MX2018002699A - Piridinona dicarboxamida para uso como inhibidores de bromodominio. - Google Patents
Piridinona dicarboxamida para uso como inhibidores de bromodominio.Info
- Publication number
- MX2018002699A MX2018002699A MX2018002699A MX2018002699A MX2018002699A MX 2018002699 A MX2018002699 A MX 2018002699A MX 2018002699 A MX2018002699 A MX 2018002699A MX 2018002699 A MX2018002699 A MX 2018002699A MX 2018002699 A MX2018002699 A MX 2018002699A
- Authority
- MX
- Mexico
- Prior art keywords
- dicarboxamide
- pyridinone
- bromodomain inhibitors
- compounds
- bromodomain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula (I) y sales de los mismos, a composiciones farmacéuticas que contienen tales compuestos y a su uso en terapia (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562213137P | 2015-09-02 | 2015-09-02 | |
PCT/EP2016/070519 WO2017037116A1 (en) | 2015-09-02 | 2016-08-31 | Pyridinone dicarboxamide for use as bromodomain inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018002699A true MX2018002699A (es) | 2018-04-13 |
Family
ID=56943472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018002699A MX2018002699A (es) | 2015-09-02 | 2016-08-31 | Piridinona dicarboxamida para uso como inhibidores de bromodominio. |
Country Status (22)
Country | Link |
---|---|
US (2) | US10428026B2 (es) |
EP (1) | EP3344615A1 (es) |
JP (1) | JP6532599B2 (es) |
KR (1) | KR102088157B1 (es) |
CN (1) | CN108137542B (es) |
AR (1) | AR105875A1 (es) |
AU (1) | AU2016315360B2 (es) |
CA (1) | CA2996245C (es) |
CL (1) | CL2018000565A1 (es) |
CO (1) | CO2018002211A2 (es) |
CR (1) | CR20180138A (es) |
DO (1) | DOP2018000062A (es) |
EA (1) | EA033679B1 (es) |
HK (1) | HK1249504A1 (es) |
IL (1) | IL257431B (es) |
MA (1) | MA43940A (es) |
MX (1) | MX2018002699A (es) |
PE (1) | PE20181273A1 (es) |
PH (1) | PH12018500446A1 (es) |
TW (1) | TWI724022B (es) |
UY (1) | UY36875A (es) |
WO (1) | WO2017037116A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20181273A1 (es) | 2015-09-02 | 2018-08-03 | Glaxosmithkline Ip No 2 Ltd | Compuestos |
KR20180052762A (ko) | 2015-09-22 | 2018-05-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 브로모도메인 억제제로서 사용하기 위한 피리디논 디카르복스아미드 |
BR112018006545A2 (pt) | 2015-10-05 | 2018-10-16 | Glaxosmithkline Ip No 2 Ltd | ?composto, composição farmacêutica, combinação, uso de um composto, e, método para tratamento de uma doença ou condição? |
CA3018358A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridyl derivatives as bromodomain inhibitors |
AU2017269673A1 (en) * | 2016-05-24 | 2018-11-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridine dicarboxamide derivatives as bromodomain inhibitors |
GB201703282D0 (en) | 2017-03-01 | 2017-04-12 | Glaxosmithkline Intellectual Property (No 2) Ltd | Compounds |
JOP20190192A1 (ar) | 2017-03-01 | 2019-08-08 | Glaxosmithkline Ip No 2 Ltd | مشتقات بيرازول بوصفها مثبطات برومودومين |
CN108003085A (zh) * | 2017-12-19 | 2018-05-08 | 张开良 | 一种药物中间体芳甲酰基吲哚衍生物的合成方法 |
CN108484494B (zh) * | 2018-06-15 | 2021-07-30 | 沈阳药科大学 | 2-氧代-1,2-二氢吡啶-4-甲酸类化合物 |
GB201814167D0 (en) | 2018-08-31 | 2018-10-17 | Glaxosmithkline Ip No 2 Ltd | Compounds |
KR20230026461A (ko) | 2020-06-23 | 2023-02-24 | 제넨테크, 인크. | 거대고리 화합물 및 이의 사용 방법 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2433158C (en) * | 2000-12-28 | 2011-05-10 | Shionogi & Co., Ltd. | Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor |
JPWO2003070277A1 (ja) | 2002-02-19 | 2005-06-09 | 塩野義製薬株式会社 | 抗掻痒剤 |
AU2003273675A1 (en) | 2002-10-09 | 2004-05-04 | Wayne R. Danter | Protein tyrosine kinase inhibitors |
EP1562901B1 (en) | 2002-11-18 | 2010-06-02 | Schering Corporation | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
EP1433788A1 (en) | 2002-12-23 | 2004-06-30 | Aventis Pharma Deutschland GmbH | Pyrazole-derivatives as factor Xa inhibitors |
SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200700392A (en) | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
RU2490265C2 (ru) * | 2007-11-15 | 2013-08-20 | Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти С.П.А. | Пиридазиноновые производные в качестве ингибиторов parp |
WO2009158315A1 (en) * | 2008-06-25 | 2009-12-30 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
CA2874953A1 (en) | 2012-06-12 | 2013-12-19 | Abbvie Inc. | Pyridinone and pyridazinone derivatives |
MX2015005562A (es) | 2012-11-08 | 2015-07-23 | Squibb Bristol Myers Co | Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa. |
WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
CN105593224B (zh) | 2013-07-31 | 2021-05-25 | 恒元生物医药科技(苏州)有限公司 | 作为溴结构域抑制剂的新型喹唑啉酮类化合物 |
DE102013215912B3 (de) * | 2013-08-12 | 2015-02-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Farbneutral beschichteter kupferhaltiger Gegenstand, Verfahren zu dessen Herstellung sowie Verwendung einer entsprechenden farbneutralen Beschichtung |
EP3089970B1 (en) * | 2013-12-09 | 2018-10-17 | AbbVie Inc. | Dihydropyridinone and dihydropyridazinone derivatives useful as bromodomain inhibitors |
AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
PE20181273A1 (es) * | 2015-09-02 | 2018-08-03 | Glaxosmithkline Ip No 2 Ltd | Compuestos |
BR112018006545A2 (pt) | 2015-10-05 | 2018-10-16 | Glaxosmithkline Ip No 2 Ltd | ?composto, composição farmacêutica, combinação, uso de um composto, e, método para tratamento de uma doença ou condição? |
CA3018358A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridyl derivatives as bromodomain inhibitors |
AU2017269673A1 (en) | 2016-05-24 | 2018-11-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Pyridine dicarboxamide derivatives as bromodomain inhibitors |
-
2016
- 2016-08-31 PE PE2018000339A patent/PE20181273A1/es unknown
- 2016-08-31 UY UY0001036875A patent/UY36875A/es not_active Application Discontinuation
- 2016-08-31 CR CR20180138A patent/CR20180138A/es unknown
- 2016-08-31 CA CA2996245A patent/CA2996245C/en active Active
- 2016-08-31 US US15/757,199 patent/US10428026B2/en active Active
- 2016-08-31 AU AU2016315360A patent/AU2016315360B2/en not_active Ceased
- 2016-08-31 WO PCT/EP2016/070519 patent/WO2017037116A1/en active Application Filing
- 2016-08-31 KR KR1020187009349A patent/KR102088157B1/ko active IP Right Grant
- 2016-08-31 MX MX2018002699A patent/MX2018002699A/es unknown
- 2016-08-31 TW TW105128127A patent/TWI724022B/zh not_active IP Right Cessation
- 2016-08-31 CN CN201680059250.XA patent/CN108137542B/zh active Active
- 2016-08-31 JP JP2018511236A patent/JP6532599B2/ja active Active
- 2016-08-31 EA EA201890331A patent/EA033679B1/ru not_active IP Right Cessation
- 2016-08-31 AR ARP160102662A patent/AR105875A1/es unknown
- 2016-08-31 EP EP16766865.6A patent/EP3344615A1/en active Pending
- 2016-08-31 MA MA043940A patent/MA43940A/fr unknown
-
2018
- 2018-02-08 IL IL257431A patent/IL257431B/en active IP Right Grant
- 2018-02-27 CO CONC2018/0002211A patent/CO2018002211A2/es unknown
- 2018-03-01 PH PH12018500446A patent/PH12018500446A1/en unknown
- 2018-03-02 DO DO2018000062A patent/DOP2018000062A/es unknown
- 2018-03-02 CL CL2018000565A patent/CL2018000565A1/es unknown
- 2018-07-11 HK HK18108983.2A patent/HK1249504A1/zh unknown
-
2019
- 2019-08-08 US US16/535,139 patent/US10927080B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10428026B2 (en) | 2019-10-01 |
AU2016315360A1 (en) | 2018-03-22 |
UY36875A (es) | 2017-03-31 |
DOP2018000062A (es) | 2018-03-30 |
IL257431B (en) | 2021-04-29 |
CR20180138A (es) | 2018-07-16 |
PH12018500446A1 (en) | 2018-09-10 |
KR102088157B1 (ko) | 2020-03-12 |
US20190359572A1 (en) | 2019-11-28 |
CL2018000565A1 (es) | 2018-07-06 |
IL257431A (en) | 2018-04-30 |
HK1249504A1 (zh) | 2018-11-02 |
WO2017037116A1 (en) | 2017-03-09 |
TWI724022B (zh) | 2021-04-11 |
JP6532599B2 (ja) | 2019-06-19 |
CO2018002211A2 (es) | 2018-05-21 |
KR20180043366A (ko) | 2018-04-27 |
US20180258044A1 (en) | 2018-09-13 |
BR112018003827A2 (pt) | 2018-09-25 |
TW201718504A (zh) | 2017-06-01 |
EA201890331A1 (ru) | 2018-08-31 |
JP2018526383A (ja) | 2018-09-13 |
CN108137542A (zh) | 2018-06-08 |
US10927080B2 (en) | 2021-02-23 |
PE20181273A1 (es) | 2018-08-03 |
EA033679B1 (ru) | 2019-11-15 |
AR105875A1 (es) | 2017-11-15 |
CA2996245C (en) | 2023-10-17 |
AU2016315360B2 (en) | 2019-09-12 |
MA43940A (fr) | 2018-12-12 |
CA2996245A1 (en) | 2017-03-09 |
CN108137542B (zh) | 2023-10-27 |
EP3344615A1 (en) | 2018-07-11 |
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