RS50948B - Karbamatna jedinjenja za upotrebu u sprečavanju ili lečenju neuropatskog bola - Google Patents
Karbamatna jedinjenja za upotrebu u sprečavanju ili lečenju neuropatskog bolaInfo
- Publication number
- RS50948B RS50948B YUP-46/04A YUP4604A RS50948B RS 50948 B RS50948 B RS 50948B YU P4604 A YUP4604 A YU P4604A RS 50948 B RS50948 B RS 50948B
- Authority
- RS
- Serbia
- Prior art keywords
- neuropathic pain
- preventing
- carbamate compounds
- phenyl
- treating neuropathic
- Prior art date
Links
- 208000004296 neuralgia Diseases 0.000 title abstract 2
- 208000021722 neuropathic pain Diseases 0.000 title abstract 2
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Abstract
Upotreba jedinjenja formule (I) u proizvodnji leka za sprečavanje ili lečenje neuropatskog bola;u kojojfenil je supstituisan sa X, sa jednim do pet atoma halogena izabranih iz grupe koju čine fluor, hlor, brom i jod; iR1, R2, R3 i R4 su nezavisno izabrani iz grupe koju čine vodonik i C1-C4 alkil; gde C1-C4 alkil je opciono supstituisan sa fenilom (gde je fenil opciono supstituisan sa supstituentima nezavisno izabranim iz grupe koju čine halogen, C1-C4 alkil, C1-C4 alkoksi, amino, nitro i cijano).Prijava sadrži još 7 patentnih zahteva.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30563601P | 2001-07-16 | 2001-07-16 | |
| PCT/US2002/021897 WO2003007934A1 (en) | 2001-07-16 | 2002-07-11 | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
| US10/193,600 US20030083372A1 (en) | 2001-07-16 | 2002-07-11 | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RS4604A RS4604A (en) | 2006-12-15 |
| RS50948B true RS50948B (sr) | 2010-08-31 |
Family
ID=26889161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-46/04A RS50948B (sr) | 2001-07-16 | 2002-07-11 | Karbamatna jedinjenja za upotrebu u sprečavanju ili lečenju neuropatskog bola |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US20030083372A1 (sr) |
| EP (1) | EP1408954B1 (sr) |
| JP (1) | JP4362367B2 (sr) |
| KR (1) | KR20040016994A (sr) |
| CN (1) | CN1259911C (sr) |
| AT (1) | ATE435014T1 (sr) |
| BR (1) | BR0211244A (sr) |
| CA (1) | CA2454049A1 (sr) |
| CY (1) | CY1109429T1 (sr) |
| DE (1) | DE60232796D1 (sr) |
| DK (1) | DK1408954T3 (sr) |
| ES (1) | ES2327721T3 (sr) |
| HK (1) | HK1063435A1 (sr) |
| HU (1) | HUP0401367A2 (sr) |
| IL (1) | IL159847A0 (sr) |
| MX (1) | MXPA04000554A (sr) |
| NO (1) | NO20040176L (sr) |
| NZ (1) | NZ549752A (sr) |
| PL (1) | PL368164A1 (sr) |
| PT (1) | PT1408954E (sr) |
| RS (1) | RS50948B (sr) |
| RU (1) | RU2303445C2 (sr) |
| WO (1) | WO2003007934A1 (sr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04000554A (es) * | 2001-07-16 | 2005-02-17 | Johnson & Johnson | Compuestos de carbamato para utilizarse en la prevencion o tratamiento del dolor neuropatico y el dolor asociado con la cefalea acuminada y migranosa. |
| KR20140113919A (ko) | 2011-12-27 | 2014-09-25 | (주)바이오팜솔루션즈 | 다발성 경화증의 치료 또는 예방에 사용되는 페닐카바메이트 화합물 |
| WO2018041755A1 (en) | 2016-08-31 | 2018-03-08 | Evonik Oil Additives Gmbh | Comb polymers for improving noack evaporation loss of engine oil formulations |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
| US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| US3505055A (en) * | 1966-12-07 | 1970-04-07 | Uniroyal Inc | Method of controlling plant growth with carboxamidothiazoles |
| CA2081935C (en) * | 1991-11-22 | 2004-05-25 | Karl Eicken | Anilide derivatives and their use for combating botrytis |
| DE4231519A1 (de) * | 1992-09-21 | 1994-03-24 | Basf Ag | Cyclohex(en)ylcarbonsäureamide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen |
| DE4231517A1 (de) * | 1992-09-21 | 1994-03-24 | Basf Ag | Carbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen |
| US5633218A (en) * | 1995-05-24 | 1997-05-27 | E. I. Du Pont De Nemours And Company | Herbicidal benzodioxoles and benzodioxanes |
| DE19531813A1 (de) * | 1995-08-30 | 1997-03-06 | Basf Ag | Bisphenylamide |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
| DE19735224A1 (de) * | 1997-08-15 | 1999-02-18 | Basf Ag | Biphenylamide |
| GB0012671D0 (en) * | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| EP1305082B1 (en) | 2000-07-21 | 2004-05-26 | Ortho-McNeil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain |
| CN1250215C (zh) | 2001-02-27 | 2006-04-12 | 奥索-麦克尼尔药品公司 | 用于预防或治疗双相性精神障碍的氨基甲酸酯化合物 |
| PT1404312E (pt) * | 2001-02-27 | 2011-02-01 | Ortho Mcneil Pharm Inc | Compostos carbamato para utilização no tratamento de dor |
| EP1401424B1 (en) | 2001-02-27 | 2006-11-29 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating psychotic disorders |
| US6589985B2 (en) | 2001-02-27 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Carbamate compounds for use in preventing or treating movement disorders |
| MXPA04000554A (es) * | 2001-07-16 | 2005-02-17 | Johnson & Johnson | Compuestos de carbamato para utilizarse en la prevencion o tratamiento del dolor neuropatico y el dolor asociado con la cefalea acuminada y migranosa. |
| DE10204390A1 (de) * | 2002-02-04 | 2003-08-14 | Bayer Cropscience Ag | Disubstituierte Thiazolylcarboxanilide |
| DE10204391A1 (de) * | 2002-02-04 | 2003-08-14 | Bayer Cropscience Ag | Difluormethylthiazolylcarboxanilide |
| DE10215292A1 (de) * | 2002-02-19 | 2003-08-28 | Bayer Cropscience Ag | Disubstitutierte Pyrazolylcarbocanilide |
| DE10246959A1 (de) * | 2002-10-09 | 2004-04-22 | Bayer Cropscience Ag | Thiazolylbiphenylamide |
| DE10347090A1 (de) * | 2003-10-10 | 2005-05-04 | Bayer Cropscience Ag | Synergistische fungizide Wirkstoffkombinationen |
-
2002
- 2002-07-11 MX MXPA04000554A patent/MXPA04000554A/es active IP Right Grant
- 2002-07-11 EP EP02756434A patent/EP1408954B1/en not_active Expired - Lifetime
- 2002-07-11 WO PCT/US2002/021897 patent/WO2003007934A1/en active IP Right Grant
- 2002-07-11 KR KR10-2004-7000649A patent/KR20040016994A/ko active IP Right Grant
- 2002-07-11 RS YUP-46/04A patent/RS50948B/sr unknown
- 2002-07-11 JP JP2003513542A patent/JP4362367B2/ja not_active Expired - Fee Related
- 2002-07-11 IL IL15984702A patent/IL159847A0/xx unknown
- 2002-07-11 RU RU2004100966/14A patent/RU2303445C2/ru not_active IP Right Cessation
- 2002-07-11 HU HU0401367A patent/HUP0401367A2/hu unknown
- 2002-07-11 PT PT02756434T patent/PT1408954E/pt unknown
- 2002-07-11 ES ES02756434T patent/ES2327721T3/es not_active Expired - Lifetime
- 2002-07-11 NZ NZ549752A patent/NZ549752A/xx not_active IP Right Cessation
- 2002-07-11 DE DE60232796T patent/DE60232796D1/de not_active Expired - Lifetime
- 2002-07-11 AT AT02756434T patent/ATE435014T1/de not_active IP Right Cessation
- 2002-07-11 BR BR0211244-2A patent/BR0211244A/pt not_active IP Right Cessation
- 2002-07-11 CN CNB028180194A patent/CN1259911C/zh not_active Expired - Fee Related
- 2002-07-11 CA CA002454049A patent/CA2454049A1/en not_active Abandoned
- 2002-07-11 US US10/193,600 patent/US20030083372A1/en not_active Abandoned
- 2002-07-11 PL PL02368164A patent/PL368164A1/xx not_active Application Discontinuation
- 2002-07-11 DK DK02756434T patent/DK1408954T3/da active
-
2004
- 2004-01-15 NO NO20040176A patent/NO20040176L/no not_active Application Discontinuation
- 2004-06-16 US US10/869,406 patent/US7087643B2/en not_active Expired - Fee Related
- 2004-08-20 HK HK04106260.6A patent/HK1063435A1/xx not_active IP Right Cessation
-
2005
- 2005-02-24 US US11/120,278 patent/US20050250847A1/en not_active Abandoned
-
2006
- 2006-05-26 US US11/442,445 patent/US20090105334A1/en not_active Abandoned
-
2009
- 2009-09-24 CY CY20091100998T patent/CY1109429T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04000554A (es) | 2005-02-17 |
| US20030083372A1 (en) | 2003-05-01 |
| US20040259944A1 (en) | 2004-12-23 |
| JP2005502631A (ja) | 2005-01-27 |
| PT1408954E (pt) | 2009-07-28 |
| IL159847A0 (en) | 2004-06-20 |
| US7087643B2 (en) | 2006-08-08 |
| CA2454049A1 (en) | 2003-01-30 |
| RU2303445C2 (ru) | 2007-07-27 |
| PL368164A1 (en) | 2005-03-21 |
| HK1063435A1 (en) | 2004-12-31 |
| US20050250847A1 (en) | 2005-11-10 |
| NZ549752A (en) | 2008-04-30 |
| BR0211244A (pt) | 2004-07-27 |
| HUP0401367A2 (hu) | 2004-12-28 |
| KR20040016994A (ko) | 2004-02-25 |
| NO20040176L (no) | 2004-03-12 |
| EP1408954A1 (en) | 2004-04-21 |
| WO2003007934A8 (en) | 2004-04-29 |
| ATE435014T1 (de) | 2009-07-15 |
| EP1408954B1 (en) | 2009-07-01 |
| DK1408954T3 (da) | 2009-10-12 |
| CN1555258A (zh) | 2004-12-15 |
| RS4604A (en) | 2006-12-15 |
| RU2004100966A (ru) | 2005-03-10 |
| CN1259911C (zh) | 2006-06-21 |
| JP4362367B2 (ja) | 2009-11-11 |
| CY1109429T1 (el) | 2014-08-13 |
| US20090105334A1 (en) | 2009-04-23 |
| DE60232796D1 (de) | 2009-08-13 |
| WO2003007934A1 (en) | 2003-01-30 |
| ES2327721T3 (es) | 2009-11-03 |
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