MX367488B - Derivados de 1-[1-(benzoil)-pirrolidin-2-carbonil]-pirrolidin-2-ca rbonitrilo. - Google Patents

Derivados de 1-[1-(benzoil)-pirrolidin-2-carbonil]-pirrolidin-2-ca rbonitrilo.

Info

Publication number
MX367488B
MX367488B MX2015005931A MX2015005931A MX367488B MX 367488 B MX367488 B MX 367488B MX 2015005931 A MX2015005931 A MX 2015005931A MX 2015005931 A MX2015005931 A MX 2015005931A MX 367488 B MX367488 B MX 367488B
Authority
MX
Mexico
Prior art keywords
pyrrolidine
benzoyl
carbonyl
carbonitrile derivatives
carbonitrile
Prior art date
Application number
MX2015005931A
Other languages
English (en)
Other versions
MX2015005931A (es
Inventor
Giralt Lledó Ernest
Tarragó Clua Teresa
Prades Cosano Roger
Royo Gracia Soledad
Original Assignee
Univ Barcelona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Barcelona filed Critical Univ Barcelona
Publication of MX2015005931A publication Critical patent/MX2015005931A/es
Publication of MX367488B publication Critical patent/MX367488B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Epidemiology (AREA)

Abstract

La presente invención se refiere a derivados de 1-[1-(benzoil) -pirrolidin-2-carbonil] -pirrolidin-2-carbonitrilo que tienen actividad farmacológica (ver Fórmula) a procedimientos de preparación de tales compuestos, a composiciones farmacéuticas que los comprenden y a su uso en terapia y/o profilaxis de un trastorno cognitivo.
MX2015005931A 2012-11-12 2013-11-11 Derivados de 1-[1-(benzoil)-pirrolidin-2-carbonil]-pirrolidin-2-ca rbonitrilo. MX367488B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12382446.8A EP2730571A1 (en) 2012-11-12 2012-11-12 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
PCT/EP2013/073460 WO2014072498A1 (en) 2012-11-12 2013-11-11 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

Publications (2)

Publication Number Publication Date
MX2015005931A MX2015005931A (es) 2016-02-05
MX367488B true MX367488B (es) 2019-08-20

Family

ID=47278735

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015005931A MX367488B (es) 2012-11-12 2013-11-11 Derivados de 1-[1-(benzoil)-pirrolidin-2-carbonil]-pirrolidin-2-ca rbonitrilo.

Country Status (25)

Country Link
US (2) US10125097B2 (es)
EP (2) EP2730571A1 (es)
JP (1) JP6203278B2 (es)
KR (1) KR102151290B1 (es)
CN (1) CN104903314B (es)
AU (1) AU2013343430B2 (es)
BR (1) BR112015010377A8 (es)
CA (1) CA2890042C (es)
CY (1) CY1118818T1 (es)
DK (1) DK2917209T3 (es)
EA (1) EA028422B1 (es)
ES (1) ES2621672T3 (es)
HR (1) HRP20170485T1 (es)
HU (1) HUE032472T2 (es)
LT (1) LT2917209T (es)
ME (1) ME02706B (es)
MX (1) MX367488B (es)
NZ (1) NZ709096A (es)
PL (1) PL2917209T3 (es)
PT (1) PT2917209T (es)
RS (1) RS55865B1 (es)
SI (1) SI2917209T1 (es)
SM (1) SMT201700202T1 (es)
WO (1) WO2014072498A1 (es)
ZA (1) ZA201504269B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
EP3031458A1 (en) * 2014-12-09 2016-06-15 Iproteos S.L. Use of 1-[(2-phenylcycloprop-1-yl)carbonyl]-2-[(1,3-thiazolidin-3-yl)carbonyl]perhydroindole in the treatment of schizophrenia-associated cognitive deficits
IL275333B2 (en) 2017-12-15 2023-09-01 Praxis Biotech LLC Inhibitors of fibroblast activation protein
CN113811529A (zh) 2018-12-21 2021-12-17 普拉西斯生物技术有限责任公司 成纤维细胞激活蛋白抑制剂
AU2021303440A1 (en) * 2020-07-07 2023-02-02 Accure Therapeutics, S.L. 1-(1-(4-benzyloxy-3,5-difluoro-benzoyl)-4-fluoro-pyrrolidine-2-carbonyl)-pyrrolidine-2-carbonitrile
MY208099A (en) * 2020-12-28 2025-04-15 Sarawak Biodiversity Council Compound for treating neurodegenerative diseases and its isolation method thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018891A1 (en) * 1990-06-04 1991-12-12 Pfizer Inc. Aromatic pyrrolidine and thiazolidine amides
US6159938A (en) 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
HUT76640A (en) * 1995-08-17 1997-10-28 Chinoin Gyogyszer Es Vegyeszet Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use
DE19603510A1 (de) 1996-02-01 1997-08-07 Knoell Hans Forschung Ev Die Verwendung von Terrecyclolsäure A und Terrecyclolsäure A-Derivate als neue Inhibitoren der humanen Prolyl-Oligopeptidase
BR0112580A (pt) * 2000-07-19 2003-06-17 Hoffmann La Roche Compostos, composições farmacêuticas que contêm os mesmos, utilização desses compostos, processo para tratamento terapêutico e/ou profilático e processo para a preparação desses compostos
FI20011466A0 (fi) 2001-07-04 2001-07-04 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö
FI20030014A0 (fi) 2003-01-03 2003-01-03 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
FI20031018A0 (fi) 2003-07-04 2003-07-04 Orion Corp Parannus aivovammasta toipumiseen
WO2005027934A1 (ja) 2003-09-24 2005-03-31 Nippon Kayaku Kabushiki Kaisha プロリルオリゴペプチダーゼ阻害剤
US7667044B2 (en) 2003-11-03 2010-02-23 Probiodrug Ag Compounds for the treatment of neurological disorders
EP1760076A1 (en) * 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors
ES2302473B1 (es) 2006-12-22 2009-06-12 Universidad De Barcelona Agente terapeutico para el tratamiento del desorden afectivo bipolar en mamiferos.
US20120053222A1 (en) * 2009-01-23 2012-03-01 Mark Gorrell Novel Metabolic Disease Therapy
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

Also Published As

Publication number Publication date
NZ709096A (en) 2018-04-27
SMT201700202T1 (it) 2017-05-08
LT2917209T (lt) 2017-04-25
EP2917209B1 (en) 2017-02-08
BR112015010377A8 (pt) 2018-01-16
EP2730571A1 (en) 2014-05-14
BR112015010377A2 (pt) 2017-07-11
JP6203278B2 (ja) 2017-09-27
CY1118818T1 (el) 2018-01-10
AU2013343430A1 (en) 2015-07-02
ES2621672T3 (es) 2017-07-04
CA2890042C (en) 2021-06-01
MX2015005931A (es) 2016-02-05
WO2014072498A1 (en) 2014-05-15
KR20150082634A (ko) 2015-07-15
US10611727B2 (en) 2020-04-07
US10125097B2 (en) 2018-11-13
RS55865B1 (sr) 2017-08-31
HUE032472T2 (en) 2017-10-30
PL2917209T3 (pl) 2017-09-29
AU2013343430B2 (en) 2017-05-25
US20190084927A1 (en) 2019-03-21
CA2890042A1 (en) 2014-05-15
US20160168088A1 (en) 2016-06-16
EA201590942A1 (ru) 2015-10-30
HK1214597A1 (en) 2016-07-29
CN104903314A (zh) 2015-09-09
EA028422B1 (ru) 2017-11-30
HRP20170485T1 (hr) 2017-06-02
CN104903314B (zh) 2018-06-05
PT2917209T (pt) 2017-03-31
KR102151290B1 (ko) 2020-09-03
ME02706B (me) 2017-10-20
EP2917209A1 (en) 2015-09-16
JP2015536965A (ja) 2015-12-24
SI2917209T1 (sl) 2017-05-31
DK2917209T3 (en) 2017-04-18
ZA201504269B (en) 2016-09-28

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