RS63793B1 - Cnp prolekovi kod kojih je nosač povezan sa cikličnom komponentom - Google Patents
Cnp prolekovi kod kojih je nosač povezan sa cikličnom komponentomInfo
- Publication number
- RS63793B1 RS63793B1 RS20221110A RSP20221110A RS63793B1 RS 63793 B1 RS63793 B1 RS 63793B1 RS 20221110 A RS20221110 A RS 20221110A RS P20221110 A RSP20221110 A RS P20221110A RS 63793 B1 RS63793 B1 RS 63793B1
- Authority
- RS
- Serbia
- Prior art keywords
- ring moiety
- carrier attachment
- cnp prodrugs
- cnp
- prodrugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16150625 | 2016-01-08 | ||
| EP16179288 | 2016-07-13 | ||
| EP16191460 | 2016-09-29 | ||
| EP17700496.7A EP3400019B1 (en) | 2016-01-08 | 2017-01-05 | Cnp prodrugs with carrier attachment at the ring moiety |
| PCT/EP2017/050209 WO2017118698A1 (en) | 2016-01-08 | 2017-01-05 | Cnp prodrugs with carrier attachment at the ring moiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS63793B1 true RS63793B1 (sr) | 2022-12-30 |
Family
ID=57821955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20221110A RS63793B1 (sr) | 2016-01-08 | 2017-01-05 | Cnp prolekovi kod kojih je nosač povezan sa cikličnom komponentom |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11413351B2 (sr) |
| EP (2) | EP3400019B1 (sr) |
| JP (2) | JP6968802B2 (sr) |
| AU (3) | AU2017205688C1 (sr) |
| CA (1) | CA3007979C (sr) |
| DK (1) | DK3400019T3 (sr) |
| ES (1) | ES2934582T3 (sr) |
| HR (1) | HRP20221339T1 (sr) |
| HU (1) | HUE060521T2 (sr) |
| LT (1) | LT3400019T (sr) |
| PL (1) | PL3400019T3 (sr) |
| RS (1) | RS63793B1 (sr) |
| SI (1) | SI3400019T1 (sr) |
| WO (1) | WO2017118698A1 (sr) |
| ZA (1) | ZA201804415B (sr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL259658B2 (en) | 2016-01-08 | 2024-06-01 | Ascendis Pharma Growth Disorders As | Controlled-release CNP agonists with reduced side effects |
| MX2018008050A (es) | 2016-01-08 | 2018-08-23 | Ascendis Pharma Growth Disorders As | Agonistas de peptido natriuretico tipo c (cnp) de liberacion controlada con estabilidad endopeptidasa neutral (nep) incrementada. |
| WO2017118704A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with low npr-c binding |
| DK3400019T3 (da) | 2016-01-08 | 2022-10-24 | Ascendis Pharma Growth Disorders As | CNP-prodrugs med bærerbinding ved ringenheden |
| AU2017205693B2 (en) | 2016-01-08 | 2022-03-31 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
| AU2017205268B2 (en) * | 2016-01-08 | 2022-02-17 | Ascendis Pharma Growth Disorders A/S | CNP prodrugs with large carrier moieties |
| IL290054B2 (en) | 2016-09-29 | 2024-03-01 | Ascendis Pharma Growth Disorders As | Combined treatment with CNP agonists with controlled release |
| EP3592393B1 (en) | 2017-03-10 | 2021-12-01 | QuiaPEG Pharmaceuticals AB | Releasable conjugates |
| BR112021004689A2 (pt) | 2018-09-12 | 2021-06-08 | Quiapeg Pharmaceuticals Ab | conjugados glp-1 liberáveis |
| CA3129352A1 (en) | 2019-02-11 | 2020-08-20 | Ascendis Pharma Growth Disorders A/S | Dry pharmaceutical formulations of cnp conjugates |
| CN114616242A (zh) * | 2019-09-16 | 2022-06-10 | 生物马林药物股份有限公司 | Cnp变体和其共轭物 |
| WO2023227505A1 (en) | 2022-05-23 | 2023-11-30 | Ascendis Pharma Growth Disorders A/S | Liquid pharmaceutical formulations of cnp compounds |
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| US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| CA2345414A1 (en) | 1998-09-28 | 2000-04-06 | Santen Pharmaceutical Co., Ltd. | Eyedrops for promoting lacrimal secretion or treating keratoconjunctival disorders containing natriuretic peptide as active ingredient |
| BRPI0203172B8 (pt) | 2001-09-28 | 2021-05-25 | Nakao Kazuwa | composição farmacêutica para acondroplasia |
| BRPI0213207B1 (pt) | 2001-10-10 | 2021-06-15 | Novo Nordisk A/S | Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação |
| US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| PL377813A1 (pl) * | 2002-11-26 | 2006-02-20 | Biocon Limited | Modyfikowane związki natriuretyczne, ich koniugaty oraz zastosowania |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| CA2521784C (en) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| BR122019000248B8 (pt) | 2004-03-23 | 2021-07-27 | Complex Biosystems Gmbh | reagente de ligador de pró-fármaco de cascata polimérico |
| GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
| CU23556A1 (es) | 2005-11-30 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| CA2662453A1 (en) | 2006-09-08 | 2008-03-13 | Mayo Foundation For Medical Education And Research | Aquaretic and natriuretic polypeptides lacking vasodilatory activity |
| AU2007296054B2 (en) | 2006-09-15 | 2013-03-28 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| MX2009004856A (es) | 2006-11-09 | 2009-06-05 | Alcon Res Ltd | Matriz polimerica insoluble en agua para suministro de farmaco. |
| KR20080098216A (ko) | 2007-05-04 | 2008-11-07 | 한미약품 주식회사 | 캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체 |
| CA2691386C (en) | 2007-06-21 | 2014-12-23 | Technische Universitaet Muenchen | Biological active proteins having increased in vivo and/or in vitro stability |
| US20090016985A1 (en) | 2007-07-11 | 2009-01-15 | Enzon Pharmaceuticals, Inc. | Polymeric drug delivery system containing a multi-substituted aromatic moiety |
| AR069409A1 (es) * | 2007-11-21 | 2010-01-20 | Biomarin Pharm Inc | Variantes de peptidos natriureticos de tipo c |
| PT2237799T (pt) * | 2008-02-01 | 2019-07-05 | Ascendis Pharma As | Pró-fármaco compreendendo um ligador autoclivável |
| TW201004648A (en) | 2008-05-23 | 2010-02-01 | Enzon Pharmaceuticals Inc | Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides |
| ES2566830T3 (es) * | 2008-05-23 | 2016-04-15 | Daiichi Sankyo Company, Limited | Péptido capaz de extender la semivida de péptido de interés en plasma |
| WO2009156481A1 (en) | 2008-06-25 | 2009-12-30 | Ascendis Pharma As | Pegylated bnp |
| WO2010033217A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of cd-np peptides |
| EP2393828B1 (en) | 2009-02-03 | 2016-10-12 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
| AR078044A1 (es) * | 2009-05-20 | 2011-10-12 | Biomarin Pharm Inc | Variantes de peptidos natriureticos de tipo c |
| US9173953B2 (en) | 2009-07-31 | 2015-11-03 | Ascendis Pharma As | Prodrugs containing an aromatic amine connected by an amido bond to a linker |
| WO2011031441A1 (en) | 2009-08-28 | 2011-03-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Therapy with a chimeric molecule and a pro-apoptotic agent |
| WO2011075471A2 (en) | 2009-12-18 | 2011-06-23 | Alcon Research, Ltd. | Novel npr-b agonists and methods of use for the treatment of c-type natriuretic peptide-mediated disorders |
| WO2011082368A2 (en) | 2009-12-31 | 2011-07-07 | Enzon Pharmaceuticals, Inc | Polymeric conjugates of aromatic amine containing compounds including releasable urea linker |
| EP2525831B1 (en) | 2010-01-22 | 2019-05-15 | Ascendis Pharma A/S | Carrier-linked carbamate prodrug linkers |
| EP2525830B1 (en) | 2010-01-22 | 2016-05-11 | Ascendis Pharma A/S | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
| US20130030359A1 (en) | 2010-01-22 | 2013-01-31 | Ascendis Pharma A/S | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
| EP2552967A4 (en) | 2010-04-02 | 2014-10-08 | Amunix Operating Inc | BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE |
| DK2566335T3 (en) | 2010-05-05 | 2016-10-03 | Prolynx Llc | Controlled release of active ingredients from macromolecular CONJUGATES |
| JP5964815B2 (ja) | 2010-05-05 | 2016-08-03 | プロリンクス リミテッド ライアビリティ カンパニー | 固体担体からの放出制御薬物 |
| EP3473261A1 (en) | 2010-05-21 | 2019-04-24 | XL-protein GmbH | Biosynthetic proline/alanine random coil polypeptides and their uses |
| CA2843504C (en) | 2011-08-12 | 2020-08-25 | Ascendis Pharma A/S | Protein carrier-linked prodrugs |
| US20140296257A1 (en) | 2011-08-12 | 2014-10-02 | Ascendis Pharma A/S | High-Loading Water-Soluable Carrier-Linked Prodrugs |
| WO2013024053A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Carrier-linked prodrugs having reversible carboxylic ester linkages |
| WO2013024052A1 (en) | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Carrier-linked treprostinil prodrugs |
| US20140243254A1 (en) | 2011-08-12 | 2014-08-28 | Ascendis Pharma A/S | Polymeric Hyperbranched Carrier-Linked Prodrugs |
| WO2013036857A1 (en) | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
| CA2868925C (en) | 2012-04-25 | 2020-01-21 | Ascendis Pharma A/S | Prodrugs of hydroxyl-comprising drugs |
| EP2853273A4 (en) | 2012-04-25 | 2016-01-13 | Daiichi Sankyo Co Ltd | BONE REPAIR ACCELERATOR |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| JP6536871B2 (ja) | 2013-12-02 | 2019-07-03 | 国立大学法人京都大学 | Ｆｇｆｒ３病の予防および治療剤ならびにそのスクリーニング方法 |
| US20170080049A1 (en) | 2014-02-27 | 2017-03-23 | Daiichi Sankyo Company, Limited | Medicine against growth failure induced by administration of steroid |
| US11633487B2 (en) | 2014-08-06 | 2023-04-25 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
| SG10202011002WA (en) | 2015-01-09 | 2020-12-30 | Ascendis Pharma Growth Disorders As | Cnp prodrugs |
| JP7104625B2 (ja) | 2015-12-08 | 2022-07-21 | バイオマリン ファーマシューティカル インコーポレイテッド | 骨関節炎を処置するためのｃ型ナトリウム利尿ペプチド変異体の使用 |
| WO2017118704A1 (en) | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with low npr-c binding |
| AU2017205693B2 (en) | 2016-01-08 | 2022-03-31 | Ascendis Pharma Growth Disorders A/S | Controlled-release CNP agonists with low initial NPR-B activity |
| DK3400019T3 (da) | 2016-01-08 | 2022-10-24 | Ascendis Pharma Growth Disorders As | CNP-prodrugs med bærerbinding ved ringenheden |
| MX2018008050A (es) | 2016-01-08 | 2018-08-23 | Ascendis Pharma Growth Disorders As | Agonistas de peptido natriuretico tipo c (cnp) de liberacion controlada con estabilidad endopeptidasa neutral (nep) incrementada. |
| IL259658B2 (en) | 2016-01-08 | 2024-06-01 | Ascendis Pharma Growth Disorders As | Controlled-release CNP agonists with reduced side effects |
| AU2017205268B2 (en) | 2016-01-08 | 2022-02-17 | Ascendis Pharma Growth Disorders A/S | CNP prodrugs with large carrier moieties |
| IL290054B2 (en) | 2016-09-29 | 2024-03-01 | Ascendis Pharma Growth Disorders As | Combined treatment with CNP agonists with controlled release |
| MX2021001762A (es) | 2018-08-16 | 2021-04-19 | Beyondspring Pharmaceuticals Inc | Metodo y composicion para estimular la respuesta inmunitaria. |
| CA3129352A1 (en) | 2019-02-11 | 2020-08-20 | Ascendis Pharma Growth Disorders A/S | Dry pharmaceutical formulations of cnp conjugates |
-
2017
- 2017-01-05 DK DK17700496.7T patent/DK3400019T3/da active
- 2017-01-05 CA CA3007979A patent/CA3007979C/en active Active
- 2017-01-05 RS RS20221110A patent/RS63793B1/sr unknown
- 2017-01-05 EP EP17700496.7A patent/EP3400019B1/en active Active
- 2017-01-05 LT LTEPPCT/EP2017/050209T patent/LT3400019T/lt unknown
- 2017-01-05 EP EP22197366.2A patent/EP4162955A1/en active Pending
- 2017-01-05 US US16/067,095 patent/US11413351B2/en active Active
- 2017-01-05 WO PCT/EP2017/050209 patent/WO2017118698A1/en active Application Filing
- 2017-01-05 PL PL17700496.7T patent/PL3400019T3/pl unknown
- 2017-01-05 HU HUE17700496A patent/HUE060521T2/hu unknown
- 2017-01-05 HR HRP20221339TT patent/HRP20221339T1/hr unknown
- 2017-01-05 ES ES17700496T patent/ES2934582T3/es active Active
- 2017-01-05 AU AU2017205688A patent/AU2017205688C1/en active Active
- 2017-01-05 JP JP2018535367A patent/JP6968802B2/ja active Active
- 2017-01-05 SI SI201731268T patent/SI3400019T1/sl unknown
-
2018
- 2018-07-02 ZA ZA2018/04415A patent/ZA201804415B/en unknown
-
2021
- 2021-10-27 JP JP2021175180A patent/JP2022025104A/ja active Pending
- 2021-11-30 AU AU2021277638A patent/AU2021277638C1/en active Active
-
2022
- 2022-06-16 US US17/842,436 patent/US20220331438A1/en active Pending
-
2023
- 2023-08-02 AU AU2023210599A patent/AU2023210599A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017118698A1 (en) | 2017-07-13 |
| HRP20221339T1 (hr) | 2023-01-06 |
| JP2019510735A (ja) | 2019-04-18 |
| AU2017205688B2 (en) | 2021-11-04 |
| EP3400019B1 (en) | 2022-09-28 |
| JP6968802B2 (ja) | 2021-11-17 |
| AU2023210599A1 (en) | 2023-08-24 |
| AU2021277638A1 (en) | 2021-12-23 |
| PL3400019T3 (pl) | 2023-01-23 |
| DK3400019T3 (da) | 2022-10-24 |
| ES2934582T3 (es) | 2023-02-23 |
| ZA201804415B (en) | 2019-03-27 |
| CA3007979A1 (en) | 2017-07-13 |
| AU2017205688A1 (en) | 2018-06-07 |
| SI3400019T1 (sl) | 2023-01-31 |
| AU2017205688C1 (en) | 2022-03-10 |
| HUE060521T2 (hu) | 2023-03-28 |
| US20220331438A1 (en) | 2022-10-20 |
| AU2021277638B2 (en) | 2023-05-18 |
| AU2021277638C1 (en) | 2023-11-09 |
| LT3400019T (lt) | 2022-12-12 |
| US11413351B2 (en) | 2022-08-16 |
| US20190008977A1 (en) | 2019-01-10 |
| JP2022025104A (ja) | 2022-02-09 |
| EP4162955A1 (en) | 2023-04-12 |
| CA3007979C (en) | 2023-12-19 |
| EP3400019A1 (en) | 2018-11-14 |
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