. D. Robert Hines | Method for treating erectile dysfunction |
| US6916845B2 (en) * | 1999-06-17 | 2005-07-12 | Zhongcheng Xin | Method for prevention and treatment of male and female sexual dysfunction |
| US6730065B1 (en) * | 2000-09-15 | 2004-05-04 | Ocularis Pharma, Inc. | Night vision composition |
| US6399591B1 (en) * | 2000-01-19 | 2002-06-04 | Yung-Shin Pharmaceutical Ind. Co., Ltd. | Chargeable pharmaceutical tablets |
| US6730691B1 (en) | 2000-02-10 | 2004-05-04 | Miles A. Galin | Uses of alpha adrenergic blocking agents |
| EP1328281B1 (en) * | 2000-06-27 | 2007-08-15 | Qualilife Pharmaceuticals Inc. | Compositions and methods for treating females sexual response |
| BRPI0003386B8 (pt) * | 2000-08-08 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | pró-droga homo ou heterodiméricas úteis no tratamento de doenças ou disfunções mediadas por fosfodiesterases; composições farmacêuticas contendo a pró-droga ou seus sais farmacêuticos aceitáveis; processo de obtenção destas pró-drogas |
| US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| KR20020020536A (ko) * | 2000-09-09 | 2002-03-15 | 장우영 | 발기유발제 |
| US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| US20060211753A1 (en) * | 2000-11-03 | 2006-09-21 | Ocularis Pharma, Inc. | Method and composition which reduces stimulation of muscles which dilate the eye |
| US20020107230A1 (en) * | 2000-12-22 | 2002-08-08 | Waldon R. Forrest | Methods and formulations for the treatment of female sexual dysfunction |
| KR20100036390A (ko) | 2001-03-06 | 2010-04-07 | 셀러지 파마세우티칼스, 인크 | 비뇨생식기 장애 치료용 화합물 및 그 방법 |
| US20020172712A1 (en) * | 2001-03-19 | 2002-11-21 | Alan Drizen | Antiemetic, anti-motion sustained release drug delivery system |
| US20030138494A1 (en) * | 2001-05-15 | 2003-07-24 | L.A.M. Pharmaceutical Corporation | Drug preparations for treating sexual dysfunction |
| WO2003013515A1 (en) | 2001-08-10 | 2003-02-20 | Molectular Design International Inc. | Novel alpha adrenergic agents |
| JP4450365B2 (ja) * | 2001-08-28 | 2010-04-14 | シェーリング コーポレイション | 多環式グアニンホスホジエステラーゼｖ阻害剤 |
| GB0130704D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | New use |
| US8133903B2 (en) * | 2003-10-21 | 2012-03-13 | Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center | Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases |
| AU2003286555A1 (en) * | 2002-10-22 | 2004-05-13 | Harbor-Ucla Research And Education Institute | Phosphodiester inhibitors and nitric oxide modulators for treating peyronie's disease, arteriosclerosis and other fibrotic diseases |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| CN100336506C (zh) * | 2004-04-23 | 2007-09-12 | 北京科信必成医药科技发展有限公司 | 甲磺酸酚妥拉明口腔崩解片及其制备方法 |
| JP2007537247A (ja) | 2004-05-11 | 2007-12-20 | エモーショナル ブレイン ビー．ブイ． | 女性性的機能不全の治療における薬学的製剤およびその使用方法 |
| EP1750862B1 (en) * | 2004-06-04 | 2011-01-05 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical composition containing irbesartan |
| US20060052402A1 (en) * | 2004-09-08 | 2006-03-09 | Woodward John R | Method of female sexual enhancement |
| US20060167022A1 (en) * | 2004-09-08 | 2006-07-27 | Woodward John R | Method of female sexual enhancement |
| US20060252734A1 (en) * | 2004-09-08 | 2006-11-09 | Woodward John R | Methods of female sexual enhancement |
| US20080119445A1 (en) * | 2004-09-08 | 2008-05-22 | Woodward John R | Methods of female sexual enhancement |
| US20060276442A1 (en) * | 2004-09-08 | 2006-12-07 | Woodward John R | Methods of female sexual enhancement |
| WO2006042701A1 (de) * | 2004-10-18 | 2006-04-27 | Polymun Scientific Immunbiologische Forschung Gmbh | Liposomale zusammensetzung einen wirkstoff zur relaxierung glatter muskulatur enthaltend, die herstellung dieser zusammensetzung und deren therapeutische verwendung |
| EP1853272A1 (en) * | 2005-02-03 | 2007-11-14 | Duramed Pharmaceuticals, Inc. | Compositions of unconjugated estrogens and methods for their use |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| JP5584415B2 (ja) | 2005-10-12 | 2014-09-03 | ユニメッド・ファーマシューティカルズ・エルエルシー | 改良したテストステロンゲル製剤及び使用の方法 |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| EP1925307A1 (en) * | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| US20110022149A1 (en) | 2007-06-04 | 2011-01-27 | Cox Brian J | Methods and devices for treatment of vascular defects |
| CA2893761C (en) | 2012-12-05 | 2021-03-02 | Ge Nutrients, Inc. | Use of fenugreek extract to enhance female libido |
| AU2014212275B2 (en) | 2013-02-01 | 2018-09-06 | Ocuphire Pharma, Inc. | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
| DK2950648T3 (da) * | 2013-02-01 | 2019-12-02 | Ocuphire Pharma Inc | Vandige oftalmiske opløsninger af phentolamin og medicinske anvendelser deraf |
| CN104013588A (zh) * | 2014-04-14 | 2014-09-03 | 杨荣辰 | 一种甲磺酸酚妥拉明分散片及其制备方法 |
| WO2016167254A1 (ja) * | 2015-04-17 | 2016-10-20 | 株式会社山田養蜂場本社 | 蜂の子を含有する滋養強壮剤 |
| WO2017100324A1 (en) * | 2015-12-10 | 2017-06-15 | Repros Therapeutics Inc. | Combination therapy for treating female hypoactive sexual desire disorders |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| SG11202104094YA (en) | 2018-10-26 | 2021-05-28 | Ocuphire Pharma Inc | Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders |
| CN115368310A (zh) | 2021-05-18 | 2022-11-22 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2503059A (en) * | 1950-04-04 | Nxchj | ||
| US3937834A (en) * | 1970-10-02 | 1976-02-10 | Ciba-Geigy Corporation | Pharmaceutical preparations |
| US3943246A (en) * | 1972-07-10 | 1976-03-09 | Sandoz Ltd. | Organic compounds |
| US4139617A (en) * | 1974-05-13 | 1979-02-13 | Richardson-Merrell Inc. | 19-Oxygenated-androst-5-enes for the enhancement of libido |
| GB1500300A (en) * | 1975-01-06 | 1978-02-08 | Ciba Geigy Ag | Pharmaceutical preparation for the treatment of circulatory disorders |
| NZ179623A (en) * | 1975-01-06 | 1978-03-06 | Ciba Geigy | Pharmaceutical preparation containing a beta-receptor blocking compound, a compound regulating thrombocyte function and optionally an alpha-receptor blocking compund |
| US4127118B1 (en) * | 1977-03-16 | 1995-12-19 | Alvaro Latorre | Method of effecting and enhancing an erection |
| DE2965278D1 (en) * | 1978-07-21 | 1983-06-01 | Ciba Geigy Ag | Pharmaceutical mixtures containing an amantadine compound |
| US4521421A (en) * | 1983-09-26 | 1985-06-04 | Eli Lilly And Company | Treatment of sexual dysfunction |
| US4530920A (en) * | 1983-11-07 | 1985-07-23 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist |
| EP0152379A3 (de) * | 1984-02-15 | 1986-10-29 | Ciba-Geigy Ag | Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen enthaltend unilamellare Liposomen |
| US4885173A (en) * | 1985-05-01 | 1989-12-05 | University Of Utah | Methods and compositions for noninvasive dose-to-effect administration of drugs with cardiovascular or renal vascular activities |
| US4863911A (en) * | 1986-08-04 | 1989-09-05 | University Of Florida | Method for treating male sexual dysfunction |
| US4801587A (en) * | 1987-03-02 | 1989-01-31 | Gene Voss | Impotence ointment |
| US5256652A (en) * | 1987-11-12 | 1993-10-26 | Pharmedic Co. | Topical compositions and methods for treatment of male impotence |
| SE463851B (sv) * | 1988-09-02 | 1991-02-04 | Amsu Ltd | Komposition foer behandling av erektil dysfunktion via uretra |
| US5059603A (en) * | 1989-06-12 | 1991-10-22 | Centuries Laboratories, Inc. | Method and composition for treating impotence |
| WO1990015583A1 (en) * | 1989-06-16 | 1990-12-27 | Vsesojuzny Nauchno-Issledovatelsky I Ispytatelny Institut Meditsinskoi Tekhniki | Device for treating sexual weakness in men |
| FR2649613B1 (fr) * | 1989-07-11 | 1991-09-27 | Virag Ronald | Medicament vaso-actif |
| US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
| US5236904A (en) * | 1989-09-18 | 1993-08-17 | Senetek, Plc | Erection-inducing methods and compositions |
| US5270323A (en) * | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
| US5399581A (en) * | 1990-12-26 | 1995-03-21 | Laragh; John H. | Method and compositions for treatment of sexual impotence |
| US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
| US5565466A (en) * | 1993-08-13 | 1996-10-15 | Zonagen, Inc. | Methods for modulating the human sexual response |
| US5731339A (en) * | 1995-04-28 | 1998-03-24 | Zonagen, Inc. | Methods and formulations for modulating the human sexual response |
-
1995
- 1995-04-28 US US08/431,145 patent/US5731339A/en not_active Expired - Lifetime
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1996
- 1996-04-11 IL IL11787196A patent/IL117871A/xx not_active IP Right Cessation
- 1996-04-26 EP EP96913174A patent/EP0767660B1/en not_active Expired - Lifetime
- 1996-04-26 NZ NZ307020A patent/NZ307020A/xx not_active IP Right Cessation
- 1996-04-26 KR KR1019970707656A patent/KR100363056B1/ko not_active IP Right Cessation
- 1996-04-26 AR AR33632696A patent/AR001739A1/es not_active Application Discontinuation
- 1996-04-26 CA CA002219502A patent/CA2219502C/en not_active Expired - Lifetime
- 1996-04-26 WO PCT/US1996/005816 patent/WO1996033705A1/en active IP Right Grant
- 1996-04-26 JP JP53273896A patent/JP3469901B2/ja not_active Expired - Lifetime
- 1996-04-26 EP EP99114470A patent/EP0962225A3/en not_active Withdrawn
- 1996-04-26 AU AU55768/96A patent/AU710111B2/en not_active Expired
- 1996-04-26 RU RU2000100756/15A patent/RU2239424C2/ru active
- 1996-04-26 SI SI9620058A patent/SI9620058A/sl unknown
- 1996-04-26 UA UA97105248A patent/UA70277C2/uk unknown
- 1996-04-26 CZ CZ19973393A patent/CZ294350B6/cs not_active IP Right Cessation
- 1996-04-26 AT AT96913174T patent/ATE185695T1/de active
- 1996-04-26 DK DK96913174T patent/DK0767660T3/da active
- 1996-04-26 PT PT96913174T patent/PT767660E/pt unknown
- 1996-04-26 SK SK1458-97A patent/SK283847B6/sk unknown
- 1996-04-26 MD MD98-0007A patent/MD1663C2/ru unknown
- 1996-04-26 RU RU97119646/14A patent/RU2177786C2/ru active
- 1996-04-26 PL PL96323087A patent/PL185528B1/pl unknown
- 1996-04-26 EE EE9700276A patent/EE03472B1/xx not_active IP Right Cessation
- 1996-04-26 BR BR9604983A patent/BR9604983A/pt not_active Application Discontinuation
- 1996-04-26 RO RO97-01998A patent/RO116866B1/ro unknown
- 1996-04-26 ES ES96913174T patent/ES2140847T3/es not_active Expired - Lifetime
- 1996-04-26 TR TR97/01260T patent/TR199701260T1/xx unknown
- 1996-04-26 TR TR1999/01973T patent/TR199901973T2/xx unknown
- 1996-04-26 HU HU9802825A patent/HU222044B1/hu active IP Right Grant
- 1996-04-26 CN CN200910151335A patent/CN101816638A/zh active Pending
- 1996-04-26 DE DE69604762T patent/DE69604762T2/de not_active Expired - Lifetime
- 1996-04-29 ZA ZA963380A patent/ZA963380B/xx unknown
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1997
- 1997-10-24 IS IS4598A patent/IS4598A/is unknown
- 1997-10-27 LV LVP-97-209A patent/LV12038B/en unknown
- 1997-10-27 NO NO19974965A patent/NO314746B1/no not_active IP Right Cessation
- 1997-10-28 LT LT97-168A patent/LT4404B/lt not_active IP Right Cessation
- 1997-10-29 US US08/959,672 patent/US5981563A/en not_active Expired - Lifetime
- 1997-10-31 BG BG102010A patent/BG63071B1/bg unknown
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1998
- 1998-03-10 US US09/037,898 patent/US6100286A/en not_active Expired - Lifetime
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1999
- 1999-07-28 US US09/362,825 patent/US6051594A/en not_active Expired - Lifetime
- 1999-07-28 US US09/362,486 patent/US6124337A/en not_active Expired - Lifetime
- 1999-07-28 US US09/362,518 patent/US6166061A/en not_active Expired - Lifetime
- 1999-12-17 GR GR990403268T patent/GR3032182T3/el unknown
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2001
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