RS54933B1 - Vakcine herpes simpleks virusa - Google Patents

Vakcine herpes simpleks virusa

Info

Publication number
RS54933B1
RS54933B1 RS20160443A RSP20160443A RS54933B1 RS 54933 B1 RS54933 B1 RS 54933B1 RS 20160443 A RS20160443 A RS 20160443A RS P20160443 A RSP20160443 A RS P20160443A RS 54933 B1 RS54933 B1 RS 54933B1
Authority
RS
Serbia
Prior art keywords
sequence
hsv
promoter
sequence encoding
tet
Prior art date
Application number
RS20160443A
Other languages
English (en)
Inventor
Feng Yao
Original Assignee
Brigham & Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital Inc filed Critical Brigham & Womens Hospital Inc
Publication of RS54933B1 publication Critical patent/RS54933B1/sr

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/525—Virus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N2710/00011—Details
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    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
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    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
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    • C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56994—Herpetoviridae, e.g. cytomegalovirus, Epstein-Barr virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Organic Chemistry (AREA)
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Abstract

Replikaciono-defektan, dominantno-negativan Herpes simpleks virus 2 (HSV-2) rekombinovani virus, koji unutar svog genoma obuhvata:a) prvu sekvencu koja kodira prvi HSV-2 glikoprotein D (gD2), pri čemu je pomenuta sekvenca operativno povezana sa prvim tet-O-sadržanim HSV-1ICP4 promoterom;b) drugu sekvencu koja kodira drugi HSV-2 gD2, pri čemu je pomenuta druga sekvenca operativno povezana sa drugim tet-O-sadržanim HSV-1ICP4 promoterom;c) treću sekvencu koja kodira prvi UL9 C535C protein (SEQ ID NO: 2), pri čemu je pomenuta treća sekvenca operativno povezana sa prvim tet-O-sadržanim hCMV neposredno ranim promoterom sa skraćivanjem na -236bp pune dužine promotera; id) četvrtu sekvencu koja kodira drugi UL9 C535C protein (SEQ ID NO: 2) pri čemu je pomenuta četvrta sekvenca operativno povezana sa drugim tet-O-sadržanim hCMV neposredno ranim promoterom sa skraćivanjem na -236bp pune dužine promotera;i gde pomenuti genom ne obuhvata sekvencu koja kodira funkcionalni ICPO protein.Prijava sadrži još 9 patentnih zahteva.
RS20160443A 2009-12-21 2010-12-20 Vakcine herpes simpleks virusa RS54933B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28883609P 2009-12-21 2009-12-21
EP10840033.4A EP2516629B1 (en) 2009-12-21 2010-12-20 Herpes simplex virus vaccines
PCT/US2010/061320 WO2011079073A2 (en) 2009-12-21 2010-12-20 Herpes simplex virus vaccines

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RS54933B1 true RS54933B1 (sr) 2016-10-31

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US (3) US8809047B2 (sr)
EP (1) EP2516629B1 (sr)
JP (2) JP5845191B2 (sr)
KR (1) KR101747987B1 (sr)
CN (1) CN102666843B (sr)
AU (1) AU2010333749B2 (sr)
BR (1) BR112012015172A2 (sr)
CA (1) CA2783330A1 (sr)
DK (1) DK2516629T3 (sr)
HK (1) HK1175807A1 (sr)
HR (1) HRP20160573T1 (sr)
HU (1) HUE029564T2 (sr)
PL (1) PL2516629T3 (sr)
PT (1) PT2516629T (sr)
RS (1) RS54933B1 (sr)
SI (1) SI2516629T1 (sr)
SM (1) SMT201600187B (sr)
WO (1) WO2011079073A2 (sr)
ZA (1) ZA201204192B (sr)

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US20080008686A1 (en) 2006-07-10 2008-01-10 The Brigham And Women's Hospital, Inc. Tetracycline repressor regulated oncolytic viruses
US8796440B2 (en) 2009-08-31 2014-08-05 The Brigham And Women's Hospital, Inc. Promote system for regulatable gene expression in mammalian cells
SI2516629T1 (sl) 2009-12-21 2016-10-28 The Brigham And Women's Hospital, Inc. Cepiva proti virusu herpes simplex
CN106794243A (zh) * 2014-08-26 2017-05-31 哈斯福制药公司 新型免疫剂及其使用方法
BR112019018630A2 (pt) 2017-03-09 2020-04-28 Xiamen University vírus hsv recombinante, vetor viral, célula hospedeira, método para obter o vírus hsv recombinante, composição farmacêutica, método para tratar um tumor e uso do vírus hsv recombinante
US20200172928A1 (en) * 2017-06-05 2020-06-04 The Brigham And Women's Hospital, Inc. Vero cell lines stably expressing hsv icp0 protein
WO2019152821A1 (en) * 2018-02-05 2019-08-08 The Brigham And Women's Hospital, Inc. Recombinant herpes simplex virus-2 expressing glycoprotein b and d antigens
JP2022514112A (ja) 2018-10-15 2022-02-09 リジェネクスバイオ インコーポレイテッド 複製欠損型ウイルスベクター及びウイルスの感染性を測定するための方法

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US9408905B2 (en) 2016-08-09
US20140314811A1 (en) 2014-10-23
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WO2011079073A3 (en) 2012-02-02
SMT201600187B (it) 2016-11-10
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KR20120095450A (ko) 2012-08-28
EP2516629B1 (en) 2016-04-13
US8809047B2 (en) 2014-08-19
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EP2516629A2 (en) 2012-10-31
JP2013514784A (ja) 2013-05-02
AU2010333749B2 (en) 2015-07-30
KR101747987B1 (ko) 2017-06-15
US20120263752A1 (en) 2012-10-18
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BR112012015172A2 (pt) 2017-03-07

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