RS55865B1 - Derivati 1-[1-(benzoil)-pirolidin-2-karbonil]-pirolidin-2-karbonitrila - Google Patents

Derivati 1-[1-(benzoil)-pirolidin-2-karbonil]-pirolidin-2-karbonitrila

Info

Publication number
RS55865B1
RS55865B1 RS20170362A RSP20170362A RS55865B1 RS 55865 B1 RS55865 B1 RS 55865B1 RS 20170362 A RS20170362 A RS 20170362A RS P20170362 A RSP20170362 A RS P20170362A RS 55865 B1 RS55865 B1 RS 55865B1
Authority
RS
Serbia
Prior art keywords
formula
compound
carbonitrile
benzyloxy
carbonyl
Prior art date
Application number
RS20170362A
Other languages
English (en)
Serbian (sr)
Inventor
Lledó Ernest Giralt
Clua Teresa Tarragó
Cosano Roger Prades
Gracia Soledad Royo
Original Assignee
Univ Barcelona
Fundació Inst De Recerca Biomédica (Irb Barcelona)
Iproteos S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Barcelona, Fundació Inst De Recerca Biomédica (Irb Barcelona), Iproteos S L filed Critical Univ Barcelona
Publication of RS55865B1 publication Critical patent/RS55865B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Epidemiology (AREA)
RS20170362A 2012-11-12 2013-11-11 Derivati 1-[1-(benzoil)-pirolidin-2-karbonil]-pirolidin-2-karbonitrila RS55865B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12382446.8A EP2730571A1 (en) 2012-11-12 2012-11-12 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
PCT/EP2013/073460 WO2014072498A1 (en) 2012-11-12 2013-11-11 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
EP13794837.8A EP2917209B1 (en) 2012-11-12 2013-11-11 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

Publications (1)

Publication Number Publication Date
RS55865B1 true RS55865B1 (sr) 2017-08-31

Family

ID=47278735

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20170362A RS55865B1 (sr) 2012-11-12 2013-11-11 Derivati 1-[1-(benzoil)-pirolidin-2-karbonil]-pirolidin-2-karbonitrila

Country Status (25)

Country Link
US (2) US10125097B2 (OSRAM)
EP (2) EP2730571A1 (OSRAM)
JP (1) JP6203278B2 (OSRAM)
KR (1) KR102151290B1 (OSRAM)
CN (1) CN104903314B (OSRAM)
AU (1) AU2013343430B2 (OSRAM)
BR (1) BR112015010377A8 (OSRAM)
CA (1) CA2890042C (OSRAM)
CY (1) CY1118818T1 (OSRAM)
DK (1) DK2917209T3 (OSRAM)
EA (1) EA028422B1 (OSRAM)
ES (1) ES2621672T3 (OSRAM)
HR (1) HRP20170485T1 (OSRAM)
HU (1) HUE032472T2 (OSRAM)
LT (1) LT2917209T (OSRAM)
ME (1) ME02706B (OSRAM)
MX (1) MX367488B (OSRAM)
NZ (1) NZ709096A (OSRAM)
PL (1) PL2917209T3 (OSRAM)
PT (1) PT2917209T (OSRAM)
RS (1) RS55865B1 (OSRAM)
SI (1) SI2917209T1 (OSRAM)
SM (1) SMT201700202T1 (OSRAM)
WO (1) WO2014072498A1 (OSRAM)
ZA (1) ZA201504269B (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
EP3031458A1 (en) * 2014-12-09 2016-06-15 Iproteos S.L. Use of 1-[(2-phenylcycloprop-1-yl)carbonyl]-2-[(1,3-thiazolidin-3-yl)carbonyl]perhydroindole in the treatment of schizophrenia-associated cognitive deficits
IL275333B2 (en) 2017-12-15 2023-09-01 Praxis Biotech LLC Inhibitors of fibroblast activation protein
US11504364B2 (en) 2018-12-21 2022-11-22 Praxis Biotech LLC Inhibitors of fibroblast activation protein
BR112023000335A2 (pt) 2020-07-07 2023-01-31 Accure Therapeutics S L 1-[1-(4-benzilóxi-3,5-diflúor-benzoil)-4-flúor-pirrolidina-2-carbonil]-pirrolidina-2-carbonitrila
MY208099A (en) * 2020-12-28 2025-04-15 Sarawak Biodiversity Council Compound for treating neurodegenerative diseases and its isolation method thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0536163A1 (en) * 1990-06-04 1993-04-14 Pfizer Inc. Aromatic pyrrolidine and thiazolidine amides
US6159938A (en) 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
HUT76640A (en) * 1995-08-17 1997-10-28 Chinoin Gyogyszer Es Vegyeszet Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use
DE19603510A1 (de) 1996-02-01 1997-08-07 Knoell Hans Forschung Ev Die Verwendung von Terrecyclolsäure A und Terrecyclolsäure A-Derivate als neue Inhibitoren der humanen Prolyl-Oligopeptidase
KR100568841B1 (ko) * 2000-07-19 2006-04-10 에프. 호프만-라 로슈 아게 엔도텔린-전환 효소의 억제제로서의 피롤리딘 유도체
FI20011466A0 (fi) 2001-07-04 2001-07-04 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö
FI20030014A0 (fi) * 2003-01-03 2003-01-03 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
FI20031018A0 (fi) 2003-07-04 2003-07-04 Orion Corp Parannus aivovammasta toipumiseen
JP4630192B2 (ja) 2003-09-24 2011-02-09 日本化薬株式会社 プロリルオリゴペプチダーゼ阻害剤
US7667044B2 (en) 2003-11-03 2010-02-23 Probiodrug Ag Compounds for the treatment of neurological disorders
EP1760076A1 (en) * 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors
ES2302473B1 (es) 2006-12-22 2009-06-12 Universidad De Barcelona Agente terapeutico para el tratamiento del desorden afectivo bipolar en mamiferos.
US20120053222A1 (en) * 2009-01-23 2012-03-01 Mark Gorrell Novel Metabolic Disease Therapy
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

Also Published As

Publication number Publication date
SMT201700202T1 (it) 2017-05-08
ZA201504269B (en) 2016-09-28
ES2621672T3 (es) 2017-07-04
EP2730571A1 (en) 2014-05-14
AU2013343430A1 (en) 2015-07-02
CA2890042C (en) 2021-06-01
US10125097B2 (en) 2018-11-13
KR102151290B1 (ko) 2020-09-03
HUE032472T2 (en) 2017-10-30
US20190084927A1 (en) 2019-03-21
HK1214597A1 (en) 2016-07-29
MX367488B (es) 2019-08-20
ME02706B (me) 2017-10-20
NZ709096A (en) 2018-04-27
US10611727B2 (en) 2020-04-07
BR112015010377A2 (pt) 2017-07-11
JP6203278B2 (ja) 2017-09-27
LT2917209T (lt) 2017-04-25
EP2917209A1 (en) 2015-09-16
AU2013343430B2 (en) 2017-05-25
BR112015010377A8 (pt) 2018-01-16
CN104903314B (zh) 2018-06-05
PL2917209T3 (pl) 2017-09-29
MX2015005931A (es) 2016-02-05
WO2014072498A1 (en) 2014-05-15
SI2917209T1 (sl) 2017-05-31
EP2917209B1 (en) 2017-02-08
CY1118818T1 (el) 2018-01-10
HRP20170485T1 (hr) 2017-06-02
PT2917209T (pt) 2017-03-31
EA028422B1 (ru) 2017-11-30
EA201590942A1 (ru) 2015-10-30
DK2917209T3 (en) 2017-04-18
CN104903314A (zh) 2015-09-09
US20160168088A1 (en) 2016-06-16
CA2890042A1 (en) 2014-05-15
JP2015536965A (ja) 2015-12-24
KR20150082634A (ko) 2015-07-15

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