RS65143B1 - Postupci izrade i upotrebe pde9 inhibitora - Google Patents

Postupci izrade i upotrebe pde9 inhibitora

Info

Publication number
RS65143B1
RS65143B1 RS20240126A RSP20240126A RS65143B1 RS 65143 B1 RS65143 B1 RS 65143B1 RS 20240126 A RS20240126 A RS 20240126A RS P20240126 A RSP20240126 A RS P20240126A RS 65143 B1 RS65143 B1 RS 65143B1
Authority
RS
Serbia
Prior art keywords
making
methods
pde9 inhibitors
pde9
inhibitors
Prior art date
Application number
RS20240126A
Other languages
English (en)
Serbian (sr)
Inventor
Niels Svenstrup
Jun Zhang
Jikui Sun
Yuyin Chen
Jianshe Kong
Rujian Ma
Junhua Zhang
Liang Qin
Huanming Xiao
Jinxu Sun
Xiao Meng
Fenglai Sun
Jingyang Zhu
Original Assignee
Cardurion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardurion Pharmaceuticals Inc filed Critical Cardurion Pharmaceuticals Inc
Publication of RS65143B1 publication Critical patent/RS65143B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RS20240126A 2017-05-26 2018-05-25 Postupci izrade i upotrebe pde9 inhibitora RS65143B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762511367P 2017-05-26 2017-05-26
EP18805780.6A EP3630772B1 (en) 2017-05-26 2018-05-25 Methods of making and using pde9 inhibitors
PCT/US2018/034566 WO2018218104A1 (en) 2017-05-26 2018-05-25 Methods of making and using pde9 inhibitors

Publications (1)

Publication Number Publication Date
RS65143B1 true RS65143B1 (sr) 2024-02-29

Family

ID=64396048

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20240126A RS65143B1 (sr) 2017-05-26 2018-05-25 Postupci izrade i upotrebe pde9 inhibitora

Country Status (23)

Country Link
US (2) US11370795B2 (ko)
EP (1) EP3630772B1 (ko)
JP (1) JP2020527535A (ko)
KR (1) KR102627975B1 (ko)
CN (2) CN115746003B (ko)
BR (1) BR112019024877A2 (ko)
CA (1) CA3064004A1 (ko)
DK (1) DK3630772T3 (ko)
EA (1) EA201992721A1 (ko)
ES (1) ES2969895T3 (ko)
FI (1) FI3630772T3 (ko)
HR (1) HRP20240146T1 (ko)
HU (1) HUE065158T2 (ko)
IL (1) IL270792B2 (ko)
LT (1) LT3630772T (ko)
MA (1) MA48793A (ko)
MX (2) MX2019014049A (ko)
PL (1) PL3630772T3 (ko)
PT (1) PT3630772T (ko)
RS (1) RS65143B1 (ko)
SI (1) SI3630772T1 (ko)
TW (2) TWI843393B (ko)
WO (1) WO2018218104A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3865484T (pt) 2015-07-07 2024-01-30 H Lundbeck As Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas
HUE065158T2 (hu) 2017-05-26 2024-05-28 Cardurion Pharmaceuticals Inc PDE9 gátlószereinek elõállítására és alkalmazására szolgáló eljárások
SI3801526T1 (sl) 2018-05-25 2024-05-31 Cardurion Pharmaceuticals, Inc. Monohidratne in kristalinične oblike 6-((3s, 4s)-4-metil-1-(pirimidin-2-ilmetil)pirolidin-3-il)-3-tetrahidropiran-4- il-7h-imidazo (1.5 - a) pirazin-8-ona
CN109734653B (zh) * 2019-02-21 2020-07-14 北京悦康科创医药科技股份有限公司 一种阿加曲班起始原料异构体杂质的拆分方法
WO2020202183A1 (en) * 2019-03-29 2020-10-08 Mylan Laboratories Limited The process for the preparation of upadacitinib and its intermediates
JP2022527630A (ja) * 2019-04-05 2022-06-02 イマラ インク． 鎌状赤血球症を治療するためのｐｄｅ９阻害剤
WO2022036111A1 (en) * 2020-08-13 2022-02-17 Imara Inc. Methods and compositions for treating sickle cell disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100365171B1 (ko) 1994-08-08 2003-02-19 드바이오팜 에스.아. 약학적으로안정한옥살리플라티늄제제
US20040220078A1 (en) 2001-03-02 2004-11-04 Houssam Ibrahim Device for packaging an oxaliplatinum solution
IL161155A0 (en) * 2001-11-02 2004-08-31 Pfizer Prod Inc Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors
WO2004037311A2 (en) 2002-10-21 2004-05-06 Kensey Nash Corporation Device and methods for sequential, regional delivery of multiple cytotoxic agents
GB0522569D0 (en) 2005-11-04 2005-12-14 Univ Bath Biocompatible drug delivery device
JP4579346B2 (ja) 2007-05-11 2010-11-10 ファイザー・インク アミノ複素環式化合物
TWI404721B (zh) 2009-01-26 2013-08-11 Pfizer 胺基－雜環化合物
WO2012040230A1 (en) 2010-09-20 2012-03-29 Envivo Pharmaceuticals, Inc. Imidazotriazinone compounds
SG11201502728WA (en) * 2011-10-10 2015-05-28 Lundbeck & Co As H Pde9i with imidazo pyrazinone backbone
CN104093720B (zh) 2012-01-26 2017-04-12 H.隆德贝克有限公司 具有咪唑并三嗪酮骨架的pde9抑制剂
WO2013170069A1 (en) 2012-05-09 2013-11-14 Massachusetts Institute Of Technology Medicament, method, and drug delivery device for treatment of ovarian cancer
BR112015003836A2 (pt) 2012-08-31 2017-07-04 Taris Biomedical Llc sistemas e métodos para distribuição de drogas para tratamento de câncer de bexiga
WO2014169137A1 (en) 2013-04-10 2014-10-16 Massachusetts Institute Of Technology Local drug delivery devices and methods for treating cancer
WO2015023557A1 (en) 2013-08-12 2015-02-19 Nanomedical Systems, Inc. Device and method for sustained release of low water solubility therapeutic agent in solubilizer
PT3865484T (pt) * 2015-07-07 2024-01-30 H Lundbeck As Inibidor da pde9 com esqueleto de imidazo pirazinona para tratamento de doenças periféricas
HUE065158T2 (hu) 2017-05-26 2024-05-28 Cardurion Pharmaceuticals Inc PDE9 gátlószereinek elõállítására és alkalmazására szolgáló eljárások

Also Published As

Publication number Publication date
MX2023000191A (es) 2023-02-09
TWI843393B (zh) 2024-05-21
EP3630772B1 (en) 2023-11-01
US11370795B2 (en) 2022-06-28
CN115746003B (zh) 2024-08-09
PL3630772T3 (pl) 2024-08-05
TW201908319A (zh) 2019-03-01
CN111183140A (zh) 2020-05-19
HRP20240146T1 (hr) 2024-04-12
SI3630772T1 (sl) 2024-05-31
IL270792B1 (en) 2023-09-01
JP2020527535A (ja) 2020-09-10
IL270792B2 (en) 2024-01-01
CA3064004A1 (en) 2018-11-29
PT3630772T (pt) 2024-02-05
US20230183244A1 (en) 2023-06-15
HUE065158T2 (hu) 2024-05-28
DK3630772T3 (da) 2024-02-05
EA201992721A1 (ru) 2020-09-10
MX2019014049A (es) 2020-07-28
FI3630772T3 (fi) 2024-01-31
TW202334156A (zh) 2023-09-01
IL270792A (en) 2020-01-30
US11999741B2 (en) 2024-06-04
MA48793A (fr) 2020-04-08
EP3630772A1 (en) 2020-04-08
WO2018218104A1 (en) 2018-11-29
CN111183140B (zh) 2022-12-02
TWI791021B (zh) 2023-02-01
US20200157108A1 (en) 2020-05-21
LT3630772T (lt) 2024-02-26
KR20200016891A (ko) 2020-02-17
KR102627975B1 (ko) 2024-01-19
BR112019024877A2 (pt) 2020-06-09
CN115746003A (zh) 2023-03-07
ES2969895T3 (es) 2024-05-23
EP3630772A4 (en) 2021-01-13

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