EA201590942A1 - Производные 1-[1-(бензоил)пирролидин-2-карбонил]пирролидин-2-карбонитрила - Google Patents

Производные 1-[1-(бензоил)пирролидин-2-карбонил]пирролидин-2-карбонитрила

Info

Publication number
EA201590942A1
EA201590942A1 EA201590942A EA201590942A EA201590942A1 EA 201590942 A1 EA201590942 A1 EA 201590942A1 EA 201590942 A EA201590942 A EA 201590942A EA 201590942 A EA201590942 A EA 201590942A EA 201590942 A1 EA201590942 A1 EA 201590942A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolidin
carbonyl
carbonitrile
derivatives
benzoil
Prior art date
Application number
EA201590942A
Other languages
English (en)
Other versions
EA028422B1 (ru
Inventor
Эрнест Хиральд Льедо
Тереса Тарраго Клуа
Рохер Прадес Косано
Соледад Ройо Грасия
Original Assignee
Университат Де Барселона
Фундасио Институт Де Ресерка Биомедика (Ирб Барселона)
Ипротеос С.Л
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Университат Де Барселона, Фундасио Институт Де Ресерка Биомедика (Ирб Барселона), Ипротеос С.Л filed Critical Университат Де Барселона
Publication of EA201590942A1 publication Critical patent/EA201590942A1/ru
Publication of EA028422B1 publication Critical patent/EA028422B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Настоящее изобретение относится к производным 1-[1-(бензоил)пирролидин-2-карбонил]пирролидин-2-карбонитрила формулы (I), обладающим фармакологической активностью, к способам получения таких соединений, к фармацевтическим композициям, содержащим указанные соединения, и к их применению в терапии и/или в профилактике когнитивного расстройства.
EA201590942A 2012-11-12 2013-11-11 Производные 1-[1-(бензоил)пирролидин-2-карбонил]пирролидин-2-карбонитрила EA028422B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12382446.8A EP2730571A1 (en) 2012-11-12 2012-11-12 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
PCT/EP2013/073460 WO2014072498A1 (en) 2012-11-12 2013-11-11 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

Publications (2)

Publication Number Publication Date
EA201590942A1 true EA201590942A1 (ru) 2015-10-30
EA028422B1 EA028422B1 (ru) 2017-11-30

Family

ID=47278735

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590942A EA028422B1 (ru) 2012-11-12 2013-11-11 Производные 1-[1-(бензоил)пирролидин-2-карбонил]пирролидин-2-карбонитрила

Country Status (25)

Country Link
US (2) US10125097B2 (ru)
EP (2) EP2730571A1 (ru)
JP (1) JP6203278B2 (ru)
KR (1) KR102151290B1 (ru)
CN (1) CN104903314B (ru)
AU (1) AU2013343430B2 (ru)
BR (1) BR112015010377A8 (ru)
CA (1) CA2890042C (ru)
CY (1) CY1118818T1 (ru)
DK (1) DK2917209T3 (ru)
EA (1) EA028422B1 (ru)
ES (1) ES2621672T3 (ru)
HK (1) HK1214597A1 (ru)
HR (1) HRP20170485T1 (ru)
HU (1) HUE032472T2 (ru)
LT (1) LT2917209T (ru)
ME (1) ME02706B (ru)
MX (1) MX367488B (ru)
NZ (1) NZ709096A (ru)
PL (1) PL2917209T3 (ru)
PT (1) PT2917209T (ru)
RS (1) RS55865B1 (ru)
SI (1) SI2917209T1 (ru)
WO (1) WO2014072498A1 (ru)
ZA (1) ZA201504269B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
EP3031458A1 (en) * 2014-12-09 2016-06-15 Iproteos S.L. Use of 1-[(2-phenylcycloprop-1-yl)carbonyl]-2-[(1,3-thiazolidin-3-yl)carbonyl]perhydroindole in the treatment of schizophrenia-associated cognitive deficits
JP2021506972A (ja) 2017-12-15 2021-02-22 プラクシス バイオテック エルエルシー 線維芽細胞活性化タンパク質の阻害剤
CN113811529A (zh) 2018-12-21 2021-12-17 普拉西斯生物技术有限责任公司 成纤维细胞激活蛋白抑制剂
CN117545738A (zh) 2020-07-07 2024-02-09 安克瑞治疗公司 1-[1-(4-苄氧基-3,5-二氟-苯甲酰基)-4-氟-吡咯烷-2-羰基]吡咯烷-2-腈
WO2022146137A1 (en) * 2020-12-28 2022-07-07 Sarawak Biodiversity Council Compound for treating neurodegenerative diseases and its isolation method thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2511605B2 (ja) * 1990-06-04 1996-07-03 ファイザー・インコーポレーテッド 芳香性ピロリジンおよびチアゾリヂンアミド類
US6159938A (en) 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
HUT76640A (en) * 1995-08-17 1997-10-28 Chinoin Gyogyszer Es Vegyeszet Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use
DE19603510A1 (de) 1996-02-01 1997-08-07 Knoell Hans Forschung Ev Die Verwendung von Terrecyclolsäure A und Terrecyclolsäure A-Derivate als neue Inhibitoren der humanen Prolyl-Oligopeptidase
MXPA03000223A (es) * 2000-07-19 2003-06-06 Hoffmann La Roche Derivados de pirrolidina como inhibidores de la enzima conversor de endotelina.
FI20011466A0 (fi) 2001-07-04 2001-07-04 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö
FI20030014A0 (fi) 2003-01-03 2003-01-03 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
FI20031018A0 (fi) 2003-07-04 2003-07-04 Orion Corp Parannus aivovammasta toipumiseen
JP4630192B2 (ja) 2003-09-24 2011-02-09 日本化薬株式会社 プロリルオリゴペプチダーゼ阻害剤
US7667044B2 (en) 2003-11-03 2010-02-23 Probiodrug Ag Compounds for the treatment of neurological disorders
EP1760076A1 (en) * 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors
ES2302473B1 (es) 2006-12-22 2009-06-12 Universidad De Barcelona Agente terapeutico para el tratamiento del desorden afectivo bipolar en mamiferos.
US20120053222A1 (en) * 2009-01-23 2012-03-01 Mark Gorrell Novel Metabolic Disease Therapy
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

Also Published As

Publication number Publication date
SI2917209T1 (sl) 2017-05-31
CY1118818T1 (el) 2018-01-10
EP2917209A1 (en) 2015-09-16
BR112015010377A8 (pt) 2018-01-16
JP2015536965A (ja) 2015-12-24
AU2013343430B2 (en) 2017-05-25
US20190084927A1 (en) 2019-03-21
ME02706B (me) 2017-10-20
WO2014072498A1 (en) 2014-05-15
JP6203278B2 (ja) 2017-09-27
ZA201504269B (en) 2016-09-28
MX367488B (es) 2019-08-20
BR112015010377A2 (pt) 2017-07-11
US20160168088A1 (en) 2016-06-16
KR20150082634A (ko) 2015-07-15
CA2890042C (en) 2021-06-01
ES2621672T3 (es) 2017-07-04
HK1214597A1 (zh) 2016-07-29
HRP20170485T1 (hr) 2017-06-02
MX2015005931A (es) 2016-02-05
KR102151290B1 (ko) 2020-09-03
EA028422B1 (ru) 2017-11-30
LT2917209T (lt) 2017-04-25
PT2917209T (pt) 2017-03-31
PL2917209T3 (pl) 2017-09-29
EP2730571A1 (en) 2014-05-14
US10611727B2 (en) 2020-04-07
HUE032472T2 (en) 2017-10-30
NZ709096A (en) 2018-04-27
US10125097B2 (en) 2018-11-13
CN104903314B (zh) 2018-06-05
CN104903314A (zh) 2015-09-09
CA2890042A1 (en) 2014-05-15
DK2917209T3 (en) 2017-04-18
RS55865B1 (sr) 2017-08-31
AU2013343430A1 (en) 2015-07-02
EP2917209B1 (en) 2017-02-08

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM